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   mice bearing sarcoma 的翻译结果: 查询用时:0.175秒
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mice bearing sarcoma
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  “mice bearing sarcoma”译为未确定词的双语例句
     Pharmacokinetics of 4- [4" -(2" ,2" ,6" ,6"-tetramethyl-1"-piperidinyloxy)amino]-4'-demethylepipodophyllotoxin in mice bearing sarcoma 180
     4-[4″-(2″,2″,6″,6″-四甲基哌啶氮氧自由基)氨基]-4′-去甲表鬼臼毒素在荷肉瘤180小鼠体内的药物动力学(英文)
短句来源
     of 10~100 mg/kg/day to mice bearing Sarcoma 180 significantly inhibit tumor growth and the inhibition rate of tumor weight reached at 44.72%~70.49%.
     每天10、50、100 mg/kg,对S180荷瘤鼠的瘤重抑制率分别为44.72%、66.50%和70.49%;
短句来源
     OBJECTIVE: To investigate the tumor-inhibiting action Ethyl acetate extraction of Lonicera caerulea L. Var. edulis Turcz. Ex Herd (EELC) on mice bearing sarcoma 180(S180) and hepatocarcinoma 22(H22), and its therapeutic mechanism.
     目的:研究蓝靛果乙酸乙酯提取物(Ethyl acetate extraction of Lonicera caerulea L.Var.edulis Turcz. ex Herd, EELC)对S180和H22荷瘤小鼠抑瘤作用及其作用机制。
短句来源
     Effect of “Yang Wei Kang Liu” Granula on Expression of P~(53) and PCNA in Mice Bearing Sarcoma 180
     养胃抗瘤颗粒对S_(180)肉瘤小鼠P~(53)和PCNA表达的影响
短句来源
     RESULTS: The tumor weights of mice bearing sarcoma180 were obviously decreased in the groups of cyclophosphamide (CTX 5 mg/kg) associated with Guiyuan oral solution(10, 4, 1.6 g/kg) as compared with that in the CTX group.
     结果:归元口服液10,4和1.6g生药/kg与CTX5mg/kg合用肿瘤抑制率高于单用CTX组;
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  相似匹配句对
     to MFC bearing mice combining with CTX.
     结果表明,缝裂层孔菌对CTX治疗小鼠胃癌MFC具有增效作用。
短句来源
     Methods Mice bearing H 22 ? S 180 ?
     方法 :以昆明小鼠为荷瘤鼠研究DHA复合物对H2 2 、S180 、艾氏腹水瘤 3株癌细胞的抑制作用 ;
短句来源
     Effects of TWHF on Sarcoma Weight in S180 Sarcoma -bearing Mice
     雷公藤对荷S(180)小鼠的抑瘤作用的实验研究
短句来源
     bearing design;
     轴承设计问题;
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     The Cat and the Mice
     猫和老鼠
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  mice bearing sarcoma
Antitumor efficacy of Poly(dimer acid-dodecanedioic acid) copolymer in mice bearing Sarcoma-180 tumor
      
The oral doses of these agents required to achieve 50% growth inhibition (ED50) in mice bearing sarcoma 180 tumors were 19, 34, 10, and 13 mg kg-1 day-1, respectively, whereas that of CF3dUrd was 63 mg kg-1 day-1.
      
Pharmacokinetics of 1-alkylcarbamoyl-5-fluorouracils was examined in mice bearing sarcoma 180.
      
When B-liposomes encapsulating gallium-67 deferoxamine were intravenously administered to mice bearing sarcoma 180, large amounts of 67Ga were delivered to tumours by 4 h after injection, though the 67Ga blood level remained high.
      
Recently, the two related cinnamic acid derivatives were found to possess in vivo tumoricidal activity in mice bearing sarcoma S-180 cells.
      
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The antitumor activity of Sb-derivatives of complexones has not yet been reported in the literature.In this work we found that Sb-26 (Sb Na ethylenediamine tetraacetate 15—20 mg/kg), Sb-57(Sb Na propylenediamine tetraacetate 30—50 mg/kg),Sb-66(Sb β-hydroxyethyl imino- diacetic acid 25—30 mg/kg)and Sb-71(Sb ammonia triacetic acid 20—40 mg/kg)could significantly inhibit the growth of Ehrlich ascites carcinoma of mice and prolonged the survival time for 4—22 days(36—147%,P<0.05)in comparison with the control group.These...

