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anti-implantation effect
相关语句
  抗着床作用
     A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.
     醋炔诺酮肟对实验动物有明显的抗着床作用
短句来源
     A possible mechanism of anti-implantation effect of gossypol seems to be due to the decrease of Δ~5-3β-SDH activity and blocking of the biological synthesis of progesterone.
     以上结果提示△~5-3β羟甾脱氢酶活性下降,孕酮合成受阻,可能是醋酸棉酚抗着床作用的机理之一。
短句来源
     EXPERIMENTAL OBSERVATION ON ANTI-IMPLANTATION EFFECT OF SOLUBLE SALTS OF ALUMINUM
     可溶性铝盐抗着床作用的动物实验观察
短句来源
     ANTI-IMPLANTATION EFFECT OF HYDROXYTAMOXIFEN AND ITS INFLUENCES ON THE CONTENT OF UTERINE ESTRADIOL AND PROGESTERONE RECEPTOR IN MICE
     羟泰米酚的抗着床作用及其对小鼠子宫雌二醇和孕酮受体含量的影响
短句来源
     The anti-implantation effect of mifepristone was investigated.
     研究了米非司酮对大鼠的抗着床作用
短句来源
更多       
  “anti-implantation effect”译为未确定词的双语例句
     ANTI-IMPLANTATION EFFECT OF PINELLIN IN RABBITS
     半夏蛋白的抗兔胚泡着床作用
短句来源
     d on day 1/3 of gestation resulted in 100% anti-implantation effect. However, yuehchukene at 4 mg/kg.
     金黄地鼠于妊娠1~3天,sc月橘烯碱4mg/kg·d却无此作用。
短句来源
     Studies on Anti-implantation Effect of Saccharides—Effects on Preimplantation Mouse Endometrium
     糖类物质抗着床效应研究——对着床前小鼠子宫内膜的作用
短句来源
     ANTI-IMPLANTATION EFFECT OF PROPRANOLOL IN RAT
     心得安抗植入作用的实验研究
短句来源
     The results of this experiment suggest that the hCG-like substance and PGF2α produced by the mouse blastocysts during the preimplantation stage and the anti-implantation effect of the anti-sera of hCG and PGF2α were significant on mice.
     研究结果证明; 着床前小鼠胚泡能分泌和合成hCG样糖蛋白物质和PGF_(2σ),而hCG和PGF_(2σ)抗血清对小鼠胚泡着床有显著的抑制效应。
短句来源
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  相似匹配句对
     The anti-implantation effect of mifepristone was investigated.
     研究了米非司酮对大鼠的抗着床作用。
短句来源
     ANTI-IMPLANTATION EFFECT OF PROPRANOLOL IN RAT
     心得安抗植入作用的实验研究
短句来源
     ANTI-IMPLANTATION EFFECT OF PINELLIN IN RABBITS
     半夏蛋白的抗兔胚泡着床作用
短句来源
     On anti-butterfly effect
     反蝴蝶效应浅析
短句来源
     Anti-Implantation Action of Nylestriol and Its Effect on Endometrium in Rabbits
     尼尔雌醇对兔的抗着床作用及对子宫内膜的影响
短句来源
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A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.In mice,rats and rabbits implantation was totally inhibitedwhen the drug was orally administered from day 2 of pregnancy at a daily dose of 0.51,and 2 mg/kg respectively for 3 days.The same effect could also be demonstrated in rats receiving a single dose of 5 or 10mg/kg of the drug on day 2 or 3 of pregnancy.4 healthy rabbits used for testing the toxicity received the drug orally at a dose of...

A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.In mice,rats and rabbits implantation was totally inhibitedwhen the drug was orally administered from day 2 of pregnancy at a daily dose of 0.51,and 2 mg/kg respectively for 3 days.The same effect could also be demonstrated in rats receiving a single dose of 5 or 10mg/kg of the drug on day 2 or 3 of pregnancy.4 healthy rabbits used for testing the toxicity received the drug orally at a dose of 10mg/kg/day(about 500 times as much as the clinical dose)for 3 weeks,and all were nor-mal in blood routine and renal function tests but a raised change was shown in their liverfunction(completely restored 2 weeks after cessation of the drug).3 dogs were given the drug at the dose of 1-2 mg/kg/day(about 50-100 times as muchas the clinical dose )for 14 months,no obvious toxic effect being observed.

醋炔诺酮肟对实验动物有明显的抗着床作用。小鼠、大鼠和家兔在妊娠第2天起,分别给予醋炔诺酮肟0.5、1和2毫克/公斤,每天一次,连续3天,均有显著的抗着床作用。大鼠在妊娠第2或3天一次给醋炔诺肟酮5或10毫克/公斤,亦有明显的抗着床作用。家兔4只,每日灌服醋炔诺酮肟10毫克/公斤(约为临床剂量500倍),连续3周,给药后肝功能升高,停药2周后恢复正常,血象和肾功能均无明显变化。犬3只,每日灌服醋炔诺酮肟1~2毫克/公斤(约为临床剂量50~100倍),连服14个月,无明显毒性。

This paper reports the pharmacological study on a new synthetic progestogen 3-cyclo-pentyl propionate of megestrol acetate(Progestin No.1),which has been synthesized in Chinaas a new antifertility agent for women.Bioassay results have indicated that the compoundhas significant progestogenic activity and some estrogenic activity.It has definite anti-ovulation and anti-implantation effects.A certain relationship exsists between anti-implan-tation effectiveness and time of administration.Progestin No.1 had...

