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target plasma concentrations
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  靶浓度
     Anesthesia was induced with proprofol and vecuroninm. After the tracheal intubation, the patients were ventilated with 0.6/1.0 MAC isoflurane in pure oxygen, and after 20 minutes, propofol was administered with TCI according to the different target plasma concentrations from 1.0 g/mL to 3.0 g/mL(increasing 0.5 g/mL each time).
     异丙酚和维库溴铵诱导气管内插管后,吸入异氟醚,呼末浓度分别为0.6/1.0MAC,稳定20min后靶控输注异丙酚,靶浓度从1.0μg/mL开始,以0.5μg/mL递增,靶浓度稳定在3.0μg/mL开始手术。
短句来源
     ECG, invasive BP, HR, and SpO2 were monitored before and during anesthesia. The patients were randomized to receive remifentanil by TCI at target plasma concentrations of 1, 2, 3, 4, 5 and 6 ng·ml-1( n = 10 each) . It takes 5-6 min to achieve the balance between the plasma and effect-site concentration.
     方法择期全麻手术病人60例,ASAⅠ或Ⅱ级,年龄加~65岁,体重40~75 kg,随机分为6组(n=10):瑞芬太尼靶控输注(TCI),血浆靶浓度分别为1、2、3、4、5、6 ng/ml;
短句来源
     Laryngeal mask insertion conditions at different target plasma concentrations of propofol combined with fentanyl in patients scheduled for minor surgery
     短小手术患者不同靶浓度异丙酚复合芬太尼麻醉喉罩的置入条件
短句来源
     Objective To investigate the effects of different target plasma concentrations of propofol given by TCI on end-tidal isoflurane concentration when the depth of anesthesia was maintained at BIS 50 and evaluate the reliability of electromyography (EMG) as an anesthesia depth monitor.
     目的 以脑电双频指数(BIS)值45-55作为麻醉深度监测指标,观察不同靶浓度异丙酚对腹部手术病人异氟醚呼气末有效浓度的影响,并初步探讨额肌电(EMG)作为麻醉深度监测指标的意义。
短句来源
     Objective To evaluate the effect of different target plasma concentrations of remifentanil on intraocular pressure during induction of general anesthesia.
     目的评价不同靶浓度瑞芬太尼对麻醉诱导时病人眼内压(IOP)的影响。
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  “target plasma concentrations”译为未确定词的双语例句
     The effects of remifentanil in various target plasma concentrations on hemodynamic response to tracheal intubation induced with etomidate
     瑞芬太尼对依托咪酯乳剂全麻诱导插管时血流动力学的影响
短句来源
     Methods Propofol at the target plasma concentrations of 0.5, 1.0,1.5 and 2.0 μg/ml respectively was administered to 30 ASA gradeⅠ~Ⅱadult patients to be operated on by computer controlled infusion technique.
     方法 对30例美国麻醉医师协会病情估计分级 (ASA)为Ⅰ~Ⅱ级的择期手术病人 ,通过计算机靶控输注系统(TCI)经静脉输入异丙酚。
短句来源
     Methods Sixty ASAⅠpatients undergoing general anesthesia were randomly divided into 4 groups ( n = 15 each) : groupⅠcontrol group received a bolus of fentanyl 3μg·kg-1; groupⅡ,Ⅲ,Ⅵreceived TCI of remifentanil at target plasma concentrations of 2, 4 and 6 ng·ml-1 . The patients were unpremedicated.
     方法60例ASAⅠ级择期行鼻内窥镜手术病人,随机分为4组:R0组、R2组、R4组、R6组,每组15例。
短句来源
  相似匹配句对
     N TARGET
     命中目标
短句来源
     The plasma concentrations were determined by HPLC.
     药物血浆浓度采用HPLC法测定;
短句来源
     plasma;
     血浆游离DNA ;
短句来源
     The decline in concentrations was rapid in plasma.
     小鼠血浆浓度很快减少。
短句来源
     The Effect of Acute Hypervolemic Hemodilution on Plasma Concentrations of Propofol and Performance during Target-Controlled Infusion
     急性超容血液稀释对靶控输注异丙酚血药浓度及系统性能的影响
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  target plasma concentrations
Infusions schemes are derived from a knowledge of the desired target plasma concentrations, and the pharmacokinetic variables of the given drug.
      


Objective To assess the usefulness of auditory steady state response index (ASSR index) in monitoring the depth of sedation with propofol. Methods Propofol at the target plasma concentrations of 0.5, 1.0,1.5 and 2.0 μg/ml respectively was administered to 30 ASA gradeⅠ~Ⅱadult patients to be operated on by computer controlled infusion technique. Two minutes after equilibration of the effect compartment′s concentration electively the plasma propofol concentration, the 40 Hz ASSR was recorded immediately...

