助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   multifunctional protease 的翻译结果: 查询用时:0.172秒
图标索引 在分类学科中查询
所有学科
更多类别查询

图标索引 历史查询
 

multifunctional protease
相关语句
  多功能蛋白酶
     Objective To investigate the relationship of polymorphism of large multifunctional protease (LMP) 2 genes to insulin dependent diabetes mellitus (IDDM) and DR3 gene.
     目的探讨大多功能蛋白酶(LMP)2基因多态性与胰岛素依赖型糖尿病(IDDM)及DR3基因的关系。
短句来源
     TTC staining and immunohistochemistry method were used to evaluate the effect of MCI186 on infarct area and expression of apurinic/apyrimidinic endonuclease (DNA prosthetic multifunctional protease)/oxidoreduction factor1 protein in ischemic penumbra in ischemic brain tissue.
     采用TTC染色、免疫组织化学染色等技术,观察MCI-186对脑梗死面积、半暗带区脱嘌呤脱嘧啶核酸内切酶(DNA修复的多功能蛋白酶)/氧化还原因子1蛋白(氧化还原因子)表达水平的影响。
短句来源
     Thrombin is a multifunctional protease generated at sites of vascular injury. Thrombin is a critical enzyme in a variety of blood coagulation responses to vascular injury or wounding.
     凝血酶(thrombin,Ⅱa)是一种生成于损伤处血管内皮细胞的多功能蛋白酶,它是参与凝血过程各个环节反应中的关键酶。
短句来源
  相似匹配句对
     In conclusion, all results indicated that jerdonase was a multifunctional venom serine protease.
     总之 ,所有的结果表明Jerdonase是一个具有多功能活性的蛇毒丝氨酸蛋白酶
短句来源
     Multifunctional Alarm for Vehicle
     汽车多功能报警器
短句来源
     Multifunctional calibrator of the sphygmomanometer
     多功能血压计校准仪
短句来源
     A protease primer
     蛋白酶简介
短句来源
     CONCLUSION Protease rev.
     结论:蛋白酶、rev.
短句来源
查询“multifunctional protease”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  multifunctional protease
Thrombin is a multifunctional protease that, in addition to its critical role in thrombotic processes, has also been described as inducing cellular and molecular events relevant to tissue remodeling.
      


Thrombin is a multifunctional protease generated at sites of vascular injury. Thrombin is a critical enzyme in a variety of blood coagulation responses to vascular injury or wounding. Thrombin may mediate not only hemostatic but perhaps also inflammatory and proliferative or reparative responses. The recent cloning of a platelet thrombin receptor has provided a framework for understanding above phenomenon. Meanwhile, it is to be defined whether there be some special functions of the segment of 41 amino...

Thrombin is a multifunctional protease generated at sites of vascular injury. Thrombin is a critical enzyme in a variety of blood coagulation responses to vascular injury or wounding. Thrombin may mediate not only hemostatic but perhaps also inflammatory and proliferative or reparative responses. The recent cloning of a platelet thrombin receptor has provided a framework for understanding above phenomenon. Meanwhile, it is to be defined whether there be some special functions of the segment of 41 amino acids from N terminal of thrombin receptor.

凝血酶(thrombin,Ⅱa)是一种生成于损伤处血管内皮细胞的多功能蛋白酶,它是参与凝血过程各个环节反应中的关键酶。在发挥止血作用的同时,还可能诱发炎症、增生及修复等反应。最近发现的凝血酶受体(thrombinreceptor,TR)分子可能为解释上述现象提供了一个理论框架。同时,TRN端被Ⅱa切下的41个氨基酸片段是否具有特殊功效,值得研究探讨

Objective To investigate the relationship of polymorphism of large multifunctional protease (LMP) 2 genes to insulin dependent diabetes mellitus (IDDM) and DR3 gene. Methods The polymorphism of LMP2 genes was identified by polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) in 68 IDDM patients and 71 healthy controls. IDDM patients and healthy controls were respectively divided into 2 groups according to DR3 genotyping. One group included subjects with DR3 gene, and another...

