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fibrinogen receptors
相关语句
  纤维蛋白原受体
     Characteristics of human platelet fibrinogen receptors regulated by anti CD 9 monoclonal antibodies
     CD_9单克隆抗体对人血小板膜纤维蛋白原受体调控特征研究
短句来源
     Objective To investigate the regulatory effect of two anti CD 9 monoclonal antibodies (McAbs), HI117 and SJ9A4, on human platelet fibrinogen receptors, and explore their potential mechanisms.
     目的 研究两种 C D9 单克隆抗体( Mc Ab) H I117 和 S J9 A4 对人血小板膜纤维蛋白原受体功能的调控作用及其可能的作用机制。
短句来源
     Endotoxin -induced exposure of fibrinogen receptors and breakdown of phosphoinositides in human platelet
     内毒素诱导血小板纤维蛋白原受体显露和磷脂酰肌醇代谢
短句来源
     CONCLUSION: Complement activator CVF induced platelet aggregation and ATP release, and increased prothrombinase activity on platelet surface. These actions were dependent on fibrinogen receptors on the platelet surface, elevation in intracellular free calcium ion, and reduction in cAMP.
     结论:补体激活剂CVF能诱导大鼠血小板聚集、ATP释放,增加血小板表面凝血酶原酶活性,其激活血小板的作用与血小板表面纤维蛋白原受体及血小板内游离钙升高、cAMP下降有关。
短句来源
     AIM:To construct and characterize two recombinant p roteins, which are expected to be antagonists of fibrinogen receptors.
     目的:构建两个预期能够成为纤维蛋白原受体拮抗剂的重组融合蛋白。
短句来源
  “fibrinogen receptors”译为未确定词的双语例句
     LIPOPOLYSACCHARIDE INDUCES EXPOSURE OF FIBRINOGEN RECEPTORS ON HUMAN PLATELETS
     LIPOPOLYSACCHARIDE INDUCES EXPOSURE OF FIBRINOGEN RECEPTORS ON HUMAN PLATELETS
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  fibrinogen receptors
Thromboxane A2 is a known inducer of platelet aggregation probably through the exposure of platelet fibrinogen receptors.
      
It is clear that platelet to platelet interactions require exposure of platelet fibrinogen receptors, the binding of fibrinogen to these receptors, platelet crossbridging, and subsequent platelet aggregation.
      
As it has been shown that an increased membrane lipid rigidity leads to a greater exposure of membrane proteins, including fibrinogen receptors, this might facilitate a formation of molecular linkages between neighboring platelets.
      
Labelling of fibrinogen receptors on BHT platelets was similar to control dogs and humans.
      
To investigate the former possibility we have used colloidal gold probes to examine the binding of fibrinogen and the post-ligand binding reorganisation of fibrinogen receptors on adherent platelets.
      
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In the present experiment, binding of fibrinogen with its receptors on washed human platelets was measured to study the effect of endotoxin on the eXposure of fibrinogen receptors.It was found that endotoxin could significantly incrcase the fibrino-gen binding. ̄(125)Ⅰ-fibrinogen bound to receptors was increased to 19.1±6.5 ng/10 ̄8 cells (P<0.0,n=4)by 500μg/ml endotoxin in comparison to control( 5.2± 3.5 ng/10 ̄8 cells,showing the exposure of fibrinogen receptors.Scatchard...

In the present experiment, binding of fibrinogen with its receptors on washed human platelets was measured to study the effect of endotoxin on the eXposure of fibrinogen receptors.It was found that endotoxin could significantly incrcase the fibrino-gen binding. ̄(125)Ⅰ-fibrinogen bound to receptors was increased to 19.1±6.5 ng/10 ̄8 cells (P<0.0,n=4)by 500μg/ml endotoxin in comparison to control( 5.2± 3.5 ng/10 ̄8 cells,showing the exposure of fibrinogen receptors.Scatchard analysis revealed that the fibrinogen receptors had a Kd of 2. 05 × 10 ̄-8mol/L and Bmax of 963 molecules of fibri-nogen per platelet.In order to explore the mechanism of the exposure of fibrinogen recep-tors,the phosphotidic acid (PA )which is mainly formed from DG-one of the important products of the breakdown of PIP_2 (phosphoinositidy1-4,5-biphosphate),was also mea-sured. The results showed that endotoxin could induced the synthesis of PA.500μg/ml endotoxin caused an increase of 176 ±22% vs control with 90 s( P<0. 05,n=6).PA ose rapidly and peaked at 90 s,indicating the hydrolysis of PIP_2.These results suggested that endotoxin could induced the exposure of fibrinogen receptors and endotoxin-induced breakdown of PIP_2 with formation of IP_3 and DG may be involved in this process.

