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voltage independent
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  电压依赖性
     The inhibition of SKF38393 and Clonidine on GABA A receptors is noncompetitive and voltage independent.
     ③SKF38393及Clonidine对GABAA 受体的抑制作用是非竞争性抑制 ,并且为非电压依赖性
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     RESULTS The amplitudes of voltage gated calcium currents were increased (14±8)%, (41±13)% and (58±9)%, when 1, 10 and 100 μmol·L -1 of corticosterone was applied, respectively. The potentiation was concentration dependent, but voltage independent. The characteristics of calcium channel were not influenced.
     结果 皮质酮 1、10和 10 0μmol·L- 1可使神经元电压门控性钙电流的幅度分别增加 (14± 8) %、(41± 13) %和 (5 8± 9) % ,其增强效应具有明显的浓度依赖性特征 ,但没有电压依赖性 ,也不改变钙通道的电学特征。
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     ⑤Tail current, which is voltage independent, primarily has only one component.
     ⑤尾电流成分较为单一 ,不表现电压依赖性
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     With the increases in stimulating frequency and commanding potential, no significant change in IKur was seen. The results suggested CMCS inhibit IKur in a voltage independent and frequency independent manners.
     增加刺激频率及指令电压IKur的变化均不显著 ,提示CMCS对IKur的抑制作用不具有电压依赖性和频率依赖性。
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  “voltage independent”译为未确定词的双语例句
     Small conductance Ca 2+ activated potassium channels ( SK channels) are potassium selective , voltage independent, and Ca 2+ high sensitivity. SK channels are widely distributed in neurons.
     小电导的钙激活钾通道 (SK)具有K+ 选择性 ,Ca2 + 高敏性和电压不依赖等特性 ,广泛分布在神经元上。
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     Bandgap reference provides reference voltage for overall circuits. It using two parasitic PNP BJTs in CMOS process creats reference voltage independent of temperature and power supply by op amp feedback. The simulation of the bandgap reference using ideal resistents shows that It's precision is 16.6 ppm.
     带隙基准电路为整个系统提供基准电平,它使用两个在CMOS工艺中寄生的PNP型的双极性晶体管,通过运算放大器的反馈实现独立于温度和电压的带隙基准电压,在使用理想电阻的情况下仿真,其精度达到16.6ppm。
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     As for Boost converters with certain load, output capacitor and switching frequency, some important conclusions are drawn. The converter in CCM-CISM has the smallest output ripple voltage independent of the inductance.
     指出对于给定负载、电容和开关频率的BoostDC-DC变换器,CCM-CISM模式的输出纹波电压最小且与电感无关;
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  相似匹配句对
     Relation between Cutset Voltage and Independent Node Voltage
     割集电压与独立节点电压之间的关系
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     of rated voltage.
     额定电压下,出口发生三相短路时,不会造成损坏。
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     were independent species.
     ]作为鳞伞属中独立的种;
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     Modules are independent.
     各功能模块之间相互独立。
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     voltage. with the increase of r.
     放电电压增加 ,热稳定性增加。
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  voltage independent
Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium cha
      
The magnitude of l/f spectra is voltage independent for small bias voltages, but is proportional to the square of the photocurrent (I).
      
The channel observed under these conditions had a single-channel conductance of about 2.5 nS in 1 M KCl, was cation selective, and was found to be virtually voltage independent.
      
In summary, the inhibition of Ito by S49 was dose dependent, time dependent but voltage independent.
      
Block by linopirdine was readily reversible, voltage independent, and surmountable at high concentrations of ACh, thus suggestive of a competitive type of interaction with the receptor.
      
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The effect of rhynchophylline (Rhy) on L-type Ca2+ channel current was studied in rat ventricular myocytes using patch-clamp whole-cell recording technique. When the holding potential was -40 mV, cells were depolarized to 0 mV for 250 ms at frequency of 0 . 5 Hz , Rhy 1 0 and 5 0 μmol ·L-1 reduced verapamil-sensitive Ca2+ inward current by 60 % and 80 %, respectively, without affecting the voltage-dependency of the maximal activation of Ca2+ current. This indicated that the effect of Rhy on the activation...

The effect of rhynchophylline (Rhy) on L-type Ca2+ channel current was studied in rat ventricular myocytes using patch-clamp whole-cell recording technique. When the holding potential was -40 mV, cells were depolarized to 0 mV for 250 ms at frequency of 0 . 5 Hz , Rhy 1 0 and 5 0 μmol ·L-1 reduced verapamil-sensitive Ca2+ inward current by 60 % and 80 %, respectively, without affecting the voltage-dependency of the maximal activation of Ca2+ current. This indicated that the effect of Rhy on the activation of Ca2+ channel was voltage-independent. The effect of Rhy on Ca2+ current reached the maximum at 10 min and was partially recovered by washout of Rhy. A pD2 value of 5. 91 and Hill coefficent of 1. 1 were obtained from the concentration-response curve.

