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newborns with pulmonary hemorrhage
相关语句
  新生儿肺出血
     Levels of surfactant protein A and TNF-α in bronchoalveolar lavage fluid of newborns with pulmonary hemorrhage
     新生儿肺出血支气管肺泡灌洗液SP-A及TNF-α的变化及其相关性研究(英文)
短句来源
     Objective To investigate the dynamic alterations of parameters of platelet in newborns with pulmonary hemorrhage(PHN).
     目的研究血小板参数在新生儿肺出血(PHN)中的动态变化规律。
短句来源
  “newborns with pulmonary hemorrhage”译为未确定词的双语例句
     Change and significance of surfactant protein A in BALF of newborns with pulmonary hemorrhage
     肺出血新生儿肺泡灌洗液中肺表面活性蛋白A的变化及意义
短句来源
     This study examined the levels of SPA and TNF-α in bronchoalveolar lavage fluid (BALF) and their relationship in newborns with pulmonary hemorrhage(PH).
     大量研究表明肺表面活性蛋白A(SPA)和肿瘤坏死因子-α(TNFα)参与了ALI的损伤过程,但有关两者在肺出血新生儿支气管肺泡灌洗液(BALF)中的变化及关系鲜有报道。
短句来源
     Objective To study the change of surfactant protein A(SP-A)in bronchoalveolar lavage fluid(BALF)and the relationship with prognosis in newborns with pulmonary hemorrhage.
     目的研究肺表面活性蛋白A(SP-A)在肺出血新生儿支气管肺泡灌洗液(BALF)中的变化及其与预后的关系。
短句来源
     Results The content of SP-A in BALF in newborns with pulmonary hemorrhage was significantly lower than that in group control(P<0.01).
     结果肺出血组BALF中SP-A含量较对照组显著降低(P<0.01);
短句来源
     Changes and significance of nitric oxide and endothelin-1 in blood of newborns with pulmonary hemorrhage
     肺出血新生儿血中一氧化氮和内皮素-1水平变化及意义
短句来源
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Objective To study the changes of nitric oxide (NO) and endothelin-1 (ET-1) and the relationship between these changes and this prognosis in newborns with pulmonary hemorrhage (PH). Methods Nitric acid reductase and radioimmunoassay methods were respectively used to measure concentrations of serum NO and plasma ET-1 in group control (n=15), group survival with PH within an acute phase (survival, n=13), group survival with PH within a recovery phase (recovery, n=13) and group deadth with PH (deadth,...

Objective To study the changes of nitric oxide (NO) and endothelin-1 (ET-1) and the relationship between these changes and this prognosis in newborns with pulmonary hemorrhage (PH). Methods Nitric acid reductase and radioimmunoassay methods were respectively used to measure concentrations of serum NO and plasma ET-1 in group control (n=15), group survival with PH within an acute phase (survival, n=13), group survival with PH within a recovery phase (recovery, n=13) and group deadth with PH (deadth, n=7). Results The concentrations of serum NO were 63.0±10.7 μmol/L, 32.0±7.5 μmol/L, 68.2±6.9μmol/L and 20.1±5.2 μmol/L in group control, group survival, group recovery and group death respectively. The concentrations of ET-1 were 19.6 ± 4.0 ng/L, 43.0 ± 8.9 ng/L, 20.7 ± 4.5 ng/L and 54.1±3.9 ng/L respectively. The rates of NO/ET-1 were 3.21, 0.74, 3.29 and 0.37 respectively. The differences among the four groups were markedly significant.Conclusions The concentration of NO is decreased, while the concentration of ET-1 is elevated in newborns with PH.The rate of NO/ET-1 is strongly correlated with the severity of illness and may be considered as an indicator of the prognosis of PH.

目的 研究一氧化氮(NO)和内皮素- 1(ET- 1) 在肺出血新生儿血中的变化及其与预后的关系。方法 用硝酸还原酶法和放射免疫法分别测定对照组(n= 15) ,肺出血存活极期组( 存活组,n = 13),肺出血恢复期组( 恢复组,n= 13) 和肺出血死亡组( 死亡组,n= 7) 四组新生儿血中NO 和ET- 1 的水平。结果 对照组,存活组,恢复组和死亡组的NO 水平分别为63.0 ±10 .7 μmol/L,32.0 ±7.5 μmol/L ,68 .2 ±6.9 μmol/L 和20 .1 ±5 .2 μmol/L;ET- 1 水平分别为19.6 ±4.0ng/L, 43 .0±8.9 ng/L ,20.7 ±4 .5 ng/L和54.1 ±3 .9 ng/L;NO/ET- 1 比值分别为3 .21 ,0.74,3 .29 和0.37。NO 与ET- 1 浓度之间呈负相关,r = - 0.79 (P<0 .01)。各组之间差异有显著意义( P<0 .01 或P< 0 .05) 。结论 肺出血新生儿血中NO 降低,ET- 1 升高, 二者呈负相关,NO/ET-1 比值降低与疾病严重程度密切相关,后者可作...

