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orthopedic clinical
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  骨科临床
     DATA SOURCES:A computer-based search was conducted in Medline for articles related to the BMP in orthopedic clinical trials published between January l 997 and December 2005 with the of "BMP,fracture,bone",and the language was limited in English.
     资料来源:应用计算机检索Medline 1997-01/2005-12期间与骨形态发生蛋白在骨科临床试验研究有关的文章,检索词“BMP,fracture,bone”,并限定文章语言种类为“English”。
短句来源
     Application of EBM in orthopedic clinical teaching
     循征医学在骨科临床实习带教中的运用
短句来源
     AIM: To analyze anxiety, depression and related factors in fracture inpatients by means of questionnaire investigation, so as to provide evidence for orthopedic clinical psychological intervention.
     目的:采用问卷调查法分析骨折住院患者的焦虑抑郁及其相关因素,为骨科临床心理干预提供依据。
短句来源
  “orthopedic clinical”译为未确定词的双语例句
     Deng’s orthopedic clinical research treatment for Ischemic Necrosis of the Femoral Head using poultice
     邓氏骨伤科膏药治疗股骨头坏死的临床研究
短句来源
     Conclusion: This system can fit the needs of information digitization in most hospitals in China and it can be used widely in orthopedic clinical practice.
     结论:该系统能满足我国绝大多数医院数字化建设的需要,具有广阔的应用前景.
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  相似匹配句对
     Application of EBM in orthopedic clinical teaching
     循征医学在骨科临床实习带教中的运用
短句来源
     Applying of Clinical Pathway in orthopedic diseases
     临床路径在骨科的运用研究
短句来源
     In clinical stage C and D.
     其中C、D期与A、B期相比有显著性差异(P<0.01)。
短句来源
     The clinical study.
     临床研究部分。
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  orthopedic clinical
The plain radiograph remains a key tool in the orthopedic clinical management of hip OA.
      
Orthopedic clinical biomechanics laboratory The Department of Orthopaedic Surgery, The University of Tokyo.
      


Objective: To introduce PDA based on Infrastructure WLANs in hospital information system. Methods: (1) Backstage: operative system based on Windows XP, procedure developed by C#.NET, database based on MicroSoft SQLServer2000,C/S model. (2) Foreground: PDA,Windows CE 2003,802.11b wireless network,the procedure developed by ASP NET,B/S three-layered model. Results: The system is compatible with wireless movable digital equipments and the traditional equipments for diagnosis and therapy. Conclusion: This system...

Objective: To introduce PDA based on Infrastructure WLANs in hospital information system. Methods: (1) Backstage: operative system based on Windows XP, procedure developed by C#.NET, database based on MicroSoft SQLServer2000,C/S model. (2) Foreground: PDA,Windows CE 2003,802.11b wireless network,the procedure developed by ASP NET,B/S three-layered model. Results: The system is compatible with wireless movable digital equipments and the traditional equipments for diagnosis and therapy. Conclusion: This system can fit the needs of information digitization in most hospitals in China and it can be used widely in orthopedic clinical practice.

目的:介绍以掌上电脑为终端(PDA)的非独立式无线局域网络在医院信息系统中的应用.方法:服务器采用Windows2000Server操作系统,数据库采用MicroSoftSQLServer2002,后台系统基于中文WindowsXP操作系统,采用C#·NET进行开发,C/S结构;前台系统采用PDA,WindowsCE2003操作系统,IEEE802,11b无线网络,使用ADP·NET开发,B/S3层结构.建模采用PowerDesigner9·5;服务器与台式机之间采用星型拓普网络结构.结果:基于以掌上电脑为终端的非独立式无线局域网络开发出的医院信息系统具有强大网络漫游功能,可同时兼容无线移动数字化诊疗设备和传统诊疗设备,安全稳定,性能卓越.结论:该系统能满足我国绝大多数医院数字化建设的需要,具有广阔的应用前景.