The antitumor activity of Sb-derivatives of complexones has not yet been reported in the literature.In this work we found that Sb-26 (Sb Na ethylenediamine tetraacetate 15—20 mg/kg), Sb-57(Sb Na propylenediamine tetraacetate 30—50 mg/kg),Sb-66(Sb β-hydroxyethyl imino- diacetic acid 25—30 mg/kg)and Sb-71(Sb ammonia triacetic acid 20—40 mg/kg)could significantly inhibit the growth of Ehrlich ascites carcinoma of mice and prolonged the survival time for 4—22 days(36—147%,P<0.05)in comparison with the control group.These com- pounds at the above mentioned dosages inhibited also the growth of Guerin’s carcinoma.The degree of inhibition was about 58—70%(P<0.05).The survival time of mice bearing spindle cell sarcoma(in ascitic form)was also prolonged for 5—16 days(50—160%,P<0.05)by treatment with the latter three drugs,among which Sb-71 was most active. Experiments were carried out on mice bearing sarcoma 180 or sarcoma AK treated with Sb-26,Sb-57,Sb-71 or Sb-66 and on mice bearing Ehrlich carcinoma or lymphatic leucemia (solid form)treated with the former three drugs.It was found that only Sb-71 possessed certain inhibitory action on sarcoma 180. In the present study,Sb-8,Sb-11,Sb-42,Sb-15,Sb-64 and Sb-85 were all lacking in inhibitory effect on Ehrlich ascites carcinoma of mice. In mice,the acute LD_(50)levels after intraperitoneal injections of Sb-57 and Sb-71 were found to be 131 and 62 mg/kg respectively;the subacute LD_(50)(10 injections)were equal to 75 and 58 mg/kg respectively.

1.锑胺羧螯合物是一种新型的抗肿瘤药物,应用 Sb-26(EDTA-SbNa)、Sb-57(PDTA-SbNa)、Sb-66(HEDT-Sb)和 Sb-71(ATA-Sb)分别为15—20、30—50、25—30和20—40毫克/公斤剂量时,均能显著地抑制小白鼠 Ehrlich 腹水瘤的生长,平均延长生存时间4—22天,延长率36—147%.上述剂量对大白鼠 Guerin 氏癌也有抑制作用,抑制率为58—70%.后3个药物,还能使小白鼠梭形细胞肉瘤腹水型的生存时间延长5—16天,延长率50—160%,其中以 Sb-71的疗效最著.Sb-26、Sb-57、Sb-71、Sb-66对肉瘤180和 AK 肉瘤及前3者对 Ehrlich 固体瘤和淋巴白血病固体型的实验结果,除 Sb-71对肉瘤180有抑制作用外,其他均无疗效.2.4 类锑化合物:3个(月弟)酸化合物(Sb-8,Sb-11和 Sb-42)及1个酒石酸锑(Sb-15),与螯合的间苯二酚锑(Sb-64)和8羟基喹啉锑(Sb-85)各1个,对 Ehrlich 腹水瘤的实验结果,均无明显疗效.3.小白鼠的急性半数致死量,Sb-57和 Sb-71分别为131和62...

1.锑胺羧螯合物是一种新型的抗肿瘤药物,应用 Sb-26(EDTA-SbNa)、Sb-57(PDTA-SbNa)、Sb-66(HEDT-Sb)和 Sb-71(ATA-Sb)分别为15—20、30—50、25—30和20—40毫克/公斤剂量时,均能显著地抑制小白鼠 Ehrlich 腹水瘤的生长,平均延长生存时间4—22天,延长率36—147%.上述剂量对大白鼠 Guerin 氏癌也有抑制作用,抑制率为58—70%.后3个药物,还能使小白鼠梭形细胞肉瘤腹水型的生存时间延长5—16天,延长率50—160%,其中以 Sb-71的疗效最著.Sb-26、Sb-57、Sb-71、Sb-66对肉瘤180和 AK 肉瘤及前3者对 Ehrlich 固体瘤和淋巴白血病固体型的实验结果,除 Sb-71对肉瘤180有抑制作用外,其他均无疗效.2.4 类锑化合物:3个(月弟)酸化合物(Sb-8,Sb-11和 Sb-42)及1个酒石酸锑(Sb-15),与螯合的间苯二酚锑(Sb-64)和8羟基喹啉锑(Sb-85)各1个,对 Ehrlich 腹水瘤的实验结果,均无明显疗效.3.小白鼠的急性半数致死量,Sb-57和 Sb-71分别为131和62毫克/公斤,亚急性半数致死量分别为75和58毫克/公斤.

The ability to transfer anti-tumor immunity by spleen RNA of tumor bearing donors was evaluated both in in vitro and in vivo experiments in animals and human patients. In in vitro test of mixed lymphocyte-tumor cells reaction, it was found that normal lymphocytes behaved like the tumor-sensitized lymphocytes after the preincubation with spleen RNA of mice bearing Sarcoma180 in blastogenic response to these tumor cells, and thus the mediation of anti-tumor immunological responsiveness by spleen RNA...

