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immune induced rat
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  免疫诱导型
     Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation, strong expression of TIMP-1, TIMP-2 mRNA and protein and lasted for longer time, on the other hand, the toxin induced rat liver fibrosis model presented weak expression of TIMP-1, TIMP-2 mRNA and protein , and shorter period of liver fibrosis after stopping toxin attack.
     结果造模结束后,免疫诱导型模型肝组织病理改变具有进行性加重趋势,TIMP1、TIMP2mRNA及蛋白表达强度高、持续时间长; 而毒素诱导型模型具有TIMP1、TIMP2mRNA及蛋白表达强度弱、肝纤维化持续时间短等特点。
短句来源
     Conclusion The toxin induced rat liver fibrosis model was not appropriate for observation of anti-fibrotic drugs due to its fast sponteneous absorption, the immune induced rat liver fibrosis model is good for the observation of anti-fibrotic drug effects and study on the mechanism of liver fibrosis due to its slow sponteneous absorption, and has the trend of aggrevation within three months after.
     结论毒素诱导型肝纤维化模型自然吸收较快,不利于抗肝纤维化药物疗效的观察; 免疫诱导型肝纤维化模型自然吸收时间较慢,且在造模结束后1~3个月有逐渐加重趋势,有利于抗肝纤维化药物疗效观察及肝纤维化机制研究。
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  相似匹配句对
     Induced into E.
     将表达载体转化E.
短句来源
     Induced Immune Tolerance for Therapy of EAU
     诱导免疫耐受治疗实验性自身免疫性葡萄膜炎
短句来源
     Immune Suppression in Skin Induced by UV
     紫外线照射对皮肤免疫系统的抑制作用
短句来源
     Effects of valsartan on immune induced hepatic fibrosis in rats
     缬沙坦对免疫性大鼠肝纤维化的影响
短句来源
     Immune tolerance induced by anergic T cells generated in vitro
     无能T淋巴细胞的建立及其免疫生物学特性的研究
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Objective To investigate the difference of the location and expression of TIMP-1,2 liver fibrosis model in rats between immune induced and toxin induced. Methods Immune rats were injected with 20% human serum albumin and intoxic rats with CCL 4 respectively , then liver tissue of rats stained with HE, VG and observed with electron microscope. The location and expression of TIMP-1, TIMP-2 protein and mRNA were studied. Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation,...

Objective To investigate the difference of the location and expression of TIMP-1,2 liver fibrosis model in rats between immune induced and toxin induced. Methods Immune rats were injected with 20% human serum albumin and intoxic rats with CCL 4 respectively , then liver tissue of rats stained with HE, VG and observed with electron microscope. The location and expression of TIMP-1, TIMP-2 protein and mRNA were studied. Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation, strong expression of TIMP-1, TIMP-2 mRNA and protein and lasted for longer time, on the other hand, the toxin induced rat liver fibrosis model presented weak expression of TIMP-1, TIMP-2 mRNA and protein , and shorter period of liver fibrosis after stopping toxin attack. The TIMP-1, TIMP-2 related antigens in liver of immune induced model were expressed in myofibroblast and fibroblast. This was most obvious in portal area and fibrous septum. The positive signal located at cytoplasm, not in nucleus. Such distribution and location were also revealed in the in situ hybridization.Conclusion The toxin induced rat liver fibrosis model was not appropriate for observation of anti-fibrotic drugs due to its fast sponteneous absorption, the immune induced rat liver fibrosis model is good for the observation of anti-fibrotic drug effects and study on the mechanism of liver fibrosis due to its slow sponteneous absorption, and has the trend of aggrevation within three months after.