目的 研究一氧化氮(NO)和内皮素- 1(ET- 1) 在肺出血新生儿血中的变化及其与预后的关系。方法 用硝酸还原酶法和放射免疫法分别测定对照组(n= 15) ,肺出血存活极期组( 存活组,n = 13),肺出血恢复期组( 恢复组,n= 13) 和肺出血死亡组( 死亡组,n= 7) 四组新生儿血中NO 和ET- 1 的水平。结果 对照组,存活组,恢复组和死亡组的NO 水平分别为63.0 ±10 .7 μmol/L,32.0 ±7.5 μmol/L ,68 .2 ±6.9 μmol/L 和20 .1 ±5 .2 μmol/L;ET- 1 水平分别为19.6 ±4.0ng/L, 43 .0±8.9 ng/L ,20.7 ±4 .5 ng/L和54.1 ±3 .9 ng/L;NO/ET- 1 比值分别为3 .21 ,0.74,3 .29 和0.37。NO 与ET- 1 浓度之间呈负相关,r = - 0.79 (P<0 .01)。各组之间差异有显著意义( P<0 .01 或P< 0 .05) 。结论 肺出血新生儿血中NO 降低,ET- 1 升高, 二者呈负相关,NO/ET-1 比值降低与疾病严重程度密切相关,后者可作为肺出血患儿预后估计的指标。

Objective Recent studies have suggested that acute lung injury (ALI ) is an important cause of pulmonary hemorrhage of the newborn (PHN) and that surfactant protein A (SP-A) and tumor necrosis factor-α (TNF-α) are involved in the development of ALI. This study examined the levels of SPA and TNF-α in bronchoalveolar lavage fluid (BALF) and their relationship in newborns with pulmonary hemorrhage(PH). Methods Twenty newborn infants with PH and 15 sick neonates but without PH (Control group) were enrolled...

Objective Recent studies have suggested that acute lung injury (ALI ) is an important cause of pulmonary hemorrhage of the newborn (PHN) and that surfactant protein A (SP-A) and tumor necrosis factor-α (TNF-α) are involved in the development of ALI. This study examined the levels of SPA and TNF-α in bronchoalveolar lavage fluid (BALF) and their relationship in newborns with pulmonary hemorrhage(PH). Methods Twenty newborn infants with PH and 15 sick neonates but without PH (Control group) were enrolled in this study. According to the prognosis, the PH group was subdivided into Survival group (n=14) and Death group (n=6). The Western-dot blot analysis and enzyme-linked immunoadsorbent assay (ELISA) were used to detect the levels of SP-A and TNF-α in BALF and serum TNF-α level. Results The SP-A levels in BALF in the survival PH patients in the acute stage and in the death PH cases were significantly lower than those of the Control group. The death PH patients showed a much lower SP-A level in BALF than the survival ones in the acute stage. Whilst the recovery stage of PH, the SP-A level in BALF in the survival patients increased significantly and remained the similar level as the Control group. The TNF-α levels in both serum and BALF in the survival PH patients in the acute stage and in the death PH cases were significantly higher than those in the Control group. The death PH cases showed a higher level of TNF-α in serum and BALF than PH survival cases in the acute stage. The increased extent of TNF-α level in BALF was obviously greater than of that in serum. In the recovery stage, the level of TNF-α in BALF was significantly reduced and almost returned to the level of the Control group in the survival PH cases compared with that in the acute stage. There was a negative correlation between the BALF SP-A and TNF-α levels in newborns with PH (r = - 0.635,P = 0.003). Conclusions SP-A and TNF-α may be involved in the process of lung injury in PHN. Monitoring the levels of SP-A and TNF-α is useful for the early diagnosis and treatment and the evaluation of the outcome of PHN.

