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gamma gene
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    Methods Using PCR and gene scanning techniques we analysed immunogloblin heavy chain (IgH) and T cell receptor (TCR) gamma gene rearrangements in 3 cases with expression of CD45RO, CD20 and CD79a but not CD3 in 48 cases of B cell non-Hodgkin's lymphoma from Inner Mongolia.
    方法 从 4 8例B细胞淋巴瘤中筛选出 3例CD4 5RO、CD2 0和CD79a(+) ,CD3(- )的淋巴瘤。 采用免疫组化、PCR和基因扫描技术对其免疫表型 ,免疫球蛋白重链基因重排(IgH)和T细胞受体基因重排 (TCR)进行深入研究。
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  gamma gene
Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis
      
These four genes are the TATA box binding protein gene, the taube nuss-like gene, the eukaryotic elongation factor 1-gamma gene, and the beta-actin-1 gene.
      
Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE
      
The human glia maturation factor-gamma gene: genomic structure and mutation analysis in gliomas with chromosome 19q loss
      
The human T-cell receptor gamma gene region spans 160 kb genomic DNA.
      
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The beta and gamma chain gene rearrangements of the T-cell receptors(TCR)were studied with Southern blot hybridization and polymerase chain reaction in 13 cases of non-Hodgkin's lymphoma with T-cell phenotype.It was found that 11 out of the 13 cases(86%)exhibited TCR beta gene rearragnement and 12 out of the 13(91%)displayed TCR gamma gene rearrangement.The findings suggest that gene rearrangements are more sensitive and specific markers to establish T-cell monoclonality and lineage and helpful to...

The beta and gamma chain gene rearrangements of the T-cell receptors(TCR)were studied with Southern blot hybridization and polymerase chain reaction in 13 cases of non-Hodgkin's lymphoma with T-cell phenotype.It was found that 11 out of the 13 cases(86%)exhibited TCR beta gene rearragnement and 12 out of the 13(91%)displayed TCR gamma gene rearrangement.The findings suggest that gene rearrangements are more sensitive and specific markers to establish T-cell monoclonality and lineage and helpful to the morphological diagnosis and immunophenotyping for non-Hodgkin's lymphoma.

应用Southern blot和PCR技术对13例T细胞免疫表型的NHL进行基因重排分析。结果显示,11例(86%)肿瘤出现TCRβ基因克隆性重排,其中10例(91%)伴有TCRγ基因重排。提示基因重排分析是确立NHL克隆性和细胞源性的敏感而特异的标记。

Thirty six cases of Non Hodgkin′s lymphoma(NHL) and 19 cases of reactive hyperplasia of lymph node were analyzed with polymerase chain reaction for the gene rearrangements of T cell receptor (TCR) gamma and immunoglobulin heavy chain(IgH) Thirty four out of 36 cases of NHL(94 4%) showed clonal rearranged IgH and TCR gamma genes, among which, 91% B NHL had IgH and 95% T NHL had TCR gamma genes rearrangement In 19 patients with reactive hyperplasia, germline rearrangement bands...

Thirty six cases of Non Hodgkin′s lymphoma(NHL) and 19 cases of reactive hyperplasia of lymph node were analyzed with polymerase chain reaction for the gene rearrangements of T cell receptor (TCR) gamma and immunoglobulin heavy chain(IgH) Thirty four out of 36 cases of NHL(94 4%) showed clonal rearranged IgH and TCR gamma genes, among which, 91% B NHL had IgH and 95% T NHL had TCR gamma genes rearrangement In 19 patients with reactive hyperplasia, germline rearrangement bands were found in 14 patients, the other 5 patients showed clonal IgH or TCR gamma gene rearrangement and the following clinical sign and chemotherapeutic response supported the diagnosis of lymphoma The results suggested that antigen receptor gene rearrangement was reliable maker of lymphoma on molecular level and was helpful in defining the origin and differentiation stage of tumour cells, especially had pratical value in the differential diagnosis of hyperplastic disorders of lymph node

