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high grade gliomas
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  高级别胶质瘤
     (2) The cyclin D1 positive ratios were 31.25%(10/32) and 61.53%(32/ 52) in the low grade gliomas and the high grade gliomas, respectively. There was significant difference between two groups (P< 0.01).
     (2)低级别胶质瘤cyclinD1阳性率为31.25%(10/32),高级别胶质瘤阳性率为61.53%(32/52),差异有显著性(P<0.01);
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     Results The rCBV in high grade gliomas(n=13) varied from 1.77 to 35.70,with a mean of 9.38±6.52,and in the low-grade group(n=10) varied from 1.17 to 4.33, with a mean of 2.41 ±1.24. This difference in rCBV was statistically significant.
     结果 高级别胶质瘤(13例)的rCBV值为9.38±6.52(1.77~35.70),低级别胶质瘤(10例)rCBV值为2.41±1.24(1.17~4.33)。
短句来源
     Results: The rCBV in high grade gliomas (n=13) varied from 1. 77 to 35. 7, with a mean of 9. 38±6. 52, and in the low-grade group (n=10) varied from 1. 17 to 4. 33, with a mean of 2. 41±1. 24. This difference in rCBV was statistically significant.
     结果:高级别胶质瘤(13例)的rCBV值为9.38±6.52(1.77-35.70),低级别胶质瘤(10例)的rCBV值为2.41±1.24(1.17-4.33),二者差异有统计学意义(t=2.56,P=0.018)。
短句来源
     In dead group, the cyclin D1 positive ratios wer e 86.66%(13/15) and 16.66%(1/6) in the high grade gliomas and the low grade gl iomas, respectively. There was significant difference between two groups (P< 0.0 5).
     死亡组21例中,高级别胶质瘤cyclinD1阳性率为86.66%(13/15),低级别胶质瘤阳性率为16.66%(1/6),差异有显著性(P<0.01)。
短句来源
     The NF-κB expression in 41 of 52 cases of the gliomas was positive. The positive expression rate of NF-κB in the high grade gliomas was significantly higher than that in the low grade ones(P<0.01).
     在52例脑胶质瘤中NF-κB有41例表达,其在高级别胶质瘤中的阳性表达率高于低级别胶质瘤(P<0.01)。
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  高分级胶质瘤
     Results The 1 , 3 , and 5 year cumulative survival rates of patients with low grade gliomas were 91%, 89%, 82%, as compared with 53%, 40%, 36% for those patients with high grade gliomas.
     结果 低分级胶质瘤的 1、3、5年生存率分别为 91%、89%、82 % ; 高分级胶质瘤的 1、3、5年生存率分别为 5 3%、40 %、36 %。
短句来源
     Of these, 79 had low grade , 47 had high grade gliomas, 24 had ependymal gliomas , and 14 had oligodendroglioma.
     其中低分级胶质瘤 79例 ,高分级胶质瘤 47例 ,室管膜细胞瘤 2 4例 ,少突胶质细胞瘤 14例。
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  “high grade gliomas”译为未确定词的双语例句
     TTP values are 0.93 ± 0.42, 1.02±0.18, 1.02± 0.31.The rCBV values of correspondence parts of high grade gliomas are2.29±1.31,3.99±0.68,1.23±0.56;
     TTP值分别为0.93±0.42,1.02±0.18,1.02±0.31。 高级别肿瘤各相应部位rCBV值分别为2.29±1.31,3.99±0.68,1.23±0.56;
短句来源
     Results:p53 gene mutation was found in 11 out of 100 cases of brain tumors(11%). The frequency of mutation was 37. 5%(6/16) in high grade gliomas, 4. 3%(l/23) in low grade gliomas, 6. 9 (2/29) in meningiomas and 40%(2/5)in metastatic tumors.
     结果:p53基因突变率为11%(11/100),其中高恶度胶质瘤为37.5%(6/16),低恶度胶质瘤4.3%(1/23),脑膜瘤6.9%(2/29),转移瘤40.0%(2/5)。
短句来源
     (2)The positive rates of nm23 and PCNA were 56%(14 cases) and 64%(16 cases) in 25 cases of low grade gliomas, while the positive rates of nm23 and PCNA were 12%(3 cases) and 88%(22 cases) in 25 cases of high grade gliomas.
     (2)25例低度恶性胶质瘤中nm23阳性14例(56%),PCNA阳性16例(64%); 而25例高度恶性胶质瘤中nm23阳性3例(12%),PCNA阳性22例(88%)。
短句来源
     Results: The 1-,2- ,and 3-year survival rates of patients with low grade gliomas were 100%, 100%, 83.3%, 80%,70%、50% for those patients with high grade gliomas .
     结果低分级脑胶质瘤(I、II级)1、2、3年生存率为100%(6/6)、100%(6/6)、83.3%(5/6),高分级脑胶质瘤(III、IV级)1、2、3年生存率为80%(8/10)、70%(7/10)、50%(5/10)。
短句来源
     while the label indexes of nm23 and PCNA in high grade gliomas were 1.72±0.18 and 6.20±0.23, respectively. There was significant difference between the two groups(P< 0.05).
     高度恶性胶质瘤nm23LI为1.72±0.18,PCNALI为6.20±0.23,有显著性差异(P<0.05);
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  high grade gliomas
Extracellular Levels of Amino Acids and Choline in Human High Grade Gliomas: An Intraoperative Microdialysis Study
      
