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   b cell chronic lymphocytic leukemia 的翻译结果: 查询用时:0.201秒
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b cell chronic lymphocytic leukemia
相关语句
  慢性b淋巴细胞白血病
     Defective expression of B7.2 in B cell chronic lymphocytic leukemia B cells
     慢性B淋巴细胞白血病B细胞B7.2分子表达缺陷的研究
短句来源
     Modulate the expression of B7.2 in B cells of B cell chronic lymphocytic leukemia by γ-interferon
     γ-干扰素调控慢性B淋巴细胞白血病B细胞B7.2分子表达
短句来源
     Objective To investigate effects of γ-interferon on B7.2 expression in B cells of B cell chronic lymphocytic leukemia and the impact of latter on immune-triggering.
     目的 :研究观察γ 干扰素调控慢性B淋巴细胞白血病 (BCLL)B细胞B7.2分子的表达 ,并观察B7.2水平的变化对免疫反应的影响。
短句来源
  “b cell chronic lymphocytic leukemia”译为未确定词的双语例句
     ZAP-70 Expression in 24 Patients with B Cell Chronic Lymphocytic Leukemia
     ZAP-70在24例B细胞慢性淋巴细胞白血病中的表达研究
短句来源
     Objective To study the rearrangement of Bcl 1 gene (Bcl 1/IgH gene rearrangement)in B cell chronic lymphocytic leukemia,and its clinical signification.
     目的 探讨Bcl- 1基因重排 (即Bcl- 1/IgH基因重排 )在B细胞慢性淋巴细胞白血病中的发生情况及其临床意义。
短句来源
     The patients were classified into category of B cell chronic lymphocytic leukemia(B-CLL), hairy cell leukemia(HCL) and other B-cell lymphoproliferative disorders(LPDs) by using the scoring system that was recommended by world health organization (WHO).
     采用WHO引用的计分系统 ,将病例分为B 慢性淋巴细胞白血病 (B CLL) ,毛细胞白血病 (HCL)和其他B淋巴细胞增殖性疾病。
短句来源
  相似匹配句对
     Bcl-1 rearrangement in B-cell chronic lymphocytic leukemia
     B细胞慢性淋巴细胞白血病发生Bcl-1基因重排的研究
短句来源
     T-Cell chronic lymphocytic leukemia:Case report and literature review
     T细胞性慢性淋巴细胞白血病1例报告和文献复习
短句来源
     Study of immunophenotype in chronic lymphocytic leukemia
     慢性淋巴细胞白血病的免疫表型研究
短句来源
     Defective expression of B7.2 in B cell chronic lymphocytic leukemia B cells
     慢性B淋巴细胞白血病B细胞B7.2分子表达缺陷的研究
短句来源
     ZAP-70 Expression in 24 Patients with B Cell Chronic Lymphocytic Leukemia
     ZAP-70在24例B细胞慢性淋巴细胞白血病中的表达研究
短句来源
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  b cell chronic lymphocytic leukemia
B cell chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by accumulation of malignant CD5+ B cells.
      
Karyotype analysis of B-Lymphocytes transformed by Epstein-Barr virus in 21 patients with B cell chronic lymphocytic leukemia
      
Although molecular remission is now detected, it is still unknown whether we have the tools to cure B cell chronic lymphocytic leukemia (referred to as CLL).
      
Earlier, we reported an association between lowin vitro andin vivo IL-1 and IL-6 production, decreased IL-1β and IL-10 mRNA expression and B cell chronic lymphocytic leukemia (B-CLL) disease progression.
      
Studies in this laboratory have recently focused on two hemic neoplasms: B cell chronic lymphocytic leukemia (B-CLL) and a T cell disorder, Sézary syndrome.
      
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Nonrandom chromosome aberrations are associated with human malignancies and belived to play a key role in the pathogenesis of these diseases by disturbing cellular genes involved in the control of cell growth, bcl-2 Gene becomes transcriptionally deregulated in the majority of low-grade non-Hodgkin's lymphomas as a result of t( 14, 18) translations that place the bcl-2 gene at 18q21 into juxtaposition with the Ig heavy-chain locus at 14q32. This rearrangement and non-rearranged overexpression of bcl-2...

Nonrandom chromosome aberrations are associated with human malignancies and belived to play a key role in the pathogenesis of these diseases by disturbing cellular genes involved in the control of cell growth, bcl-2 Gene becomes transcriptionally deregulated in the majority of low-grade non-Hodgkin's lymphomas as a result of t( 14, 18) translations that place the bcl-2 gene at 18q21 into juxtaposition with the Ig heavy-chain locus at 14q32. This rearrangement and non-rearranged overexpression of bcl-2 gene have been reported to occur in some cases of B-cell chronic lymphocytic leukemia(B-CLL). By using immunohistochemical staining method and polymerase chain reaction (PCR) analysis, the expression and rearrangement of bcl-2 gene in 11 cases of chronic lymphocytic leukemia(CLL) were detected. Overexpression of bcl-2 gene was found in all cases; 1 of 11 cases had t(14,18) (q32, q21) translations. The data indicated that high levels of bcl-2 gene expression occur frequently in CLL, and bcl-2 gene plays a pivotal role in pathogenesis and progression of CLL.

