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-deiodinase
相关语句
  5′-脱碘酶
     5'-DEIODINASE ACTIVITIES DECLINE BY SELENIUM DEFICIENCY IN RAT TISSUES
     硒缺乏降低大鼠组织中5′-脱碘酶活性
短句来源
     After 2, 4, and 6 weeks, GSH-Px and 5'-deiodinase activities in selenium deficient rat tissues were significantly lower than that in control.
     试验进行2、4、6周后,试验组大鼠组织中GSH-Px及5′-脱碘酶活性比对照组显著降低。
短句来源
     Modulation of type Ⅰ iodothyronine 5'-deiodinase activity by selenium is probably due to selenium's direct role as a cofactor of the enzyme;
     硒调节5′-脱碘酶活性可能因为硒是Ⅰ型脱碘酶的辅助因子;
短句来源
     Male weanling Hooded Lister rats were used as an animal model, which were fed semi-synthetic diets with different selenium content (0.005 ppm Se in basal diet, and 0.105 ppm Se in control diet) for six weeks. The influence of selenium nutritional status on the iodothyronine 5'-deiodinase activities in rat liver, kidney, brain, pituitary and brown adipose tissue (BAT) were studied.
     用不同硒含量的半合成饲料(试验组饲料含硒0.005ppm,对照组饲料含硒0.105ppm),饲喂断奶的Hooded Lister大鼠6周,研究了在不同硒营养状态下,大鼠肝、肾、脑、垂体及褐脂中5′-脱碘酶活性的变化。
短句来源
     In liver, the GSH-Px activity decreased 94%, 99% and 99.92%, while the 5'-deiodinase activity decreased 62%,80% and 90%, after six weeks's selenium depletion.
     按组织中GSH-Px及5′-脱碘酶活性下降幅度的大小,可把各组织分别排序为:肝>肾>褐脂>垂体>脑和肝>肾>褐脂>脑>垂体。
短句来源
  “5 '-deiodinase”译为未确定词的双语例句
     Serum TT4, TT3 , rT3 and TSH of the progenies were determined on postnatal day 14 and 28. Activities of T4 5'-deiodinase and 5-deiodinase in the cerebrum of filial mice were measured too.
     测定14和28日龄仔鼠血清TSH、TT4、TT3和rT3水平,及0、14和28日龄仔鼠大脑5’-和5-脱碘酶活性。
短句来源
     The activity of T_4 5'- deiodinase in rat liver and brain and serum T_4,T_3 and rT_3 content were determined at 30 weeks of experiment.
     测定了喂养30周大鼠肝脏、大脑组织T_45'—脱碘酶活性以及血清T_4、T_3及rT_3水平。
短句来源
     On postnatal day 0 and 14, iodothyronine 5'-deiodinase activities in the cerebrum of the progenies in the iodine excess group were significantly higher than those in the control group , while the iodine excess plus selenium group were lower than those in the iodine excess group (P<0.05);
     0和14日龄仔鼠脑5’-脱碘酶活性高碘组显著高于对照组(P<0.05),高碘补硒组显著低于高碘组。
短句来源
     The results showed that the activity of hepatic T_4 5'-deiodinase in two Se-deficient groups (I~+Se~- and I~-Se~-) was significantly lower than that in two Se-supplemented groups (I~+Se~+ and I~-Se~+), but there was no effect of iodine deficiency or supplement on this.
     结果表明大鼠肝脏T_45'—脱碘酶活性于低硒组(I~+Se~-和I~-Se~-)明显低于补硒组(I~+Se~+和1~-Se~+),而碘因素对此无影啊;
短句来源
     Thyroid hormones and 5'-deiodinase and 5-deiodinase in serum and cerebrum were determined on postnatal day 0 and 14.Results:On postnatal day 0 and 14,TT4 level in serum,TT3 and rT3 concentrations in the cerebrum of progeny of mice were lower significantly in iodine excess group than those in control group(P < 0.05).
     结果:高碘组14d仔鼠血清TT4水平以及0d、14d仔鼠脑组织TT4、TT3和rT3含量显著低于对照组,脑5’-脱碘酶活性显著高于对照组,脑5-脱碘酶活性显著低于对照组。
短句来源
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  相似匹配句对
     5. P.E.
     5.当前高校体育课程资源没有得到合理的开发与利用。
短句来源
     (5)
     (5)没有发现雌核发育的异精效应。
短句来源
     [1-5].
     dinger方程的求解,由此可以利用文[1]和[3~5]中的方法得到这两类问题的通解;
短句来源
     5'-DEIODINASE ACTIVITIES DECLINE BY SELENIUM DEFICIENCY IN RAT TISSUES
     硒缺乏降低大鼠组织中5′-脱碘酶活性
短句来源
     (5)If R-(?)
     (5)如(?)
短句来源
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  -deiodinase
Differential responses of rat pineal thyroxine type II 5'-deiodinase andN-acetyltransferase activities to either light exposure,
      