Objective To investigate the relationship of polymorphism of large multifunctional protease (LMP) 2 genes to insulin dependent diabetes mellitus (IDDM) and DR3 gene. Methods The polymorphism of LMP2 genes was identified by polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) in 68 IDDM patients and 71 healthy controls. IDDM patients and healthy controls were respectively divided into 2 groups according to DR3 genotyping. One group included subjects with DR3 gene, and another group subjects without DR3 gene. Results In the subjects with DR3 gene, the frequencies of LMP2 R/H, LMP2 R/R, LMP2 H/H were 47%, 47% and 6% in the IDDM patients, 13%, 87%, 0% in the controls. Compared with the Controls, the IDDM patients had a higher frequency of LMP2 R/H ( P <0.05) and a lower frequency of LMP2 R/R ( P <0.05). In the subjects without DR3 gene, the frequencies of LMP2 R/H, LMP2 R/R, LMP2 H/H were 58%, 39%, 2.8% respectively in the IDDM patients, and 32%, 54%, 14% respectively in the controls. Compared with the controls, the IDDM patients had a higher frequency of LMP2 R/H ( P <0.05), the frequency of LMP2 R/R in the IDDM patients did not have a significant difference from that in the controls ( P >0.05). Conclusions There may be a significant association of LMP2 R/H and LMP2 R/R with the susceptibility to IDDM. The LMP2 R/H is a susceptible gene. The people with LMP2 R/H have a higher risk of suffering from IDDM. The LMP2 R/R is a protective gene. The people with LMP2 R/R have a decreased risk of suffering from IDDM. The effects of LMP2 on ID DM are not affected by DR3 gene.

目的探讨大多功能蛋白酶(LMP)2基因多态性与胰岛素依赖型糖尿病(IDDM)及DR3基因的关系。方法以68例IDDM患者及71例正常人(对照组)为研究对象,采用聚合酶链反应限制性片段长度多态性分析技术进行LMP2基因分型。根据DR3基因分型将IDDM患者及对照组分为DR3阳性组与DR3阴性组,并分别比较LMP2基因频率在IDDM患者与对照组之间的差异。结果DR3阳性组,LMP2R/H、LMP2R/R及LMP2H/H基因频率在IDDM组分别为47%、47%、6%,对照组分别为13%、87%、0%;LMP2R/H基因频率在IDDM组显著高于对照组,LMP2R/R基因频率显著低于对照组,LMP2H/H在2组间差异无显著性意义。DR3阴性组,LMP2R/H、LMP2R/R及LMP2H/H基因频率在IDDM组分别为58%、39%、23%,对照组分别为32%、54%、14%。LMP2R/H基因频率在IDDM组显著高于对照组;LMP2R/R及LMP2H/H基因频率在2组间差异无显著性意义。结论LMP2R/H基因阳性者患IDDM的危险性增加,它可能是IDDM的易感基因;LMP2R/R阳性者患I?

AIM: To study the protective effect of edaravone(MCI186),a free radical scavenger,on brain injury by investigating the effects of MCI186 on expression of oxidoreduction protein in brain tissue and infarct areas in experimental rats after focal ischemia.METHODS:The experiment was performed in the Institute of Neurology, Zhujiang Hospital of Southern Medical University from May to September 2004.Totally 60 healthy male SpraqueDawley rats were divided randomly into MCI186 and control groups (n=6),the rest 48...

AIM: To study the protective effect of edaravone(MCI186),a free radical scavenger,on brain injury by investigating the effects of MCI186 on expression of oxidoreduction protein in brain tissue and infarct areas in experimental rats after focal ischemia.METHODS:The experiment was performed in the Institute of Neurology, Zhujiang Hospital of Southern Medical University from May to September 2004.Totally 60 healthy male SpraqueDawley rats were divided randomly into MCI186 and control groups (n=6),the rest 48 rats were divided into normal, sham operation, 1, 6, 12, 24 and 48 hours of cerebral ischemia and MCI186 groups (n=6), and they were observed by using immunohistochemistry method. Rats expect in normal and control groups were established models by intraluminal filament occlusion of middle cerebral artery. Rats in two MCI186 groups were injected with MCI186 (0.3 mg/ kg) into caudal vein 30 minutes and 12 hours following cerebral ischemia.TTC staining and immunohistochemistry method were used to evaluate the effect of MCI186 on infarct area and expression of apurinic/apyrimidinic endonuclease (DNA prosthetic multifunctional protease)/oxidoreduction factor1 protein in ischemic penumbra in ischemic brain tissue.RESULTS:Finally 60 rats were involved in the result analysis.①The infarct area decreased significantly in MCI186 groups as compared with that in control group [(31.2±2.3), (46.5±8.6)mm2, t=4.236, P=0.002].②The expression of apurinic/apyrimidinic endonuclease/ oxidoreduction factor1 protein in ischemic penumbra in MCI186 groups decreased at hour one following ischemia, and reached to the peak at hour 48, and there was significantly difference as compared with that in normal group[(25.9±4.7), (74.8±7.3)/mm2, F= 99.4, P=0.000 297].MCI186 could increase its positive expression [(45.8±4.3) /mm2, P< 0.05].CONCLUSION: Through upregulating the expression of apurinic/apyrimidinic endonuclease, MCI186 can improve the repair ability of brain tissue in the course of ischemic injury, decrease the infarct area, so as to protect ischemic brain injury.

