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coronary atherosclerosis plaque
相关语句
  冠状动脉粥样硬化斑块
     Association of the stability of coronary atherosclerosis plaque with high sensitive C-reactive protein,pregnancy-associated plasma protein A and matrix metalloproteinase-3 tissue inhibitor 1 expression
     冠状动脉粥样硬化斑块稳定性与超敏C反应蛋白和妊娠相关血浆蛋白A及基质金属蛋白酶组织抑制剂1表达的关系
短句来源
     Conclusions MCP-1 expression is increased in coronary atherosclerosis plaque of SCD patients.
     结论冠状动脉粥样硬化斑块中MCP-1的表达增加与SCD的发生密切相关,为SCD的诊断和临床对冠心病防治的研究提供新的途径。
短句来源
     Monocyte chemotactic protein-1 expression in coronary atherosclerosis plaque of sudden coronary death patients
     冠心病猝死冠状动脉粥样硬化斑块单核细胞趋化蛋白1表达的研究
短句来源
     Objective To investigate the expression of monocyte chemotactic protein 1(MCP-1) in coronary atherosclerosis plaque of sudden coronary death (SCD) patients and the relationship between MCP-1 expression and SCD.
     目的探讨单核细胞趋化蛋白-1(MCP-1)在冠心病猝死(SCD)和非SCD病例冠状动脉粥样硬化斑块中表达的差异及其与SCD的关系。 方法从本教研室2001至2003年尸检档案中挑选病例及心脏标本共90例。
短句来源
     (6)clinical by-stage of pathological state of coronary atherosclerosis plaque and treatment based on syndrome differentiation.
     (6)冠状动脉粥样硬化斑块的病理状态临床分期与辨证施治。
短句来源
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  “coronary atherosclerosis plaque”译为未确定词的双语例句
     Objective: To observe the stabilization effect of Chinese medicine prescription to coronary atherosclerosis plaque and explore its mechanism of effect.
     目的 观察中药组方对冠状动脉粥样硬化(CAS)斑块的稳定作用并探讨其作用机制。
短句来源
     DATA SOURCES:An online search of Medline was undertaken to identify articles about COX-2 and plaque vulnerability in atherosclerosis published in English between January 1998 and June 2005 by using the Keywords of "cyclooxygenase,coronary atherosclerosis,plaque vulnerability".
     资料来源:应用计算机检索Medline数据库1998-01/2005-06与环氧合酶及动脉粥样硬化斑块稳定性相关的文章,检索词“cyclooxygenase,coronaryatherosclerosis,plaquevulnelrability”,并限定文章语言种类为English。
短句来源
     Conclusion: Levels of serum soluble E-selectin can reflect the stable status of coronary atherosclerosis plaque. soluble E-selectin can be involved in the pathogenesis of ACS.
     结论:血清sE-selectin水平可反映动脉粥样硬化斑块的稳定性,sE-selectin与急性冠脉综合征发生密切相关。
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  相似匹配句对
     Identification of Stability in Coronary Artery Atherosclerosis Plaque
     冠状动脉粥样硬化斑块稳定性鉴别的研究进展
短句来源
     Advances of MR imaging in coronary atherosclerosis plaque
     冠状动脉粥样硬化斑块磁共振成像研究进展
短句来源
     Adiponectin and Coronary Atherosclerosis
     脂联素与冠状动脉粥样硬化
短句来源
     Adiponectin and Coronary Atherosclerosis
     脂联素与冠状动脉粥样硬化的研究现状
短句来源
     Carotid atherosclerotic plaque in coronary atherosclerosis disease patients.
     颈动脉粥样斑块与冠状动脉病变
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AIM: To evaluate the relationship between the plaque stability and the cell components in human coronary atherosclerosis plaque and to investigate the interrelation of cell components.METHODS: One hundred and twenty-five cases of coronary cardiac diseases including acute myocardial infarction,unstable angina and stable angina,who died in recent 12 years and had full data,were selected.The coronary arteries of each case were transversely cut,embedded and stained with HE.After observing and analyzing...