Objective To assess the usefulness of auditory steady state response index (ASSR index) in monitoring the depth of sedation with propofol. Methods Propofol at the target plasma concentrations of 0.5, 1.0,1.5 and 2.0 μg/ml respectively was administered to 30 ASA gradeⅠ~Ⅱadult patients to be operated on by computer controlled infusion technique. Two minutes after equilibration of the effect compartment′s concentration electively the plasma propofol concentration, the 40 Hz ASSR was recorded immediately at every concentration. Then the infusion was discontinued. When the patients opened their eyes to verbal commands of normal intonation, the 40 Hz ASSR was recorded again. The ASSR index was calculated as the sum of the square root of the absolute difference between every two successive 0.5 ms segments of the auditory steady state response′s waveform. The level of sedation was determined by the observer′s assessment based on the alertness/sedation scale (OAA/S). The OAA/S score of 2 or less was considered unconscious. Result The amplitudes of Pa and Pb waves and the ASSR index were linearly decreasing with the increase of propofol target concentration and the deepening of level of sedation dose dependently with the association coefficients as r =0.780, r =0.826, and r =0.759 respectively, P <0 01. The corresponding regression equations are as follows: Pa=-0.354×target concentration +1.018, and Pb= -0.468×target concentration +1.247, ASSR index=-2.924×target concentration +11.78. The ASSR index reflected the amplitudes of Pa and Pb, especially the amplitude of Pa ( r =0.811 and 0.735 respectively, P <0.01). In addition, ASSR index was correlated with the depth of patient′s sedation ( r =0.815, P <0.01). When the patients fell asleep from drowsy state, the amplitude of Pa decreased from 0.9 μv to 0.6 μv, and the ASSR index decreased from 10.5 to 8.6 with statistical significance ( P <0.05). The patients would not fall asleep until the ASSR index reduced to about 8.5, while reliable unconsciousness happened only when the ASSR index was lower than 5.6. Conclusion ASSR index is useful in monitoring the depth of sedation with propofol. Compared with the amplitudes of Pa and Pb observed traditionally, ASSR index is more accurate and simple and convenient.

目的 评价听觉稳态诱发反应 (ASSR)指数对异丙酚镇静深度的监测作用。方法 对30例美国麻醉医师协会病情估计分级 (ASA)为Ⅰ~Ⅱ级的择期手术病人 ,通过计算机靶控输注系统(TCI)经静脉输入异丙酚。按顺序维持 4种目标浓度 :0 5 μg/ml、1 0 μg/ml、1 5 μg/ml及 2 0 μg/ml,待效应室浓度与血浆浓度平衡 2min后记录 40HzASSR曲线 ,并依照OAA/S评分表判断病人的镇静深度。停止输注异丙酚 ,待病人对正常语调呼唤睁眼有反应时再次记录 40HzASSR曲线。ASSR指数的计算方法为ASSR波上每隔 5ms的两点波幅绝对差值的平方根之和。结果 Pa、Pb波幅及ASSR指数与目标浓度呈现良好的剂量相关性 ,相关系数分别为r =0 780 ,r=0 82 6 ,r =0 75 9,P <0 0 1,它们相应的回归方程分别为Pa =- 0 35 4×目标浓度 +1 0 18,Pb =- 0 46 8×目标浓度 +1 2 47,ASSR指数 =- 2 92 4×目标浓度 +11 78;ASSR指数可准确反应Pa、Pb波幅的变化 ,尤其与Pa存在更好的相关性 ...