About 71 consecutive patients with high grade gliomas, who were seen in the neurooncology clinic in 2004, were included.
      
Introduction Treating high grade gliomas in the elderly is a challenge for multidisciplinary teams.
      
Treating high grade gliomas in the elderly: the end of ageism
      
TGF-β2 secretion by high grade gliomas has been implicated as one of the major factors contributing to tumor growth, alterations in the host immune response to tumor, and failure of gliomas to respond to current immunotherapy strategies.
      
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Epidermal growth factor(EGF) mRNA level in various grade of gliomas,malignant human glioma cell lines and normal brain tissues were examined by Northern blot and dot blot. and found relative expression of a 5.0kb transcript in all tissues and cell lines with different levels.The EGFmRNA level in malignant glioma was considerably higher than those in low grade gliomas and normal brains, but no significant difference was observed between low grade gliomas and normal brains.The EGFmRNA overexpression was high...

Epidermal growth factor(EGF) mRNA level in various grade of gliomas,malignant human glioma cell lines and normal brain tissues were examined by Northern blot and dot blot. and found relative expression of a 5.0kb transcript in all tissues and cell lines with different levels.The EGFmRNA level in malignant glioma was considerably higher than those in low grade gliomas and normal brains, but no significant difference was observed between low grade gliomas and normal brains.The EGFmRNA overexpression was high grade gliomas.EGFmRNA expression was positively correlated with tumor grade.The results of the present study suggested that EGF can be synthesized in human gliomas.It might participate or promote the malignant transforming process of gliomas.

采用Northern杂交和斑点杂交的方法检测了50例胶质瘤、4个恶性胶质瘤体外细胞系和7例正常脑组织表皮生长因子(EGF)mRNA表达水平。结果显示:上述组织或细胞都可表达5.0kb的EGFmRNA片断,高恶度胶质瘤较低恶度胶质瘤和正常脑组织EGFmRNA表达水平增高,低恶度胶质瘤与正常脑组织的表达无显著差异。在50例胶质瘤中29例(58%)EGFmRNA过表达,其中多见于恶性胶质瘤,EGFmRNA表达与肿瘤的分级呈正相关。提示胶质瘤可以合成EGF,在胶质瘤的发生发展过程中,EGF参与或促进了其恶性进展。

EGF mRNA levels in various grade of gliomas,malignant human glioma cell lines and normal brain tissues were examined by Northern blot and dot blot,and relative expression of a 5.0kb transcript in all tissues and cell lines with different levels were found. The EGF mRNA levels in malignant glioma were considerably higher than those in low grade gliomas and normal brains,but no significant differences were observed between low grade gliomas and normal brains. The EGF mRNA overexpression was found in 29 cases out...