用膜片钳全细胞记录的方法研究了钩藤碱(Rhy)对大鼠心叽细胞钙离子通道的阻滞作用,Rhy明显抑制verapamil敏感的L型钙通道,减少钙离子内向电流,但不改变最大激活时的膜电位水平以及激活时间常数,提示Rhy非电压依赖地抑制钙通道,其最大反应出现在给药10分钟,为浓度依赖的作用,pD_2值为5.91,Hill系数1.1。

The effect of tanshinone II-A (TSN) on L-type Ca 2+ current of single ventricular myocyte from guinea pig was studied by using whole cell voltage-clamp technique. Langendorff apparatus and method of recirculating digestion with proteinase ( 0.2 g·L -1 ) were also used and, 70% to 80% isolated cells were rod-shaped Ca 2+ -tolerant myocytes with a clear striation. When the membrane potential was held at -40 mV, cell was depolarized to 0 mV for 250 ms at a frequency of 0.5 Hz....

The effect of tanshinone II-A (TSN) on L-type Ca 2+ current of single ventricular myocyte from guinea pig was studied by using whole cell voltage-clamp technique. Langendorff apparatus and method of recirculating digestion with proteinase ( 0.2 g·L -1 ) were also used and, 70% to 80% isolated cells were rod-shaped Ca 2+ -tolerant myocytes with a clear striation. When the membrane potential was held at -40 mV, cell was depolarized to 0 mV for 250 ms at a frequency of 0.5 Hz. TSN 10, 20 and 40 μmol·L -1 markedly reduced Ca 2+ inward current by 35.2%, 57.7% and 74.7% respectively, without affecting the voltage-dependence of maximal Ca 2+ current activation. After washing out TSN, the Ca 2+ current partially recovered. In addition, TSN shortened the action potential duration in a concentration-dependent manner. These data indicate that the blocking effect of TSN on the activation of L-type calcium channels is voltage-independent.

本实验采用全细胞膜片钳技术,观察了丹参酮Ⅱ-A对分离的豚鼠单个心室肌细胞L-型钙电流及跨膜电位的影响.使用Langendorf装置和蛋白酶循环消化(0.2g·L-1)的方法,获取了70%~80%的横纹清晰,呈杆状的耐钙心肌细胞.并使用pCLAMP5.51微机程序和ELP-7膜片钳放大器记录心肌细胞膜电流和跨膜电位的变化.丹参酮采用累积加药法,所有的观察指标均在同一细胞完成.数据分析采用配对t检验.当使心肌细胞的保持电压为-40mV,除极到0mV,刺激电压的时程为250ms,频率为0.5Hz时,10,20和40μmol·L-1的丹参酮Ⅱ-A可使维拉帕米敏感的钙内向电流分别减少35.2%,57.7%和74.7%(P<0.05),并能使动作电位时程亦呈剂量依赖性缩短,冲洗后两指标均部分恢复.该药的三种不同浓度,对不同电压最大激活的钙电流的电压依赖曲线均无影响.结果表明,丹参酮Ⅱ-A具有类似维拉帕米样L-型钙通道阻断剂作用,其阻断作用呈非电压依赖性.

IM: To examine the effects of imipramine on transient outward potassium current ( I to ) in rat ventricular myocytes. METHODS: The patch clamp whole cell recording techniques were used. RESULTS: Imipramine resulted in a concentration dependent inhibition of I to with the IC 50 of 6 0 μmol·L -1 and a concentration dependent accelera ̄tion of I to inactivation. The blocking showed no difference at different testing membrane potentials. Imipramine produced slight effects...

IM: To examine the effects of imipramine on transient outward potassium current ( I to ) in rat ventricular myocytes. METHODS: The patch clamp whole cell recording techniques were used. RESULTS: Imipramine resulted in a concentration dependent inhibition of I to with the IC 50 of 6 0 μmol·L -1 and a concentration dependent accelera ̄tion of I to inactivation. The blocking showed no difference at different testing membrane potentials. Imipramine produced slight effects (about 3 and 4 mV, respectively) on steady state activation and inactivation curves of I to , and tended to prolong the recovery of I to from inactivation (τ control =37±11 ms; τ drug =58±17 ms), but not significant ( n =4, P >0 05). The inhibitory effect of imipramine on I to was increased when the prepulses were prolonged progressively from 0 to 120 ms. (τ control =22±8 ms; τ drug =14±5 ms). CONCLUSIONS: Imipramine blocked I to in concentration dependent but voltage independent manners, and with “open channel blocking” properties.

目的:研究丙咪嗪对大鼠心室细胞瞬间外向钾电流(Ito)的抑制作用.方法:膜片箝全细胞记录法.结果:丙咪嗪对Ito有浓度依赖性抑制作用,IC50为60μmol·L-1,并明显加速该电流的灭活时程.在不同的测试电位下,丙咪嗪对该电流的抑制百分率没有差别.丙咪嗪对Ito的稳态激活和灭活曲线的半数膜电位都无明显影响,对Ito灭活后的再复活时程有延长趋势,但不显著(τcontrol=37±11ms,τdrug=58±17ms,P>005),但可明显加速条件刺激时程对Ito的灭活(τcontrol=22±8ms,τdrug=14±5ms,P<005).结论:丙咪嗪对大鼠心室细胞瞬间外向钾电流有浓度依赖性和电压非依赖性抑制作用,作用特点属于开放通道阻断.

 
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