This result suggests that erythromycin can reverse drug resistance by saturating the drug-binding sites on the P-glycoprotein, thereby reducing the capacity Of this protein to pump drugs out of resistant cells.
As to K562/S cells,however,this compound couldn't affect them. Conclusion:In K562/A02 cells,oridonin can induce cell apoptosis,reverse multi drug resistance,so this compound is a kind of very promising anti leukemia traditional chinese drug.
In conclusion, BBM could increase intracellular concentration of ADR in K562/A02 that down regulated expression level of mdr1 mRNA and P gp and survivin so that the sensitivity of K562/A02 to ADR was increased significantly.
The aims of this study were not only to elucidate the relationship between drug resistance of MCF-7/ADR to ADR and GST- or DNA TopoII, but also to investigate the mechanism through which CEP reverses drug resistance.
Objective:To study the effects of oridonin on inducing the multi drug resistant cell line K562/A02 to apoptosis and reversing their multi drug resistance.
Most previous research has focused on approaches to reverse drug resistance once it has arisen, that is, on the use of agents which can make drug-resistant tumors more sensitive to chemotherapy.