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Sixty selected cases of chronic bronchitis during exacerbation were randomly divided into 3 groups (n=20 each) and were treated with aminophylline, corticosteroid and combined cortcosteroid and small-dose aminophylline respectively. It was found that the rate of FEV1 after 3 days of treatment and the time needed for patients to recover from exacerbation were better in corticosteroid group than in aminophylline group (12. 05% and 7. 05d vs 5. 80% and 11. 60d, P<0. 001). The therapeutic effects after 7 days of... Sixty selected cases of chronic bronchitis during exacerbation were randomly divided into 3 groups (n=20 each) and were treated with aminophylline, corticosteroid and combined cortcosteroid and small-dose aminophylline respectively. It was found that the rate of FEV1 after 3 days of treatment and the time needed for patients to recover from exacerbation were better in corticosteroid group than in aminophylline group (12. 05% and 7. 05d vs 5. 80% and 11. 60d, P<0. 001). The therapeutic effects after 7 days of longer treatment seemed to be better in combined corticosteroid and small-dose aminophylline group than in corticosteroid group, but the difference was of no statistical significance (19. 10% and 6. 35 d vs 17. 50% and 7. 05d, P>0. 2 and>0.1 respectively). Our observation indicates that hormonal therapy can rapidly control the acute exacerbation of chronic bronchitis and shorten its course, whith the combined use of small-dose aminophylline with corticosteroids may have even better effects practically and theoretically. 观察了分别应用糖皮质激素(20例)、氨茶碱(20例)和糖皮质激素与小剂量氨茶碱联合(20例)治疗慢性支气管炎急性发作的疗效。结果发现治疗后3d1s用力呼气量(FEV1)改善率及恢复至病前水平的天数在应用激素(分别为12.05%和7.05d)者优于应用氨茶碱(分别为5.80%和11.60d)者,两者比较差异极显著(P均<0.001);应用激素与小剂量氨茶碱联合者治后7dFEV1改善率(19.10%)和恢复至病前水平的天数(6.35d)优于应用激素者,但差异不显著(P分别>0.2和>0.1)。表明激素治疗可以迅速有效地控制慢性支气管炎急性发作,缩短病程,联用小剂量氨茶碱效果尤佳。 It was reported on clinical effect of levofloxacin lactate used in treating of lower respiratory tract infection on 60 cases of the elderly who have either acute bronchitis, or acute exacerbation of chronic bronchitis, or pneumonia or bronchiectasisor acute infection with asthma. Taking levofloxacin lactate 200mg i.v bid for 7~14 days. The cure rate reached 55.6%; the efficacy rate 88.9% and bacterial eradication rate was 90% respectively; and the adverse effect was 8.2%. It was showed that levofloxacin... It was reported on clinical effect of levofloxacin lactate used in treating of lower respiratory tract infection on 60 cases of the elderly who have either acute bronchitis, or acute exacerbation of chronic bronchitis, or pneumonia or bronchiectasisor acute infection with asthma. Taking levofloxacin lactate 200mg i.v bid for 7~14 days. The cure rate reached 55.6%; the efficacy rate 88.9% and bacterial eradication rate was 90% respectively; and the adverse effect was 8.2%. It was showed that levofloxacin lactate was positive and effective in treating of lower respiratory tract infections in the elderly, especially those with respiratory infection which are considered difficult to be cured. It was also showed, on the other hand, that its adverse effect is light so that it is safe to use. 本文报告乳酸左氧氟沙星治疗老年人下呼吸道感染60例的临床疗效。下呼吸道感染分别为急性支气管炎、慢性支气管炎急性发作、肺炎、支气管扩张继发感染和支气哮喘继发感染。每日400mg,分2次静脉滴注,疗程7~14d。痊愈率55.6%,有效率88.9%,细菌清除率90%,不良反应发生率8.2%。提示乳酸左氧氟沙星对老年人下呼吸道感染疗效肯定,特别对呼吸系统难治感染有较好的抗菌效果,不良反应轻,安全性好。 Oral moxifloxacin has a good effect in the treatment of community-acquired pneumonia (400mg once daily for 10 days) and acute exacerbation of chronic bronchitis (400mg once daily for 5 days). The once daily dosing regimen of moxifloxacin can offer an advantage in terms of improving patients compliance and convenient outpatient treatment. 莫西沙星以400mg·d-1的剂量,口服10d,对社区获得性肺炎有较好的治疗作用,对慢性支气管炎,只需口服5天,也有理想疗效。莫西沙星每日只需给药一次,有利于患者服药的顺应性,方便了门诊患者的治疗。
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