This paper reports the pharmacological study on a new synthetic progestogen 3-cyclo-pentyl propionate of megestrol acetate(Progestin No.1),which has been synthesized in Chinaas a new antifertility agent for women.Bioassay results have indicated that the compoundhas significant progestogenic activity and some estrogenic activity.It has definite anti-ovulation and anti-implantation effects.A certain relationship exsists between anti-implan-tation effectiveness and time of administration.Progestin No.1 had 100% anti-implanta-tion effect when a single dose(1.5mg/kg)of it was given to rabbits on day-3 of coition(day 0 being the mating day).However,it did not show any efficacy when administeredpostcoitally.The experiments has also shown that as the compound was given in smalldoses(0.2mg/kg) on 3 consecutive days(day-2,-1,0),a total dosage of 0.6 mg,whichwas only 40% of the single dose,was sufficient for anti-implantation.The subacute toxicity test on the dog demonstrated that a very high dose of ProgestinNo.1(totally eight doses were given,each equivalent to 250 times the clinical dose)did notcause significant pathological changes in sex and other organs.Besides,few gastro-intes-tinal side-effects occurred in the treated animals.The clinical relevance of the results of the present study was also discussed.

本文报道了我国合成的一种长效孕激素化合物、甲地孕醇-3-环戊烷丙酸酯(简称甲孕环酯,曾称孕素1号)的药理学研究。生物检定表明该化合物具有一定的孕激素活性与雌激素活性。对家兔有显著的抗排卵与抗着床作用。实验表明药物的抗着床效果与投药时间有一定关系:交配前3天给家兔灌服单次剂量(1.5毫克/公斤)时显示100%抗着床效果;而交配当天(配前1小时)或交配后次日投药均无抗着床作用。此外,交配前连续3天(-2,-1,0天)投药、达100%抗着床效果的总剂量为0.6毫克/公斤,较单次剂量)1.5毫克/公斤)低2.5倍。狗的毒性实验表明,每次剂量相当于临床剂量250倍的甲孕环酯,在投药8次后(每二周一次),未引起性器官或其他脏器的明显病理变化,对胃肠道也无明显的副反应。本文还结合复方甲孕环酯片的临床应用,以及如何发展以孕激素为主要成分的长效避孕药进行了讨论。

The experiments were performed in rats and divided into three groups.1.On day 4,5 or 7 of pregnancy,a potent LH-RH analogue,[D-Ala~6][Des Gly~(10)]LH-RH.EA,(100 μg/100 μl)was injected into the lateral ventricle of rats,while the sameamount of saline was given to the control animals.The animals were sacrificed on day11 of pregnancy.At autopsy the number of pregnant animals and the sites of their implan-tation were counted and examined.It was found that if the LH-RH analogue was given on day 4 or 5,it could terminatethe...

The experiments were performed in rats and divided into three groups.1.On day 4,5 or 7 of pregnancy,a potent LH-RH analogue,[D-Ala~6][Des Gly~(10)]LH-RH.EA,(100 μg/100 μl)was injected into the lateral ventricle of rats,while the sameamount of saline was given to the control animals.The animals were sacrificed on day11 of pregnancy.At autopsy the number of pregnant animals and the sites of their implan-tation were counted and examined.It was found that if the LH-RH analogue was given on day 4 or 5,it could terminatethe pregnancy in rats with an effective rate of 40 % and 72%.However,the LH-RH analo-gue showed no effect on the pregnancy of rats injected on day 7 of pregnancy.2.On day 5 of pregnancy LH-RH analogue was given intraventricularly to the rats,and then,on the next day,0.5 ml 2.5% solution of pontamine blue was given intravenouslyto the same animals.It was found that the sites of implantation were seen only in 1/6 ofthe rats.3.Following intraventricular administration of ~(125)I-LH-RH,the radioactivity of va-rious organs was determined in rats.The control animals were sacrificed by decapitationand the radioactivity in the various organs was calculated.The results indicated that the radioactivity of ~(125)I-LH-RH was injected with Na~(125)I ofthe same radioactivity.After 3 minutes,the rats were selectively concentrated in thehypothalamus and the hypophysis.Accordingly,it seems that the anti-implantation effect of LH-RH analogue might beeffected through the hypothalamus and hypophysis.

本文报道了侧脑室注射LHRH类似物(100微克/只)对大鼠胚泡着床、早孕的影响,以及侧脑室注射~(125)I-LHRH 在大鼠体内的分布。结果表明,于大鼠着床前或着床期侧脑室注射LHRH 类似物具有明显的抗着床作用,但于着床后给药无抗早孕作用;~(125)I-LHRH 的放射活性特异地集中于下丘脑和垂体,提示侧脑室注射LHRH 类似物的抗着床作用可能主要是通过下丘脑和垂体而实现的。

 
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