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The pharmaceutical sciences are advancing rapidly in the post-genomic era of the 21st century with the completion of the human genome, as well as those of many other organisms including bacteria and parasites, and the rapid advances in proteomics.
      
Aqueous and organic solvent extracts tested by agar-well diffusion method against 12 human pathogenic bacteria and 3 fungal strains showed activity to most of the organisms.
      
These findings provide compelling evidence that DNA is the ultimate target of these drugs that act on the human genome.
      
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.
      
STUDIES ON NOVEL NON-IMIDAZOLE HUMAN H4 RECEPTOR ANTAGONISTS USING GFA AND FREE-WILSON ANALYSIS
      
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1. This paper deals with the blood-sucking Ceratopogonidae collected fromSzechuan province.2. The female flies. of Lasiohelea taiwana, Culicoides sugimotonis and Culi-coides oxystoma have been studied morphologically in detail. Apart fromTaiwan Province, these species are recorded for the first time in China.3. The proportional length of the antennal segments, the shape of sonsorypore of the maxillary palpus and the distribution of wing spots are thespecific characters for the identification of these species.4....

1. This paper deals with the blood-sucking Ceratopogonidae collected fromSzechuan province.2. The female flies. of Lasiohelea taiwana, Culicoides sugimotonis and Culi-coides oxystoma have been studied morphologically in detail. Apart fromTaiwan Province, these species are recorded for the first time in China.3. The proportional length of the antennal segments, the shape of sonsorypore of the maxillary palpus and the distribution of wing spots are thespecific characters for the identification of these species.4. The blood-sucking habits of these species are quite different Lasioheleataiwana prefers human blood, Culicoides sugimotonis is a domestic fowlfeeder and sometimes also may feed on human blood while Culicoidesoxystoma is a preference for animal blood.

(一)本文所叙述三种蠛蠓,亦称墨蚊,采集地区包括四川省重庆之歌乐山、北碚之缙云山、澄江镇、宜宝及嘉定等地。 (三)三种蠛蠓之学名为Lasiohelea taiwana,Culicoides sugimotonis及Culicoides oxystoma,除台湾已有报告外,国内其他各地尚系首次记录。 (三)本文所记载的蠛蠓均系雌性成虫,其雄虫,蛹及幼虫之生态以及与传播疾病之可能性诸问题,尚有继续研究之必要。 (四)触角、触须、腿肢各节之比长,翅斑之分布及感觉毛开口孔之形状等为蠛蠓分类上之主要特征。 (五)三种蠛蠓之嗜血习性各不同:Lasiohelea taiwana之吸血对象为人类;Culicoides sugimotonis吸血对象为家禽有时亦吸人血;Culicoides oxystoma之吸血对象则为家畜。

Three adult human brain stems which presented an unilateral hyprtrophy ofthe striae medullares of the fourth ventricle were studied in serial Weigert sec-tions with the following results. The unilateral hypertrophy of the striae medullares is correlated with thehypertiophy of the contralateral nucleus arcuatus. In the hypertrophied nucleus arcuatus the fibers collect themselves towardsthe bottom of the ventral median fissure. The large bundle thus formed coursesdorsally along the raphe, crosses to the...

Three adult human brain stems which presented an unilateral hyprtrophy ofthe striae medullares of the fourth ventricle were studied in serial Weigert sec-tions with the following results. The unilateral hypertrophy of the striae medullares is correlated with thehypertiophy of the contralateral nucleus arcuatus. In the hypertrophied nucleus arcuatus the fibers collect themselves towardsthe bottom of the ventral median fissure. The large bundle thus formed coursesdorsally along the raphe, crosses to the other side ed emerges on the floor ofthe fourth ventricle. It then turns laterally in the subependymal layer, windingaround the tuberculum acusticum to approach the cerebellum. Besides the main nucleus arcuatus, the fibers of the accessory nuclei on themedioventral surface of the pyramid and of the ventral part of the nucleusraphes also paticipate apparently in the formation of the striae. The scatteredgray patches on the lateral part of the ventricular floor are minor relay stationsof the striae medullares. The nucleus arcuatus and allied nuclear masses are the caudally displacedpontine nuclei. The striae medullares behave just like an aberrent bundle ofthe brachium pontis and, as such, they conduct towards the cerebellum. Besides the striae medullares, the fibers of the nucleus arcuatus are also in-corporated into the ventral external arcuate fibers on the same and oppositesides, which curve around the ventrolateral surface of the medulla oblongatatowards the cerebellum.

