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graves diseases
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  graves病
     The clinical importance of RAIU determination to Graves diseases treated with ~(131)Ⅰ
     Graves病~(131)Ⅰ治疗后RAIU测定的临床意义
短句来源
     ② diffuse enlargement type:including 11 multinodular goiter, 11 thyroid carcinoma,8 Hashimoto thyroiditis and 2 Graves,diseases.
     ②弥漫肿大型 :结节性甲状腺肿 11例 ,甲状腺癌 11例 ,桥本氏病 8例 ,Graves病 2例。
短句来源
     Objective To investigate the clinical significance of Sβ2M in Graves diseases(GD).
     目的探讨Graves病患者血清β2M测定的意义。
短句来源
     THE SIGHIFICANCE OF SERUM β_2MICROGLOBULIN(Sβ2M) IN GRAVES DISEASES
     Graves病患者血清β_2微球蛋白测定的意义
短句来源
     The expression of prendrin protein may be related to the function of follicles: its expression level increased significantly both in Graves diseases and toxic adenomas, but significantly decreased in differentiated thyroid carcinoma.
     pendrin的表达水平与滤泡功能相关:在Graves病和高功能腺瘤中,pendrin高表达,在甲状腺癌中其表达显著降低;
短句来源
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  “graves diseases”译为未确定词的双语例句
     METHODS Serum TNF-α, IL-1, IL-2, IL-6, TSH, TT 3 and TT 4 levels of 32 Graves diseases patients (12 male and 20 female , aged 34.1±9.8 years) at the time of diagnosis and after 6 weeks and 6 mont hs of treatment were measured.
     方法  32例 GD患者在确诊时、治疗约 6周和 6月时用放射免疫法测定血清 TNF- α,IL- 1,IL- 2 ,IL- 6 ,TSH,TT3,TT4的水平 .
短句来源
     Methods TTF-1 expression were determined by immunohistochemistry(S-P method) in 45 hyperplastic lesions(including 31 goiters,12 adenomas and 2 Graves diseases)and 19 normai tissue.
     方法 采用免疫组化S- P法检测4 5例甲状腺良性增生性病变和19例正常甲状腺组织标本的TTF -1表达。
短句来源
     Blastogenic response of peripheral blood mononuclear cell's (PBMC) to PHA wassignificantly diminished in patients with Graves diseases as compared with that in the healthyvolunteers (P<0.01).
     此外,GD 患者外周血单个核细胞对PHA 增殖应答能力低下。
短句来源
     Conclusion Grave disease accompanied by periodic paralysis should be paid much attention to and it was very important to control the symptoms of Graves diseases and supplement potassium.
     结论 周期性麻痹继发于甲亢的高比例应引起重视 ,治疗的关键在于补钾和甲亢的控制
短句来源
     Methods The VEGF expression was detected by immunohistochemistry in 57 DTCs (43 cases of papillary and 14 cases of follicular),45 hyperplastic lesions (31 cases of goiters,12 cases of adenomas and 2 cases of Graves diseases) and 19 normal thyroid tissues that had been fixed in formalin and embedded in paraffin.
     方法采用免疫组化SP法检测57例分化型甲状腺癌、45例甲状腺良性病变和19例正常组织标本中的VEGF表达。
短句来源
  相似匹配句对
     A CDFI Research of the Retrobulbar Hemodynamics in Graves Diseases
     彩色多普勒对Graves病球后血流动力学的研究
短句来源
     Study on chemokines and their receptors in patients with Graves' diseases
     Graves病血清趋化因子与其受体变化的关系研究
短句来源
     Apoptosis and Diseases
     细胞凋亡与疾病
短句来源
     Course of diseases
     吃药能治的病别打吊针
短句来源
     Graves-Morris and E.
     Graves—Morris和E.
短句来源
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  graves diseases
The immune mechanism of Graves' diseases (GD) and the roles of regulator T cells were investigated.
      
In a case report of a 49-year-old man with a clinical diagnosis of Graves' diseases.
      
Another two PCOS patients but no controls had been thyroidectomized because of Graves' diseases.
      


Thyroid stimulating antibody(TSAb)was detected by radioreceptor assay of TSHin patients with Graves' disease.The ability of serum Ig to displace the labelled TSHfrom the receptors is referred to as“TSH displacement activity(TDA)”.In untreatedGraves' disease,TDA was above normal in 24(85.7%)of 28 cases,and in patientswith Graves' disease treated with anti-thyroid drugs for less than 3 months,TDA waspositive in 7 of 10 cases.Among Graves' disease patients with symptoms...

Thyroid stimulating antibody(TSAb)was detected by radioreceptor assay of TSHin patients with Graves' disease.The ability of serum Ig to displace the labelled TSHfrom the receptors is referred to as“TSH displacement activity(TDA)”.In untreatedGraves' disease,TDA was above normal in 24(85.7%)of 28 cases,and in patientswith Graves' disease treated with anti-thyroid drugs for less than 3 months,TDA waspositive in 7 of 10 cases.Among Graves' disease patients with symptoms controlledby maintenance dose of anti-thyroid drugs and those in remission without anti-thyroiddrug maintenance,TDA was positive in only 2 of 12 cases.Among 3 patients withrecurrence of hyperthyroidism,TDA was positive in 2 cases.All the 5 patients withsimple goiter had normal TDA.TDA levels correlated well with 4-hour thyroidal ~(131)Iuptake in 20 Graves' disease patients.Thus,TSAb appears to be a prerequisite ofhyperthyroidism manifestations of Graves' disease,and this method may be employedto detect immunological remission of Graves' disease.