目的近年研究发现急性肺损伤(ALI)是致新生儿肺出血的重要原因。大量研究表明肺表面活性蛋白A(SPA)和肿瘤坏死因子-α(TNFα)参与了ALI的损伤过程,但有关两者在肺出血新生儿支气管肺泡灌洗液(BALF)中的变化及关系鲜有报道。该研究旨在探讨SPA和TNFα在新生儿肺出血发生中的作用,两者间的关系及对预后的影响。方法采用斑点免疫印迹法和酶联免疫吸附法分别测定对照组(n=15),肺出血存活组急性期(n=14)、恢复期(n=14)和肺出血死亡组(n=6)新生儿BALF中SPA,TNFα和血清TNFα水平。结果存活组和死亡组新生儿肺出血急性期BALF中SPA含量(38.50±7.62,29.43±6.57)较对照组(44.88±7.48)显著降低(P=0.024,P=0),且死亡组SPA明显低于存活组急性期(P=0.015),存活组肺出血恢复期SPA水平(45.16±7.25)明显升高,接近对照组(P>0.05);而肺出血存活组和死亡组BALF中TNFα含量(208.54±64.69ng/L,319.16±46.79ng/L)较对照组(96.40±37.82ng/L)显著增加(P=0.011,P=0),死亡组比...

目的近年研究发现急性肺损伤(ALI)是致新生儿肺出血的重要原因。大量研究表明肺表面活性蛋白A(SPA)和肿瘤坏死因子-α(TNFα)参与了ALI的损伤过程,但有关两者在肺出血新生儿支气管肺泡灌洗液(BALF)中的变化及关系鲜有报道。该研究旨在探讨SPA和TNFα在新生儿肺出血发生中的作用,两者间的关系及对预后的影响。方法采用斑点免疫印迹法和酶联免疫吸附法分别测定对照组(n=15),肺出血存活组急性期(n=14)、恢复期(n=14)和肺出血死亡组(n=6)新生儿BALF中SPA,TNFα和血清TNFα水平。结果存活组和死亡组新生儿肺出血急性期BALF中SPA含量(38.50±7.62,29.43±6.57)较对照组(44.88±7.48)显著降低(P=0.024,P=0),且死亡组SPA明显低于存活组急性期(P=0.015),存活组肺出血恢复期SPA水平(45.16±7.25)明显升高,接近对照组(P>0.05);而肺出血存活组和死亡组BALF中TNFα含量(208.54±64.69ng/L,319.16±46.79ng/L)较对照组(96.40±37.82ng/L)显著增加(P=0.011,P=0),死亡组比存活组急性期增加更明显(P=0),且BALF中TNFα的变化较血清中更明显,存活组恢复期BALF中TNFα水平(112.06±35.22ng/L)明显下降,接近对照组(P>0.05);肺出血患儿BALF中SPA水平的下降与TNFα的增高呈负相关(r=0.635,P=0.003)。结论SPA和TNFα参与了新生儿肺出血的肺损伤过程,为从SPA及细胞因子角度进一步认识新生儿肺出血的发病机制提供了实验依据,为新生儿肺出血的早期防治及预后判断提供了一种新的方法。

Objective To study the change of surfactant protein A(SP-A)in bronchoalveolar lavage fluid(BALF)and the relationship with prognosis in newborns with pulmonary hemorrhage.Methods SP-A was measured by Western-dot blot analysis in group control(n=15),group survival with pulmonary hemorrhage within an acute phage(survival,n=14),group survival with pulmonary hemorrhage within a recover phage(recovery,n=14)and group death(death,n=6).Results The content of SP-A in BALF in newborns with...

Objective To study the change of surfactant protein A(SP-A)in bronchoalveolar lavage fluid(BALF)and the relationship with prognosis in newborns with pulmonary hemorrhage.Methods SP-A was measured by Western-dot blot analysis in group control(n=15),group survival with pulmonary hemorrhage within an acute phage(survival,n=14),group survival with pulmonary hemorrhage within a recover phage(recovery,n=14)and group death(death,n=6).Results The content of SP-A in BALF in newborns with pulmonary hemorrhage was significantly lower than that in group control(P<0.01).The level of SP-A in BALF in group death was found significantly lower than that in group survival(P<0.05).The level of SP-A in group recovery elevated to approach that in group control(P>0.05).Conclusion The content of SP-A in BALF may be considered as an indicator of the predict and the prognosis of pulmonary hemorrhage in newborns.

目的研究肺表面活性蛋白A(SP-A)在肺出血新生儿支气管肺泡灌洗液(BALF)中的变化及其与预后的关系。方法用斑点免疫印迹法分别测定对照组(n=15),肺出血存活极期组(存活组,n=14),肺出血恢复期组(恢复组,n=14)和肺出血死亡组(死亡组,n=6)新生儿BALF中SP-A水平。结果肺出血组BALF中SP-A含量较对照组显著降低(P<0.01);死亡组SP-A降低更明显,明显低于存活极期组(P<0.05);肺出血恢复期,SP-A水平明显恢复,接近对照组(P>0.05)。结论肺出血新生儿BALF中SP-A降低,与疾病严重程度密切相关,可作为肺出血高危新生儿预警和预后指标。

 
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