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artemether
相关语句
  蒿甲醚
     Determination of Cu, Pb,Zn,As,Sb and Cdin Artemether by ICP-AES
     ICP-AES法测定蒿甲醚中Cu、Pb、Zn、As、Sb和Cd
短句来源
     The Effect of Artemether on the Expression of IL-10 and IL-12 in HaCaT Cells after Exposure to UV
     蒿甲醚对紫外线照射后HaCaT细胞表达IL-10和IL-12的影响
短句来源
     RESULTS Dihydroartemisinin(≥62.5 μmol·L -1 ) and artemether(≥250 μmol·L -1 ) could inhibit cell viability of PC12 cells.
     结果 双氢青蒿素 (≥62 .5 μmol·L-1)和蒿甲醚 (≥ 2 5 0 μmol·L-1)减低PC1 2细胞的存活率 ;
短句来源
     Anti-tumor Effect of Artemether in CT-26 Colorectal Cancer Bearing BALB/c Mice
     蒿甲醚对BALB/c小鼠CT-26结直肠癌抑瘤作用
短句来源
     Results:Artemether has a significantly inhibitory effect on the proliferation of A549 cells in a dose-dependent manner in vitro,and the IC50 was 1.34 mg/L.
     结果:蒿甲醚对A549细胞株的半数抑制浓度(IC50)为1.34 mg/L。
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  “artemether”译为未确定词的双语例句
     high dose group,66.6mg/kg; Artemether 50mg/kg plus ferralia 1.5mg/kg; positive control group,DDP 5mg/kg;
     随机分为6组,每组8只,分别为低剂量(33.3mg/kg)、中剂量(50mg/kg)、高剂量(66.6mg/kg)和中剂量(50mg/kg)+铁剂(1.5mg/kg)组,阳性对照组为顺铂(5mg/kg),空白对照组为等体积生理盐水。
短句来源
     Results:The average recovery of artemether was 100 8%,with RSD of 1 5%( n=6 ).
     线性范围 :5 0~ 2 5 0 μg (r =0 9998)。 平均回收率为 10 0 8% ,RSD =1 5 % (n =6 )。
短句来源
     ID 50 of benflumetolum, artemether and dihydroarteannuin were 72.3, 14.6 and 13.4 nmol/L to the sensitive isolates respectively;
     结果上述 3种药物对青蒿琥酯敏感株恶性疟原虫的 ID5 0 分别为 72 .3、14.6及 13.4nm ol/ L ;
短句来源
     A combined action of artemether and daphnetin was assessed. Results Artemether 0.4mg/(kg·d)×4d exhibited no detectable antimalarial effect, while artemether 0.4mg/(kg·d)×4d combined with daphnetin 7.7 mg/kg.
     [A0 .4mg/(kg·d) +D7.7mg/(kg·d) ]× 4d的抗疟效果提高 ,与对照组相比差异有显著性 (P <0 .0 5 )。
短句来源
     The d 7schistosomules and d 35 adult worms were more susceptible to arteether or artemether withrespective worm reduction rates of 77.5% ~87.2% and 51.7% ~61.3%.
     特别是d7童虫和d35成虫组的减虫率较高,分别达77.5~87.2%和51.7~61.3%。
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  相似匹配句对
     Preparation of artemether capsules
     蒿甲醚胶囊的制备
短句来源
     The effect of artemether is dose-dependent.
     蒿甲醚还呈现一定程度的剂量依赖性。
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  artemether
Artemether-Lumefantrin wurde im Jahr 2005 als offizielle Standardtherapie für die Behandlung der unkomplizierten Plasmodium falciparum Malaria in Bangladesh eingeführt.
      
Four (6.6%) cases were resistant to quinine and responded to artemether.
      
Neither artemether nor tribendimidine showed activity against P.
      
At day 103 post-infection, four dogs were treated orally for 3?days with either artemether (total dose, 66.7 and 75?mg/kg) or tribendimidine (total dose, 100?mg/kg).
      
Artemether and tribendimidine are active against several trematode species, but no data are available regarding the lung fluke Paragonimus westermani.
      
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Artemether (Dihydro-artemisinine-12-β-methyl ether), an ether derivative of reduced qinghaosu, has been found to possess schistosomicidal actions.Mice, rabbits and dogs were exposed to 50±2 and 250±2 of Schistosoma japonicum cercariae. When infected mice were treated orally with artemether suspension at the dosages of 400~800 mg/kg in 1~4 day-course, the worm reduction rates were 55.3%~79.9%. If the drug in oil formulation was given subcutaneously, to infected mice at the dosages of 225~435 mg/kg in 3...

