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内分泌腺及全身性疾病
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anti neutrophil
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  抗中性粒细胞
     Objective To study whether the Chinese ulcerative colitis (UC) patients are associated with interleukin (IL) 1β, IL 1RA and IL 4 gene polymorphisms and to analyze the relationship among gene polymorphisms, antineutrophil cytoplasmic antibodies (ANCA) and clinical classification of UC.
     目的 研究溃疡性结肠炎 (UC)病人的白细胞介素 (IL) 1β、IL 1受体拮抗剂 (IL 1RA)、IL 4基因多态性 ,并分析其与抗中性粒细胞胞质抗体 (ANCA)及临床分型的关系。
短句来源
     Objective To discuss the expression of two primary target antigens protein 3(PR3) and myeloperoxidase (MPO) of serum antineutrophil cytoplasmic autoantibodies(ANCA)and its relationship with the onset of preeclampsia.
     目的探讨重度子癎前期患者血清中抗中性粒细胞胞浆抗体(antineutrophil cytoplas- mic autoantibodies,ANCA)两种主要靶抗原蛋白酶3(protein3,PR3)和髓过氧化物酶(myeloperoxi- dase,MPO)的表达与子癎前期发病的关系。
短句来源
     Clinical Application and Laboratory Detection of Antineutrophil Cytoplasmic Autoantibodies
     抗中性粒细胞胞浆抗体自身抗体谱的临床应用价值及实验室检测
短句来源
     Antineutrophil cytoplasmic autoantibodies (ANCA) were detected in all sera, and standard IIF (indirect immunofluorescence) method and antigen specific ELISA, using PR3 (proteinase 3) and MPO (myeloperoxidase) as solid phase ligands, were employed.
     患者血清均行抗中性粒细胞胞浆抗体(antineutrophilcytoplasmicautoantibodies,ANCA)检测,IIF法(indirectimmunofluorescence)区分cANCA和pANCA,抗原特异性ELISA以高度纯化的PR3(proteinase3)和MPO(myeloperoxidase)为靶抗原。
短句来源
     The remaining 9 patients were both anti GBM antibody and antineutrophil cytoplasmic antibody (ANCA) positive (double positive); 7 of the 9 were female with an average age of (44.5±19.6) years.
     9/ 41例抗GBM抗体伴抗中性粒细胞胞浆抗体 (ANCA)阳性 ,其中 7/ 9例为女性 ,平均年龄 (4 4 5± 19 6 )岁。
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  抗中性粒细胞
     Objective To study whether the Chinese ulcerative colitis (UC) patients are associated with interleukin (IL) 1β, IL 1RA and IL 4 gene polymorphisms and to analyze the relationship among gene polymorphisms, antineutrophil cytoplasmic antibodies (ANCA) and clinical classification of UC.
     目的 研究溃疡性结肠炎 (UC)病人的白细胞介素 (IL) 1β、IL 1受体拮抗剂 (IL 1RA)、IL 4基因多态性 ,并分析其与抗中性粒细胞胞质抗体 (ANCA)及临床分型的关系。
短句来源
     Objective To discuss the expression of two primary target antigens protein 3(PR3) and myeloperoxidase (MPO) of serum antineutrophil cytoplasmic autoantibodies(ANCA)and its relationship with the onset of preeclampsia.
     目的探讨重度子癎前期患者血清中抗中性粒细胞胞浆抗体(antineutrophil cytoplas- mic autoantibodies,ANCA)两种主要靶抗原蛋白酶3(protein3,PR3)和髓过氧化物酶(myeloperoxi- dase,MPO)的表达与子癎前期发病的关系。
短句来源
     Clinical Application and Laboratory Detection of Antineutrophil Cytoplasmic Autoantibodies
     抗中性粒细胞胞浆抗体自身抗体谱的临床应用价值及实验室检测
短句来源
     Antineutrophil cytoplasmic autoantibodies (ANCA) were detected in all sera, and standard IIF (indirect immunofluorescence) method and antigen specific ELISA, using PR3 (proteinase 3) and MPO (myeloperoxidase) as solid phase ligands, were employed.
     患者血清均行抗中性粒细胞胞浆抗体(antineutrophilcytoplasmicautoantibodies,ANCA)检测,IIF法(indirectimmunofluorescence)区分cANCA和pANCA,抗原特异性ELISA以高度纯化的PR3(proteinase3)和MPO(myeloperoxidase)为靶抗原。
短句来源
     The remaining 9 patients were both anti GBM antibody and antineutrophil cytoplasmic antibody (ANCA) positive (double positive); 7 of the 9 were female with an average age of (44.5±19.6) years.
     9/ 41例抗GBM抗体伴抗中性粒细胞胞浆抗体 (ANCA)阳性 ,其中 7/ 9例为女性 ,平均年龄 (4 4 5± 19 6 )岁。
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  “anti neutrophil”译为未确定词的双语例句
     Objective To observe the clinical si g nificance of serum thrombomodulin(TM), antineutrophil cytoplasmic autoantibodies (ANCA)and anti-cardiolipin antibody(ACL) in systemic lupus erythematosus(SLE) .
     目的 :探讨患者血浆中血栓调节蛋白 (TM ) ,血清中性粒细胞胞浆抗体 (ANCA )及抗心磷脂抗体 (ACL)在系统性红斑狼疮 (SLE)中的临床意义。
短句来源
     Whole blood sample detection of antineutrophil antibody with flow cytometry and its clinical application
     全血法流式细胞术检测中性粒细胞抗体方法建立及临床应用
短句来源
     Conclusions The detection of antineutrophil antibody with flow cytometry is quite simple, and the results seem reliable, which has the potential in the clinical application and the enlargement of detecting items.
     结论:流式细胞术检测中性粒细胞抗体方法简单,初步结果较为可靠,有临床应用和扩大检测项目的前景。
短句来源
     Objective To establish a method to detect the antineutrophil antibodies in whole blood sample in clinical application in order to provide the evidences for the diagnosis of immune neutropenia.
     目的:建立可用于临床检测中性粒细胞抗体的方法,为诊断免疫性粒细胞减少症提供依据,并减少临床标本用血量。
短句来源
     The significance of fluorescent patterns of antineutrophil cytoplasmic antibodies (ANCA) in renal diseases
     肾脏疾病患者血清中ANCA的荧光模式及其意义
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  anti neutrophil
The negative test for anti neutrophil cytoplasmic antibodies makes Wegener's granulomatosis or other forms of pulmonary vasculitis unlikely.
      
