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ovary axis
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  卵巢轴
     Effect of Ningxin Hongqi Capsule on Function of Pituitary Gland and Ovary Axis of Female Senile Rats
     宁心红杞胶囊对雌性老龄大鼠垂体-卵巢轴功能的影响
短句来源
     The distribution of oxytocin on hypothalamus hypophysis ovary axis in dairy goat during estrous cycle was determined by immunohistochemical ABC method.
     用免疫组化 ABC法 ,对发情周期中奶山羊下丘脑 -垂体 -卵巢轴催产素 (OT)分布进行了观察研究。
短句来源
     Conclusion: PrRP may be involved in the regulation of female hypothalamus pituitary ovary axis (HPOA) and EA may normalize the deviant function of HPOA via affecting PrRP expression in medulla oblongata.
     结论 :PrRP可能参与雌性大鼠下丘脑 垂体 卵巢轴 (HPOA)的调节 ; 电针对HPOA异常功能的调整作用 ,可能部分是通过脑内PrRP系统实现的
短句来源
     CONCLUSION Ningxin Hongqi Capsule can relieve the atrophy of the pituitary gland,ovary and adrenal and regulate the functions of pituitary gland and ovary axis.
     结论宁心红杞胶囊能缓解垂体、卵巢、肾上腺的萎缩,调节垂体-卵巢轴功能。
短句来源
  “ovary axis”译为未确定词的双语例句
     Hyperprolactinemia and the functions of hypothalamic-pituitary ovary axis
     高泌乳素血症与下丘脑-垂体-卵巢功能
短句来源
     Estrogen replacement therapy (ERT) is one of the most important and efficacious ways in the prevention and treatment of osteoporosis, and might alleviate postmenopausal symptoms caused by the feedback disorder in hypothalamus—pituitary—ovary axis.
     雌激素替代疗法是防治绝经后骨质疏松症最重要也是疗效最确切的治疗方法,它能减少更年期因下丘脑—垂体轴反馈紊乱而引起的更年期综合症。
短句来源
  相似匹配句对
     Progress on Mammalian Hypothalamus-Pituitary-Ovary Axis
     哺乳动物下丘脑-垂体-卵巢轴的研究进展
短句来源
     Hyperprolactinemia and the functions of hypothalamic-pituitary ovary axis
     高泌乳素血症与下丘脑-垂体-卵巢功能
短句来源
     (2)Axis;
     (2)枢椎组;
短句来源
     fixed ovary;
     卵巢位置固定;
短句来源
     b is the molecular axis.
     分子轴为b轴
短句来源
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  ovary axis
To investigate the clinical effects of raloxifene, one of the selective estrogen receptor modulators (SERMs), on the pituitary-ovary axis and prolactin, a prospective, randomized, double-blinded study on 59 healthy postmenopausal women was performed.
      
Effects of raloxifene, one of the selective estrogen receptor modulators, on pituitary-ovary axis and prolactin in postmenopausa
      
The PBL case for this week is related to the hypothalamic-pituitary-ovary axis, using an in vitro fertilization or a pregnancy case.
      
Correlations among body growth and factors in the gonadotropin-ovary axis.
      


The intravaginal ring was made by synthetic silicon rubber tube containing 200 mg of solid megestrol acetate,with an outer diameter of 40mm.The in vitroreleasing test showed it had a release rate of approximately 100 μg per day.The clinical study group consisted of 2,470 volunteer women and the totaltreatment cycles were 16,124 women months.The ring sustainedly releasedsteroid and could provide contraceptive effeciency for one year.There were522 subjects up to present who had been using a ring for one year.The...

The intravaginal ring was made by synthetic silicon rubber tube containing 200 mg of solid megestrol acetate,with an outer diameter of 40mm.The in vitroreleasing test showed it had a release rate of approximately 100 μg per day.The clinical study group consisted of 2,470 volunteer women and the totaltreatment cycles were 16,124 women months.The ring sustainedly releasedsteroid and could provide contraceptive effeciency for one year.There were522 subjects up to present who had been using a ring for one year.The over allpregnancy rate was 2.15 per cent due to less muscular tension of vagina,no ir-ritation and erosion of vaginal mucosa was observed after the insertion of the ringfor one year.The main side effect was break through bleeding,accounting fornearly 7 per cent of treatment cycles.Uncomfortable sense usually occurredwithin the first three month of treatment.There was no apparent suppression of ovulation in the cases of using the meges-trol acetate intravaginal rings,according to our limited cnical and laboratory studies.There was obvious change in mucus,which was unfavorable for thepenetration of sperm.The majority of the cases had secretory endometrium ofdeficient glandular secretion which was unfavorable for nidation.In other words,sustained release of lower dosage of megestrol acetate from the intravaginal ringgave little disturbance to hypothalamus-pituitary-ovary axis,but it provided asatisfactory contraceptive effect.