采用体外基因扩增多聚酶链反应(PCR),研究了36例非霍奇金淋巴瘤(NHL)及19例淋巴结反应性增生(RH)患者的免疫球蛋白重链(IgH)和T细胞受体γ(TCRγ)基因重排。结果36例NHL中,34例出现克隆性IgH和TCRγ基因重排(94.4%),其中91%的B-NHL出现IgH基因重排,95%的T-NHL出现TCRγ基因重排。19例RH患者,14例上述基因保持胚系状态,5例检测到克隆性IgH或TCRγ基因重排。此5例随后的临床表现及治疗反应,均支持恶性淋巴瘤的诊断。表明抗原受体基因重排是淋巴瘤分子水平可靠的克隆性标记,有助于在基因水平确定肿瘤细胞的来源及其分化阶段,尤其在良、恶性淋巴结增殖性疾病的鉴别诊断方面,具有重要的临床应用价值。

Objective To clarify the origin of lymphomas with aberrant phenotype. Methods Using PCR and gene scanning techniques we analysed immunogloblin heavy chain (IgH) and T cell receptor (TCR) gamma gene rearrangements in 3 cases with expression of CD45RO, CD20 and CD79a but not CD3 in 48 cases of B cell non-Hodgkin's lymphoma from Inner Mongolia. Results In the 3 cases there were 1 male and 2 female patients with age 70, 32 and 43 years,respectively. All the lymphomas were from extranodular lymphoid tissues...

Objective To clarify the origin of lymphomas with aberrant phenotype. Methods Using PCR and gene scanning techniques we analysed immunogloblin heavy chain (IgH) and T cell receptor (TCR) gamma gene rearrangements in 3 cases with expression of CD45RO, CD20 and CD79a but not CD3 in 48 cases of B cell non-Hodgkin's lymphoma from Inner Mongolia. Results In the 3 cases there were 1 male and 2 female patients with age 70, 32 and 43 years,respectively. All the lymphomas were from extranodular lymphoid tissues including tonsil, ileum and skin with 1 follicular lymphoma and 2 diffuse large B cell lymphoma. Clonal IgH gene rearrangement was successfully amplified in all cases, which was further confirmed in gene scanning analysis. On the other hand, TCR rearrangement was not detected in these cases, although there were a low peak in gene scanning in 2 of 3 cases. The low peak might rather represent clonal ampplification of the tumor cells than a few reactive T cells in the tissue. Conclusions The 3 cases of lymphoma with expression of CD45RO, CD20 and CD79a but not CD3 are derived from B cells. This finding shows that CD45RO is not specific antigen, suggesting that CD45RO positive cells are not automatically equal to T cells. Therefore, it is necessary to use combination of at least two sets of antibodies in research and clinical diagnosis of lymphomas.

目的 研究免疫表型异常淋巴瘤的起源。方法 从 4 8例B细胞淋巴瘤中筛选出 3例CD4 5RO、CD2 0和CD79a(+) ,CD3(- )的淋巴瘤。采用免疫组化、PCR和基因扫描技术对其免疫表型 ,免疫球蛋白重链基因重排(IgH)和T细胞受体基因重排 (TCR)进行深入研究。结果  3例淋巴瘤均为结外淋巴瘤。 1例为滤泡性淋巴瘤 ,2例为弥漫性大B细胞性淋巴瘤。PCR和基因扫描显示 3例均有IgH克隆性扩增 ;PCR未显示TCR扩增 ;高敏感性基因扫描显示低峰值TCR克隆性扩增 ,提示可能为背景T细胞扩增。结论 CD4 5RO不是T细胞特异性抗原 ,CD4 5RO阳性细胞不能完全等同于T细胞 ,因此 ,在研究和临床病理诊断中应选用多种抗体配合使用。

 
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