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gene rb
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  rb基因
     Methods: In vitro experiments, MTT assay and clonal formation experiment were used to determine the cell growth inhibitory effect. Western blotting was performed to detect the protein expression of gene Rb and cyclin E. RT-PCR was performed to detect the mRNA expression of gene Rb.
     方法:采用MTT实验和集落形成实验观察Gen对人乳腺癌细胞增殖影响,Westernblotting检测Rb基因、细胞周期素cyclinE蛋白表达情况,RT-PCR检测Rb基因mRNA的表达。
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  “gene rb”译为未确定词的双语例句
     Expression of Tumor Suppressor gene Rb,MTS1 and Prognosis of Bladder Cancer
     抑癌基因Rb、MTS_1的表达与膀胱癌的预后
短句来源
     Expression of tumor suppressor gene Rb and P16 in esophageal precancerous lesions
     食管癌前病变组织 Rb 和 P16 蛋白的表达
短句来源
     PHENOTYPIC REVERSION OF A MALIGNANT TRANSFORMED MOUSE MAMMARY EPITHELIAL CELL LINE (11A1) BY TUMOR SUPPRESSOR GENE RB
     抑癌基因 RB 对小鼠乳腺上皮恶性转化细胞系 11A1 的表型逆转作用
短句来源
     The Expression of Tumor Suppressor Gene Rb and P16 Protein and Their Relationships in Osteosarcoma
     抑癌基因Rb与P16蛋白在骨肉瘤中的表达及其相互关系
短句来源
     Objective:To study the relationship between the expression of tumor suppressor gene Rb and MTS1 and prognosis of bladder cancer.
     目的 :研究抑癌基因 Rb、MTS1 的表达与膀胱癌的预后。
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  相似匹配句对
     THE EXPRESSION OF Rb GENE IN RETINOBLASTOMA
     视网膜母细胞瘤Rb基因表达
短句来源
     RB Gene and Tumor Suppression .
     RB基因与肿瘤抑制
短句来源
     GENE FOR BREASTS
     破解乳房的基因密码
短句来源
     The gene of xylanase B from T.
     但编码该酶的基因xynB在大肠杆菌中的表达较困难。
短句来源
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  gene rb
Since the human retinoblastoma susceptibility gene (RB1)along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.
      
A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1)in mouse.
      
The retinoblastoma susceptibility gene (RB), the prototype of the class of tumor suppressor genes, is inactivated in a number of human malignancies.
      
In mammalian cells, the cell cycle is suppressed at the G1 phase by the activities of retinoblastoma tumor suppressor gene (RB) family proteins, depending on their phosphorylation state.
      
The late blight resistance gene RB is a single functional locus embedded within a cluster of related sequences.
      
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The latest progress in molecular mechanisms for transcriptional regulation of 9oncogenes (c-myc, c-fos, c-jun, ETS-2, c-myb, c-erbB_2/neu, c-Ha-ras, c-Ki-ras, c-rel) and2 tumor suppressor genes (Rb, p53) was reviewed.

概述了9种癌基因(c-myc、c-fos、c-jun、ETS-2、c-myb、c-erbB_2/neu、c-Ha-ras、c-Ki-ras、c-rel)和2种抑癌基因(Rb、p53)转录调控的分子机制研究在近年来所取得的主要进展。

Retinoblastoma gene (Rb) is a well-known tumorsuppressor gene.Rb deletion or aberration was found in many kinds of tumors, but no report has been appeared in the literature concerning the relationship between Rb gene and Wilms tumor(WT).By the use of a 3.8 kb cDNA Rb probe,a case of WT with deletion of the Rb gene was demonstrated after screening of 14 WT cases.Further indirect evidence was obtained by using PCR-amplification of exon 8,12,and 27 of the Rb...

Retinoblastoma gene (Rb) is a well-known tumorsuppressor gene.Rb deletion or aberration was found in many kinds of tumors, but no report has been appeared in the literature concerning the relationship between Rb gene and Wilms tumor(WT).By the use of a 3.8 kb cDNA Rb probe,a case of WT with deletion of the Rb gene was demonstrated after screening of 14 WT cases.Further indirect evidence was obtained by using PCR-amplification of exon 8,12,and 27 of the Rb gene.The results were briefly discussed.

用视网膜母细胞瘤(Rb)基因3.8kb的cDNA探针,以Southern印迹杂交法,在14例肾母细胞瘤中,发现1例有Rb基因的缺失,在文献中尚未见报道。

Recent advances in the study of tumor suppressor genes, especially p53 gene, and their roles in the control of cell cycle are briefly reviewed. Generally, germ line mutations in tumor suppr essor-genes are the basis of tumor susceptibility, but recent studies revealed another kind of molecular basis for tumor susceptibility, i. e. , the mutations of mismatch repair genes. This article points out that no deletions or mutations of a series of tumor suppressor genes (Rb, p53...

Recent advances in the study of tumor suppressor genes, especially p53 gene, and their roles in the control of cell cycle are briefly reviewed. Generally, germ line mutations in tumor suppr essor-genes are the basis of tumor susceptibility, but recent studies revealed another kind of molecular basis for tumor susceptibility, i. e. , the mutations of mismatch repair genes. This article points out that no deletions or mutations of a series of tumor suppressor genes (Rb, p53 gene, WAF1, MTS1 and VHL gene) were found in nasopharyngeal carcinoma, a highly incident malignancy in South China. Therefore new strategies should be formulated for studying the molecular basis of NPC carcinogenesis and susceptibility.

本文简要综述近二年来在抑瘤基因,特别是p53基因,抑瘤基因与细胞周期调控关系方面的研究进展。种系细胞中抑瘤基因的杂合性丢失通常是肿瘤易感性的基础。最近发现肿瘤易感性的另一种分子基础,即错配基因的突变。文章还指出,我国南方高发的鼻咽癌中,Rb,p53基因,WAF1,MTS1,VHL等抑瘤基因均无缺失或突变,有待采用新的策略探讨鼻咽癌变和易感性的分子基础。

 
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