Methods Thirtysix patients with acute exacerbation of COPD 〔7.25≤arterial blood pH (pHa)<7.35, partial pressure of carbon dioxide in artery (PaCO_2)>45 mm Hg, 1 mm Hg=0.133 kPa〕 were enrolled in the study.
Results CRP was abnormal in 95% of patients with acute exacerbation of COPD, the rate of abnormal CRP was significantly higher than that of abnormal WBC.
The effect decreased the serum GM CSF,IL 1β,IL 6,IL 8 and increased of IL 2 might be one of mechanism Tongse grain of TCM′s treating acute exacerbation of COPD.
Methods A total of 40 patients suffering from respiratory failure due to acute exacerbation of COPD were randomly divided into NIPPV group (NIPPV plus routine therapy) and control group (routine comprehensive therapy).
Methods Thirtysix patients with acute exacerbation of COPD 〔7.25≤arterial blood pH (pHa)<7.35, partial pressure of carbon dioxide in artery (PaCO_2)>45 mm Hg, 1 mm Hg=0.133 kPa〕 were enrolled in the study.
Results CRP was abnormal in 95% of patients with acute exacerbation of COPD, the rate of abnormal CRP was significantly higher than that of abnormal WBC.
The effect decreased the serum GM CSF,IL 1β,IL 6,IL 8 and increased of IL 2 might be one of mechanism Tongse grain of TCM′s treating acute exacerbation of COPD.
METHODS Serum samples from 84 patients with acute exacerbation of COPD and 23 healthy subjects were tested for specific IgM and IgG of respiratory syncytial virus (RSV), herpes simplex virus type 1 (HSV-1), parainfluenza virus (PIV), adenovirus (ADV) and cytomegalovirus (CMV) with indirect enzyme-linked immunosorbent assay (ELISA).
Mothods: 47 patients with acute exacerbation of COPD were selected, which were divided into three groups: group I of 14 cases with mild COPD, groupⅡof 18 cases with moderate COPD and group Ⅲ of 15 cases with severe COPD;
METHODS: Serum samples from 86 patients with acute exacerbation of COPD (Group A) and 32 patients with stable COPD (Group B) were tested for the specific IgG and IgM of respiratory syncytial virus (RSV), adenovirus (Adv), Coxsackievirus (Cox) and Cytomegalovirus (CMV) by Biochip technique-indirect immunofluorescence test.
Methods: Serum samples from 86 patients with acute exacerbation of COPD (Group A), 32 patients with stable COPD (Group B) were tested for the specific IgG and IgM for Respiratory Syncytial virus (RSV), Adenovirus (ADV), Coxsackievirus (COX) and Cytomegalovirus (CMV) with Biochip technique-indirect immunofluorescence test.
ResultsAbout 97.9%(47/48) of the patients had more than one underlying diseases,79% of which were acute exacerbation of COPD,68.8% were immunocompromised. Decreased level of albumin,prior use of broad-spectrum antibiotics and invasive treatment were found in 79.2%,100% and 72.9% of the cases respectively.
Results The 92 , 72, 82, 62 kD levels of lung in acute exacerbation of COPD animal model group, stable model group of COPD, high dosage group, low dosage group, Chinese herbal medicine control group, western medicine control group were all higher than those of normal controls.
The correlation between infection and prothrombogenesis has not been assessed in acute exacerbation of chronic obstructive pulmonary disease (COPD) in elderly person. We have evaluated AT-Ⅲ: Ag and fibronectin (Fn) in 35 patients (age 72±8 years) with clinical evidence of exacerbation (PaO_2 7.4±1.1kPa). AT-Ⅲ: Ag was found decreased (<22.96 mg%) in 21 patients, and Fn decreasd (<185μg/ml) in 10 patients. AT-Ⅲ:Ag was decreased in all patients (n=10) in whom Fn was decreased. The values...