AIM: To analyze anxiety, depression and related factors in fracture inpatients by means of questionnaire investigation, so as to provide evidence for orthopedic clinical psychological intervention.METHODS: From May 2003 to April 2004, 200 inpatients with fracture were selected as objects from Department of Orthopedics, the Second Affiliated Hospital of Dalian Medical University, Department of Orthopedics of Dalian Second People's Hospital Department of Orthopedics, Dalian Fourth People's Hospital, and...

AIM: To analyze anxiety, depression and related factors in fracture inpatients by means of questionnaire investigation, so as to provide evidence for orthopedic clinical psychological intervention.METHODS: From May 2003 to April 2004, 200 inpatients with fracture were selected as objects from Department of Orthopedics, the Second Affiliated Hospital of Dalian Medical University, Department of Orthopedics of Dalian Second People's Hospital Department of Orthopedics, Dalian Fourth People's Hospital, and Department of Orthopedics of the 210 Hospital of Chinese PLA. Totally 110 healthy subjects were selected from personnel, relatives and students in Zhongshan college of Dalian Medical University as the control group. The general information of the inpatients were investigated with the self-designed general questionnaire. Anxiety was assessed with self-rating anxiety scale (SAS), consisted of 20 items, each symptom scored by 1 to 4 grades, each score add together to get the total crude score and the total crude score multiplied by 1.25 as the standard score, the value of delimitation was 50. Depression was assessed with self-rating depression scale (SDS), consisted of 20 items, each symptom scored by 1 to 4 grades, each score add together to get the total crude score and the total crude score multiplied by 1.25 as the standard score, the value of delimitation was 53. Personality was evaluated with adult Eysenck personality questionnaire (EPQ), consisted of 85 items and 4 factors including introversion and extraversion, neuroticism, psychoticism and conceal, the crude scores were compared directly. Degree of perceived social support came from various social sources, for example family, friends and others, was evaluated on perceived social support scale (PSSS), including 12 items, each item scored by 1 to 7 grades, analyzed by total support score, the higher the better. Inpatients with fracture were interviewed by questionnaire investigation, 3-7 days after admission; students in the control group had no exam in course of assessment. The t test, χ2 test, rank sum test, Pearson correlation analysis, simple and multiple linear regression analysis were applied.RESULTS: Totally 200 questionnaires and scales were sent out, and 185 of them were qualified, the effective rate was 92.5% in the facture group. Totally 110 questionnaires and scales were sent out, and 101 of them were qualified, the effective rate was 91.8% in the control group. ① The incidence rate of anxiety was 45.4% (84/185) and that of depression was 50.3% (93/185) in the fracture group, which were significantly different from those in the control group 10.9% (11/101); 22.8% (23/101) . The incidence rate of anxiety plus depression was 33.5% (62/185). Correlation analysis showed that there was a high positive correlation between anxiety and depression (r=0.605, P < 0.01), anxiety and depression respectively had a significantly positive correlation with personality of neuroticism and psychoticism scores, expenses and days of hospitalization (P < 0.05), but respectively had significantly negative correlation with perceived social support, introversion and extraversion, lie (P < 0.05). The standard scores of anxiety and depression were significantly higher in the fracture group than in the control group (P < 0.01). ② Scores of SAS and SDS in the fracture group were regarded as dependent variables and age as independent variables when we performed simple linear regression analysis. Regression equation of anxiety was Y=41.441+0.161X, and regression equation of depression was Y=42.966+0.169X. The level of anxiety was significantly different in fracture patients of different age (F=10.886, P < 0.01); The level of depression was significantly different in fracture patients of different age (F=14.946, P < 0.01). Scores of anxiety and depression were increased gradually with aging. ③ Scores of SAS and SDS in the fracture group were regarded as dependent variables and gender, age, marriage, education degree, vocation, income per year, fracture position, operation, physical disease, expenses and days of hospitalization, insurance, personality, perceived social support as independent variables when we did Backward multiple linear stepwise regression analysis. It showed that there were five factors entered regression equation of anxiety, they were perceived social support, personality of neuroticism score, gender, days of hospitalization and single; And there were six factors entered the regression equation of depression, they were personality of neuroticism score, perceived social support, expenses of hospitalization, unmarried, physical disease and education degree. CONCLUSION: It is concluded that the levels of anxiety and depression are very high in fracture inpatients, and it is associated with multi-factors. Perceived social support, personality of neuroticism score, gender, days of hospitalization and single have influence on anxiety of fracture patients, and personality of neuroticism score, perceived social support, expenses of hospitalization, unmarried, physical disease and education degree have influence on depression of fracture patients.

