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   chronic bronchitis model 在 呼吸系统疾病 分类中 的翻译结果: 查询用时:0.08秒
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chronic bronchitis model
相关语句
  慢性支气管炎模型
    Establshment of rat chronic bronchitis model by intratracheal instillation or lipopolysaccharide
    气管内注入脂多糖法建立大鼠慢性支气管炎模型
短句来源
    Methods 21 Sprague-Dawley (SD) rats were randomly divided into three groups : ambroxol chloride treatment group ( group A) with intraperitoneal injection of ambroxol chloride basing on chronic bronchitis model, chronic bronchitis model group( group B) induced by lipopolysaccharide instilling into the tracheas of experimental rats combining cigarette smoking, control group(group C).
    方法:21只SD大鼠随机分为AMB干预组(A组)、模型组(B组)、实验对照组(C组); 脂多糖-香烟烟雾诱导法建立慢性支气管炎模型,AMB 30mg/kg腹腔注射进行干预;
短句来源
    Methods Rat chronic bronchitis model was established by intratracheal instillation of small dose of lipopolysaccharide (LPS, 1 g/L). Experiments were performed in 28 male Sprague Dawley rats, which comprised four groups in random, i.e. chronic bronchitis model group, normal saline treated group, dexamethasone treated group and healthy control group.
    方法 雄性SD大鼠气管内注入浓度为 1g/L的脂多糖 2 0 0 μl制成大鼠慢性支气管炎模型 ,随机分为健康对照组、模型组、生理盐水组及氟美松组 ,每组 7只。
短句来源
  慢支模型
    Rats were treated by bilirubin (20mg/kg/d) through feeding 2 hours before the chronic bronchitis model had been estabilished in bilirubin treated group, once a day, 21 days in all.
    胆红素干预组:在制备慢支模型前2小时给予间接胆红素灌胃20mg/kg/日,每日一次,共21天。
短句来源
    Rat chronic bronchitis model was estabilished by intratracheal instillation of small dose of Lipopolysaccharide (LPS, lg/L) in chronic bronchitis group.
    慢支组:采用大鼠气管内注入脂多糖(LPS,浓度为1g/L的200μl)的方法制备慢支模型
短句来源
  “chronic bronchitis model”译为未确定词的双语例句
    Expression of EGR-1、PDGF-BB in Chronic Bronchitis Model of Rats and the Interference of Drugs
    慢性支气管炎大鼠支气管肺组织EGR-1、PDGF-BB的表达及药物干预的影响
短句来源
    Results (1) The levels of TNFα and MIP 2 in BALF and lung tissues, and MPO in lung tissues of chronic bronchitis model group were significantly increased than those of control group ( P <0.05).
    结果 模型组、生理盐水组及氟美松组BALF和肺组织中TNFα和MIP 2的含量显著高于健康对照组 (P <0 .0 5 ) ;
短句来源
    A study on tumor necrosis factor-α, macrophage inflammatory protein-2 and myeloperoxidase in blood, broncho alveolar fluid and lung tissues of rat chronic bronchitis model
    慢性支气管炎大鼠肿瘤坏死因子-α、巨噬细胞炎症蛋白-2及髓过氧化物酶的研究
短句来源
    Methods 24 male Sprague-Dawley rats were divided into three groups at random, i.e. control group (8), chronic bronchitis model group (8), bilirubin treated group (8).
    方法 取健康清洁级雄性SD大鼠24只,随机分为对照组(8只)、慢支组(8只)和胆红素干预组(8只)。
短句来源
    The purpose of the study is to investigate a new method of establishment a rat chronic bronchitis model for experimental use.
    摸索建立大鼠慢性支气管炎(慢支)模型的新方法。
短句来源
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Objective To study the nature and mechanisms of airway inflammation in chronic bronchitis and observe the effects of inhaled glucocorticoids on inflammatory indices. Methods Rat chronic bronchitis model was established by intratracheal instillation of small dose of lipopolysaccharide (LPS, 1 g/L). Experiments were performed in 28 male Sprague Dawley rats, which comprised four groups in random, i.e. chronic bronchitis model group, normal saline treated group, dexamethasone treated group and healthy...