The correlation between infection and prothrombogenesis has not been assessed in acute exacerbation of chronic obstructive pulmonary disease (COPD) in elderly person. We have evaluated AT-Ⅲ: Ag and fibronectin (Fn) in 35 patients (age 72±8 years) with clinical evidence of exacerbation (PaO_2 7.4±1.1kPa). AT-Ⅲ: Ag was found decreased (<22.96 mg%) in 21 patients, and Fn decreasd (<185μg/ml) in 10 patients. AT-Ⅲ:Ag was decreased in all patients (n=10) in whom Fn was decreased. The values of AT-Ⅲ:Ag were 22.23±4.87mg% and 12.45±2.86 mg% respectively in patients with normal level and decreased level of Fn (P<0.01). There was a significant correlation between the values of AT-Ⅲ:Ag and Fn (r 0.61 P<0.01). It is thus concluded that during acute exacerbation of COPD in elderly persons, inflammation, hypoxemia, and hypercapnia provoke the development of prethrombogenesis state which induces the vicoous circle, and AT-Ⅲ:Ag is the objective indicator for early detection of widespread prethrombogenesis state.
The C-reactive protein (CRP) and haptoglobin(Hp) measurements in 26 patients (age 75±8) with acute exacerbation of chronic obstructive pulmonary disease (COPD) in elderly patients were evaluated. These patients had serial measurements of CRP, Hp, ESR Fg, the absolute numbers and differential counts of the peripheral white cell, analysis of blood acid-base and gas contents, body temperature, and chest X-ray, in addition to serial sputum bacteriological studies. CRP was elevated in all patient...
The C-reactive protein (CRP) and haptoglobin(Hp) measurements in 26 patients (age 75±8) with acute exacerbation of chronic obstructive pulmonary disease (COPD) in elderly patients were evaluated. These patients had serial measurements of CRP, Hp, ESR Fg, the absolute numbers and differential counts of the peripheral white cell, analysis of blood acid-base and gas contents, body temperature, and chest X-ray, in addition to serial sputum bacteriological studies. CRP was elevated in all patient (n=26). white cell count was lowered with therapy, showing a positive correlation with the CRP level (r=0.60, P<0.01). Hp was increased in 24 patients. ESR was quickened in 16 patients, the percentage of increased Hp was significantly higher than that of quickened ESR in all Patient (X~26.93, P<0.01). Hp was increased in all patients in whom ESR was quickened, exhibiting a positive correlation with the elevated ESR level (r=0.54, P<0.05). It was concluded that in the assessment of acute exacerbation of COPD in elderly patients, the measurment of serum CRP may provide an early, reliable, and sensitive objective indicator of infection, and the measurement of serum Hp may provide an stable, and sensitive indicator of active infection.
Objective To summarize the results of patients of severe respiratory failure using multiple times mechnical ventilation (MV) via tracheal intubation (or via tracheotomy). Methods We retrospectively analysed clinical information and follow up results of 15 acute exacerbation of COPD patients using MV more than 3 times. Results MV was used 77 times in 15 patients. The highest number of MV was 20. 86% were weaned successfully. The mean duration of MV via intubation was 13 days and via tracheotomy was...
Objective To summarize the results of patients of severe respiratory failure using multiple times mechnical ventilation (MV) via tracheal intubation (or via tracheotomy). Methods We retrospectively analysed clinical information and follow up results of 15 acute exacerbation of COPD patients using MV more than 3 times. Results MV was used 77 times in 15 patients. The highest number of MV was 20. 86% were weaned successfully. The mean duration of MV via intubation was 13 days and via tracheotomy was 37 days, mean 649 days via the latest brocheotomy after using MV multiple times. The survival duration after the first MV varied from 196 to 4 420 days in 15 patients, mean 1 093 days, medium survival duration of the patients was 1 673 days, survival rates after 1,2,3 and 5 years were 73%, 64%, 33% and 25% respectively. The causes of death were failure of multiple organs or disfunction of other vital organs. Conclusions Repeated application of MV may prolong the survival rates of COPD with severe respiratory failure. It′s important to take strictly the indication of MV, correctly to select the methods of artifical airway, combining invasive and noninvasive ventilation, properly to apply the strategies of MV.
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acute exacerbation of copd
copd急性加重
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