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   myc mrna 的翻译结果: 查询用时:0.008秒
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myc mrna
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  myc基因
     The mechanism of such changes described may be associated with the higher expression of nm23 mRNA, and the lower expression of c myc mRNA as well as the apoptosis in sense TGFβ 1 gene transfected cells.
     其机制可能与正义TGFβ1基因转染细胞nm23基因表达增加,c-myc基因表达减少以及诱发细胞凋亡有关。
短句来源
     Methods FISH was used to observe N myc gene amplifiction, RT PCR and immunohistochemistry techniques were used to detect N myc mRNA and N myc protein respectively.
     方法 应用荧光原位杂交 (FISH)技术检测N myc基因扩增 ,应用RT PCR和免疫组化技术分别检测N myc转录和蛋白水平表达。
短句来源
     Methods PLA 801D cells were transfected with an expression vector containing a full length human sense or antisense TGFβ 1 gene by gene transfer. The changes of cell proliferation, expressions of nm23 mRNA and c myc mRNA and the feature of apoptosis were studied on transfected cells and untransfected cells.
     方法通过基因转染方法,将TGFβ1正、反义基因分别导入PLA-801D细胞,观察转染和未转染细胞体内外增殖变化、nm23基因和c-myc基因表达以及细胞凋亡特征。
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     ③ The expressions of bcl 2 and c myc mRNA in SHG 44 cells were decreased after the treatment with 100μmol/L NDGA, which was apparently consistent with the immunohistochemical results.
     ③原位杂交结果显示 ,NDGA处理细胞不同时间后 ,出现SHG 44细胞bcl 2、c myc基因mRNA的表达水平降低 ,结果与免疫组化检测一致。
短句来源
     Objective To study the effects of transretinoic acid on DNA, cMYC mRNA exepression and apoptosis of gastric cancer in rats.
     目的 研究维甲酸对大鼠胃粘膜癌变DNA含量、c myc基因mRNA表达及细胞凋亡的影响。
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  “myc mrna”译为未确定词的双语例句
     Definite dose of VitD3 could induce U937 cells to autocrine TGF β1 and down regulate expression of C myc mRNA.
     一定剂量范围的VitD3能促进U937细胞自分泌TGF β1,并下调C mycmRNA表达 ,这可能是VitD3联合TGF β1诱导U937细胞分化的一个途径。
短句来源
     RESULTS: hTERT and c myc mRNA were detected in 24 of 28 (85.7%) and 20 of 28 (71.4%) respectively in TCC urine samples, while 2 of 15 (13.3%) and 4 of 15 (26.7%) in controls.
     结果 :尿脱落细胞hTERT和c myc阳性表达率分别为 85 .7%和 71.4 % ,对照组为 13.3%和 2 6 .7% ;
短句来源
     Results In the HXO Rb44 cells the signals for c fos mRNA,N myc mRNA,and p21ras mRNA were localized in the cytoplasm. The c Fos IR,N Myc IR were localized in the nuclei,while P 21ras IR localized in the cytoplasm.
     结果在人HXORb44细胞,cfosmRNA、NmycmRNA及p21rasmRNA定位于胞质,cFosIR及NMycIR定位于胞核,而P21rasIR则位于胞质。
短句来源
     CONCLUSIONS C myc antisense oligonucleotide can inhibit the expression of c myc mRNA and induce the differentiation of HL60 cells.
     结论cmyc反义寡核苷酸能够抑制cmyc基因的表达并能诱导HL60细胞分化。
短句来源
     Results:C myc mRNA positive rate in 29 cases of benign and 7 cases of malignant adrenal pheochromocytomas were 27.5%(8/29) and 71.5%(5/7) C myc protein's expression rate of benign and malignant pheochromocytomas were 31.0%(9/29) and 71.4%(5/7).
     结果 :原位杂交结果显示 :C mycmRNA在良性肾上腺嗜铬细胞瘤中表达率为 2 7.5 % (8 2 9) ,而在恶性肾上腺嗜铬细胞瘤中为 71.4(5 7) (P <0 .0 5 ) ; 免疫组化结果显示 :C myc蛋白表达率分别为 31.0 % (9 2 9)和 71.4% (5 7) (P <0 .0 5 ) ;
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  相似匹配句对
     Research on the expression of c-myc mRNA in ameloblastoma
     c-myc mRNA在成釉细胞瘤中的表达
短句来源
     The mRNA Expression of c myc and c fos in Meningiomas and Its Function
     脑膜瘤中c-myc和c-fos mRNA的表达及作用
短句来源
     Oncoprotein such as c-myc?
     测序后将c-myc基因亚克隆入Tet-On系统的pTRE2载体中,获得pTRE2-c-myc重组载体。
短句来源
     Non coding mRNA.
     非编码的mRNA
短句来源
     EnhancedGFAPex-pressionwastheresultofupregulationofGFAP-mRNA.
     (2)反应性星形胶质化时,GFAP表达增强是转录水平上GFAP-mRNA增加的结果;
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  myc mrna
Inhibition of ERK1/2 by PD98059 attenuated Ang II-induced c-fos and c-myc mRNA expression (by 75% and 100%, respectively) but was ineffective in preventing Ang II induction of c-jun.
      
AF64A produced a maximal decrease in N-myc mRNA with a return to steady state levels at later time points.
      
Thus, 18:1/DHA-PE might enhance dbcAMP-induced HL-60 cell differentiation and growth inhibition by regulation of c-jun and c-myc mRNA and their products.
      
The decreases of c-myc mRNA by 18:1/DHA-PE and/or dbcAMP was correlated with growth inhibition effect.
      