AIM: To evaluate the relationship between the plaque stability and the cell components in human coronary atherosclerosis plaque and to investigate the interrelation of cell components.METHODS: One hundred and twenty-five cases of coronary cardiac diseases including acute myocardial infarction,unstable angina and stable angina,who died in recent 12 years and had full data,were selected.The coronary arteries of each case were transversely cut,embedded and stained with HE.After observing and analyzing the morphologic features,parts of the coronary artery segments were selected for immunohistochemical staining of 6 markers(against) α-smooth muscle actin(SMA),CD20,CD3,CD68,HLA-DR and mast cell tryptase.RESULTS: More macrophages,T lymphocytes and mast cells were observed infiltrated in unstable plaque and smooth muscle cells were more common in stable plaque.A significant negative correlation was found between the expression of SMA and CD68,CD3,tryptase.CONCLUSION: The decrease in the number of smooth muscle cells and the increase in the number of macrophages,T lymphocytes and mast cells may be the major pathologic mechanism responsible for plaque instability.The infiltration of macrophages,T lymphocytes and mast cells is closely related to the decrease of smooth muscle cells in plaque.

目的:探讨人冠状动脉粥样硬化斑块内细胞成分与斑块稳定性之间的关系,以及各种细胞成分之间有无必然的联系.方法:选取解放军总医院近12年间具有完整资料的急性心肌梗死、不稳定心绞痛和稳定心绞痛尸体解剖病例共125例,对每一例的全部冠状动脉进行取材制片,观察分析形态学指标,并从中挑选一部分蜡块切片行免疫组化染色(包括:SMA,CD3,CD68,CD20,HLA-DR,mast cell tryptase).结果:免疫组化标记不稳定斑块组SMA的表达明显低于稳定斑块组,而CD68,CD3和mast cell tryptase的表达正好相反(P<0.05);SMA的表达与CD68,CD3和mast cell tryptase的表达呈明显负相关关系.结论:斑块内平滑肌细胞明显减少,巨噬细胞、T淋巴细胞和肥大细胞显著增高,可能是导致斑块不稳定的主要病理学机制;斑块内平滑肌细胞数量减少与巨噬细胞、T淋巴细胞和肥大细胞浸润密切相关.

Objective To investigate the expression of monocyte chemotactic protein 1(MCP-1) in coronary atherosclerosis plaque of sudden coronary death (SCD) patients and the relationship between MCP-1 expression and SCD. Methods Autopsy heart samples (n=90) collected during 2001-2003 were divided to SCD group (n=36) and 2 control groups: control groupⅠ, non-SCD CHD ( n=28), control groupⅡ, non-cardiac death (n=26). The immuno-histochemistry SABC techniques (R, positive MCP-1 cell area/tod area) and computerized...

Objective To investigate the expression of monocyte chemotactic protein 1(MCP-1) in coronary atherosclerosis plaque of sudden coronary death (SCD) patients and the relationship between MCP-1 expression and SCD. Methods Autopsy heart samples (n=90) collected during 2001-2003 were divided to SCD group (n=36) and 2 control groups: control groupⅠ, non-SCD CHD ( n=28), control groupⅡ, non-cardiac death (n=26). The immuno-histochemistry SABC techniques (R, positive MCP-1 cell area/tod area) and computerized images analysis (A) were performed to detect the expression of MCP-1 in different groups. Results R and A in plaques are significant higher in SCD group than control groupⅠandⅡ(0.1264±0.013 vs 0.0269±0.0110 and 0.0267±0.0100.P =0.04), (0.4534±0.083 vs 0.2303±0. 040 and 0. 2158±0.0400, P=0.00), and similar between control groupⅠand control groupⅡ. Conclusions MCP-1 expression is increased in coronary atherosclerosis plaque of SCD patients.

目的探讨单核细胞趋化蛋白-1(MCP-1)在冠心病猝死(SCD)和非SCD病例冠状动脉粥样硬化斑块中表达的差异及其与SCD的关系。方法从本教研室2001至2003年尸检档案中挑选病例及心脏标本共90例。分为SCD组(36例)、对照组Ⅰ(28例,冠心病但不是SCD)和对照组Ⅱ(26例,无明显动脉粥样硬化)。通过免疫组化SABC法及图像分析技术对不同组的MCP-1在斑块内的表达进行阳性细胞面积/扫描面积(R)、平均吸光度值(A)的半定量检测,并分析比较各组表达的差异性。结果SCD组的R值和A值与对照组Ⅰ、对照组Ⅱ相比差异有统计学意义[(0.1264±0.0130比0.0269±0.0110和0.0267±0.0100,P=0.04),(0.4534±0.0830比0.2303±0.0400和0.2158±0.0400,P=0.00)]。而对照组Ⅰ的R值和A值与对照组Ⅱ相比无统计学意义(0.0269±0.0110比0.0267±0.0100,P>0.05),(0.2303±0.0400比0.2158±0.0400,P>0.05)。结论冠状动脉粥样硬化斑块中MCP-1的表达增加与SCD的发生密切相关,为SCD的诊断和...

