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   fleroxacin 在 药学 分类中 的翻译结果: 查询用时:0.19秒
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fleroxacin
相关语句
  氟罗沙星
    TOLERANCE TRIALS AND PHARMACOKINETICS STUDY OF FLEROXACIN IN NORMAL VOLUNTEERS
    国产氟罗沙星正常人体耐受性及药代动力学比较研究
短句来源
    CLINICAL EVALUATION OF FLEROXACIN AND LOMEFLOXACIN IN TREATMENT OF BACTERIAL INFECTIONS
    氟罗沙星与洛美沙星治疗细菌性感染的临床评价
短句来源
    Studies on Synthesis of Fluoroquinolone Antimicrobial Agent Fleroxacin
    氟喹诺酮类抗菌剂氟罗沙星合成工艺研究
短句来源
    Pharmacokinetics of fleroxacin in ten healthy volunteers
    多剂量氟罗沙星在健康人体内的药代动力学研究
短句来源
    Study on antihacterial activity of fleroxacin in vitro
    氟罗沙星体外抗菌活性的研究
短句来源
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  “fleroxacin”译为未确定词的双语例句
    The drug concentration in plasma and urine were assayed byHPLC method. The plasma concentration-time curve of fleroxacin administeredorally could be best described by an open one-compartment model. Their mainmean parameters were as follows: AUC: 82. 30±14. 30, 81. 13±8. 45 and 83. 92±14. 2 h·mg/L;
    血、尿药浓度用HPLC检测.结果表明:体内过程符合一室模型,主要药代动力学参数分别为:AUC:82.30±14.30、81.13±8.45与83.92±14.27h·mg/L;
短句来源
    The clinical cure rates of acute bacillary dysentery were 93.3%,100% and 100% and the bacterial clearance rates were 93.3%, 100% and 100% in the lomefloxacin, fleroxacin and ofloxacin group respectively.
    3种抗菌药物治疗急性细菌性痢疾各30例的治愈率分别为100%、100%及93.3%。
短句来源
    All were 0. 2-0. 4 g iv drip, qd (fleroxacin) or bid (ciprofloxacin) for 714 d.
    环丙沙星对照组用环丙沙星,0.2~0.4 g,静脉滴注,bid; 疗程均为 7~14d。
短句来源
    Fleroxacin was administered orally 200mg twice daily or 400mg once daily for 5~14 days.
    给药方法为每次口服2 0 0 mg、每日 2次或 40 0 mg、每日 1次 ,疗程 5~ 14d。
短句来源
    RESULTS:The photodegradation of fleroxacin injection obeys zero kinetics:A=A 0+ k·Et .
    结果 :该药在光照试验中颜色变化遵从零级动力学规律 :A =A0 +κ·Et。
短句来源
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  fleroxacin
In the present study, the transport system for fleroxacin was characterized in isolated rat choroid plexus.
      
It is reported that the cerebrospinal fluid (CSF) to plasma unbound concentration ratio of fleroxacin at steady-state is approximately 0.5 in experimental animals.
      
Characterization of the Transport Properties of a Quinolone Antibiotic, Fleroxacin, in Rat Choroid Plexus
      
Evaluation of Free Tissue Concentrations of Fleroxacin After Oral Administration
      
In contrast, ofloxacin, lomefloxacin, fleroxacin, sparfloxacin, and levofloxacin markedly promoted neutrophil death without affecting neutrophil apoptosis.
      
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Fleroxacin has excellent activity against aerobic gram-negative

三氟哌酸对需氧的革兰氏阴性杆菌和葡萄球菌有优异的抗菌活性,但对链球菌和厌氧菌活性低,而这些菌对利福平敏感。利福平固定为2μg/ml或8μg/ml与三氟哌酸作联合药敏试验。结果表明两药联合后不产生协同、相加和无关各占14.6%和83.6%,仅1株菌呈现拮抗(1.8%)。5株试验菌的药物联合杀菌曲线也未见协同。提示两药联合,虽然相互无关,但却能抑制一些三氟哌酸单药不足以抑制的细菌,值得进一步作临床应用研究。

This article summarized the antibacterial spectrum, pharmacokinetics and useof Fluoroquinolones. The fluoroquinolones involve norfloxacin, enoxacin, ofloxa-cin, ciprofloxacin, pefloxacin, amifloxacin, fleroxacin and PD-127391 etc, whichhave important value not only for infection of common clinical Sensitive strains,but all so for the infections by bacteria resistance against drugs. These antibioticsare effective and useful to most kind of acute and Chronic infection. The effec-tive rate was 80-90%. with...

This article summarized the antibacterial spectrum, pharmacokinetics and useof Fluoroquinolones. The fluoroquinolones involve norfloxacin, enoxacin, ofloxa-cin, ciprofloxacin, pefloxacin, amifloxacin, fleroxacin and PD-127391 etc, whichhave important value not only for infection of common clinical Sensitive strains,but all so for the infections by bacteria resistance against drugs. These antibioticsare effective and useful to most kind of acute and Chronic infection. The effec-tive rate was 80-90%. with rare and mild side effect.

本文对诺氟沙星、依诺沙星、氧氟沙星、环丙氟沙星、培氟沙星、氨氟沙星、多氟沙星、PD—127391等氟喹诺酮类抗菌药的抗菌谱、药代动力学及用途作了综述和展望。这类抗菌药物对各种急慢性感染疗效显著,有效率达80~90%以上,毒副作用少,有广阔的前景。

The synthesis of the tea ftuoroquinolones containing fleroxacin and 1-al-kyl-6,8-difluoro-1, 4-dihydro-7-heterocyctic-4-oxoquinoline-3-carboxylic acid is reported in this, paper.The N-substituted groups were methyl,ethyl, n-propyl, 2-hydroxyethyl, 2-fluoroethyl, etc. The 7-hetero-cyclic groups were 4-methyl-1-piperazinyl, piperazinyl,imidazolyl, morpholinyl, etc.The antibacterial activities of these compounds in vitro were determined and some results of the structure-activity relationship were explained...

The synthesis of the tea ftuoroquinolones containing fleroxacin and 1-al-kyl-6,8-difluoro-1, 4-dihydro-7-heterocyctic-4-oxoquinoline-3-carboxylic acid is reported in this, paper.The N-substituted groups were methyl,ethyl, n-propyl, 2-hydroxyethyl, 2-fluoroethyl, etc. The 7-hetero-cyclic groups were 4-methyl-1-piperazinyl, piperazinyl,imidazolyl, morpholinyl, etc.The antibacterial activities of these compounds in vitro were determined and some results of the structure-activity relationship were explained preliminarily.

本文采用Gould-Jacobs法合成了多氟喹诺酮(Fleroxacin)及9个类似物,其中5个化合物尚未见报道。测定了这些化合物的体外抗菌活性,并由抑菌结果对其构效关系作了初步的说明。

 
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