目的:采用问卷调查法分析骨折住院患者的焦虑抑郁及其相关因素,为骨科临床心理干预提供依据。方法:于2003-05/2004-04选择大连医科大学附属第二医院骨科,大连市第二医院骨科,大连市第四医院骨科,解放军第二一○医院骨科的住院骨折患者200例为骨折组观察对象。对照组主要在大连医科大学中山学院工作人员、家属及学生中选取躯体功能健康者110人。采用自制的一般情况调查表获悉骨折患者的基本情况。焦虑状况评定采用焦虑自评量表,每项症状按1~4级评分,各项得分相加得总粗分,将总粗分乘以1.25即得标准分,50分为临界值。抑郁评定采用抑郁自评量表,每项症状按1~4级评分,各项得分相加得总粗分,将总粗分乘以1.25即得标准分,53分为临界值。人格评定采用成人艾森克人格问卷,共85题,分内外向、神经质、精神质和掩饰4个因子,直接对粗分进行比较分析。对来自各种社会资源如家庭、朋友和其他方面支持的感受程度的评定采用领悟社会支持量表,包括12个自评项目,采用1~7级计分法,以支持总分参加分析,分数越高领悟支持总程度越好。采用访谈式问卷调查。骨折组患者调查时间统一选在入院后3~7d内进行。对照组学生在测定期间无考试。结果数据进行t检...

目的:采用问卷调查法分析骨折住院患者的焦虑抑郁及其相关因素,为骨科临床心理干预提供依据。方法:于2003-05/2004-04选择大连医科大学附属第二医院骨科,大连市第二医院骨科,大连市第四医院骨科,解放军第二一○医院骨科的住院骨折患者200例为骨折组观察对象。对照组主要在大连医科大学中山学院工作人员、家属及学生中选取躯体功能健康者110人。采用自制的一般情况调查表获悉骨折患者的基本情况。焦虑状况评定采用焦虑自评量表,每项症状按1~4级评分,各项得分相加得总粗分,将总粗分乘以1.25即得标准分,50分为临界值。抑郁评定采用抑郁自评量表,每项症状按1~4级评分,各项得分相加得总粗分,将总粗分乘以1.25即得标准分,53分为临界值。人格评定采用成人艾森克人格问卷,共85题,分内外向、神经质、精神质和掩饰4个因子,直接对粗分进行比较分析。对来自各种社会资源如家庭、朋友和其他方面支持的感受程度的评定采用领悟社会支持量表,包括12个自评项目,采用1~7级计分法,以支持总分参加分析,分数越高领悟支持总程度越好。采用访谈式问卷调查。骨折组患者调查时间统一选在入院后3~7d内进行。对照组学生在测定期间无考试。结果数据进行t检验、χ2检验、秩和检验、Pearson相关分析、一元及多元线性回归分析。结果:骨折组发放问卷200份,收回合格问卷185份,有效率92.5%;对照组发放问卷110份,收回合格问卷101份,有效率91.8%。①骨折患者焦虑和抑郁的发生率分别为45.4%(84/185)和50.3%(93/185);对照组中分别仅有10.9%(11/101)、22.8%(23/101)存在焦虑、抑郁情绪,二者差异有高度显著性(P<0.01)。焦虑合并抑郁的发生率为33.5%(62/185);相关分析揭示焦虑与抑郁高度正相关(相关系数为0.605,P<0.01);焦虑、抑郁分别与神经质、精神质、住院费用、住院天数呈显著正相关(P<0.05),而与领悟社会支持、内外向、掩饰呈显著负相关(P<0.05)。骨折组焦虑、抑郁的标准分均值均高于对照组健康人群,差异有高度显著性(P<0.01)。②以骨折组焦虑与抑郁评分为因变量,年龄为自变量,进行一元线性回归分析。焦虑的一元线性回归方程为Y=41.441+0.161X;抑郁的一元线性回归方程为Y=42.966+0.169X。不同年龄骨折患者焦虑水平差异有显著性(F=10.886,P<0.01);不同年龄骨折患者抑郁水平差异有显著性(F=14.946,P<0.01);随着年龄的增加,焦虑、抑郁水平逐渐升高。③骨折组焦虑、抑郁评分为因变量,以骨折患者性别、年龄、婚姻、文化程度、职业、年经济收入、骨折部位、是否手术、伴随疾病、住院费用、住院天数、有无保险、人格(内外向、神经质、精神质和掩饰因子分)、领悟社会支持为自变量,行Backward线性逐步回归分析,结果显示在α=0.05水平上,有5个因素进入焦虑回归方程,依次是领悟支持程度、神经质、性别、住院天数、未婚;有6个因素进入抑郁回归方程,依次是神经质分、领悟支持程度、住院费用、未婚、伴随疾病、文化程度。结论:骨折住院患者焦虑、抑郁水平显著升高,且与多种因素相关。骨折患者焦虑的影响因素依次为:领悟社会支持、神经质性格、性别、住院天数和婚姻(未婚);抑郁的影响因素依次为:神经质性格、领悟社会支持、住院费用、婚姻(未婚)、伴随躯体疾病和文化程度。

