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osteocalcin
相关语句
  骨钙素
    Human Serum Osteocalcin Determined by ELISA and its Clinical Application
    人血清骨钙素ELISA测定法及临床应用
短句来源
    Changes of bone density and serum osteocalcin levels in mid and late preganacy
    中、晚期孕妇骨密度及血清骨钙素水平的改变
短句来源
    Level and significance of serum osteocalcin in patient with hemodialysis
    血液透析患者血清骨钙素的变化及其意义
短句来源
    Significance of Changes of Serum Osteocalcin Levels in Healthy Subjects and Patients with Metabolic Bone Diseases
    健康人与代谢性骨病患者血清骨钙素水平及其意义
短句来源
    Determination and analysis of serum osteocalcin and calcitonin in cord blood of new born infants and in puerperal blood
    脐血、母血血清骨钙素和降钙素含量测定及分析
短句来源
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  “osteocalcin”译为未确定词的双语例句
    Results Maternal osteocalcin level declined toward mid pregnancy[(3.30±1.46) μg/L] and increased thereafter.
    结果 孕妇血清Ost水平随妊娠发展逐渐下降 ,至孕中期最低 [(3.30± 1.4 6 )μg/L],随后又逐渐升高。
短句来源
    Serum level of osteocalcin at delivery[(12.81±4.28) μg/L] was significantly higher than those throughout pregnancy( P <0.01), but it dramatically decreased to around the baseline level of nonpregnancy in several days postpartum.
    分娩即刻产妇血清Ost水平 [(12 .81± 4 .2 8) μg/L]显著高于妊娠各阶段的水平 (P <0 .0 1) ,产后数日即显著下降至接近妊娠前的基线水平。
短句来源
    Cord blood level of osteocalcin was the lowest during mid pregnancy [(0.88±0.39) μg/L] and increased thereafter. It remained similar to maternal osteocalcin level from 24 weeks through 36 weeks of gestational age ( P <0.01).
    脐带血Ost水平在孕中期最低 [(0 .88± 0 .39) μg/L],随后则升高 ,并且自孕 2 4周保持于接近母体Ost水平 (P <0 .0 1)。
短句来源
    Methods By routine methods, we measured serum concentration of osteocalcin in 142 pregnant women, 21 nonpregnant women and 22 postparturient women, as well as cord blood levels of osteocalcin in 34 infants of various gestational ages.
    方法 采用荧光酶联免疫法测定 14 2例孕妇、2 1例非孕妇女、2 2例产妇及 34例不同孕龄胎儿的脐带血Ost水平。
短句来源
    Conclusions The level of osteocalcin may be important to the development of fetal skeletal system, because calcium accumulation by the fetus is activating during this gestational period.
    结论 由于这段妊娠期是胎儿Ost积累活跃的阶段 ,因此这种恒定的Ost水平对胎儿骨骼系统的正常发育 ,可能具有重要意义
短句来源
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  osteocalcin
The content of osteocalcin was increased after space flights.
      
The cell morphology and viability, alkaline phosphatase and osteocalcin, as markers of osteoblast proliferation were evaluated at 3, 7 and 25 days of culture.
      
Cells cultured into the COL/β-TCP scaffold presented osteoblast phenotype, intense staining of alkaline phosphatase and increased production of osteocalcin.
      
Furthermore, the mRNA expression of type I collagen, osteocalcin and osteonectin was semi-quantitively evaluated by real-time reverse transcriptase-polymerase chain reaction (RT-PCR).
      
The osteogenic differentiation of PCs was further demonstrated by the detection of type I collagen, osteocalcin and osteonectin gene expression.
      
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To observe changes of biochemical markers of bone turnover in osteoporotic bone matrix after renal transplantation, osteocalcin, bone alkaline phosphatase(BAP), PICP (carboxyterminal propeptide of type I procollagen), ICTP (carboxyterminal cross-linked telopeptide of type I collagen), parathyroid hormone (PTH) and 25-hydroxy-vitamin D (25 OHD) were measured in 7 patients with osteoporosis followingrenal transplantation (median 6 months, range 1 to 72 months). Using restrictive criteria for defining the...

To observe changes of biochemical markers of bone turnover in osteoporotic bone matrix after renal transplantation, osteocalcin, bone alkaline phosphatase(BAP), PICP (carboxyterminal propeptide of type I procollagen), ICTP (carboxyterminal cross-linked telopeptide of type I collagen), parathyroid hormone (PTH) and 25-hydroxy-vitamin D (25 OHD) were measured in 7 patients with osteoporosis followingrenal transplantation (median 6 months, range 1 to 72 months). Using restrictive criteria for defining the presence of osteoporosis when bone mineral density (BMD) measured using dual energy X-ray absorptiometry lay more than 2 SD below the mean of normal subjects of the same age and sex. Mean serum values of bone formation markers such as osteocalcin, BAP, PICP, and bone resorption marker such as ICTP were significantly higher in patients group than those of 38 noormal subjects. Serum PTH and 25OH D levels were normal. These data suggested that this osteoporosis after renal transplantation is associated with a high bone turnover (elevated osteoblastic and osteoclastic activity) without secondary hyperparathyroidism and abnormal vitamin D metabolism.

应用放射免疫分析法和免疫放射分析法对7例已确诊有骨质疏松症的肾移植患者进行血清骨代谢指标检测。结果表明患者成骨细胞活性指标(血清特异性骨碱性磷酸酶、骨钙素和Ⅰ型前胶原蛋白羧基末端前肽)和破骨细胞功能指标(血清Ⅰ型胶原交联羧基末端肽)明显高于正常对照组。患者血清甲状旁腺素和25羟维生素D水平正常。提示肾移植后伴骨质疏松症患者的成骨细胞活性和破骨细胞活性明显增高,但无继发性甲状旁腺功能亢进和维生素D代谢异常

Intact osteocalcin(BGP) levels in human serum were measured by enzyme linked immunosorbent assay(ELISA). Serum BGP levels in 254 normal subjects and 87 patients with various internal diseases or pregnancy-induced hypertension were determined. The results showed that BGP levels changed with age and sex,but a significant peak appeared in 5-10 year age groups. Compared with normal control groups,BGP levels were elevated in renal failure,rickets,multiple myeloma and osteoporosis(P <0. 001,P<0. 05,P<0. 02 and...