人类恶性肿瘤常伴有非随机性染色体异常,并由于使调控细胞生长的基因表达失控而在肿瘤的发生中发挥十分关键的作用。bcl-2基因由于t(14,18)染色体易位而激活在低恶度的非霍奇金淋巴瘤的发生和演变中的作用已举世公认。类似的重排和非重排引起的bcl-2过度表达也见于慢性淋巴细胞白血病。我们应用免疫组化染色和聚合酶链反应检测了11例慢性淋巴细胞白血病bcl-2基因表达和重排,结果发现所有病例均高度表达Bcl-2蛋白,1例有t(14,18)(q32,q21)染色体易位。结论提示慢性淋巴细胞白血病普遍存在bcl-2基因高表达,bcl-2基因在慢性淋巴细胞白血病的发生和发展中发挥着十分重要的作用。

Objective To study the rearrangement of Bcl 1 gene (Bcl 1/IgH gene rearrangement)in B cell chronic lymphocytic leukemia,and its clinical signification.Methods Hemi nested polymerase chain reaction (PCR) was used to amplify the genomic DNA obtained from fresh peripheral blood and bone marrow.The rearrangment of Bcl 1 gene was analyzed in 13 patients with chronic lymphocytic leukemia (CLL) and 10 volunteers (with normal bone marrow) as controls.Results Four(31%)CLL...

Objective To study the rearrangement of Bcl 1 gene (Bcl 1/IgH gene rearrangement)in B cell chronic lymphocytic leukemia,and its clinical signification.Methods Hemi nested polymerase chain reaction (PCR) was used to amplify the genomic DNA obtained from fresh peripheral blood and bone marrow.The rearrangment of Bcl 1 gene was analyzed in 13 patients with chronic lymphocytic leukemia (CLL) and 10 volunteers (with normal bone marrow) as controls.Results Four(31%)CLL patients displayed Bcl 1 rearrangem entahile,no volunteers showed the rearrangement of the Bcl 1 gene.All 13 patients with CLL had B cell neoplasms.Conclusions Bcl 1 rearrangement is often present in B cell chronic lymphoproliferative leukemia.B cell chronic lymphoproliferative leukemia with Bcl 1 rearrangement has a higher proportion of lymphoblast and prolymphocytes in peripheral blood.

目的 探讨Bcl- 1基因重排 (即Bcl- 1/IgH基因重排 )在B细胞慢性淋巴细胞白血病中的发生情况及其临床意义。方法 我们对 13例慢性淋巴细胞白血病 (CLL)进行了Bcl- 1基因重排的检测 ;对照组为 10例骨髓正常者。运用半筑巢式多聚酶链反应 (PCR)技术对从外周血、骨髓中提取的基因组DNA进行扩增。结果 这 13例CLL均为B细胞型 ,在 13例CLL中检出 4例 (31% )的Bcl- 1基因重排 ;10例骨髓正常者的对照组中未检测出Bcl- 1/IgH基因重排。结论  (1)B细胞慢性淋巴细胞白血病常发生Bcl- 1基因重排 ,骨髓正常者未检出Bcl- 1/IgH基因重排。 (2 )发生Bcl- 1基因重排的B细胞慢性淋巴细胞白血病外周血中原始或幼稚淋巴细胞增多。

Objective To investigate the characteristic immunophenotype of B cell chronic lymphoid leukemia in china. Method Single and multiparameter flow cytometry were used to analysis 163 cases of B cell chronic lymphoid leukemia. Results 71.8%(117/163) of cases co-expressed CD5 and B cell markers. The patients were classified into category of B cell chronic lymphocytic leukemia(B-CLL), hairy cell leukemia(HCL) and other B-cell...

Objective To investigate the characteristic immunophenotype of B cell chronic lymphoid leukemia in china. Method Single and multiparameter flow cytometry were used to analysis 163 cases of B cell chronic lymphoid leukemia. Results 71.8%(117/163) of cases co-expressed CD5 and B cell markers. The patients were classified into category of B cell chronic lymphocytic leukemia(B-CLL), hairy cell leukemia(HCL) and other B-cell lymphoproliferative disorders(LPDs) by using the scoring system that was recommended by world health organization (WHO). The B-CLL typically display the composite phenotypes: CD5+,CD23+,CD20+,CD19+,HLA-DR+,but the CD22,CD11c,CD25 and FMC7 were variable present in some B-CLL cases.CD103 seems the most specific marker for HCL.To differentiate diagnosis of atypical B-CLL with B-prolymphocytic leukemia(B-PLL) or mantle cell lymphoma(MCL), one must not rely exclusively on immunophenotypic dates, cytogenetic or molecular biology detection would be helpful. The index of froward scatter( FSC) and antigens expression of tumor B cells could be calculated by dividing the relevant value of residual normal T cell within same sample as internal control, so the cell size and the intensity of antigen expression could be comparable each other and quantitative between different investigations. Conclusion immunophenotypic analysis is an extremely useful adjunct in the diagnosis of chronic lymphoid leukemia.

目的 研究国内慢性淋巴细胞系统白血病的免疫表型特点。方法 采用单参数和多参数流式细胞术分析了 16 3例慢性淋巴细胞系统白血病的免疫表型。结果  71 8% ( 117/ 16 3)患者共表达CD5和B细胞标志。采用WHO引用的计分系统 ,将病例分为B 慢性淋巴细胞白血病 (B CLL) ,毛细胞白血病 (HCL)和其他B淋巴细胞增殖性疾病。典型的B CLL表达CD5、CD2 3、CD2 0、CD19、HLA DR ,但仍有部分患者表达CD2 2、CD11c、CD2 5和FMC7。CD10 3似为HCL最特异的标志。但仅仅依靠免疫表型难以鉴别非典型B CLL、B细胞 幼淋巴细胞白血病 (B PLL)和外套细胞淋巴瘤 (MCL) ,细胞遗传学或分子生物学检查将有助于鉴别诊断。以同一标本中残存的正常淋巴细胞为内参照 ,计算前向角光散射 (FSC)指数和抗原表达指数 ,可定量地表示细胞的大小和抗原表达的强度 ,使不同的标本具有可比性。结论 免疫表型分析是诊断慢性淋巴细胞系统白血病非常有用的依据。

 
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