OBJECTIVE:To review the literatures published in recent years on the application of bone morphogenetic protein(BMP)in bone tissue engineering,and explain the prospect of BMP application in orthopedic surgery and some problems need to be tackled.DATA SOURCES:A computer-based search was conducted in Medline for articles related to the BMP in orthopedic clinical trials published between January l 997 and December 2005 with the of "BMP,fracture,bone",and the language was limited in English.Meanwhile,relevant...

OBJECTIVE:To review the literatures published in recent years on the application of bone morphogenetic protein(BMP)in bone tissue engineering,and explain the prospect of BMP application in orthopedic surgery and some problems need to be tackled.DATA SOURCES:A computer-based search was conducted in Medline for articles related to the BMP in orthopedic clinical trials published between January l 997 and December 2005 with the of "BMP,fracture,bone",and the language was limited in English.Meanwhile,relevant Chinese articles published from January 2000 to December 2005 were searched in CNKI database with key words of "BMP" in Chinese.STUDY SELECTION:Data were checked in the first trial,and literatures with strong aim published in recent years were selected.Literatures in the same field published lately or published in authoritative journals were included,while old articles or repetitive studies were excluded. DATA EXTRACTION:A total of 54 relevant articles were collected,including 35 repeated research literatures,and the rest 19 articles were classified and reviewed.DATA SYNTHESIS:① The osteoinductive potentiality of BMP:There was a strong osteoinductive potentiality in BMP,which could induce the irreversible differentiation of mesenchymal cells into tissues of bone and cartilage.② Clinical trials have been performed to assess the efficacy of BMP in the treatment of newly fractures,bone nonunion,osteonecrosis of the femoral head and enhancement of primary spinal fusion in human:The American food and drug administration(FDA)granted the use of BMP-2(BMP-2 in a collagen carrier)for acute open tibial fractures in 2004,approved the BMP-7(3.5 mg of BMP-7 compounded with 1 g of collagen carrier)to treat nonunion of long bone in 2001 and approved the use of BMP in anterior spinal fusion with the INFUSE/LT-CAGE from Medtronic Sofamor Danek.③The carrier systems and gene therapy of BMP:There are no ideal carrier materials for BMP nowadays.Additional research is still required to determine the optimal type of carrier material for particular clinical indications.Studies have shown that gene therapy has the same efficacy in inducing bone formation as that by using BMP directly in animal models and this strategy has a number of superiorities.CONCLUSION:Researches on BMP has enormously entered the period of clinical experiment in some countries,representing a excellent application prospect in the field of Orthopaedic surgery.However,more word must be done on the carrier of BMP.Primary effect of BMP gene therapy is found in the experiment period,while research on its clinical application still needs to be further probed into.