Intact osteocalcin(BGP) levels in human serum were measured by enzyme linked immunosorbent assay(ELISA). Serum BGP levels in 254 normal subjects and 87 patients with various internal diseases or pregnancy-induced hypertension were determined. The results showed that BGP levels changed with age and sex,but a significant peak appeared in 5-10 year age groups. Compared with normal control groups,BGP levels were elevated in renal failure,rickets,multiple myeloma and osteoporosis(P <0. 001,P<0. 05,P<0. 02 and P<0. 05 respectively). BGP levels in pregnancy-induced hypertension were significantly lower than normal control (P<0. 05). This study concluded that BGP as a sensitive index of bone metabolism has an important significance for the dignosis of internal diseases related to bone metabolism and the estimation of their seriousness.

采用酶联免疫学方法(ELISA)测定人血清完整骨钙素(BGP)水平,观察全年龄组BGP的正常人参考值范围,提出其在某些疾病中的临床意义。研究对象选取正常人254例,内科疾患79例,妇科妊高征8例。结果表明:BGP水平随年龄和性别变化,5~15岁青少组的BGP水平出现一明显峰值。与同年龄正常对照组相比,肾功能不全患者、佝偻病患儿、多发性骨髓瘤患者和骨质疏松患者BGP水平均升高(P<0.001,P<0.05,P<0.02及P<0.05);妊高征患者则低于对照组(P<0.05)。本研究结论:BGP作为骨代谢研究的灵敏指标,对某些与骨代谢有关的内科疾病的诊断及其严重程度的判别有参考意义。

Bone gla protein (BGP,or osteocalcin) is a bone specific protein. BGP can be synthesized by osteoblasts and secreted into blood.Serum bone gla protein (S BGP) is a valuable marker for evaluating bone turnover and bone formation. In order to understand the change tendency of S BGP in normal and pathological condition, we systematically detected the levels of S BGP by using ELISA in 122 normal humans with different age stages (from 0.5 to 80 yrs,average age 34.1±18.9 yrs,10 yrs as an age stage),46...

Bone gla protein (BGP,or osteocalcin) is a bone specific protein. BGP can be synthesized by osteoblasts and secreted into blood.Serum bone gla protein (S BGP) is a valuable marker for evaluating bone turnover and bone formation. In order to understand the change tendency of S BGP in normal and pathological condition, we systematically detected the levels of S BGP by using ELISA in 122 normal humans with different age stages (from 0.5 to 80 yrs,average age 34.1±18.9 yrs,10 yrs as an age stage),46 patients with primary osteoporosis (POP) and 66 patients with metabolic bone disease.The results are as follows.(1)The level of S BGP in normal humans was 6.2±4.9ng/ml,with 6 9±5 7ng/ml( n =60) in males and 5.8±4.3ng/ml( n =62) in females.The level of S BGP was negatively correlated with the age significantly (r=-0.452, P <0.001).(2)The levels of S BGP in patients with POP (from 42 to 88 yrs,average age 61.3±10.1 yrs) according to different age stage was 12.3±5 5ng/ml (40 49 yrs, n =5),10.9±6.4ng/ml (50 59 yrs, n =17) and 10.7±6.9ng/ml(60 80 yrs, n = 24),respectively. Every value compared respectively with S BGP in corresponding age stage of normal humans was significantly different ( P <0.001). (3)The levels of S BGP in 66 patients with metabolic bone disease (20 79 yrs,average age 46.9±15.1 yrs) were 6.6±2.6ng/ml( n =32)in chronic renal failure,8.1±3.3ng/ml( n =19) in hyperthyroidosis and,6.5±2.2ng/ml( n =16) in diabetes,respectively.These results respectively compared with the level of S BGP (4.4±1.7ng/ml) in corresponding age stage of normal humans (20 80 yrs,average age 40.4±15.8 yrs, n =96)were significantly different( P <0.001).The results of this study provide important parameters for clinical and basic research in bone metabolism.

骨钙素(Osteocalcin)又名骨谷氨酸蛋白(Boneglaprotein,BGP),为骨组织的特异性蛋白,由成骨细胞生成,分泌入血。血清骨钙素(S-BGP)是评估骨转换率及骨形成的特异性指标。本文为研究S-BGP在正常及病理状态下的变化趋势,采用ELISA法观察了122例不同年龄段(0.5~80岁,平均年龄为34.1±18.9,每隔10岁为一年龄段)正常人,46例原发性骨质疏松症及66例代谢性骨病患者的S-BGP水平。结果显示:(1)正常人S-BGP水平为6.2±4.9ng/ml,其中男性为6.9±5.7ng/ml(n=60),女性为5.8±4.3ng/ml(n=62),S-BGP与年龄呈明显负相关(r=-0.452,P<0.001);(2)46例原发性骨质疏松症患者(42~88岁,平均年龄为61.3±10.1岁)的S-BGP水平,按不同年龄段统计,其值分别为12.3±5.5ng/ml(40~49岁,n=5)、10.9±6.4ng/ml(50~59岁,n=17)及10.7±6.9ng/ml(60~88岁,n=24),各项数值分别与正常人相应年龄段S-BGP水平相比都呈显著性差异(P<0.001);(3?

 
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