Moreover, pineal NAT nocturnal peak was reached at 4 h (2 hours later than controls), while pineal type II thyroxine 5'-deiodinase (5'-D) nyctohemeral profile was not modified by ethanol administration.
      
Effect of chronic ethanol administration on the rat pineal N-acetyltransferase and thyroxine type II 5'-deiodinase activities
      
Type II thyroxine 5'-deiodinase (5'-D) activity in both pineal and Harderian glands of the Swiss mouse was studied.
      
Nyctohemeral rhythmicity of type II thyroxine 5'-deiodinase activity in the pineal gland but not in the Harderian gland of the S
      
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The acute and chronic effects of propylthiouracil (PTU) on serum thyroid hormone concentrations were assessed with that of methimazole as control. For the study of acute effects, among 54 untreated patients with hyperthyroidism selected at random, a single dose of PTU 200 mg and methimazole 20 mg were given to 29 and 25 patients respectively. And then 15 patients of each group were randomly selected for the study of chronic effects;PTU was given orally 100 mg t.i.d., and methimazole 10 mg t. i. d. for 4 weeks....

The acute and chronic effects of propylthiouracil (PTU) on serum thyroid hormone concentrations were assessed with that of methimazole as control. For the study of acute effects, among 54 untreated patients with hyperthyroidism selected at random, a single dose of PTU 200 mg and methimazole 20 mg were given to 29 and 25 patients respectively. And then 15 patients of each group were randomly selected for the study of chronic effects;PTU was given orally 100 mg t.i.d., and methimazole 10 mg t. i. d. for 4 weeks. Serum T3, T4 and rT3 were assayed. The results suggested that PTU and methimazole might exert different effects on T3 production. It seemed that PTU also inhibited the conversion of T4 to T3 by reducing the activity of 5'-deiodinase, thus resulting in normalization of T3. PTU is better than methimazole in treating severe hyperthyroidism and thyroid crisis as well. There was no significant difference between the chronic effects of both antithyroid drugs on serum thyroid hormone levels.

本文报告29例甲亢患者一次顿服PTU 200mg后血清甲状腺激素水平的急性变化,及15例患者日服PTU 300mg连续4周后血清甲状腺激素水平的慢性变化。并以Methimazole为对照进行比较,探讨了PTU急性和慢性作用的机理及临床实用意义。本研究结果表明,PTU可能通过对5'脱碘酶的抑制,减少外周组织T_4转换成T_3,迅速控制血清中生物活性较强的T_3水平,在严重甲亢或甲亢危象时应首先选用。PTU及Methimazole长期应用均可使血清甲状腺激素水平显著下降,且两药效果无明显差别。

The thyroid hormone level and cell-nuclear soluble T_3 receptor-relatedparameters in brain were determined in 1st generation neonatal rats at 20 daysafter birth by RIA,The mothers and their offsprings were all fed with iodinedeficient food from a marked iodine-deficient village(Luo-Shui-Quan Village,Chi-Feng County,Nei-Monggol Autonomous District,PRC).Our present results showed that during critical period of rat brain deve-lopment,the body and brain weights in iodine-deficient group(ID)were lowerthan those in...