Furthermore, rotenone increased the expression of c-myc mRNA to 5-fold of control values within 3 days, an effect which was still observed (3-fold) after 7 days.
      
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We have studied the relationship between expression of c-myc and P53 genes and terminal differentiation (expression of β-globin gene) during induced differentiation by DMSO,DMF,HMBA and inhibition of dif-ferentiation by TPA in Friend erythroleuke-mia cells.Induced MELC differentiation by 5 mM HMBA is associated with an early and rapidly decrease in expression of P~(53) and C-myc genes,levels of the P~(53) and c-myc mRNA markedly decrease within 1 hr and 4 hr.respectively in induced MELC.At...

We have studied the relationship between expression of c-myc and P53 genes and terminal differentiation (expression of β-globin gene) during induced differentiation by DMSO,DMF,HMBA and inhibition of dif-ferentiation by TPA in Friend erythroleuke-mia cells.Induced MELC differentiation by 5 mM HMBA is associated with an early and rapidly decrease in expression of P~(53) and C-myc genes,levels of the P~(53) and c-myc mRNA markedly decrease within 1 hr and 4 hr.respectively in induced MELC.At the same time the expression of β-globin gene and B~+ % are below detectable level.When cultured with 5mM HMBA at day 2 and day 5 the proportion of Benzidine-reactive cells was increased to 51% and 84.1% respectively.The level of accumulation of β-globin mRNA in the cytoplasm increase markedly and ex-pression of c-myc and P~(53) genes still keeped the very lower levels.By using FCM we demonstrated that the number of the cells contained Gl DNA content increase from 31% to 45% at day 2 and 68% at day 5.

本文观察了DMF,DMSO和HMBA对小鼠Friend细胞(MELC)诱导分化及TPA抑制分化过程中c-myc和P~(53)基因表达与终端分化的关系。MELC被5 mmol/L HMBA诱导分化后分别在1小时和4小时P~(53)与c-myc表达急剧下降,诱导2天,5天联苯胺阳性率和β-珠蛋白基因表达明显升高,c-myc和p~(53)基因表达仍维持在很低水平,同时G_1期细胞百分数增加。低浓度TPA明显抑制HMBA诱导分化效应,β-珠蛋白基因表达被抑制,但c-myc和P~(53)基因表达仍处于低水平,看来与增殖有关的c-myc和P~(53)表达之降低并不能直接导致分化基因的表达。

Expression of c-myc and Ha-ras oncogenes was investigated preliminiarily in human squamous lung cancer. Densitometric analysis of the autoradiographic signal from dot blots indicated a 32 and 10 fold increase of the Ha-ras and c-myc mRNA in total RNA of-human squamous lung cancer tissue, respectively, as compared to those of normal, human lung. It remains to be determined whether the elevated expression of c-myc and Ha-ras are involved in the pathogenesis of human squamous lung cancer.

本文初步研究了人肺鳞癌中c-myc及Ha-ras癌基因的表达。斑点杂交自显影密度分析的结果表明,人肺鳞癌总RNA中Ha-ras及c-myc基因的mRNA分别是正常人肺组织的32倍及10倍。这两种基因表达的增加在人肺恶性变中的作用,尚有待深入研究。

In order to study the relationship between some related genes' expression and cell proliferation, cell differentiation, the effect of 6-thioguar-ine (6-TG), interferons (IFN-α and IFN-γ ) on HL-60 human leukemia cell growth, cell differentiation and the expression of c-myc protooncogene mRNA and an int-erferon inducible gene, pIFN-IND-2, mRNA(56K mRNA) has been determined.Results show that. 6-TG has strong inhibition effect and IFNs hardly have effect on HL-60 cell clonal growth. But...

In order to study the relationship between some related genes' expression and cell proliferation, cell differentiation, the effect of 6-thioguar-ine (6-TG), interferons (IFN-α and IFN-γ ) on HL-60 human leukemia cell growth, cell differentiation and the expression of c-myc protooncogene mRNA and an int-erferon inducible gene, pIFN-IND-2, mRNA(56K mRNA) has been determined.Results show that. 6-TG has strong inhibition effect and IFNs hardly have effect on HL-60 cell clonal growth. But both of them produce similar induction of terminal differentiation of HL-60 cells in NBT assay. It is very interesting that, both of them have the similar regulation effect on related gene's mRNA expression- c-myc mRNA increased in early time, and then it decreased rapidly; 56K mRNA increased by both of them with different degrees.Results suggest that: c-myc protooncogene expression is closely related to cell differentiation and pINF-IND-2 gene might be involved with cell differentiation as well. These might be the molecular biology bases of 6-TG and IFNs.

为研究6-巯基鸟嘌呤(6—TG)和干扰素(IFN—α和IFN—γ)对HL—60细胞中相关基因表达的调控作用及其与细胞增殖和分化的关系,实验观察了这两类因子对HL—60细胞的生长抑制作用,分化诱导作用及其对C—myc原癌基因mRNA和干扰素相关基因pIFN—IND-2的56KmRNA表达的调控作用。 结果表明:对于HL—60细胞的克隆生成,6—TG是强烈的抑制剂,而干扰素类几无抑制作用。在NBT实验中,这两类因子都产生了类似程度的诱导HL-60细胞向粒细胞方向的终末期分化。对Northern Blot的结果分析发现它们对相关基因产生了相似的调控作用。C—myc mRNA早期的增加和后期的明显减少;56K mRNA则有程度不同的增加现象。 结果提示:在HL—60细胞中C—myc原癌基因与其分化密切相关,pIFN—IND—2基因也可能与之有关。对相关基因的类似调控作用可能是6—TG与干扰素联合应用的分子生物学基础。

 
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