目的 评价听觉稳态诱发反应 (ASSR)指数对异丙酚镇静深度的监测作用。方法 对30例美国麻醉医师协会病情估计分级 (ASA)为Ⅰ~Ⅱ级的择期手术病人 ,通过计算机靶控输注系统(TCI)经静脉输入异丙酚。按顺序维持 4种目标浓度 :0 5 μg/ml、1 0 μg/ml、1 5 μg/ml及 2 0 μg/ml,待效应室浓度与血浆浓度平衡 2min后记录 40HzASSR曲线 ,并依照OAA/S评分表判断病人的镇静深度。停止输注异丙酚 ,待病人对正常语调呼唤睁眼有反应时再次记录 40HzASSR曲线。ASSR指数的计算方法为ASSR波上每隔 5ms的两点波幅绝对差值的平方根之和。结果 Pa、Pb波幅及ASSR指数与目标浓度呈现良好的剂量相关性 ,相关系数分别为r =0 780 ,r=0 82 6 ,r =0 75 9,P <0 0 1,它们相应的回归方程分别为Pa =- 0 35 4×目标浓度 +1 0 18,Pb =- 0 46 8×目标浓度 +1 2 47,ASSR指数 =- 2 92 4×目标浓度 +11 78;ASSR指数可准确反应Pa、Pb波幅的变化 ,尤其与Pa存在更好的相关性 ,相关系数分别为r=0 811和r=0 735 ,P <0 0 1;ASSR指数与病人镇静深度 (OAA/S评分 )存在良好的相关性 ,相关系数为r=0 815 ,P <0 0 1;病人由嗜睡状态转入睡眠状态时 ,Pa波幅由 0 88μv降低到 0 6 0 μv ,ASSR指数由 10 5 2降低到 8 5 8,两者的降低均?

Objective To investigate the effects of different target plasma concentrations of propofol given by TCI on end-tidal isoflurane concentration when the depth of anesthesia was maintained at BIS 50 and evaluate the reliability of electromyography (EMG) as an anesthesia depth monitor. Methods Sixty ASA Ⅰ-Ⅱ patients aged 40-65 yrs weighing 40-85 kg undergoing elective abdominal surgery under general anesthesia were randomly allocated to one of three groups with 20 patients in each group : group Ⅰ isoflurane;...

Objective To investigate the effects of different target plasma concentrations of propofol given by TCI on end-tidal isoflurane concentration when the depth of anesthesia was maintained at BIS 50 and evaluate the reliability of electromyography (EMG) as an anesthesia depth monitor. Methods Sixty ASA Ⅰ-Ⅱ patients aged 40-65 yrs weighing 40-85 kg undergoing elective abdominal surgery under general anesthesia were randomly allocated to one of three groups with 20 patients in each group : group Ⅰ isoflurane; group Ⅱ isoflurane + TCI propofol (1 μg·ml-1) and group Ⅲ isoflurane + TCI propofol (2 μg·ml-1). The patients were premedicated with intramuscular phenobarbital 0.1 g and scopolamine 0.3 mg. Anesthesia was induced with midazolam 0.05 mg·kg , fentanyl 3 μg·kg-1 and propofol 0.5-1.0 μg·kg-1. Tracheal intubation was facilitated with vecuronium 0.12 mg·kg-1. After intubation anesthesia was maintained with isoflurane inhalation alone (group Ⅰ) or isoflurane combined with TCI propofol at a target plasma concentration of 1 μg·ml-1 ( group Ⅱ) or 2 μg·ml-1 ( group Ⅲ). MAP, HR, SpO2, PETCO2, BIS, EMG and end-tidal isoflurane concentration were continuously monitored during anesthesia. BIS was maintained at 45-55 after tracheal intubation during maintenance of anesthesia.Results The three groups were comparable with respect to age, sex, body weight, duration of anesthesia and the total amount of fentanyl used during anesthesia. There were no significant differences in MAP, HR and SpO2 among the 3 groups. When BIS was maintained at 50, the end-tidal isoflurane concentration was 0.76±0.03% (group Ⅰ), 0.43± 0.08% (group Ⅱ) and 0.21±0.07% (group Ⅲ) respectively. EMG was maintained at 26-29 during operation. During emergence from anesthesia EMG value increased with BIS value. When the patients opened their eyes at command EMG value was about 40. The correlation between BIS and EMG was poor. Conclusion At the samedepth of anesthesia (BIS = 50) the end-tidal isoflurane concentration was greatly reduced when combined with TCI propofol. EMG value decreases with increasing depth of anesthesia but as an anesthesia depth monitor it still needs improving.

目的 以脑电双频指数(BIS)值45-55作为麻醉深度监测指标,观察不同靶浓度异丙酚对腹部手术病人异氟醚呼气末有效浓度的影响,并初步探讨额肌电(EMG)作为麻醉深度监测指标的意义。方法 选择60例ASAⅠ-Ⅱ级择期行腹部手术的病人,随机分为三组:Ⅰ组(n=20)麻醉诱导后单纯吸入异氟醚;Ⅱ组(n=20)吸入异氟醚的同时输注靶浓度为1μg/ml的异丙酚;Ⅲ组(n=20)吸人异氟醚的同时输注靶浓度为2μg/ml的异丙酚。全麻诱导采用咪达唑仑、芬太尼、维库溴铵,气管插管后启动靶控输注异丙酚。根据BIS值的变化调节异氟醚吸入浓度,维持BIS值在45-55范围。麻醉中连续观察平均动脉压(MAP)、心率(HR)、脉搏氧饱和度(SpO2)、BIS及EMG的变化,并持续监测异氟醚的吸入和呼气末浓度。结果 三组病人年龄、性别、体重、麻醉时间、术中芬太尼用量、MAP、HR及SpCO2的变化组间比较差异无显著性(P>0.05);Ⅱ组、Ⅲ组插管后和切皮后异氟醚呼气末浓度均低于Ⅰ组(P<0.01),Ⅱ组、Ⅲ组呼气末异氟醚有效浓度分别为0.43%±0.08%、0.21%±0.06%,较Ⅰ组分别降低43.4%、72.3%(P<0.05)。...

