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acute hypoxic ischemic brain damaged
相关语句
  急性脑缺氧缺血
     The Replication of Acute Hypoxic Ischemic Brain Damaged Animal Model in Baby Mice
     新生小鼠急性脑缺氧缺血动物模型的建立
短句来源
     Objective To replicate the acute hypoxic ischemic brain damaged animal model.
     目的 建立急性脑缺氧缺血的动物模型。
短句来源
  相似匹配句对
     Objective To replicate the acute hypoxic ischemic brain damaged animal model.
     目的 建立急性脑缺氧缺血的动物模型。
短句来源
     The Replication of Acute Hypoxic Ischemic Brain Damaged Animal Model in Baby Mice
     新生小鼠急性脑缺氧缺血动物模型的建立
短句来源
     Brain hypoxic and ischemic proconditioning
     脑缺血缺氧预处理
短句来源
     Caspase and hypoxic ischemic brain damage
     半胱天冬酶与缺氧缺血性脑损伤
短句来源
     Protective Effects of Topamax in Neonate Rats with Hypoxic-Ischemic Brain Damaged
     妥泰对新生大鼠缺氧缺血性脑损伤的保护作用
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Objective To replicate the acute hypoxic ischemic brain damaged animal model.Methods The uterine arteries of full\|term pregnant mice were ligated to interrupt the blood supply by cesarean section.The baby mice with asphyxia were observed for their physical and behavior development and their pathological changes in their brains.Results With prolonging the duration of interrupting the blood supply,the morbidity in fetal mice increased.The relationship between those was positive linear correlation...

Objective To replicate the acute hypoxic ischemic brain damaged animal model.Methods The uterine arteries of full\|term pregnant mice were ligated to interrupt the blood supply by cesarean section.The baby mice with asphyxia were observed for their physical and behavior development and their pathological changes in their brains.Results With prolonging the duration of interrupting the blood supply,the morbidity in fetal mice increased.The relationship between those was positive linear correlation ( P <0.05).The development of body weight and behavior in baby mice was reatrded.The pathologic changes in the brains were apparent,which were similar to the neonatal.Conclusion The animal model can be used for the study of the neonatal hypoxic ischemic brain damage.\;

目的 建立急性脑缺氧缺血的动物模型。方法 采用足月妊娠小鼠 (查到阴道栓后 19.5d) ,用剖宫手术方法 ,暴露子宫 ,用止血钳阻断双侧子宫动脉血管 ,致使缺氧缺血后脑部发生病理改变。结果 随着阻断子宫血管时间的延长 ,胎鼠的死亡率增高 ,两者具有直线正相关关系 (P <0 .0 5 )。实验组胎鼠体重 (出生至离乳 )增长缓慢 ,胎鼠爬、翻身及对应激刺激等的运动发育明显迟缓 ,脑部的病理改变明显 ,与人的急性脑缺氧缺血的临床表现 ,脑部病理变化及其后遗症是相似的。结论 采用小鼠做急性脑缺氧缺血的动物模型 ,脑缺氧缺血效果明显 ,本模型的建立 ,可用于人的急性脑缺氧缺血的病理学、生理学及其药物治疗等诸多方面的类比实验研究

Objective To compare the apparent diffusion coefficients(ADC),proton MR spectroscopy(1H-MRS)and pathologic changes in young pigs subjected to acute hypoxic-ischemic brain damage(HIBD).Methods Thirty 7-day-old neonatal pigs were divided into sham-operation group(n=5)and hypoxic-ischemic group(n=25).HI group was divided into five small groups.ADC value,NAA/Cho,NAA/Cr,Lac/NAA,Lac/Cho and Lac/Cr were calculated on cessation of the insult,3,6,12 and 24 h after resuscitation...

