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anti-implantation action
相关语句
  抗着床作用
     Sex hormone activities, anti-implantation action and the mechanism of action of 5α-dihydronorethisterone (5α-DNE) were studied.
     本文研究了5α-双氢炔诺酮的性激素活性、抗着床作用及其机理。
短句来源
     Sex Hormone Activity and Anti-Implantation Action of 5α-Dihydronorethisterone
     5α-双氢炔诺酮的性激素活性、抗着床作用及其机理
短句来源
     A Comparison of Anti-implantation Action of Norethisterone Oxime with that of Norethisterone and Their Effects on Progesterone Secretion in Rat Ovary
     炔诺酮肟与炔诺酮抗着床作用的比较及其对卵巢孕酮分泌的影响
短句来源
     Anti-implantation Action of Nylestriol and Its Effect on Uterine Cytosol Estrogen and Progesterone Receptor in Rabbits
     尼尔雌醇对兔的抗着床作用及对子宫胞液雌二醇和孕酮受体的影响
短句来源
     Anti-Implantation Action of Nylestriol and Its Effect on Endometrium in Rabbits
     尼尔雌醇对兔的抗着床作用及对子宫内膜的影响
短句来源
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  “anti-implantation action”译为未确定词的双语例句
     The doses used were 0.125mg/kg,0.625 mg/kg. They are minimal effect doses (MED) for anti-implantation action,5 and 10 times of MED respectively. Rate and amplitude of respiration,blood pressure,and electrocadiogram were detected at 1/4,1/2,1,2,4 and 5 hours after administration.
     NETO剂量为0.125mg/kg、0.626mg/kg及1.25mg/kg,观察用药前及用药后1/4、1/2、1、2h的呼吸、血压,以及用药前、用药后1~5h的心率、心电图变化。
短句来源
     STUDIES ON MECHANISMS OF ANTI-IMPLANTATION ACTION OF NORETHISTERONE ACETATE-3-OXIME IN MICE AND RATS
     醋炔诺酮肟的抗着床作用原理的研究
短句来源
     5α-DNE had weak androgenie effect, which is 1/18 as testosterone, 5α-DNE manifested obvious anti-implantation action. 10 mg given entirely blocked the implantation process in rats.
     10mg/kg 5α-双氢炔诺酮可完全抑制大鼠着床,并显著降低假孕大鼠卵巢静脉血孕酮水平。
短句来源
     It was suggested that the mechanism of anti-implantation action of 5α-DNE consisted in antagonizing progesterone at receptor level as well as disturbing directly the ovarian synthesis of progesterone.
     其抗着床机理系在受体水平拮抗孕酮以及直接或间接抑制卵巢孕酮生物合成。
短句来源
  相似匹配句对
     The anti-implantation action ofnylestriol in rabbits was studied.
     作者探讨了尼尔雌醇对兔的抗着床作用。
短句来源
     Anti-Implantation Action of Nylestriol and Its Effect on Endometrium in Rabbits
     尼尔雌醇对兔的抗着床作用及对子宫内膜的影响
短句来源
     Anti-anemia Action of Hemin
     氯高铁血红素的抗贫血作用
短句来源
     THE ANTI-STRESS ACTION OF MELATONIN
     褪黑素的抗应激作用
短句来源
     Anti-diuresis Action of Suberogorgin
     柳珊瑚酸的抗利尿作用
短句来源
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  anti-implantation action
The effects of norethisterone oxime (NETO) on ovum transport and development, and on morphological changes of oviducts in rabbits were studied to evaluate the mechanism of its anti-implantation action.
      


The effects of norethisterone-3-oxime(NETO)on ovum transport and developmentin rabbits were studied to evaluate the mechanism of its anti-implantation action.Segments of divided oviduct and uterus were flushed with saline and ova were collectedseparately from each segment.The morphology of the ova was studied microscopically.The results indicated that ovum transport in oviducts was slightly accelerated 24~48 hr afteradministration of NETO,and then was obviously delayed so that most of the ova were retainedin...

The effects of norethisterone-3-oxime(NETO)on ovum transport and developmentin rabbits were studied to evaluate the mechanism of its anti-implantation action.Segments of divided oviduct and uterus were flushed with saline and ova were collectedseparately from each segment.The morphology of the ova was studied microscopically.The results indicated that ovum transport in oviducts was slightly accelerated 24~48 hr afteradministration of NETO,and then was obviously delayed so that most of the ova were retainedin the oviduct.Ovum development was retarded.The thickness of mucin coat was reducedand some ova degenerated.These findings demostrated that the anti-implantation action of NETO was related toits interference with ovum transport and development.Because all the changes were verysimilar to those caused by exogenic estrogens,it is suggested that the anti-implantation actionof NETO in rabbit may be due to its estrogenic activity.