EGF mRNA levels in various grade of gliomas,malignant human glioma cell lines and normal brain tissues were examined by Northern blot and dot blot,and relative expression of a 5.0kb transcript in all tissues and cell lines with different levels were found. The EGF mRNA levels in malignant glioma were considerably higher than those in low grade gliomas and normal brains,but no significant differences were observed between low grade gliomas and normal brains. The EGF mRNA overexpression was found in 29 cases out of 50 gliomas(58% ) ,most of which occurred in high grade gliomas. EGF mRNA expression was positively correlated with tumor grade and ih EGF level. There was a similar result in immunohistoche-mical study on immunoreactive human EGF(ih EGF). Not only was the number of positive cells,but the EGF staining was also different in various grade of gliomas. Both the number and the staining intensity of the EGF positive cells increased as the tumor grade rose. The results of the present study suggested that EGF can be synthesized in human gliomas. It might participate or promote the malignant transforming process of gliomas.

国内首次报道采用Northern、斑点杂交和免疫组化的方法检测了50例胶质瘤、4个恶性胶质瘤体外细胞系和7例正常脑组织表皮生长因子(EGF)的表达水平。结果显示,上述组织或细胞都可表达5.0 kb的EGF mRNA片断,高恶度胶质瘤较低恶度胶质瘤和正常脑组织EGFmRNA表达水平增高,低恶度胶质瘤与正常脑组织的表达无显著差异。在50例胶质瘤中29例(58%)EGFmRNA过表达,其中多见于恶性胶质瘤。采用免疫组化检测胶质瘤ihEGF表达发现,随胶质瘤恶性程度增加,EGF阳性细胞数及着色强度亦随之增加,EGFmRNA表达与ih EGF表达及肿瘤的分级呈正相关。提示胶质瘤可以合成EGF,在胶质瘤的发生发展过程中,EGF参与或促进了其恶性进展。

The levels of EGF in the urine and blood of 20 healthy individuals and 50 patients with glioma were measured with radioimmunoassay. Both the urine and blood EGF levels showed a stepwise increase from healthy individual to patients with low grade to high grade gliomas. Urine EGF level was found to be positively correlated with tumor grade (r=0.516,P<0.001). These data suggest the value of urine RIAEGF,as a marker of glial tumor in its diagnosis.Although not so close as the relationship of urine...

The levels of EGF in the urine and blood of 20 healthy individuals and 50 patients with glioma were measured with radioimmunoassay. Both the urine and blood EGF levels showed a stepwise increase from healthy individual to patients with low grade to high grade gliomas. Urine EGF level was found to be positively correlated with tumor grade (r=0.516,P<0.001). These data suggest the value of urine RIAEGF,as a marker of glial tumor in its diagnosis.Although not so close as the relationship of urine EGF level with the grade of glioma, the blood EGF level was also elevated with the escalation of the grade.The combination of these two parameters might be more reliable in assessment of the malignancy of glioma.The urine and blood EGF levels dropped after removal of tumor in 40 patients with a better shortterm effect,while the postoperative urine and blood EGF levels in 10 patients who underwent tumor biopsy or partial resection of tumor were not lowered or rather elevated, and the surgical outcome in them was poor in these 10 patients. 

对50例胶质瘤患者的血、尿和瘤组织EGF含量进行了检测。结果发现,恶性胶质瘤患者尿液EGF含量显著高于低恶度胶质瘤患者尿液EGF含量。直线相关研究显示,尿EGF含量与瘤组织EGF含量及肿瘤分级呈正相关。胶质瘤患者血浆EGF含量虽与肿瘤分级呈正相关,但不如尿液EGF含量与肿瘤分级的相关性明显,若两者结合,可能对胶质瘤的恶性程度的预估更为可靠。肿瘤肉眼全切除术后胶质瘤患者血尿EGF含量低于术前,近期疗效较好;手术活检或部分切除者10例,术后血、尿EGF含量不降低或有所增高,近期疗较差。说明检测尿EGF有助于胶质瘤的临床诊断及恶性程度的评估,也可作为胶质瘤的标记之一

 
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