在三个成人脑干先见第四脑室髓纹一侧偏大,经过染片研究,发现以下的情形。一侧偏大的髓纹与对侧弓状核的偏大是相繋的。在偏大的弓状核中,纤维聚向正中裂底,大束纤维循缝际行向背侧,陆续越边,自室底中線折向外侧,遶过听结节,接近小脑。除了弓状主核,前外侧的副核、缝际核前部似也参加髓纹的合成。室底外侧部的零散核团也收发髓纹纤维。弓状核和连属的核团是脑桥核的下延部分。髓纹相当向下移位的脑桥臂纤维,是傅向小脑的。弓状核的纤维除形成髓纹外,一部进入同边和对边的前外弓状纤维,遶行延髓前外面,似趋奔小脑。

A brief mosquito survey was made from Hainan Island and the Leichowpeninsula of Kwangtung Province during April and May, 1953. Collections were madeon adults as well as on larvae and pupae from various habitations. Altogether 31species were discovered. They included: (1) Aedes aegypti, (2) Aedes albopictus(3) Aedes scutellaris (4) Aedes togoi (5) Aedes vittatus (6) Culex fatigans (7) Culextritaeniorhynchus (8) Culex bitaeniorhynchus (9) Culex vagans (10) Culex vishnui(11) Culex mimeticus (12) Culex mimulus (13)...

A brief mosquito survey was made from Hainan Island and the Leichowpeninsula of Kwangtung Province during April and May, 1953. Collections were madeon adults as well as on larvae and pupae from various habitations. Altogether 31species were discovered. They included: (1) Aedes aegypti, (2) Aedes albopictus(3) Aedes scutellaris (4) Aedes togoi (5) Aedes vittatus (6) Culex fatigans (7) Culextritaeniorhynchus (8) Culex bitaeniorhynchus (9) Culex vagans (10) Culex vishnui(11) Culex mimeticus (12) Culex mimulus (13) Culex sitiens (14) Culex vorax(15) Culex fuscanus (16) Armigeres obturbans (17) Mansonia uniformis(18) Anopheles hyrcanus var. sinensis (19) Anopheles hyrcanus nigerrimus(20) Anopheles vagus (21) Anopheles minimus (22) Anopheles jeyporiensis var.,candidiensis (23) Anopheles fluviatilis (24) Anopheles varuna (25) Anophelesphilippinensis (26) Anopheles splendidus (27) Anopheles karwari (28) Anophelesannularis (29) Anopheles leucosphyrus, (30) Anopheles kochi (31) Anopheles bar-birostris. In the hilly regions A. minimus and A. jeyporiensis were-by far the commonestspecies found in human dwellings while A, hyrcanus var. sinensis was less common.In the coastal regions the reverse was true. A key for the identification of all species of mosquitoes reported up to thepresent from Hainan Island was given.

1.本文叙述1953年4月至5月作者参加海南岛与雷州半岛蚊类采集调查情况,共获蚊类31种,将其地理分布与捕集场所详加描述。 2.本文将以往海南岛与雷州半岛的蚊类调查研究的文献作总的温习并扼要列举之。 3.本文内将海南岛及雷州半岛的地理环境与蚊种的分布情况。加以讨论。 4.最后将海南岛已知蚊种编为检索表以便研究及参考。

 
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