Objective To study the nature and mechanisms of airway inflammation in chronic bronchitis and observe the effects of inhaled glucocorticoids on inflammatory indices. Methods Rat chronic bronchitis model was established by intratracheal instillation of small dose of lipopolysaccharide (LPS, 1 g/L). Experiments were performed in 28 male Sprague Dawley rats, which comprised four groups in random, i.e. chronic bronchitis model group, normal saline treated group, dexamethasone treated group and healthy control group. The levels of myeloperoxidase (MPO) of blood and lung tissues, and tumor necrosis factor(TNF)α and macrophage inflammatory protein 2 (MIP 2) of plasma, broncho alveolar fluid(BALF) and lung tissues were determined by biochemical and ELISA methods. Total and differential white blood cell counts of BALFwere carried out. Results (1) The levels of TNFα and MIP 2 in BALF and lung tissues, and MPO in lung tissues of chronic bronchitis model group were significantly increased than those of control group ( P <0.05). (2)More significant increase in total white blood cell count and neutrophils in BALF was found in rat chronic bronchitis group than in control group ( P <0.001). (3) Significant positive correlations were observed between the level of MPO and MIP 2 of lung tissues, the level of MPO and TNFα of lung tissue and the total cell counts and the level of MIP 2 of BALF and lung tissue. (4) More significant decrease in total cell counts and neutrophils of BALF and levels of MPO in lung tissue was found in dexamethasone treated group as compared to those of chronic bronchitis group. Conclusion Recruitment and activation of neutrophils seem to be the characteristics of chronic bronchitis. TNFα and MIP 2 may be involved in the process of chemotaxis and activation in airway inflammation in chronic bronchitis. Inhaled steroids might have some effects on chronic bronchitis by limiting the airway inflammation.

目的 探索慢性支气管炎气道炎症的特点。方法 雄性SD大鼠气管内注入浓度为 1g/L的脂多糖 2 0 0 μl制成大鼠慢性支气管炎模型 ,随机分为健康对照组、模型组、生理盐水组及氟美松组 ,每组 7只。应用ELISA法测定血浆、支气管肺泡灌洗液 (BALF)及肺组织中肿瘤坏死因子 (TNF)α、巨噬细胞炎症蛋白 2 (MIP 2 )含量 ,生化法检测血和肺组织中髓过氧化物酶 (MPO)水平 ,并进行BALF中细胞计数和分类。结果 模型组、生理盐水组及氟美松组BALF和肺组织中TNFα和MIP 2的含量显著高于健康对照组 (P <0 .0 5 ) ;肺组织中MPO的含量 ,模型组 [( 15 .0 0 2 +1.85 7)U/g]和生理盐水组 [( 11 888+0 92 6)U/g]显著高于健康对照组 [( 7 812 +1 0 4 3 )U/g](P <0 .0 5 ) ,而氟美松组[( 6 14 1+0 3 64 )U/g]则显著低于模型组 (P <0 .0 5 ) ;模型组肺组织中MPO与TNFα和MIP 2含量之间呈正相关 (r=0 788,r=0 963 ;P <0 .0 5 ,P <0 ....

目的 探索慢性支气管炎气道炎症的特点。方法 雄性SD大鼠气管内注入浓度为 1g/L的脂多糖 2 0 0 μl制成大鼠慢性支气管炎模型 ,随机分为健康对照组、模型组、生理盐水组及氟美松组 ,每组 7只。应用ELISA法测定血浆、支气管肺泡灌洗液 (BALF)及肺组织中肿瘤坏死因子 (TNF)α、巨噬细胞炎症蛋白 2 (MIP 2 )含量 ,生化法检测血和肺组织中髓过氧化物酶 (MPO)水平 ,并进行BALF中细胞计数和分类。结果 模型组、生理盐水组及氟美松组BALF和肺组织中TNFα和MIP 2的含量显著高于健康对照组 (P <0 .0 5 ) ;肺组织中MPO的含量 ,模型组 [( 15 .0 0 2 +1.85 7)U/g]和生理盐水组 [( 11 888+0 92 6)U/g]显著高于健康对照组 [( 7 812 +1 0 4 3 )U/g](P <0 .0 5 ) ,而氟美松组[( 6 14 1+0 3 64 )U/g]则显著低于模型组 (P <0 .0 5 ) ;模型组肺组织中MPO与TNFα和MIP 2含量之间呈正相关 (r=0 788,r=0 963 ;P <0 .0 5 ,P <0 .0 0 1)。结论 气道内中性粒细胞聚集是慢性支气管炎的重要特点 ,TNFα和MIP 2参与了中性粒细胞的激活和趋化过程 ,中性粒细胞产生大量的MPO可造成气道损伤。

The purpose of the study is to investigate a new method of establishment a rat chronic bronchitis model for experimental use. The animal model was produce by intratracheal instillation of small dose of lipopolysaccharide (LPS 200 g/ L). Pathologic changes were observed in tracheal, bronchi and lung tissues. Total and different white blood cell counts of BALF were carried out. (1) Significant reduction in weight gaining was seen in chronic bronchitis model group than that in control group (P<0.05)....

