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acute ischemic brain
相关语句
  急性缺血性脑
    Cooling for acute ischemic brain damage (COOL AID): A feasibility trial of endovascular cooling
    降温治疗急性缺血性脑损伤:血管内降温的可行性试验
短句来源
    Objective To investigate the change of cognitive function in the elders with first acute ischemic brain stroke.
    目的 探讨老年急性缺血性脑卒中患者首次发病后认知功能的改变。
短句来源
  “acute ischemic brain”译为未确定词的双语例句
    A experimental study of neutral mucopolysaccharide on the acute ischemic brain edema
    中性粘多糖对急性缺血性脑水肿作用的实验研究
短句来源
    A Prospective,Double-blind,Randomized,Placebo Controlled Triall Research on Defibrase for the Treatment of Acute Ischemic Brain Infarction
    降纤酶治疗急性脑梗死前瞻性、随机双盲对照研究
短句来源
    RESULTS AND CONCLUSION: The expression of MARCKS and p-MARCKS protein in acute ischemic brain were elevated compared with the normal and control group (P<0.05), and the overexpression of these proteins may be correlated with injury of brain tissues. [
    结果及结论MARCKS及p-MARCKS在大鼠造模后3d海马及皮层中表达明显高于正常对照组(P<005),这种异常表达与脑缺血损害发生有关。
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he leukocyte count,leukocyte activation, lipoperoxidant(Lpo)of leukocytes and C_3 in the eperipheral blood were determined in 44 patients with acute ischemic stroke and the results were compared with those in age-matched healthy controls,No significant difference in mean leukocyte counts was observed between the patients and controls,he levels of leukocyte activation in the patients were significantly higher thanthose in the controls(137.94±38.86U/L vs 92; 22±20. 29U/L,P<0. 01),while the levels of Lpo of leukocytes...

he leukocyte count,leukocyte activation, lipoperoxidant(Lpo)of leukocytes and C_3 in the eperipheral blood were determined in 44 patients with acute ischemic stroke and the results were compared with those in age-matched healthy controls,No significant difference in mean leukocyte counts was observed between the patients and controls,he levels of leukocyte activation in the patients were significantly higher thanthose in the controls(137.94±38.86U/L vs 92; 22±20. 29U/L,P<0. 01),while the levels of Lpo of leukocytes and C_3 were significantly lower than those in the controls (0.90±0.87μmol/L and 0. 96±0.72 g/L vs 1. 57±1.29μmol/L and 1.69±0.70g/L,P<0.01).The changes of these levels were in correla-tion with the extent of cerebral infarction. It is suggested that leukocytes might be involved in the patho-physiological process of acute ischemic brain damage, ts mechanisms and route of activation were discussed briefly.

测定44例急性缺血性中风患者周围血白细胞计数、白细胞激活、白细胞脂质过氧化物(Lpo)和C_3,结果显示,患者白细胞计数和健康对照组无显著差异,白细胞激活明显高于对照组(137.94±38.86U/L对98.22±20.29U/L,P<0.01),白细胞Lpo和C_3则明显低于对照组(0.90±0.87Pmol/L和0.96±0.72g/L对1.57±1.29Pmol/L和1.69±0.70g/L,P<0.01),且和梗塞面积大小相关。提示白细胞可能参与急性缺血性脑损伤的病理生理,初步探讨了白细胞的作用机理和免疫激活途径。

Objective It was documented in previous studies that a high level of B cell responses occurred in the cerebrospinal fluid (CSF) in patients with acute cerebral infarction (ACI), we examined CNS myelin antigen specific memory T cells which secrted IFN γ in patients with ACI and controls. Method Autoreactive IFN γ secreting T cells responded to myelin antigens and their peptides were detected by using enzyme linked immunosorbent assay (ELISA) in the peripheral blood and CSF of 32 patients with ACI and in...

Objective It was documented in previous studies that a high level of B cell responses occurred in the cerebrospinal fluid (CSF) in patients with acute cerebral infarction (ACI), we examined CNS myelin antigen specific memory T cells which secrted IFN γ in patients with ACI and controls. Method Autoreactive IFN γ secreting T cells responded to myelin antigens and their peptides were detected by using enzyme linked immunosorbent assay (ELISA) in the peripheral blood and CSF of 32 patients with ACI and in the two controlled groups of patients with other inflammatory and non inflammatory neurological diseases. Results The numbers of IFN γ secreting cells responded to myelin basic protein (MBP). Its peptides and proteolipid protein (PLP) were very significantly elevated in the peripheral blood of the ACI patients compared with those of two control groups ( P <0.01) The number of MBP autoreactive T cells in CSF of patients with ACI also significantly higher than those of the two control groups. Moreover, the number of MBP specific memory T cells secreted IFN γ in CSF was much higher that that in peripheral blood. Conclusion A specific T cell responses with myelin antigen existed in the patients with acute cerebral infarct, the findings strongly suggest that acute ischemic brain damage may lead to an in vivo expansion of myelin antigen reactive T cells. Hypothetically such autoimmune responses most probably succeed ischemic brain damage and strongly occurred in CSF which was adjacent to target organ. The pathological effect of these autoreactive T cell responses remained unknown.

通过计数分泌细胞因子γ-干扰素记忆性T细胞,观察急性脑梗塞(ACI)患者的特异性T细胞免疫应答。方法采用酶联免疫斑点法(ELISA)检测了32例ACI、24例炎症性神经疾病(OIND)和25例其他神经疾病(OND)患者髓鞘素抗原及其多肽应答性T细胞。结果ACI患者外周血髓鞘素碱性蛋白(MBP)及其多肽和含脂质蛋白(PLP)自身抗原应答性T细胞数呈显著增高,脑脊液(CSF)中MBP应答性T细胞数约为外周血中的110倍。结论这种免疫应答可能是继发于急性缺血后的脑组织损伤,且在紧邻靶器官的CSF中表现尤为明显,其病理意义还有待进一步探讨。

Objective To evaluate the efficacy and safety of domestic defibrase in the treatment of acute ischemic stroke Methods In a prospective , double blind , randomized , placebo controlled trial 43 patients received intravenous defibrase 10u,5u,5u every other day and 43 received placebo every other day for three Results The neurologic deficit score and Barthel Index of defibrase group better than placebo , but there was no significant difference in overall mean scores Defibrase group reduced significantly...

Objective To evaluate the efficacy and safety of domestic defibrase in the treatment of acute ischemic stroke Methods In a prospective , double blind , randomized , placebo controlled trial 43 patients received intravenous defibrase 10u,5u,5u every other day and 43 received placebo every other day for three Results The neurologic deficit score and Barthel Index of defibrase group better than placebo , but there was no significant difference in overall mean scores Defibrase group reduced significantly plasma fibrinogen levels than placebo group Conclusions The domestic defibrase is effective and safe in the treatment of acute ischemic brain infarction

目的 评价国产降纤酶 ( Defibrase)治疗急性脑梗死的有效性和安全性。 方法 应用随机双盲安慰剂对照方法 ,4 3例给予降纤酶 1 0 u、 5 u、 5 u隔日 1次 ,加入生理盐水中静脉滴注 ,4 3例给予安慰剂静脉滴注。 结果 降纤酶组神经功能缺损程度评分及 Barthel氏指数优于安慰剂组 ,但两组间未达到统计学差异。降纤酶组明显降低了血浆纤维蛋白原。 结论 降纤酶治疗急性脑梗死 ,具有安全性和有效性。

 
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