Objective To compare the apparent diffusion coefficients(ADC),proton MR spectroscopy(1H-MRS)and pathologic changes in young pigs subjected to acute hypoxic-ischemic brain damage(HIBD).Methods Thirty 7-day-old neonatal pigs were divided into sham-operation group(n=5)and hypoxic-ischemic group(n=25).HI group was divided into five small groups.ADC value,NAA/Cho,NAA/Cr,Lac/NAA,Lac/Cho and Lac/Cr were calculated on cessation of the insult,3,6,12 and 24 h after resuscitation in subcortical white matter,periventricular white matter and basal ganglia.Immediately after MR examinations,injury of the brains was evaluated by hematoxylin-eosin-stained and histopathologic study.Results The hypoxic-ischemic piglets showed ADC(3.69±1.45)reduction,NAA/Cho(0.712±0.080)and NAA/Cr(1.040±0.137)decrease,Lac/NAA(1.798±0.139),Lac/Cho(1.280±0.167)and Lac/Cr(1.876±0.357)increase on cessation of the insult;transient ADC,Lac/NAA,Lac/Cho and Lac/Cr recovery,NAA/Cho progressive decrease(P<0.05)and NAA/Cr reduction(P>0.05)from 3 h to 12 h after resuscitation;secondary ADC(4.06±1.25)reduction,Lac/NAA(1.221±0.128),Lac/Cho(0.716±0.088)and Lac/Cr(1.212±0.177)increase 24 hours after resuscitation.Corresponding pathologic study revealed astrocytes gradually swelled and collapsed after resuscitation,while neurons changed mildly.The control piglets showed normal ADC,1H-MRS and pathologic investigations.Conclusions ADC value and 1H-MRS can sensitively detect lesions of early HIBD.NAA/Cho has the highest correlation with the pathological changes of early HIBD and is superior to ADC value and the other metabolite ratios in evaluating early HIBD.

目的结合病理学,对照研究MR表观扩散系数(ADC)和氢质子波谱(1H-MRS)在评价急性期缺氧缺血性脑损伤(HIBD)中的价值。方法出生后7d的新生猪30头,分成假手术对照组5头和缺氧缺血组25头。缺氧缺血组分成5组,分别于缺氧缺血(HI)后即刻、3、6、12、和24h测量皮层下白质、侧脑室旁白质及基底节区平均ADC值和脑内代谢物N-乙酰天冬氨酸(NAA)、乳酸(Lac)、肌酸(Cr)、胆碱复合物(Cho)的峰高比率,并作脑组织病理学检查。结果缺氧缺血组HI后即刻,ADC值(3.69±1.45)、NAA/Cho(0.712±0.080)和NAA/Cr(1.040±0.137)明显下降,Lac/NAA(1.798±0.139)、Lac/Cho(1.280±0.167)和Lac/Cr(1.876±0.357)明显增高。HI后3~12h,ADC值、Lac/NAA、Lac/Cho和Lac/Cr出现一过性恢复,NAA/Cho相邻组间比较差异均有统计学意义(P<0.05),而NAA/Cr相邻组间比较差异均无统计学意义(P>0.05)。HI后24h,ADC值再次明显下降(4.06±1.25),Lac/NAA(1.221±0...

目的结合病理学,对照研究MR表观扩散系数(ADC)和氢质子波谱(1H-MRS)在评价急性期缺氧缺血性脑损伤(HIBD)中的价值。方法出生后7d的新生猪30头,分成假手术对照组5头和缺氧缺血组25头。缺氧缺血组分成5组,分别于缺氧缺血(HI)后即刻、3、6、12、和24h测量皮层下白质、侧脑室旁白质及基底节区平均ADC值和脑内代谢物N-乙酰天冬氨酸(NAA)、乳酸(Lac)、肌酸(Cr)、胆碱复合物(Cho)的峰高比率,并作脑组织病理学检查。结果缺氧缺血组HI后即刻,ADC值(3.69±1.45)、NAA/Cho(0.712±0.080)和NAA/Cr(1.040±0.137)明显下降,Lac/NAA(1.798±0.139)、Lac/Cho(1.280±0.167)和Lac/Cr(1.876±0.357)明显增高。HI后3~12h,ADC值、Lac/NAA、Lac/Cho和Lac/Cr出现一过性恢复,NAA/Cho相邻组间比较差异均有统计学意义(P<0.05),而NAA/Cr相邻组间比较差异均无统计学意义(P>0.05)。HI后24h,ADC值再次明显下降(4.06±1.25),Lac/NAA(1.221±0.128)、Lac/Cho(0.716±0.088)和Lac/Cr(1.212±0.177)再次明显增高。各时间点病理结果进行性加重,以胶质细胞水肿的逐级加重、崩解为主要改变,神经元病变相对较轻。对照组ADC值、MRS和病理学检查均未见异常。结论ADC值和1H-MRS均能敏感地反映HIBD早期病灶;NAA/Cho的演变与HIBD早期病理学的动态变化最相一致,其准确性优于ADC值和其他代谢物比率。

 
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