本实验以生理盐水分段冲洗家兔输卵管及子宫,收集孕卵并作形态学观察。结果表明,给药后24~48小时孕卵在输卵管内的运行稍有加快,以后明显减慢以致大多数孕卵滞留在输卵管内。孕卵发育受阻,其外周粘蛋白层变薄,部分孕卵出现退行性变化。以上各种改变证实炔诺酮肟的抗着床作用是干扰了孕卵的运行及发育。由于这些变化与外源性雌激素作用相似,提示在家兔实验中炔诺酮肟抗着床作用可能与它具有的雌激素活性有关。

Sex hormone activities, anti-implantation action and the mechanism of action of 5α-dihydronorethisterone (5α-DNE) were studied. It was found in McPhail Test that 10mg of 5α-DNE had remarkable antiprogestrone action while 10 mg or even 20mg revealed little pregestational activity. Estrogenic action of 5α-DNE is trivial, its potency is only 1/3846 that of ethynylestradiol. 5α-DNE had weak androgenie effect, which is 1/18 as testosterone, 5α-DNE manifested obvious anti-implantation action....

Sex hormone activities, anti-implantation action and the mechanism of action of 5α-dihydronorethisterone (5α-DNE) were studied. It was found in McPhail Test that 10mg of 5α-DNE had remarkable antiprogestrone action while 10 mg or even 20mg revealed little pregestational activity. Estrogenic action of 5α-DNE is trivial, its potency is only 1/3846 that of ethynylestradiol. 5α-DNE had weak androgenie effect, which is 1/18 as testosterone, 5α-DNE manifested obvious anti-implantation action. 10 mg given entirely blocked the implantation process in rats. Because it significantly depressed the ovarian synthesis of progesterone in pseudopregnant rats, and competed receptors of rats uterine cytosol with progesterone. It was suggested that the mechanism of anti-implantation action of 5α-DNE consisted in antagonizing progesterone at receptor level as well as disturbing directly the ovarian synthesis of progesterone.

本文研究了5α-双氢炔诺酮的性激素活性、抗着床作用及其机理。结果表明:该化合物有显著的抗孕激素作用,孕激素活性微弱。基本无雌激素活性,雄激素活性弱。10mg/kg 5α-双氢炔诺酮可完全抑制大鼠着床,并显著降低假孕大鼠卵巢静脉血孕酮水平。与大鼠子宫胞浆孕酮受体的相对结合亲和力(RBA)为孕酮的13%。其抗着床机理系在受体水平拮抗孕酮以及直接或间接抑制卵巢孕酮生物合成。

In this paper attempt has been made to observe the effect of Anordrin and its analogue SIPPR-113 on the morphological characters of uterine endometrium in mice implantation period and after castration. 100 mice were used in two experiments. The first experiment was performed in mice after mating, it included 5 groups as follows: control, estradial, progesterone, Anordrin and SIPPR-113 groups. The mice were treated with least doses (2-4mg/kg) which can prevent implantation on dayl-2 after mating. The animals...

In this paper attempt has been made to observe the effect of Anordrin and its analogue SIPPR-113 on the morphological characters of uterine endometrium in mice implantation period and after castration. 100 mice were used in two experiments. The first experiment was performed in mice after mating, it included 5 groups as follows: control, estradial, progesterone, Anordrin and SIPPR-113 groups. The mice were treated with least doses (2-4mg/kg) which can prevent implantation on dayl-2 after mating. The animals were killed on the 5th day of pregnancy. The second, experiment contained also 5 groups: mature female mice were treated with 1/4-1/2 of above doses on the 25-26th day and were killed on the 29th day after castration. The uterine endometrium was embedded with paraffin and Epon812, histological sections and semi-thin sections (1ftm thick) and ultra-thin sections were made. They were observed under light microscope and electron microscope (Hitachi-600). Similar results were obtained in the two series of experiments. The endometrium had grown obviously and the numbers of glands and of cell's mitosis were increased, edema was indicated in stroma, as well as secretory function of glands was prevented period of implantation. Some lysosomes and lipid drops were found in the glandular cells and micro-filaments were observed in stromal cells under electron microscope. The effect of SIPPR-113 were similar to Anordrin, their anti-implantation action may be related to their estrogen and anti-progestrone action. Acknowledgement: This work was supported by WHO Special Programme in Human Reproduction.

本文旨在了解抗孕-53及其类似物SIPPR-113对着床期及阉割后小鼠子宫内膜形态的影响。选用ICR成年雌小鼠,实验分两部分进行。一、交配后小鼠。按抗着床最小有效剂量处理动物。二、切除卵巢后小鼠。按上述剂量的1/4~1/2处理动物。并与雌二醇及黄体酮进行对比。全部小鼠子宫用石蜡及Epon 812包埋,制备组织学切片、半薄切片(1μm)及超薄切片,光镜和电镜下观察。得到一致的结果:抗孕-53及SIPPR-113能促进小鼠子宫内膜发育及腺体生长,细胞核有丝分裂增多,并引起子宫及基质水肿。在第一部分实验中能抑制一部分着床期腺体的分泌。电镜图像中显示内膜细胞中溶酶体较多,并可见脂滴,少数基质细胞中微丝较多。SIPPR-113显示出与抗孕-53相似的作用,此二化合物具有雌激素样作用。

 
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