目的 以脑电双频指数(BIS)值45-55作为麻醉深度监测指标,观察不同靶浓度异丙酚对腹部手术病人异氟醚呼气末有效浓度的影响,并初步探讨额肌电(EMG)作为麻醉深度监测指标的意义。方法 选择60例ASAⅠ-Ⅱ级择期行腹部手术的病人,随机分为三组:Ⅰ组(n=20)麻醉诱导后单纯吸入异氟醚;Ⅱ组(n=20)吸入异氟醚的同时输注靶浓度为1μg/ml的异丙酚;Ⅲ组(n=20)吸人异氟醚的同时输注靶浓度为2μg/ml的异丙酚。全麻诱导采用咪达唑仑、芬太尼、维库溴铵,气管插管后启动靶控输注异丙酚。根据BIS值的变化调节异氟醚吸入浓度,维持BIS值在45-55范围。麻醉中连续观察平均动脉压(MAP)、心率(HR)、脉搏氧饱和度(SpO2)、BIS及EMG的变化,并持续监测异氟醚的吸入和呼气末浓度。结果 三组病人年龄、性别、体重、麻醉时间、术中芬太尼用量、MAP、HR及SpCO2的变化组间比较差异无显著性(P>0.05);Ⅱ组、Ⅲ组插管后和切皮后异氟醚呼气末浓度均低于Ⅰ组(P<0.01),Ⅱ组、Ⅲ组呼气末异氟醚有效浓度分别为0.43%±0.08%、0.21%±0.06%,较Ⅰ组分别降低43.4%、72.3%(P<0.05)。入室后麻醉用药前EMG为46-53(BIS值91-96)。麻醉诱导后及术中EMG维持在26-29(BIS值45-55),麻醉恢复期EMG逐渐升高,当大于40时(相应BIS值80-85),大部分病人能够呼之睁?

Objective To study pharmacodynamic changes of combined anesthesia with remifentanil at different target plasma concentrations and isoflurane at different minimal alveolar concentrations(MAC) in laparoscopic operations. Methods Forty-five patients with ASA status Ⅰ~Ⅱ,receiving selective laparoscopic cholecystectomy or laparoscopic oophorocystectomy,were included.The patients were randomly divided into three groups with 15 patients in each group.In the Group A,anesthesia was maintained with isoflurane...

Objective To study pharmacodynamic changes of combined anesthesia with remifentanil at different target plasma concentrations and isoflurane at different minimal alveolar concentrations(MAC) in laparoscopic operations. Methods Forty-five patients with ASA status Ⅰ~Ⅱ,receiving selective laparoscopic cholecystectomy or laparoscopic oophorocystectomy,were included.The patients were randomly divided into three groups with 15 patients in each group.In the Group A,anesthesia was maintained with isoflurane inhalation at the MAC of 1.3;in the Group B,anesthesia was maintained with both isoflurane inhalation at the MAC of 0.6 and remifentanil target-controlled infusion at 4 ng/L;and in the Group C,anesthesia was maintained with both isoflurane inhalation at the MAC of 0.4 and remifentanil target-controlled infusion at 6 ng/L.Pharmacodynamic parameters and recovery characteristics,including bispectral index(BIS),heart rate variability(HRV),mean arterial pressure(MAP),heart rate(HR),time to additional administration of muscle relaxants,time to the recovery of spontaneous breathing,time to eye opening,time to endotracheal extubation,time to the recovery of orientation,and follow-up survey of "awareness during operation",were compared among the 3 groups.Results ①The BIS value was lower in the Group A than in the Group B and C at the time of pneumoperitoneum for 2 min and removal of the gallbladder or the ovarian cyst.The measures of HRV were higher in the Group A than in the Group B and C at the time of pneumoperitoneum for 2 min and removal of the gallbladder or the ovarian cyst.The measures of MAP and HR in the Group A were higher than those in the Group C at the time of pneumoperitoneum for 2 min,and were lower than those in the Group C at the time of the endotracheal extubation and the recovery of consciousness.②Either isoflurane inhalation at the MAC of 0.6 combined with remifentanil target-controlled infusion at 4 ng/L or isoflurane inhalation at the MAC of 0.4 combined with remifentanil target-controlled infusion at 6 ng/L provided satisfactory anesthetic maintenance.③Significantly shorter time to endotracheal extubation,to eye opening,and to the recovery of orientation were recorded in the Group B and C than in the Group A.Conclusions Anesthesia with target-controlled infusion of remifentanil combined with inhalation of isoflurane can be used for laparoscopic surgery.Pharmarcodynamic parameters and recovery characteristics show that combined use of remifentanil infusion at 4 ng/L and isoflurane inhalation at the MAC of 0.6 provides optimal anesthetic maintenance.