本文测定了体外纤维蛋白原与人血小板纤维蛋白原受体的结合,研究内毒素对纤维蛋白原受体显露的影响。实验观察到内毒素可以使纤维蛋白原与血小板的结合显著增加,500μg/ml内毒素使血小板结合的 ̄(125)Ⅰ-纤维蛋白原从对照的5.2±3.5ng/10 ̄8cells增高为19.1±6.5ng/10 ̄8cells(P<0.01,n=4),表明内毒素可诱导血小板纤维蛋白原受体显露。用Scatchard作图法求得Kd=2.05×10 ̄-8mol/L,Bmax=963纤维蛋白原分子/血小板。内毒素能够诱导血小板生成PA。500μg/ml内毒素作用90秒可使PA增高为对照的176±22%(P<0.05,n=6)。PA升高迅速,90秒时达到高峰,提示PIP_2的分解。上述结果提示内毒素可以直接激活血小板,显露纤维蛋白原受体,可能是通过诱导PIP_2分解,产生三磷酸肌醇(IP_3)和甘油二酯(DG),进而使受体的构型发生改变,显露受体活性。

The effect of lipopolysaccharide (LPS) on the exposure of platelet fibrinogen receptors was investigated. The results showed that:l)LPS increased the binding of fibrinogen-gold complexes to platelets and the labels were primarily limited to shape-changed platelets; 2) LPS caused a dose-dependent rise in intracellular Ca2+ concentration in platelets; 3)LPS induced the activation of platelet protein kinase C (PKC) and the phosphorylation of glycoprotein llla (GPllla) which was inhibited by H-7. All...

The effect of lipopolysaccharide (LPS) on the exposure of platelet fibrinogen receptors was investigated. The results showed that:l)LPS increased the binding of fibrinogen-gold complexes to platelets and the labels were primarily limited to shape-changed platelets; 2) LPS caused a dose-dependent rise in intracellular Ca2+ concentration in platelets; 3)LPS induced the activation of platelet protein kinase C (PKC) and the phosphorylation of glycoprotein llla (GPllla) which was inhibited by H-7. All these results suggest that stimulation of platelets with LPS causes a conformational change in glycoprotein llb/llla (GPllb/llla)through platelet shape change and /or phosphorylation of GPllla via PKC, which serves to expose the fibrinogen binding sites of GPllb/llla on human platelets.

LIPOPOLYSACCHARIDEINDUCESEXPOSUREOFFIBRINOGENRECEPTORSONHUMANPLATELETSYuXichun(于希春)andWuQixia(吴其夏)(InstituteofBasicMedicalSci...

The activated rate of the platelet fibrinogcn receptor binding in whole blood is very low in normal on anvcrage of two percent. While those of the patients with heart and brainvascular disease are prounced increased. Simulated with ADP the activated expressions of platelet fibrinogen receptor of thus two kinds of patients are also increased, re-spccticely. Measuring the activated level of platelet fibrin-gen receptor with flow cytometry will provided reference index for clinical diagnosis and...

The activated rate of the platelet fibrinogcn receptor binding in whole blood is very low in normal on anvcrage of two percent. While those of the patients with heart and brainvascular disease are prounced increased. Simulated with ADP the activated expressions of platelet fibrinogen receptor of thus two kinds of patients are also increased, re-spccticely. Measuring the activated level of platelet fibrin-gen receptor with flow cytometry will provided reference index for clinical diagnosis and trcatment.

正常人周围血中血小板表面纤维蛋白原活化率很低(2%左右),心脑血管疾病患者却明显增加,ADP刺激后,血小板表面纤维蛋白原受体活性明显增高。

 
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