用合成硅橡胶材料制成的新型缓释避孕环,内含甲地孕酮200毫克,其外径为40毫米。经体外测试,药物的释放量每天约100微克左右。本环临床试用2470例,共16124妇女月经周期。由于药物能持续、缓慢释放,连续使用一年,仍保持避孕效果。现已有522例连续使用一年以上,受孕率为2.15%(按妇女年计算)。由于部分妇女阴道肌肉松弛,环易脱落,脱落率为2.15%。使用甲地孕酮硅橡胶避孕环一年以上的妇女,经医师检查未发现阴道粘膜刺激及红肿现象。主要副反应为突破性出血,突血率近7%。月经不正常情况主要发生在最初三个月,以后逐步好转。经临床及实验室研究,本环的作用不抑制排卵,而对宫颈粘液有较明显的改变,不利于精子穿透;子宫内膜虽仍属分泌期,但发育较差,不利于孕卵着床;对下丘脑—垂体—卵巢轴影响较小,且又具有较好的避孕效果。

The antifertility effects of a LHRH analogue during different phases of pregnancy in rats and the effects of reserpine on the termination of pregnancy in rats by the LHRH analo-gue were observed. On days 2~4, 5~7, 7~9 or 12~14 of pregnancy, daily doses of 200μg(0.5ml) of LHRH analogue were administered subcutaneously in the experimental group,while the same amount of saline was given to the control animals. In one group, subcutaneousadministration of reserpine (0.5mg/kg, daily) was given concomitantly with LHRH...

The antifertility effects of a LHRH analogue during different phases of pregnancy in rats and the effects of reserpine on the termination of pregnancy in rats by the LHRH analo-gue were observed. On days 2~4, 5~7, 7~9 or 12~14 of pregnancy, daily doses of 200μg(0.5ml) of LHRH analogue were administered subcutaneously in the experimental group,while the same amount of saline was given to the control animals. In one group, subcutaneousadministration of reserpine (0.5mg/kg, daily) was given concomitantly with LHRH analogue,While the same amount of reserpine was given to the control animals. The aninals were sacrificed on 72hr after the last injection. It was found that, on days 2~4, 5~7, or 7~9, LHRH analogue could effectivelyterminate the pregnancy and decrease the serum levels of progesterone, but on days 12~14,the antifertility effect of LHRH analogue could no longer be observed. Accordingly, itseems that the antifertility effect of LHRH analogue might be perfomed through the hypophy-sis-ovary axis. It was shown that if reserpine was administered concurrently with LHRH on days 5~7,the antifertility effect of LHRH analogue was abolished by reserpine, but on days 2~4,the same doses of reserpine could not antagonize the antifertility effect of LHRH analogue.From this result, it might be deduced that the mechanism of antifertility effect of LHRHanalogue in pre-implantation was different from that in post-implantation.

本工作观察了在大鼠妊娠不同阶段LHRH类似物的抗生育作用以及利血平对LHRH类似物终止妊娠作用的影响。分别于大鼠妊娠2~4天、5~7天、7~9天或12~14天,每鼠每天皮下注射一次LHRH类似物(200μg),对照组注射等量生理盐水。为观察利血平对于LHRH类似物抗生育作用的影响,于大鼠妊娠2~4天或5~7天,注射LHRH类似物同时,皮下注射利血平(0.5mg/kg),对照组注射等量利血平。每组均于最后一次给药后72小时处死,处死前取血测定血清孕酮,处死后开腹,记录妊娠动物数及正常着床胎数,并分别称量卵巢、全子宫及胚胎重量。结果表明,于大鼠妊娠2~4天、5~7天或7~9天,LHRH类似物皆具有明显的抗生育作用,并使血清孕酮水平下降,但于妊娠12~14天给药,对妊娠则无明显影响。这一结果提示,LHRH类似物的抗生育作用有可能是通过垂体一卵巢轴系实现的。于大鼠妊娠5~7天,利血平可以反转LHRH类似物的终止妊娠作用,但在妊娠2~4天,利血平则不能拮抗LHRH类似物的抗生育作用。这一结果提示,着床前应用LHRH类似物的抗生育机理可能与着床期和着床后用药的抗生育机理不尽相同,至少在大鼠着床前期,LHRH类似物的抗生育...