目的:总结近年来骨形态发生蛋白在骨组织工程中应用研究的文献,阐明骨形态发生蛋白在骨科的临床应用前景及尚待解决的问题。资料来源:应用计算机检索Medline 1997-01/2005-12期间与骨形态发生蛋白在骨科临床试验研究有关的文章,检索词“BMP,fracture,bone”,并限定文章语言种类为“English”。同时检索清华同方中文系列数据库2000-01/2005-12期间相关文章,检索词“骨形态发生蛋白”。资料选择:对资料进行初筛,选取近年发表的针对性强的文献,同一领域的文献则选择近期发表或权威杂志的文章,排除较陈旧的和重复研究的文章。资料提炼:收集到54篇相关文章,其中35篇属于重复性研究文献,对其余19篇进行分类整理用于综述。资料综合:①骨形态发生蛋白具有促成骨活性:骨形态发生蛋白具有强大的促成骨活性,能够诱导间充质细胞不可逆地分化为骨、软骨组织。②骨形态发生蛋白用于治疗新鲜骨折、骨不连、股骨头坏死及脊柱融合的临床试验:美国食品和药物管理局于2004年认可骨形态发生蛋白2与可吸收胶原海绵复合物用于临床治疗开放性胫骨骨折,2001年正式批准骨形态发生蛋白7植入物(3.5mg骨形态发生蛋白7与1g...

目的:总结近年来骨形态发生蛋白在骨组织工程中应用研究的文献,阐明骨形态发生蛋白在骨科的临床应用前景及尚待解决的问题。资料来源:应用计算机检索Medline 1997-01/2005-12期间与骨形态发生蛋白在骨科临床试验研究有关的文章,检索词“BMP,fracture,bone”,并限定文章语言种类为“English”。同时检索清华同方中文系列数据库2000-01/2005-12期间相关文章,检索词“骨形态发生蛋白”。资料选择:对资料进行初筛,选取近年发表的针对性强的文献,同一领域的文献则选择近期发表或权威杂志的文章,排除较陈旧的和重复研究的文章。资料提炼:收集到54篇相关文章,其中35篇属于重复性研究文献,对其余19篇进行分类整理用于综述。资料综合:①骨形态发生蛋白具有促成骨活性:骨形态发生蛋白具有强大的促成骨活性,能够诱导间充质细胞不可逆地分化为骨、软骨组织。②骨形态发生蛋白用于治疗新鲜骨折、骨不连、股骨头坏死及脊柱融合的临床试验:美国食品和药物管理局于2004年认可骨形态发生蛋白2与可吸收胶原海绵复合物用于临床治疗开放性胫骨骨折,2001年正式批准骨形态发生蛋白7植入物(3.5mg骨形态发生蛋白7与1g胶原载体复合)上市用于治疗长骨骨不连,2002年批准美敦力公司的INFUSE/LT-CAGE腰椎融合装置用于前路腰椎融合。③骨形态发生蛋白的载体材料及基因治疗:目前骨形态发生蛋白仍没有最理想的载体,需要根据临床要求选择合适的材料,并对载体材料进行大量的试验研究以不断改进;基因治疗与直接应用骨形态发生蛋白同样具有促进骨缺损修复的能力,且前者具有后者所不具备的一些特点。结论:骨形态发生蛋白在一些国家已进入大规模的临床实验阶段,展现出良好的应用前景。骨形态发生蛋白的载体尚需不断改进。骨形态发生蛋白的基因治疗方法在动物实验阶段已初显成效,用于临床还需研究的进一步深入。

 
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