The thyroid hormone level and cell-nuclear soluble T_3 receptor-relatedparameters in brain were determined in 1st generation neonatal rats at 20 daysafter birth by RIA,The mothers and their offsprings were all fed with iodinedeficient food from a marked iodine-deficient village(Luo-Shui-Quan Village,Chi-Feng County,Nei-Monggol Autonomous District,PRC).Our present results showed that during critical period of rat brain deve-lopment,the body and brain weights in iodine-deficient group(ID)were lowerthan those in control groups,and T_4 concentration in serum and brainhomogenate were significantly decreased(p<0.001),but the concentration ofT_3 both in serum and in brain homogenate and that of T_3 binding to nuclearreceptor were insignificantly different ascompared with those of the controlgroups.By Scatchard plotting,the corrected affinity constant(Ka)and themaximal binding capacity(MBC)of nuclear T_3 receptor in ID rat brain were insignificantly different from those of the control groups,too;however,there was a tendency for MBC of ID rats to increase.On the other hand,theT_4 5′-deiodinase activity increased markedly(p<0.001)in ID rats so as tomaintain brain T_3 level not to lower.Our findings indicated that early in the iodine-deficient period,there wou-ld be a mechanism for limited compensation in organism.

用地甲肿与地克病高发区粮食饲养大鼠,实验观察到第一代仔鼠20日龄时脑内 T_4浓度明显下降,差别非常显著;但 T_3浓度、脑细胞核 T_3受体 Ka 值与 MBC 值,经统计学处理无显著性,而 T_4 5’—脱碘酶活性则显著增高。提示在碘缺乏早期,机体存在有限的代偿机制。

Female rats were divided into three groups: 1) LI group, receiving low iodine diet and distilled water; 2) NI group being fed with the same food as LI group and distilled water supplemented with potassium iodide; and 3) N group,taking usual diet and tap water. T4 5'-deiodinase, T, and T4 content in whole brain homogenate and serum T, and T4 level of the young animals delivered by the above-mentioned rats were analyzed. Deiodinase activity was expressed in terms'of T3→T4 conversion rate (CR). The...

Female rats were divided into three groups: 1) LI group, receiving low iodine diet and distilled water; 2) NI group being fed with the same food as LI group and distilled water supplemented with potassium iodide; and 3) N group,taking usual diet and tap water. T4 5'-deiodinase, T, and T4 content in whole brain homogenate and serum T, and T4 level of the young animals delivered by the above-mentioned rats were analyzed. Deiodinase activity was expressed in terms'of T3→T4 conversion rate (CR). The results showed that the average CR in rat brain homogenates of LI group was significantly higher than those of the other two groups, it is 2.73 times of that in N group. There were no significant differences among the three groups in serum T3 concentration and T3 content of brain homogenate. But serum T4 concentration of LI group was only 10.9% of that in N group and brain homogenate T4 level was also lower, being only 38.5% of the latter. It suggested that T4 5'-deiodinase in the immature rat brain is more effective than in adult one on modulating thyroid hormone function in brain. Thus, the increased activity of brain T4 5'-deiodinase may compensate for the decreased T4 pool, maintaining a normal brain T3 content in congenital iodine-deficient rat.

将成年Wistar大鼠随机分成三组,缺碘组(LI组):饲以低碘饲料并饮用无离子水;加碘对照组(NI组):饲料同上而饮水加碘化钾;以及普食组(N组):饲以标准实验室饲料,饮用自来水。以它们的第一代仔鼠(20日龄)为实验对象,测定了全脑匀浆的T_4 5'-脱碘酶活性、血清及匀浆的T_4和T_3含量。发现LI组匀浆T_4→T_3的转化率显著高于其他两组,血清及匀浆的T_3含量三组间无显著差别。但LI组的血清T_4含量为N组的10.9%,其匀浆的T_4水平也只有N组的38.5%。提示未成熟大鼠脑组织T_45'-脱碘酶活性的提高,可以补偿T_4代谢库的不足,维持先天性缺碘仔鼠脑组织T_3含量正常。

 
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