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tumor necrosis factors tnf
相关语句
  相似匹配句对
     ④Tumor necrosis and ulceration;
     ④肿瘤坏死和溃疡;
短句来源
     ③Tumor incompletely necrosis.
     ③肿瘤不完全坏死。
短句来源
     ANTITUMOR EFFECT OF TUMOR NECROSIS SERUM (TNS) IN VIVO
     肿瘤坏死血清的体内抗肿瘤作用
短句来源
     Mitotic activity and tumor necrosis were the independent prognostic factors.
     核分裂和肿瘤性坏死是独立的风险因素。
短句来源
     STUDIES ON ANTIVIRAL EFFECT OF TUMOR NECROSIS FACTOR(TNF)
     肿瘤坏死因子的抗病毒作用研究
短句来源
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  tumor necrosis factors tnf
The PBMC from dystrophic types of EB were also deficient in production of tumor necrosis factors (TNF-α and TNF-β).
      
U937 cells were incubated with various mediators such as interleukins (IL), tumor necrosis factors (TNF), dexamethasone, thrombin, fibrin fragment D, bradykinin, complement C5a, and components of the extracellular matrix.
      
Natural killer cells activity (Nka) and interleukin-2 tumor necrosis factors (TNF) were also examined to further understand the mechanism by which Zaizhang-I reverse plasma hematopoietic activity.
      
Given the recent approval of tumor necrosis factors (TNF) inhibitors and the large number of biologic agents currently undergoing clinical trials, pharmacogenetic markers may prove to be clinically useful.
      
We observed the changes of the mortality of tumor-bearing mice, the tumor growth curves, activities of serum tumor necrosis factor (STNF) and the level of serum sialic acid (SSA) in tumor-bearing mice.
      
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Using light microscope and electron microscope,we observed the morphological changes in the SMMC-7721 human hepatocellular carcinoma cell line after it was exposed to the rabbit tumor necrosis factor (TNF)and the cytocidal effect of TNF on the heterotransplanted human hepatocellular carcinoma (SMMC-7721 cell line).It was found that the changes occurred earlier in the cell membranes than in the nuclei during the course of TNF killing SMMC-7721 cell line and there was no special...

Using light microscope and electron microscope,we observed the morphological changes in the SMMC-7721 human hepatocellular carcinoma cell line after it was exposed to the rabbit tumor necrosis factor (TNF)and the cytocidal effect of TNF on the heterotransplanted human hepatocellular carcinoma (SMMC-7721 cell line).It was found that the changes occurred earlier in the cell membranes than in the nuclei during the course of TNF killing SMMC-7721 cell line and there was no special varieties around the necrotic area in the heterotransplanted human hepatocellular carcinoma in the nude mice as compared with that appearing in SMMC-7721 cell line,In addition, we detected the DNA contents of TNF treated SMMC-7721 cells and control ones, but there was no significant difference of the DNA contents between them.Ace of ding to the results of this study, we think that the mechanism by wluch TNF exerts its tumour-selective killing effect is probably as follows.TNF binds to a specific plasma membrane receptor and then disturbs synthesis or assembly of cell membrane components, leading the changes of cell structure(for example, swollen microvilli, a number of vesicles and small holes on the surface of tumor cells), and the lysis of tumor cells.

应用光镜和电镜观察了肿瘤坏死因子(TNF)杀伤人肝癌细胞系(SMMC-7721)的过程,同时测定了其DNA含量的变化,并观察了TNF对裸鼠人肝癌移植瘤的作用。结果表明,TNF与SMMC-7721细胞接触后,癌细胞膜系统先有变化,而胞核的变化出现在后。作者认为TNF选择性杀伤肿瘤细胞的机理可能是TNF与癌细胞膜上某种正常细胞不具有的物质发生作用,引起癌细胞的膜系统损伤,终致细胞死亡。

This paper reports that tumor necrosis serum (TNS) containing tumor necrosis factor (TNF) could inhibite Plasmodium falciparum in vitro, TNS was obtained from rabbits given macrophage-activiting agent Mycobacterium tuberculosis (BCG)followed by intravenous administration of bacterial endotoxin (LPS). The results showed that TNS dilutions of 1:3, 1:6 and 1:12 cauld induce disappearance of Plasmodium falciparum (P<0.05) after being cultured 6 hours. TNS decreased red blood cell...

This paper reports that tumor necrosis serum (TNS) containing tumor necrosis factor (TNF) could inhibite Plasmodium falciparum in vitro, TNS was obtained from rabbits given macrophage-activiting agent Mycobacterium tuberculosis (BCG)followed by intravenous administration of bacterial endotoxin (LPS). The results showed that TNS dilutions of 1:3, 1:6 and 1:12 cauld induce disappearance of Plasmodium falciparum (P<0.05) after being cultured 6 hours. TNS decreased red blood cell infective rate of the parasites as compared with the control (P<0.05) after 12 hours' cultivation. TNS of 1:3 dilution had further effect at 24 hours (P<0.05). Morphological observations showed that the growth of schizonts was retarded and abnormal merozoites were found.

本文就含肿瘤坏死因子的肿瘤坏死血清(TNS)对恶性疟原虫的影响进行了体外研究。TNS来自卡介苗和细菌内毒素刺激后的兔血清。结果表明:当TNS稀释度为1:3、1:6和1:12时,6h即对恶性疟原虫发生作用,12h后红细胞感染率下降,疟原虫裂殖体退化,裂殖子数目减少,24h后1:3稀释度的TNS仍使红细胞感染率下降,裂殖体呈现固缩状态。

Rabbit Tumor Necrosis Factor (TNF) was induced with BCG and LPS. TNF purified from the TNF containing serum (TNS) by sequential DEAE-Sephadex. Sephadex G-200, Sephadex G-75 and Gon-A-Agarose chromatography showed a single protein band on SDS-PAGE and IEF. The molecular weight of TNF was 67 kD, and its isoelectric point was pH5.2. The antitumor effect of TNS/TNF showed that in vitro human gastric cancer cell lines FGC-85 and MGC-803 were sensitive to TNF,...

Rabbit Tumor Necrosis Factor (TNF) was induced with BCG and LPS. TNF purified from the TNF containing serum (TNS) by sequential DEAE-Sephadex. Sephadex G-200, Sephadex G-75 and Gon-A-Agarose chromatography showed a single protein band on SDS-PAGE and IEF. The molecular weight of TNF was 67 kD, and its isoelectric point was pH5.2. The antitumor effect of TNS/TNF showed that in vitro human gastric cancer cell lines FGC-85 and MGC-803 were sensitive to TNF, and SGC-7901 was not;TNS/TNF could cause the hemorrhagic necrosis of transplanted murine tumors (S 180, S 37, LⅡ, U 14 and melanoma) in vivo. S 180 was among the most sensitive to TNF.

本文报道用卡介苗(BCG)和内毒素(LPS)诱导兎产生瘤肿坏死因子(TNF),获得含TNF血清(TNS)。TNS序顺通过DEAE-sephadex、SephadexG-200、Sephadex G-75和con-A-Agarose柱层析纯化,可获得单一电泳纯的TNF(SDS-PAGE和IEF),其分子量为67kD,等电点为pH5.2。抗肿瘤效应的结果表明,人胃癌细胞株:FGC-85和MGC-803对TNS/TNF敏感,SGC-7901不敏感;TNS/TNF可使小鼠移植性实体瘤(S_(180)、S_(37)、L_(Ⅱ)、U_(14)和黑色素瘤)发生出血性坏死,其中S_(180)对TNF最敏感。

 
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