目的探讨人血白蛋白免疫诱导型及四氯化碳(CCl4)毒素诱导型所致大鼠肝纤维化模型肝组织中金属蛋白酶组织抑制因子(TIMP)定位及表达状态的差异。方法分别以20%人血白蛋白进行免疫攻击和CCl4毒素攻击大鼠,造模结束后对大鼠肝组织进行HE、VG染色及电镜观察;同时研究TIMP1、TIMP2蛋白及mRNA定位及表达状态。结果造模结束后,免疫诱导型模型肝组织病理改变具有进行性加重趋势,TIMP1、TIMP2mRNA及蛋白表达强度高、持续时间长;而毒素诱导型模型具有TIMP1、TIMP2mRNA及蛋白表达强度弱、肝纤维化持续时间短等特点。免疫诱导实验组肝脏中TIMP1、TIMP2相关抗原表达在肌成纤维细胞、成纤维细胞,以汇管区及纤维间隔中最明显,阳性信号位于细胞胞质中,未见细胞核表达。原位杂交检测结果亦相似。结论毒素诱导型肝纤维化模型自然吸收较快,不利于抗肝纤维化药物疗效的观察;免疫诱导型肝纤维化模型自然吸收时间较慢,且在造模结束后1~3个月有逐渐加重趋势,有利于抗肝纤维化药物疗效观察及肝纤维化机制研究。

Objective To explore the difference of the correlation between the TIMP-1 expression level and hepatic fibrosis in rat liver fibrosis models induced separately by HSA (human sreum albumin) and CCl_4. Methods The serum TIMP-1 level of experiment rats in the model induced process was detected with ELISA and compared with the results of histopathological grading of liver biopsy, in order to determine whether the serum TIMP-1 level in the two rat fibrosis models could reflect the severity...

Objective To explore the difference of the correlation between the TIMP-1 expression level and hepatic fibrosis in rat liver fibrosis models induced separately by HSA (human sreum albumin) and CCl_4. Methods The serum TIMP-1 level of experiment rats in the model induced process was detected with ELISA and compared with the results of histopathological grading of liver biopsy, in order to determine whether the serum TIMP-1 level in the two rat fibrosis models could reflect the severity of hepatic fibrosis. Furthermore, in situ hybridization was used to determine the expression difference of TIMP-1 mRNA in the two models. Results The serum TIMP-1 level in immune-induced rat liver fibrosis model can reflect the severity of hepatic fibrosis and the positive in situ hybridization signal of TIMP-1 mRNA is strong; In CCl_4-induced rat liver fibrosis model, the correlation between the serum TIMP-1 level and the severity of hepatic fibrosis is insignificant in statistics. And compared with immune-induced rat liver fibrosis model, the positive in situ hybridization signal of TIMP-1 mRNA is weaker, while the expression variation is higher for the same severity of hepatic fibrosis. Conclusion Process of pathological changes of immune-induced rat liver fibrosis model is gradual and serum TIMP-1 level can reflect the severity of fibrosis. CCl_4-induced rat liver fibrosis model developed faster in comparison with immune-induced rat liver fibrosis model and no significant correlation exists between serum TIMP-1 level and the severity of fibrosis.

目的探讨免疫诱导型和CCl4诱导型大鼠肝纤维化模型制备过程中基质金属蛋白酶组织抑制因子1(TIMP1)表达水平与肝纤维化程度相关性的差异。方法双夹心ELISA法定量监测免疫诱导和CCl4诱导大鼠肝纤维化模型制备过程中大鼠血清TIMP1水平,与常规病理学检查分级,进行相关性分析,并进一步用原位杂交法观察TIMP1mRNA在两种肝纤维化模型中的表达差异。结果免疫诱导型大鼠肝纤维化模型制备过程中其血清TIMP1水平能较好的反映肝纤维化程度,原位杂交显示TIMP1mRNA表达较强;CCl4诱导型模型制备过程中其血清TIMP1水平与肝纤维化程度相关性无统计学意义,原位杂交显示TIMP1mRNA表达较弱,且在同等级纤维化程度肝组织中表达差异较大。结论免疫诱导大鼠肝纤维化模型病变有一定发展过程,分期明显,血清TIMP1水平能较好的反应其肝纤维化程度;CCl4诱导型大鼠肝纤维化模型病变过程较快,分期不明显,血清TIMP1水平不能作为其肝纤维化程度的指标。

 
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