目的探讨单核细胞趋化蛋白-1(MCP-1)在冠心病猝死(SCD)和非SCD病例冠状动脉粥样硬化斑块中表达的差异及其与SCD的关系。方法从本教研室2001至2003年尸检档案中挑选病例及心脏标本共90例。分为SCD组(36例)、对照组Ⅰ(28例,冠心病但不是SCD)和对照组Ⅱ(26例,无明显动脉粥样硬化)。通过免疫组化SABC法及图像分析技术对不同组的MCP-1在斑块内的表达进行阳性细胞面积/扫描面积(R)、平均吸光度值(A)的半定量检测,并分析比较各组表达的差异性。结果SCD组的R值和A值与对照组Ⅰ、对照组Ⅱ相比差异有统计学意义[(0.1264±0.0130比0.0269±0.0110和0.0267±0.0100,P=0.04),(0.4534±0.0830比0.2303±0.0400和0.2158±0.0400,P=0.00)]。而对照组Ⅰ的R值和A值与对照组Ⅱ相比无统计学意义(0.0269±0.0110比0.0267±0.0100,P>0.05),(0.2303±0.0400比0.2158±0.0400,P>0.05)。结论冠状动脉粥样硬化斑块中MCP-1的表达增加与SCD的发生密切相关,为SCD的诊断和临床对冠心病防治的研究提供新的途径。

Objective To outline the clinical significances of urinary albumin to creatinine ratio(ACR) in acute coronary syndrome(ACS).Methods 79 patients with ACS were elected in observation group and 40 healthy subjects were chosen in control group,patients in observation group were subdivided into unstable angina pectoris(UAP) group and acute myocardial infarction(AMI) group.In each group,the levels of fasting blood lipid,blood sugar,C-reactive protein (CRP) and urinary ACR were measured and the correction of...

Objective To outline the clinical significances of urinary albumin to creatinine ratio(ACR) in acute coronary syndrome(ACS).Methods 79 patients with ACS were elected in observation group and 40 healthy subjects were chosen in control group,patients in observation group were subdivided into unstable angina pectoris(UAP) group and acute myocardial infarction(AMI) group.In each group,the levels of fasting blood lipid,blood sugar,C-reactive protein (CRP) and urinary ACR were measured and the correction of ACR and blood lipid,blood sugar and CRP were comparatively analyzed.Results In patients with ACS,ACR was positively associated with blood sugar,low density lipoprotein,triglyceride and CRP(r= 0.61,0.56,0.63 0.71,respectively,P<0.05 or 0.01),ACR was higher in patients with ACS,compared to normal subjects(P<0.01).Conclusion ACR can identify the stability of coronary atherosclerosis plaques and confirm whether cardiovascular risk chest pain patients have ACS or not.

目的探讨清晨尿白蛋白/肌酐浓度比值(ACR)在急性冠脉综合征(ACS)患者中的临床意义。方法选取79例ACS患者为观察组和健康成人40例为对照组,其中观察组分为不稳定型心绞痛(UAP)组和急性心肌梗塞(AMI)组,分别测定入选者清晨空腹血脂、血糖、C反应蛋白(CRP)及晨尿ACR,比较分析各组间ACR与血脂、血糖、CRP的相关性。结果ACS患者ACR与血糖、低密度脂蛋白、甘油三酯及CRP有明显的正相关(r分别为0.61,0.56,0.63,0.71,P<0.05或0.01),ACS患者ACR水平明显高于正常对照组(P均<0.01)。结论检测ACR水平对临床识别冠状动脉粥样硬化斑块的稳定性、鉴别有心血管危险因素的胸痛患者是否为ACS有一定的临床价值。

 
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