The diagnostic value of anti-neutrophil cytoplasmic antibody testing in a routine clinical setting.
      
The diagnosis of Wegener's granulomatosis had been made on the basis of a nasal biopsy and a strongly positive c-anti-neutrophil cytoplasmic antibody.
      
The differential diagnosis includes small vessel vasculitis, and anti-neutrophil cytoplasmic antibody may be positive.
      
These anti-neutrophil antibodies usually disappeared after immunosuppressive therapy and disease remission and reappeared with disease recurrence.
      
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A clinico-pathological study was carried out on 8 patients with microscopic polyar-teritis nodosa (MPAN). It was found that the renal lesions were very common and severe in this group of patients apart from the typical presentation of MPAN, including fever, myalgias, arteritis and the involvement of hematologic, gastrointestinal and cardiovascular systems. Laboratory pictures were characterized by leucocytosis, anemia and increased serum creatinine. The plasma anti-neutrophil cytoplasmic antibodies...

A clinico-pathological study was carried out on 8 patients with microscopic polyar-teritis nodosa (MPAN). It was found that the renal lesions were very common and severe in this group of patients apart from the typical presentation of MPAN, including fever, myalgias, arteritis and the involvement of hematologic, gastrointestinal and cardiovascular systems. Laboratory pictures were characterized by leucocytosis, anemia and increased serum creatinine. The plasma anti-neutrophil cytoplasmic antibodies were present and thought to be of particular importance. On light microscopy, focal, segmental necrotising glomerulonephritis was discovered which was often associated with extensive crescence formation and vasculitis. We recommend renal biopsy as a valuable tool of investigation in the diagnosis of MPAN.

本文分析微型多动脉炎(microscopic polyarteritis nodosa,MPAN)8例病人的临床,实验室检查及肾脏病理特点。结果发现,除发热、肌痛等一般症状外,最常受累的是血液系统,消化系统和心血管系统。肾脏病病情发展急骤,迅速出现肾功能损害。实验室检查常见肾功能不全,贫血和白细胞增多,60%的病例抗白细胞胞浆抗体阳性。肾活检光镜特征为局灶性、节段性、坏死性肾小球肾炎,伴新月体形成和血管炎/坏死。作者认为,MPAN病程常多迁延,预后不佳。鉴于本病缺乏特异性诊断方法,血管造影也有一定局限性,在临床上疑及本病时应及早作肾活检,有助于诊断。

BACKGROUND Anti neutrophil cytoplasmic antibodies(ANCAs) have been linked with systemic vasculitides and various kind of connective tissue diseases, but the significance of different ANCAs has not yet been extensively studied in microscopic polyangiitis(MPA). To elucidate the significance of antibodies to different neutrophil cytoplasm antigens in the diagnosis of MPA,a retrospective analysis was made in 39 patients with MPA in the present study. METHODS 〖WTBZ]IIF ANCA was detected by...