Artemether (Dihydro-artemisinine-12-β-methyl ether), an ether derivative of reduced qinghaosu, has been found to possess schistosomicidal actions.Mice, rabbits and dogs were exposed to 50±2 and 250±2 of Schistosoma japonicum cercariae. When infected mice were treated orally with artemether suspension at the dosages of 400~800 mg/kg in 1~4 day-course, the worm reduction rates were 55.3%~79.9%. If the drug in oil formulation was given subcutaneously, to infected mice at the dosages of 225~435 mg/kg in 3 day-course, the worm reduction rates were 70.5%~81.2%. In infected dogs treated orally with artemether suspension at the dosages of 25~35 mg/kg in 3 day-course, or treated intramuscularly with the drug in oil formulation at the dosages of 150~250 mg/kg in 5 day-course, the worm reduction rates were 52.6%~59.1% and 91.3%~99.3% respectively. Artemether was also effective against immature worms.When both infected and normal dogs were treated intramuscularly with artemether in oil formulation at the dosages of 30~90mg/kg/day for 5 days, anorexia and diarrhea occurred in some dogs, and subsided 4~5 days after the end of treatment. Three days after the end of medication, the average white blood cells were markedly decreased in uninfected dogs, but returned to normal 18 days after medication.Histo-patholgical changes of the normal dogs treated with artemether were examined. It was domonstrated that degeneration of mucosa of stomach and large intestine, villi of small intestine and epithelium of renal tubule; dilatation of blood vessels and retention of plasma in glomerulus; and fatty degeneration in liver and in adrenal were found. The above mentioned tissue alterations nearly recovered to normal 18~19 days or 30~31 days after the cessation of treatment. No significant changes were found in other tissues of the animals.

蒿甲醚混悬液总量120~800 mg/kg,分1~4天给,灌胃治疗病鼠和病免,减虫率为55.3%~88.5%;总量25~35 mg/kg,分3天给治疗病犬,减虫率为52.6%~59.1%。蒿甲醚油剂以225~435 mg/kg,分3天给,皮下注射治疗病鼠,减虫率为70.5%~81.2%;总量200~400mg/kg和150~250 mg/kg,分4~5天给分别肌注治疗病兔和病犬,减虫率分别为85.9%~90.7%和91.3%~99.3%。犬每天肌注油剂30~90 mg/kg,连注5天,出现较明显的胃肠道刺激症壮,组织学检查出现胃肠道、肝、肾等组织的可逆性病理损害。

O-Methylhydroartimisinine. (artemether) is one of the effective derivatives of artemisinine (qinghaosu). It has been demonstrated that this compound is a much more potent antimalarial than artemisinine. In order to carry out studies on its physiological disposition and put the dosage regimen design on a rational basis, a sensitive and specific bioanalytical method is required. Determination of MDHA in rabbit plasma by quantitative TLC is reported in this paper. The specificity of the method seemed to be...

O-Methylhydroartimisinine. (artemether) is one of the effective derivatives of artemisinine (qinghaosu). It has been demonstrated that this compound is a much more potent antimalarial than artemisinine. In order to carry out studies on its physiological disposition and put the dosage regimen design on a rational basis, a sensitive and specific bioanalytical method is required. Determination of MDHA in rabbit plasma by quantitative TLC is reported in this paper. The specificity of the method seemed to be quite good. Lower limit of detection amounted to 0.1 μg. cv was less than 13%, and a total recovery of over 83% was obtained. The results showed that this method well meet the needs of preclinical studies on MDHA.

甲基还原青蒿素(MDHA)是青蒿素的衍生物,经药理及临床试验证实其抗疟疗效优于青蒿素,为了开展体内过程及药代动力学研究,使给药方案更加科学合理,急需建立生物样品的测定方法。本文报道血浆中MDHA的薄层扫描定量法。本法特异性较高,检出下限为0.1μg,CV低于13.0%,血浆回收率达83%以上。

Histological and histochemical changes of Schistosoma japonicuin and mouse liver were observed in experimental chemotherapy with artemether at two daily doses of 300 mg/kg/day.The results showed that artemether caused degeneration in the integument, intestine and genital gland of the hepatic-shifted worms and exhibited patent schistosomacidal effect which was faster and stronger to female worms than to males. The contents of glycogen and RNA, the activity of AKP and phenolase of the hepaticshifted...

Histological and histochemical changes of Schistosoma japonicuin and mouse liver were observed in experimental chemotherapy with artemether at two daily doses of 300 mg/kg/day.The results showed that artemether caused degeneration in the integument, intestine and genital gland of the hepatic-shifted worms and exhibited patent schistosomacidal effect which was faster and stronger to female worms than to males. The contents of glycogen and RNA, the activity of AKP and phenolase of the hepaticshifted worms were markedly decreased or even disappeared after treatment with artemether. Furthermore, the histochemical changes of female worms occurred earlier than those of male worms. Hydropic degeneration of the liver cells of infected mice was also observed. The glycogen and RNA contents and the AKP activity in liver were greatly decreased or disappeared.

本文观察了蒿甲醚实验治疗小鼠血吸虫病时,其体内血吸虫及宿主肝脏的组织学与组织化学改变。发现蒿甲醚不仅能引起肝移虫的体表、肠管及生殖器官等明显退化变性,而且具有明显的杀血吸虫成虫作用,其杀雌虫作用尤为迅速和强烈。该药可使肝移虫体的糖原,碱性磷酸酶,RNA及酚酶明显减少或消失;雌虫出现这些变化较雄虫为早。同时,蒿甲醚可引起小鼠肝细胞水样变性,肝脏糖原、碱性磷酸酶及RNA明显减少甚至消失。

 
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