目的:通过自由基清除剂依达拉奉(MCI-186)对大鼠局灶性缺血性脑组织中氧化还原蛋白的表达以及对局灶性脑梗死面积的影响探讨其对大脑缺血性损伤的保护机制。方法:实验于2004-05/09在第一军医大学珠江医院全军神经医学研究所进行。取健康雄性SD大鼠60只,其中的12只被随机分为MCI-186组和对照组,每组6只,用于脑梗死面积的比较;余下的48只,随机分为正常组,假手术组,脑缺血1,6,12,24,48h组及MCI-186组8组,每组6只,用于免疫组织化学观察。除正常组和假手术组外,其他48只大鼠均采用线栓法制成局灶性脑缺血模型,两个MCI-186组于脑缺血术后30min及12h由鼠尾静脉注射MCI-186(0.3mg/kg)。采用TTC染色、免疫组织化学染色等技术,观察MCI-186对脑梗死面积、半暗带区脱嘌呤脱嘧啶核酸内切酶(DNA修复的多功能蛋白酶)/氧化还原因子1蛋白(氧化还原因子)表达水平的影响。结果:经随机补充后60只大鼠进入结果分析。①脑梗死面积:MCI-186组较对照组明显缩小[(31.2±2.3),(46.5±8.6)mm2,t=4.236,P=0.002]。②半暗带脱嘌呤脱嘧啶核酸内切酶...

目的:通过自由基清除剂依达拉奉(MCI-186)对大鼠局灶性缺血性脑组织中氧化还原蛋白的表达以及对局灶性脑梗死面积的影响探讨其对大脑缺血性损伤的保护机制。方法:实验于2004-05/09在第一军医大学珠江医院全军神经医学研究所进行。取健康雄性SD大鼠60只,其中的12只被随机分为MCI-186组和对照组,每组6只,用于脑梗死面积的比较;余下的48只,随机分为正常组,假手术组,脑缺血1,6,12,24,48h组及MCI-186组8组,每组6只,用于免疫组织化学观察。除正常组和假手术组外,其他48只大鼠均采用线栓法制成局灶性脑缺血模型,两个MCI-186组于脑缺血术后30min及12h由鼠尾静脉注射MCI-186(0.3mg/kg)。采用TTC染色、免疫组织化学染色等技术,观察MCI-186对脑梗死面积、半暗带区脱嘌呤脱嘧啶核酸内切酶(DNA修复的多功能蛋白酶)/氧化还原因子1蛋白(氧化还原因子)表达水平的影响。结果:经随机补充后60只大鼠进入结果分析。①脑梗死面积:MCI-186组较对照组明显缩小[(31.2±2.3),(46.5±8.6)mm2,t=4.236,P=0.002]。②半暗带脱嘌呤脱嘧啶核酸内切酶/氧化还原因子1蛋白的表达:自缺血1h始,其表达即开始减少,至48h减少达到高峰,与正常组比差异显著[(25.9±4.7),(74.8±7.3)个/mm2,F=99.4,P=0.000297],MCI-186能增加其阳性表达[(45.8±4.3)个/mm2,P<0.05]。结论:MCI-186可通过上调缺血脑组织中脱嘌呤/脱嘧啶核酸内切酶的表达水平,增强脑组织对缺血引起的氧自由基损伤的修复能力,缩小梗死范围,因而对缺血性脑损伤具有保护作用。

 
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关multifunctional protease的内容
在知识搜索中查有关multifunctional protease的内容
在数字搜索中查有关multifunctional protease的内容
在概念知识元中查有关multifunctional protease的内容
在学术趋势中查有关multifunctional protease的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社