目的观察瑞芬太尼、异氟烷不同配伍方式静吸复合全麻在腹腔镜手术中应用的药效学。方法选择ASAⅠ~Ⅱ级择期行腹腔镜胆囊切除术或腹腔镜卵巢囊肿切除术45例随机分为3组,每组15例。3组诱导方式均相同。麻醉维持,A组维持吸入异氟烷1.3肺泡气最低有效浓度值(m in imum alveolar concentration,MAC);B组维持吸入异氟烷0.6 MAC复合瑞芬太尼血浆靶浓度4 ng/L靶控输注;C组维持吸入异氟烷0.4 MAC复合瑞芬太尼血浆靶浓度6 ng/L靶控输注。药效学观察指标:脑电双频指数(b ispectral index,B IS)、心率变异性(heart rate variab ility,HRV)、平均动脉压(m ean arterial pressure,MAP)、心率(heart rate,HR)及追加肌松剂时间、呼吸恢复时间、睁眼时间、气管导管拔管时间、定向力恢复时间、术后“术中知晓”随访。同时记录各组维持期吸入异氟烷的肺泡MAC。药效学观察指标进行组间比较。结果①A组B IS值气腹2 m in和胆囊或卵巢肿物切下时均较B、C组低,但HRV数值在气腹2 m in和胆囊或卵巢肿物切下时...

目的观察瑞芬太尼、异氟烷不同配伍方式静吸复合全麻在腹腔镜手术中应用的药效学。方法选择ASAⅠ~Ⅱ级择期行腹腔镜胆囊切除术或腹腔镜卵巢囊肿切除术45例随机分为3组,每组15例。3组诱导方式均相同。麻醉维持,A组维持吸入异氟烷1.3肺泡气最低有效浓度值(m in imum alveolar concentration,MAC);B组维持吸入异氟烷0.6 MAC复合瑞芬太尼血浆靶浓度4 ng/L靶控输注;C组维持吸入异氟烷0.4 MAC复合瑞芬太尼血浆靶浓度6 ng/L靶控输注。药效学观察指标:脑电双频指数(b ispectral index,B IS)、心率变异性(heart rate variab ility,HRV)、平均动脉压(m ean arterial pressure,MAP)、心率(heart rate,HR)及追加肌松剂时间、呼吸恢复时间、睁眼时间、气管导管拔管时间、定向力恢复时间、术后“术中知晓”随访。同时记录各组维持期吸入异氟烷的肺泡MAC。药效学观察指标进行组间比较。结果①A组B IS值气腹2 m in和胆囊或卵巢肿物切下时均较B、C组低,但HRV数值在气腹2 m in和胆囊或卵巢肿物切下时均较B、C组高;A组MAP、HR在气腹2 m in时高于C组,但拔管后和清醒时又较C组低。②吸入异氟烷0.6 MAC伍用瑞芬太尼血浆靶浓度4 ng/L,及吸入异氟烷0.4 MAC伍用瑞芬太尼血浆靶浓度6 ng/L在腹腔镜手术中即可维持一定麻醉深度。③在拔管时间、睁眼时间、定向力恢复时间上,B、C组均较A组有明显缩短。结论吸入异氟烷0.6 MAC伍用瑞芬太尼血浆靶浓度4 ng/L,及吸入异氟烷0.4 MAC伍用瑞芬太尼血浆靶浓度6 ng/L麻醉应用于腹腔镜手术,既可保证术中不同刺激的麻醉深度,又可使患者术毕快速高质量清醒。瑞芬太尼4 ng/L复合异氟烷0.6 MAC临床应用较瑞芬太尼6 ng/L复合异氟烷0.4 MAC更为理想。

 
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