BACKGROUND Anti neutrophil cytoplasmic antibodies(ANCAs) have been linked with systemic vasculitides and various kind of connective tissue diseases, but the significance of different ANCAs has not yet been extensively studied in microscopic polyangiitis(MPA). To elucidate the significance of antibodies to different neutrophil cytoplasm antigens in the diagnosis of MPA,a retrospective analysis was made in 39 patients with MPA in the present study. METHODS 〖WTBZ]IIF ANCA was detected by indirect immunoflurence assay, MPO ANCA (anti myeloperoxidase), BPI ANCA (anti bactericidal/permeability increasing protein) and PR3 ANCA(anti proteinase 3) were measured by ELISA. Clinical and renal pathological data were analyzed with regard to the different patterns of these autoantibodies. RESULTS 〖WTBZ] Patients positive for any one of the ANCAs accounted for 64.10% in this group of MPA patients. The percentages of patients with positive IIF ANCA,MPO ANCA,BPI ANCA and PR3 ANCA were 17.95%,38.46%, 20.51% and 7.69% respectively. The most frequent ANCAs in patients with MPA was MPO ANCA. No patient was found positive for very of the four ANCAs. The percentages of patients positive for three ANCAs, two ANCAs and one ANCA were 2.56%, 15.38%, 46.15% respectively. Rapidly progressive glomerulonephritis syndrome and arthropathy were more frequent in ANCA positive patients, as compared with ANCA negative patients ( P <0.05, P <0.01). No significant difference was found in the clinical and renal pathological manifestations among patients with different patterns of ANCAs, although different patterns of ANCAs were related to different clinical and histopathology features. CONCLUSION 〖WTBZ] ANCAs are not only diagnostic parameters for MPA, but also a marker of disease activity. MPO ANCA,BPI ANCA and IIF ANCA should be detected simultaneously for the diagnosis of MPA

目的:进一步阐明不同抗原抗中性粒细胞胞浆抗体(ANCA)在微型多动脉炎(MPA)诊断中的意义。方法:首次在国内对39例MPA患者进行了间接免疫荧光(IIF)┐ANCA,髓过氧化物酶(MPO)┐ANCA,细菌渗透增强蛋白(BPI)┐ANCA和蛋白酶3(PR3)┐ANCA检测,并结合临床和病理特点进行了分析。结果:39例中ANCA阳性者25例(64.10%),其中IIF┐ANCA阳性率为17.95%,MPO┐ANCA为38.46%,BPI┐ANCA为20.51%,PR3┐ANCA为7.69%,各种ANCA试验可单独阳性,也可合并存在,以MPO┐ANCA的合并存在率最高。结论:ANCA在MPA诊断中具有肯定意义,不仅是MPA诊断的一个血清学标志,而且是疾病活动和进展的标志之一。从临床实际出发同时检测MPO┐ANCA、BPI┐ANCA、IIF┐ANCA诊断意义最强

We analyzed the clinical and pathological characteristics of patients with idiopathic rapidly progressive glomerulonephritis (idiopathic RPGN), who had been hospitalized in recent three years. Five out of 8 patients with idiopathic RPGN were positive for anti neutrophil cytoplasmic autoantibodies (ANCA), most of them showed pANCA by indirect immunofluorescence technique. Compared with those who were ANCA negative, ANCA positive patients had an elder onset age; most of them had fever, arthragia,...

We analyzed the clinical and pathological characteristics of patients with idiopathic rapidly progressive glomerulonephritis (idiopathic RPGN), who had been hospitalized in recent three years. Five out of 8 patients with idiopathic RPGN were positive for anti neutrophil cytoplasmic autoantibodies (ANCA), most of them showed pANCA by indirect immunofluorescence technique. Compared with those who were ANCA negative, ANCA positive patients had an elder onset age; most of them had fever, arthragia, myalgia, skin rash, and some patients also had deafness, eye and nasal disorders. ANCA positive patients had a positive CRP, elevated gammaglobulins and accelerated ESR (>100 mm/1h). Typical pathological findings for ANCA positive patients were focal segmental fibroid necrosis of the glomerular capillary tufts and diffuse crescents formation. After an intensive therapy, the renal functions of most ANCA positive patients were obviously improved and most of them became hemodialysis independent. The results suggested that idiopathic RPGN might be a renal limited form of small vessel vasculitis and the patients with idiopathic RPGN had a better prognosis. Early diagnosis and appropriate intensive therapy are critical for patients with idiopathic RPGN.

为了解急进性肾炎(RPGN)Ⅲ型患者的病理、临床以及发病机制的特点。对我院肾内科近3年来收治的本病患者的临床病理资料进行了回顾性研究。结果发现:8例RPGNⅢ型患者中5例抗中性粒细胞胞浆抗体(ANCA)阳性,主要为核周型。与RPGNⅢ型ANCA阴性组患者相比,ANCA阳性组发病年龄较晚,多数患者有发热、关节痛等肾外表现,血清C反应蛋白阳性、γ球蛋白升高、大多数血沉更快(>100mm/1h)。病理检查可见肾小球局灶节段性纤维素样坏死,多数患者经积极治疗后肾功能明显好转,并脱离透析,预后较好。支持多数RPGNⅢ型是以肾脏受累为主要表现的小血管炎的观点。

 
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