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retinoblastoma rb
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     Immunohistochemical Study on Retinoblastoma
     视网膜母细胞瘤的免疫组织化学研究
短句来源
     Retinoblastoma:CT diagnosis
     视网膜母细胞瘤的CT诊断
短句来源
     THE EXPRESSION OF Rb GENE IN RETINOBLASTOMA
     视网膜母细胞瘤Rb基因表达
短句来源
     Expression of P~(53)gene protein in retinoblastoma
     视网膜母细胞瘤中P~(53)蛋白的免疫组化研究
短句来源
     To explore the histopathology and histogenesis of retinoblastoma(RB).
     目的探讨视网膜母细胞瘤(RB)的病理形态特征及组织起源。
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  retinoblastoma rb
Similar to other types of cancer, essential pathways regulating apoptosis are also disrupted in malignant gliomas, notably the cell cycle control mechanisms regulated by the p53 and retinoblastoma (RB) proteins and their homologs.
      
Similar to other types of cancer, essential pathways regulating apoptosis are also disrupted in malignant gliomas, notably the cell cycle control mechanisms regulated by the p53 and retinoblastoma (RB) proteins and their homologs.
      
Altered structure and deregulated expression of the tumor suppressor gene retinoblastoma (RB1) in human brain tumors
      
Two tumor suppressors, p53 and retinoblastoma (Rb), play key roles in progression from G1 into S-phase.
      
Gossypol plasma levels were measured (n=8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n=4).
      
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In recent years, with the advancesin research work on chromosome oftumor cells, it was revealed thatthe aberration of chromosome oftumor cells was nonrandom. It hasbeen proved that retinoblastoma(RB)in some patients is associated withdeletion of one chromosome 13q ofsomatic cells and some data concern-ing the chromosomal behavior ofRB tumor cells reported in literatureare found to be similar to those con-cerning somatic cells. The aim ofthe present study was to analyzethe chromosome constitution...

In recent years, with the advancesin research work on chromosome oftumor cells, it was revealed thatthe aberration of chromosome oftumor cells was nonrandom. It hasbeen proved that retinoblastoma(RB)in some patients is associated withdeletion of one chromosome 13q ofsomatic cells and some data concern-ing the chromosomal behavior ofRB tumor cells reported in literatureare found to be similar to those con-cerning somatic cells. The aim ofthe present study was to analyzethe chromosome constitution of tu-mor cells and compare the charac-teristics of chromosome of the malig-nant cells with histological and clini-cal findings of the tumor. Results of chromosome study of so-lid tumor cells from 9 patients withRB are presented in this paper. Noneof the patients had a family historyof RB, and the examination of themetaphase of chromosome of peripher-al blood lymphocytes in 5 patientsrevealed nothing abnormal. Chromo-some preparations of the tumor cellswere obtained by using direct tech-nique and short-term culture (2 and24 h). Chromosome banding wasachieved in 4 cases only. The chromosomes in metaphase oftumor cells in all 9 cases were foundabnormal both in number and struc-ture. 30-206 metaphases of tumorcells were counted in each individualcase. The modal chromosome numberwas 45 in 3 cases, 46 in 2, 47, 66and 92 in 3 cases respectively, andhyper-tetraploidy in 1. Karyotypeanalysis revealed a considerable vari-ability. However, one to five markerchromosomes were found in each case.Six of these cases had aberrations ofD-group chromosome. Six of thesecases lost one E-group chromosome(chromosome 16) and had a metacen-tric chromosome in size similar to C-group chromosome [in some cases, itwas probably i(17q)].Four cases haddouble minutes. These results suggest-ed that the aberration of chromosomeD and E-group were probably relatedto the development and progression ofRB. The investigation of chromoso-mal, histological and clinical findingssuggested that some undifferentiatedtumors tended to have polyploid chro-mosome modes and the chromosomalpolyploidy was probably related toprotracted evolution of tumor cells inconsiderably long duration of malig-nancy too.

本文对9例视网膜母细胞瘤患者实体瘤细胞作染色体研究。瘤细胞染色体数目和结构均有畸变。据检查结果,推测D组和E组染色体的异常可能与视网膜母细胞瘤的发生有一定联系;染色体的多倍化可能与病程较长,瘤细胞长期演化有关。

The results of ultrasonic examination of 113 patients(120 eyes)with retinoblastoma (RB)in the past 10 years are reported.The diagnosis of all cases was confirmed both clinically and pathologically.The ultrasonic characteristics of RB were introduced and discussed.There was high reflectivity in most tumors of the eyes(about 79.64% high reflection in bunches),and some attenuation of sound was seen.In follow-up examination,the lesion

本文报告近十年来经临床和病理确珍为视网膜母细胞瘤共113例120只眼的超声检查结果并作分析。本文介绍和讨论了视网膜母细胞瘤在超声图上显示的典型特征:大多数患眼肿瘤具有高反射性(79.64%,多为束状高液反射);不同程度的声学衰减;随访观察异常反射增加和范围扩大;眼轴长度除少数例外大多数正常。本组病例 B-扫描声象显示五种图形:肿瘤形状规则或不规则,肿瘤边界清楚或不清楚,可有强光斑和其他异常反射(例如暗区及球后异常光团)。超声图与眼球病理密切相关,在不典型病例,超声波形和图象不典型。文中介绍了误诊病例,提出了检查诊断中的经验和体会;强调在屈光媒质混浊及视网膜脱离妨碍观察肿瘤时,超声波检查是较方便、可靠和有价值的辅助诊断方法。

The traditional 4-stage-classification of retinoblastoma (RB) seems to be not quite satisfactory. The disease, in fact, does not progress in such a way, and metastases may occur at any time. According to the clinicopathological analysis and a longterm follow-up in a serial cases (154), we found that the incidence of extra-ocular invasion of lesions in glaucomatous stage was more than 70%, and that the difference in mortality between stage Ⅰ and Ⅱ was statistically significant (p<0.05). So, glaucomatous...

The traditional 4-stage-classification of retinoblastoma (RB) seems to be not quite satisfactory. The disease, in fact, does not progress in such a way, and metastases may occur at any time. According to the clinicopathological analysis and a longterm follow-up in a serial cases (154), we found that the incidence of extra-ocular invasion of lesions in glaucomatous stage was more than 70%, and that the difference in mortality between stage Ⅰ and Ⅱ was statistically significant (p<0.05). So, glaucomatous stage should belong to the category of extra-ocular one. High ocular tension secondary to RB may be considered as an early clinical sign of the tumor extra-ocular extension. A new system of staging RB is therefore proposed to cover the whole spectrum of the disease and to offer a reliable guide to treatment and prognosis (table). We think it is simpler, more accurate and applicable to our country.

传统的视网膜母细胞瘤(RB)四期分法尚有不尽妥善处。事实上,本病的发展并非皆循此四期顺序进行,转移可发生在任一阶段:且该分法缺乏统一的分类标准。作者通过大组病例(154例)的临床病理资料分析,和长期随访,70.0%以上青光眼期病例有球外蔓延,而眼内期有球外蔓延的不及10.0%,差别有非常显著意义(P<0.01):随访结果也说明该期病死率明显高于眼内期,有统计学意义(P<0.05)。故认为青光限期病例属眼外期范畴:RB继发高眼压可视为肿瘤球外扩散的临床早期征状。结合文献复习,在四期分法基础上,拟议一个新的RB分期分类,为制定治疗方案及估计预后提供可靠依据(见附表)。本期简明确切,易于掌握,切实可行,适用于我国情况,具有一定临床实用价值,提出雏议,有待完善。

 
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