The ability to transfer anti-tumor immunity by spleen RNA of tumor bearing donors was evaluated both in in vitro and in vivo experiments in animals and human patients. In in vitro test of mixed lymphocyte-tumor cells reaction, it was found that normal lymphocytes behaved like the tumor-sensitized lymphocytes after the preincubation with spleen RNA of mice bearing Sarcoma180 in blastogenic response to these tumor cells, and thus the mediation of anti-tumor immunological responsiveness by spleen RNA of tumor bearing mice were confirmed. In in vivo tests, both animal experiments in mice and immunotherapeutic treatment in human cancer patients demonstrated that a tumor inhibitory effect could be induced by the administration of spleen RNA from the donors bearing the appropriate tumor, while the RNAs from the respective normal spleens were ineffective. The results presented indicated that spleen RNA from tumor bearing donors might have the same biological activity in effecting the transfer of immunoreactivity against tumor as that of immune RNA from spleen cells of immunized animals. No visible suppressive effect on the immunological responsiveness by spleen RNA from tumor bearing donors had been detected in experiments so far conducted in our laboratory.

本文对带瘤小鼠及肿瘤患者的脾RNA的传递免疫反应的能力进行了实验研究。用淋巴细胞——肿瘤细胞混合培养法对带S_(180)小鼠的脾RNA进行的体外培养实验表明,正常小鼠的淋巴细胞与带S_(180)小鼠的脾RNA温育后可以转变成为对S_(180)瘤细胞致敏的淋巴细胞。表现为在混合淋巴细胞——瘤细胞培养中的淋转率的提高。这就说明带瘤鼠的脾RNA可以有正常淋巴细胞传递抗S_(180)免疫反应的功能。在小鼠的活体抑瘤实验中,带S_(180)小鼠的脾RNA可对接种S_(180)小鼠的肿瘤生长有33.0—66.9%的抑瘤率,用正常脾RNA则没有效果;同样,用从胃癌患者切除的脾脏中提取的RNA对胃癌患者进行免疫治疗时,治疗组的四年存活率可达47.1%,对照组则为22.7%,治疗组的几项免疫指标均较治疗前有所提高。上述各项体外及活体实验的结果都说明带瘤供体的脾RNA可以传递特异的抗肿瘤免疫反应的信息,其效应和前人所报告的从免疫动物脾中提取的免疫RNA是完全一致的。

A metronidazole derivative (CM) was synthesized by reaction of metronidazole on mitrilotriacetic acid.A series of analyses (eg.m.p.determination, TLC,paper ele-ctrophoresis & UV, IR)proved this synthetic compound to be metronidazole derivative. When labeled with99mTc, it produced 99mTc-CM, which could concentrate and maintain a high concentration in tumor in mice bearing sarcoma180 within 24 h after iv injection. The radioactiving ratio of 99mTc retained in tumor was about 10 and 5 as compared with that...

A metronidazole derivative (CM) was synthesized by reaction of metronidazole on mitrilotriacetic acid.A series of analyses (eg.m.p.determination, TLC,paper ele-ctrophoresis & UV, IR)proved this synthetic compound to be metronidazole derivative. When labeled with99mTc, it produced 99mTc-CM, which could concentrate and maintain a high concentration in tumor in mice bearing sarcoma180 within 24 h after iv injection. The radioactiving ratio of 99mTc retained in tumor was about 10 and 5 as compared with that in muscle and brain, suggesting that 99mTc-CM has a strong tumor-localizing effect.Because of its lower concentration in the brain, its neuroto-xicity decreased. When CM was complexed with Ca+ + ,the product Ca-CM showed a strong ability to sensitize sarcoma180 to radiation(paper in preparation) .These results suggest that CM might be a new type of tumor-localizing and radiosensitizing compound. Further pharmacological experiments are in progress.

以氨三乙酸和甲硝羟乙唑为原料合成了甲硝羟乙唑衍生物。经元素分析。mp测定,TLC,纸电泳,紫外及红外光谱扫描等一系列分析证明为甲硝羟乙唑衍生物(CM),其分子式为C_(18)H_(2(?))O_(10)N_7·1/2H_2O。经~(99m)Tc标记后,在荷S_(180)小鼠中有浓集于肿瘤的作用。静脉注射后24小时内,肿瘤中始终维持在较多的水平,肿瘤与脑和肌肉组织的放射性强度比值均分别在10及5左右,有肿瘤定位作用,在脑内含量低,降低了神经毒副作用。与钙鳌合后,对肉瘤180有辐射增敏作用,将另文报道。认为是一个颇有希望的新型肿瘤定位辐射增敏剂。

 
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