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erm genes
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  erm基因
     Detection of erm genes in methicillin-resistant coagulase-negative staphylococci
     耐甲氧西林凝固酶阴性葡萄球菌红霉素耐药erm基因检测
短句来源
     Methods The erm genes of MRCNS were detected by degenerate primers amplification.
     方法 应用兼并引物扩增MRCNS菌的erm基因
短句来源
     Conclusion The erythromycin drug resistant rate with erm genes in MRCNS is 81.8%.
     结论 MRCNS菌获得erm基因的红霉素耐药率为 81.8%。
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  “erm genes”译为未确定词的双语例句
     Objective To invetigate the condition of erm genes in methicillin resistant coagulase negative staphylococci(MRCNS).
     目的 探讨耐甲氧西林凝固酶阴性葡萄球菌 (MRCNS)erm基因的存在状况。
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  erm genes
Overall, resistance to erythromycin was predominantly due to the presence of two erm genes, although with different distributions, depending on the methicillin-resistance pattern.
      
The presence of erm genes coding for ribosomal methylases and of mefE-like genes responsible for macrolide efflux was screened by a multiplex polymerase chain reaction and confirmed by DNA/DNA hybridization.
      
The epidemiology of four erythromycin-resistant methylase (erm) genes, ermA, ermB, ermC and msrA, was determined in erythromycin-resistant staphylococci, enterococci and streptococci isolated from poultry litter.
      
Sequence analysis of the regulatory regions of erm genes revealed that mutation type of ermB was just point mutation, by contraries the mutation type of ermA was either deletion or tandem duplication.
      
Erythromycin methylases, encoded by erm genes, modify an essential adenine residue in 23S rRNA and confer cross-resistance to MLSB antibiotics.
      
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A physical map, structure and function as well as mechanism of transcriptional regulation of the transposon Tn917 were described in detail, empolying computer analysis on its sequences. The transposon appears to have five significant ORFs, all of which occur on the same strand and are read from left to right. A consensus promoter site precedes a Shine Dalgarno sequence that is close to the start the site of ORF1 3. The translation of ORF5(coding Transponase) and ORF4(coding Resolvase) is coupled or closely...

A physical map, structure and function as well as mechanism of transcriptional regulation of the transposon Tn917 were described in detail, empolying computer analysis on its sequences. The transposon appears to have five significant ORFs, all of which occur on the same strand and are read from left to right. A consensus promoter site precedes a Shine Dalgarno sequence that is close to the start the site of ORF1 3. The translation of ORF5(coding Transponase) and ORF4(coding Resolvase) is coupled or closely coordinated. The Tn917 has a site between ORF3 and ORF4 homologous with res site of Tn3. The translational attenuation associated with the control of rRNA methylase(product of erm gene, corresponding ORF2)induction, within the 200 bp leader region preceding the rRNA methylase structural gene is a control peptide 36 amino acid residuces(corresponding ORF1) in length.

通过计算机分析转座子Tn917的全序列,详细阐述了其物理图谱、结构功能及其转录调节机制.Tn917的5个ORFs排列在同一条DNA链上,且阅读方向都从左至右.ORF1-3起始点的左侧翼排列有启动子序列和Shine-Dalgarno序列.ORF5(编码转座酶)和ORF4(编码拆分酶)的转录方向是一致的,翻译也紧密偶联在一起.在ORF3和ORF4之间存在1个res位点,与Tn3中的res位点基本同源.翻译衰减的功能与rRNA甲基化酶(由ORF2编码的、erm基因的产物)诱导有关,在这个结构基因的左侧翼有200bp的前导区域编码一个具调控功能的36个氨基酸组成的多肽(由ORF1编码).

A total 9 isolates of the Streptococcus uberis were tested for minimal inhibitory concentration (MIC)and antibiotic susceptibility to clindamycin by using test_tube dilution and disc diffusion methods.PCR was used to detect the erm gene in Streptococcus uberis.We find that clindamycin has strong antibacterial activities.Comparision of erm (S.uberis)and ermS(S.sanguis)sequences showed 99%(750/757)conservation,which also suggests erm gene located on both plasmid and chromosome.

采用试管稀释法和纸片法测定 9株乳房链球菌对克林霉素的耐药性 ,通过PCR反应检测克林霉素的耐药性基因 ,并进行测序比较。发现克林霉素对乳房链球菌的抗菌活力较强 ,克林霉素耐药基因同时存在于乳房链球菌的染色体和质粒上。

Objective To investigate resistance mechanism against erythromycin in Streptococcus pneumoniae from Beijing region. Methods 116 strains of erythromycin resistant Streptococcus pneumoniae were collected from 1998 to 1999 at Peking Union Medical College Hospital Serotyping was done with "capsular swelling" technique erm/mef genes were detected with PCR, pulsed field gel electrophoresis (PFGE) and penicillin binding protein (PBP) fingerprinting technique were used to detect the DNA of resistant...

Objective To investigate resistance mechanism against erythromycin in Streptococcus pneumoniae from Beijing region. Methods 116 strains of erythromycin resistant Streptococcus pneumoniae were collected from 1998 to 1999 at Peking Union Medical College Hospital Serotyping was done with "capsular swelling" technique erm/mef genes were detected with PCR, pulsed field gel electrophoresis (PFGE) and penicillin binding protein (PBP) fingerprinting technique were used to detect the DNA of resistant strains Results The prevalent serotypes in the 116 erythromycin resistant strains were 23F(30 0%),6A(19 0%),19F(13 8%),15(7 8%),23A(5 2%) 95 7% of penicillin resistant strains were also macrolide resistant, most (85%) expressing the MLS phenotype with co resistance to clindamycin The macrolide resistance determinant in 86 4% of erythromycin resistant strains was the erm gene, both the erm and mef genes were found in 6%, mef alone in 1 7% and no mechanism in 4 2% PFGE identified two clones: one a serotype 23F clone resistant to penicillin; and the other a penicillin susceptible and macrolide resistant serotype 6A clone Conclusions Ribosomal modification (erm gene coded) was the main resistance mechanism against erythromycin in Streptococcus pneumoniae in Beijing region Two resistance clones bear concern

目的 研究北京地区肺炎链球菌对红霉素的耐药机制。方法 收集本院 1998~ 1999年分离的对红霉素耐药的肺炎链球菌 116株 ,采用“荚膜肿胀”技术进行血清分型 ,聚合酶链反应(PCR)检测对红霉素耐药的基因erm/mef,脉冲场凝胶电泳 (PFGE)和青霉素结合蛋白 (PBP)基因印迹技术追踪菌株之间的同源性。结果  116株红霉素耐药株的血清型主要为 2 3F(30 0 % ) ,6A(19 0 % ) ,19F(13 8% ) ,15 (7 8% ) ,2 3A(5 2 % )。 95 7%的青霉素不敏感株同时也耐红霉素 ;85 %的菌株表现为MLS表型 ,即同时耐克林霉素 ;86 4 %的红霉素耐药株具有erm基因 ,6 %的菌株同时有erm和mef基因 ,1 7%的菌株只有mef基因 ,4 2 %未能检测到erm或mef基因。PFGE发现 2种耐药克隆 :1个是青霉素耐药的血清型为 2 3F的克隆株 ,另 1个是青霉素敏感而红霉素耐药的、血清型为 6A的克隆株。结论 核糖体突变 (erm基因编码 )是北京地区肺炎链球菌耐红霉素的主要机制 ,2种耐药克隆值得关注。

 
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