本工作观察了在大鼠妊娠不同阶段LHRH类似物的抗生育作用以及利血平对LHRH类似物终止妊娠作用的影响。分别于大鼠妊娠2~4天、5~7天、7~9天或12~14天,每鼠每天皮下注射一次LHRH类似物(200μg),对照组注射等量生理盐水。为观察利血平对于LHRH类似物抗生育作用的影响,于大鼠妊娠2~4天或5~7天,注射LHRH类似物同时,皮下注射利血平(0.5mg/kg),对照组注射等量利血平。每组均于最后一次给药后72小时处死,处死前取血测定血清孕酮,处死后开腹,记录妊娠动物数及正常着床胎数,并分别称量卵巢、全子宫及胚胎重量。结果表明,于大鼠妊娠2~4天、5~7天或7~9天,LHRH类似物皆具有明显的抗生育作用,并使血清孕酮水平下降,但于妊娠12~14天给药,对妊娠则无明显影响。这一结果提示,LHRH类似物的抗生育作用有可能是通过垂体一卵巢轴系实现的。于大鼠妊娠5~7天,利血平可以反转LHRH类似物的终止妊娠作用,但在妊娠2~4天,利血平则不能拮抗LHRH类似物的抗生育作用。这一结果提示,着床前应用LHRH类似物的抗生育机理可能与着床期和着床后用药的抗生育机理不尽相同,至少在大鼠着床前期,LHRH类似物的抗生育机理中,通过垂体-卵巢轴系可能不起主要作用。

Testosterone propionate (TP)was demonstrated to have an action of terminating early pregnancy in mice. The ED_(50) of TP to terminate early pregnancy was 0.11±0.03 mg/kg. This effect of TP was shown to be reduced by the concomitant administration of megestrol acetate (MA) or HCG. TP at doses large enough to terminate early pregnancy was found to significantly inhibit the decidual cell reaction in pseudo-pregnant mice. This inhibitory effect was abolished, by MA. In contrast, TP could not inhibit the decidual...

Testosterone propionate (TP)was demonstrated to have an action of terminating early pregnancy in mice. The ED_(50) of TP to terminate early pregnancy was 0.11±0.03 mg/kg. This effect of TP was shown to be reduced by the concomitant administration of megestrol acetate (MA) or HCG. TP at doses large enough to terminate early pregnancy was found to significantly inhibit the decidual cell reaction in pseudo-pregnant mice. This inhibitory effect was abolished, by MA. In contrast, TP could not inhibit the decidual reaction in ovariectomized mice treated with estrogen and progestin. TP showed no luteolytic effect, nor did it potentiate the effects of oxytocin and 15-methyl-PGF_(2α) on the uterine smooth muscle.It would appear that the effect of TP to terminate early pregnancy is associated with its inhibitory effect on the decidual reaction, and that the inhibitory effect of TP on the decidual cell reaction was attributable to its inhibiting effect on the hypothalamus-pituitary-ovary axis but not due to its direct effect on the deciduoma.

本文研究表明丙酸睾丸酮在小鼠有明显的抗早孕作用。其抗早孕作用的ED_(50)=0.11±0.03 mg/kg。甲地孕酮、HCG明显对抗丙睾抗早孕作用。丙睾在抗早孕剂量时能明显抑制假孕小鼠蜕膜反应。甲地孕酮能明显对抗丙睾抑制假孕小鼠蜕膜反应的作用。但丙睾对去卵巢小鼠应用外源性雌、孕激素诱发的蜕膜反应无明显抑制作用。丙睾无溶黄体作用,也不增强子宫对催产素和15-甲基-PGF_(2α)的反应。实验结果提示丙睾抗早孕作用与其抑制蜕膜反应有关。丙睾对蜕膜反应的抑制作用是其抑制下丘脑—垂体—卵巢轴,而非直接拮抗雌、孕激素的结果。

 
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