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tumor necrosis factor super family member
相关语句
  肿瘤坏死因子受体超家族成员
     Combination of tumor necrosis factor super family member and corresponding death ligand can activate apoptosis signal pathway. Tumor necrosis factor α can induce the apoptosis of chondrocyte when the other apoptosis factors exist or survival-promoting factors were lacked.
     肿瘤坏死因子受体超家族成员与相应的死亡配体结合能激活凋亡信号通路,当存在其他前凋亡因子或缺乏某些促存活因子时肿瘤坏死因子α能诱导软骨细胞凋亡。
短句来源
  相似匹配句对
     ④Tumor necrosis and ulceration;
     ④肿瘤坏死和溃疡;
短句来源
     ③Tumor incompletely necrosis.
     ③肿瘤不完全坏死。
短句来源
     Tumor necrosis factor and diabetic retinopathy
     TNF与糖尿病视网膜病变
短句来源
     RESEARCH ADVANCES OF TUMOR NECROSIS FACTOR
     肿瘤坏死因子研究进展
短句来源
     Tumor Necrosis Factor-alpha and Psoriasis
     肿瘤坏死因子α与银屑病
短句来源
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AIM: There are many results about on the incidence and developmental mechanism of osteoarthritis. Study on apoptosis factor of chondrocyte has new meaning. DATA SOURCES: Literatures about cellular apoptosis of chondrocyte in osteoarthritis from January 1985 to December 2004 were computer-searched in Medline, with the of "osteoarthritis, chondrocyte, and apoptosis" and the language was limited to English.STUDY SELECTION: Abstracts of the materials were selected by the primary trial .The literatures includes those...

AIM: There are many results about on the incidence and developmental mechanism of osteoarthritis. Study on apoptosis factor of chondrocyte has new meaning. DATA SOURCES: Literatures about cellular apoptosis of chondrocyte in osteoarthritis from January 1985 to December 2004 were computer-searched in Medline, with the of "osteoarthritis, chondrocyte, and apoptosis" and the language was limited to English.STUDY SELECTION: Abstracts of the materials were selected by the primary trial .The literatures includes those in the experimental group and control group, and the whole paper was searched. Inclusion criteria: ① Randomly controlled trial. ② Control group was included. Exclusion criteria: ① Literatures in the control group were not set. ② Reviewed literatures, Meta analysis, repeated study.DATA EXTRACTION: Totally 111 tests on apoptosis factors of chondrocyte in osteoarthritis were collected, but only 35 literatures met the inclusion criteria. Altogether 28 literatures were excluded due to reviewed papers and 48 due to repeated study. The 35 literatures were mostly about tests of chondrocyte cultured in vivro, and the apoptosis factors were evaluated separately. DATA SYNTHESIS: Among the chondrocytes of patients with osteoarthritis and aging people, inflammatory reaction of chondrocyte appeared due to degredation of extracellular matrix or normal extracellular matrix was destroyed through glycosylated and tyrosine nitroso mordification and promotes its death. Various mechanical stimulations are the important regulation factors of the function of chondrocyte. Acceleration of mechanical stress pressured determines the injury of chondrocyte and type and degree of death of chondrocyte . Normal chondrocyte affected by some cytokines and chondrocyte cultured separately produce high level of NO, which can induce the death of chondrocyte. Combination of tumor necrosis factor super family member and corresponding death ligand can activate apoptosis signal pathway. Tumor necrosis factor α can induce the apoptosis of chondrocyte when the other apoptosis factors exist or survival-promoting factors were lacked. Damage of energy metabolism can make the other death-promoting factors much sensitive. In the process of osteoarthritis related development, the exact mechanism deserves to clarify although p53 participants in the cellular death. And also no enough and direct proof to indicate c-myc can influence the survival and death of chondrocyte.CONCLUSION: There are many cellular apoptosis-influencing factors in osteoarthritis with complex mechanism. Pathway of apoptosis of chondrocyte induced by many factors deserves to further study.

目的:近年来国外对骨关节炎的发生及发展机制有许多研究成果,骨关节炎中软骨细胞凋亡影响因素的研究颇具新意。资料来源:应用计算机检索Medline1985-01/2004-12与骨关节炎中软骨细胞凋亡相关的文献,检索词“osteoarthritis,chondrocyte,apoptosis”并限定文献语种为English。资料选择:对资料的摘要进行阅读初审,选取包括试验组和对照组的文献,开始查找全文。纳入标准:①随机对照试验。②试验包括对照组。排除标准:①没有设立对照组的文献。②综述类文献、Meta分析、重复研究。资料提炼:共收集到111篇关于骨关节炎中软骨细胞凋亡影响因素的试验,纳入符合标准的文献35篇。排除的文献为综述类文献28篇和重复研究48篇。35篇文献多为软骨细胞体外培养有关的试验,分别对各种凋亡影响因素进行评价。资料综合:在骨关节炎患者和老年人的软骨中,由于细胞外基质成分降解或通过高级糖基化、酪氨酸亚硝基化等修饰作用破坏了正常的细胞外基质从而使软骨细胞发生炎症反应并促进其死亡。各种机械性刺激是软骨细胞功能的重要调节因素,施加机械压力的加速率也决定软骨损伤和软骨细胞死亡的类型与程度。经某些细胞因子作用...

目的:近年来国外对骨关节炎的发生及发展机制有许多研究成果,骨关节炎中软骨细胞凋亡影响因素的研究颇具新意。资料来源:应用计算机检索Medline1985-01/2004-12与骨关节炎中软骨细胞凋亡相关的文献,检索词“osteoarthritis,chondrocyte,apoptosis”并限定文献语种为English。资料选择:对资料的摘要进行阅读初审,选取包括试验组和对照组的文献,开始查找全文。纳入标准:①随机对照试验。②试验包括对照组。排除标准:①没有设立对照组的文献。②综述类文献、Meta分析、重复研究。资料提炼:共收集到111篇关于骨关节炎中软骨细胞凋亡影响因素的试验,纳入符合标准的文献35篇。排除的文献为综述类文献28篇和重复研究48篇。35篇文献多为软骨细胞体外培养有关的试验,分别对各种凋亡影响因素进行评价。资料综合:在骨关节炎患者和老年人的软骨中,由于细胞外基质成分降解或通过高级糖基化、酪氨酸亚硝基化等修饰作用破坏了正常的细胞外基质从而使软骨细胞发生炎症反应并促进其死亡。各种机械性刺激是软骨细胞功能的重要调节因素,施加机械压力的加速率也决定软骨损伤和软骨细胞死亡的类型与程度。经某些细胞因子作用的正常软骨和分离培养的软骨细胞产生高水平的NO,而NO产物又能诱导软骨细胞死亡。肿瘤坏死因子受体超家族成员与相应的死亡配体结合能激活凋亡信号通路,当存在其他前凋亡因子或缺乏某些促存活因子时肿瘤坏死因子α能诱导软骨细胞凋亡。正是由于能量代谢受损使软骨细胞对其他的致死因子变得更加敏感。在发育和骨关节疾病相关过程中,软骨细胞的死亡虽然有p53的参与,但其精确的机制有待阐明,同时没有足够的直接证据表明c-myc能够影响软骨细胞的存活或死亡。结论:骨关节炎中影响软骨细胞凋亡的因素很多,机制复杂,许多因素导致软骨细胞凋亡的通路有待进一步阐明。

 
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