The purpose of the study is to investigate a new method of establishment a rat chronic bronchitis model for experimental use. The animal model was produce by intratracheal instillation of small dose of lipopolysaccharide (LPS 200 g/ L). Pathologic changes were observed in tracheal, bronchi and lung tissues. Total and different white blood cell counts of BALF were carried out. (1) Significant reduction in weight gaining was seen in chronic bronchitis model group than that in control group (P<0.05). (2) Significant increase in numbers of goblet cells and mucous glands in tracheal and bronchi, loss of cilia of epithelial cells, infiltration of lymphocytes, monocytes and neutrophils in airway wall, accumulation of neutrophils and mucous in airway Lumens and pulmonary emphysema were observed under light microscope; degeneration of ciliated epithelium , compound cilias, numerous mucous granule in goblet cells, wide gap between epithelial cells and hyperplasia of type alveolar epithelial cells were seen under electron microscope; in chronic bronchitis model group Significant increases in total white blood cell numbers and neutrophils in BALF were found in rat chronic bronchitis group (p<0.001 ). A typical rat chronic bronchitis model could be produced by intratracheal instillation of LPS. The rat chronic bronchitis model shared many features of human chronic bronchitis in pathologic and BALF cytologic changes.

摸索建立大鼠慢性支气管炎(慢支)模型的新方法。用气管内注入脂多糖(LPS)法建立大鼠慢支模型。观察光镜及电镜下气管、支气管及肺组织病理学改变。气管及支气管上皮脱落,杯状细胞增生,粘液腺增生肥大,气管支气管壁见慢性炎细胞浸润,管壁增厚,管腔充满粘液及大量以中性粒细胞为主的炎细胞,支气管平滑肌增生肥厚,肺气肿形成电镜下气管支气管纤毛柱状上皮细胞变性,数量减少、复合纤毛形成;BALF白细胞总数及中性粒细胞数较对照组显著增多(P<0.001)。结论为气管内注入LPS(200 g/200 L)可制备大鼠慢支模型,气管支气管及肺组织病理学和BALF细胞学改变符合人类该病的病理表现,可应用于实验研究。

Objective To investigate the effect of ipratropium bromide and atropine on airway mucin hypersecretion in the chronic bronchitis model of rats. Methods The model was established by intratracheal instillation of small dose of lipopolysaccaride (200 μg) ipratropium bromide and atropine were administrated 3-21 d after the model was established. Pathological changes, mucin in bronchoalveolar lavage fluid (BALF) and tracheal ring culture medium were examined before and after the adnsinistration...

Objective To investigate the effect of ipratropium bromide and atropine on airway mucin hypersecretion in the chronic bronchitis model of rats. Methods The model was established by intratracheal instillation of small dose of lipopolysaccaride (200 μg) ipratropium bromide and atropine were administrated 3-21 d after the model was established. Pathological changes, mucin in bronchoalveolar lavage fluid (BALF) and tracheal ring culture medium were examined before and after the adnsinistration of ipratropium bromide and atropine. Results Characteristic pathological manifestions of chronic brochitis were found after instillation of LPS. Significant decrease in the number of tracheal epithelia goblet cells, secretion of mucin were observed in ipratropium bromide and atropine treated rats. The effect of inhibiting the secretion of mucin of ipratropium bromide was higher than atropine. Conclusion It suggests that muscarinic acetylcholine receptor plays an important role in airway mucin hypersecretion in chronic bronchitis model of rat. Ipratropium bromide exhibit a stronger inhibition effect on mucin hypersecretion than atropine, moreover no inhibition effect on mucociliary clearance which was observed in atropine.

目的 探讨毒蕈碱乙酰胆碱能受体拮抗剂溴化异丙托品及阿托品对气道粘蛋白高分泌的作用。方法 采用一次性气管内注入脂多糖复制大鼠慢支炎模型 ,观察 3周后的病理学改变、支气管肺泡灌洗液和气管环培养液中粘蛋白量的变化 ,以及雾化吸入溴化异丙托品及阿托品的影响。结果 注入脂多糖后的病理学表现符合慢支炎的改变。溴化异丙托品和阿托品都显著减少气管上皮杯状细胞数目及粘蛋白的分泌。但溴化异丙托品抑制粘蛋白分泌的作用显著强于阿托品。结论 毒蕈碱乙酰胆碱能受体途径在慢支炎大鼠气道粘蛋白的高分泌中起重要作用 ,溴化异丙托品明显抑制粘蛋白高分泌 ,其作用强于阿托品 ,且对粘液纤毛清除功能无阿托品样抑制作用

 
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