本文报道用促甲状腺激素(TSH)放射受体分析法测定 Graves 病病人血清甲状腺刺激抗体抑制或置换~(125)I-TSH 与人甲状腺细胞膜受体结合的活力,以 TSH 置换活力(TDA)表示之.在53例 Graves 病中,未治疗的28例,TDA 高于正常者占85.7%;治疗不满3个月的10例,有7例TDA 阳性;治疗一年以上并服用维持量的7例和已停止治疗而临床缓解的5例中,仅2例 TDA 阳性;复发的3例,有2例 TDA 阳性,5例单纯性甲状腺肿和10名正常对照者,TDA 均正常。Gra-ves 病的 TDA 水平与4小时吸~(131)碘率值密切相关(r=0.91,P<0.01)。以上资料表明:本试验可望成为检测 Grayes 病及判断治疗效果和预后的一种可靠方法.

In this communication, studies on the action of LATS-IgG on isolated thyroid gland from normal mice are presented. The two lobes of thyroid gland from each mouse were separated into two groups and incubated in Earle's medium. To one group LATS-IgG was added and to the other normal IgG was added as a control. After inoubation, it was found that (1) the iodine uptake by the thyroid, (2) the conversion of inorganic into organic iodine, (3) the thyronine synthesized and (4) the thyroid peroxidase activity in the...

In this communication, studies on the action of LATS-IgG on isolated thyroid gland from normal mice are presented. The two lobes of thyroid gland from each mouse were separated into two groups and incubated in Earle's medium. To one group LATS-IgG was added and to the other normal IgG was added as a control. After inoubation, it was found that (1) the iodine uptake by the thyroid, (2) the conversion of inorganic into organic iodine, (3) the thyronine synthesized and (4) the thyroid peroxidase activity in the LATS-IgG group were 37%,85%, 2.5 times and 3 times higher, respectively, than those of the control group.The effect of LATS-IgG on the release of T_3 and T_4 by the isolated thyroids was also studied. When compared with normal human serum, LATS-IgG serum resulted in a 10 times increase of T_3 and T_4. In another experiment, mice were injected with ~(125)I. Two hours later their thyroids were taken out and inoubated in Earle's medium. After incubation, it was found that in the LATS-IgG group the radioactivities of T_3 and T_4 were 16.6% and that of inorganio iodine 83.4% of the total activities, respectively, whereas in the control group they were 2.1% and 97.9%, respectively. These results indicated that LATS not only increases the total thyroid release but also affects the composition of the components secreted. Thus, our results may account for, at least in part, the pathogenesis of Graves' disease.

本文研究了长效甲状腺刺激物(简称LATS)对离体正常小鼠甲状腺合成和释放甲状腺激素的影响。用配对实验法,将小鼠甲状腺两叶分别放入两个培养瓶内,一组加LATS-IgG,另一组加正常人IgG作对照,在其他条件相同的情况下,实验组的摄碘率、碘的有机化作用和甲状腺激素的合成,分别增加37.5%、85%和150%。在相同的培养条件下,大鼠甲状腺过氧化物酶(简称TPO)活性,实验组比对照组增高了约三倍。说明LATS可能通过促进摄碘和活化TPO酶,促进甲状腺激素的合成。用离体培养和放射免疫测定方法证明,每毫升培养液中加50μlLATS血清(McKenzie活性为4,000%),正常小鼠甲状腺释放T_4和T_3均可增加十多倍。如果先用~(125)Ⅰ体内标记2小时,再将甲状腺摘出体外培养,则LATS组不仅总的释放率增加,而且释放物的组成成分,也有所不同,激素碘占16.6%,无机碘占83.4%;而对照组分别为2.1%和97.9%。

In this communication, studies on the action of LATS-IgG on isolated thyroidgland from normal mice are presented. The two lobes of thyroid gland from each mousewere separated into two groups and incubated in Earle's medium. To one group LATS-IgG was added and to the other normal IgG was added as a control. After incubation,it was found that (1)the iodine uptake by the thyroid, (2)the conversion of inorganiointo organic iodine, (3)the thyronine synthesized and(4)the thyroid peroxidase activityin the LATS-IgG...

In this communication, studies on the action of LATS-IgG on isolated thyroidgland from normal mice are presented. The two lobes of thyroid gland from each mousewere separated into two groups and incubated in Earle's medium. To one group LATS-IgG was added and to the other normal IgG was added as a control. After incubation,it was found that (1)the iodine uptake by the thyroid, (2)the conversion of inorganiointo organic iodine, (3)the thyronine synthesized and(4)the thyroid peroxidase activityin the LATS-IgG group were 37%, 85%, 2.5 times and 3 times higher, respectively,than those of the control group. The effect of LATS-IgG on the release of T_3 and T_4 by the isolated thyroids wasalso studied. When compared with normal human serum, LATS-IgG serum resultedin a 10 times increase of T_3 and T_4. In another experiment, mice were injected with~(125)I. Two hours later their thyroids were taken out and incubated in Earle's medium.After incubation, it was found that in the LATS-IgG group the radioactivities of T_3and T_4 were 16.6% and that of inorganic iodine 83.4% of the total activities, respe-ctively, whereas in the control group they were 2.1% and 97.9%, respectively. Theseresults indicated that LATS not only increases the total thyroid release but also affectsthe composition of the components secreted. Thus, our results may account for, atleast in part, the pathogenesis of Graves' disease.

本文研究了长效甲状腺刺激物(简称LATS)对离体正常小鼠甲状腺合成和释放甲状腺激素的影响。用配对实验法,将小鼠甲状腺两叶分别放入两个培养瓶内,一组加LATS-IgG,另一组加正常人IgG作对照,在其他条件相同的情况下,实验组的摄碘率、碘的有机化作用和甲状腺激素的合成,分别增加37.5%、85%和150%。在相同的培养条件下,大鼠甲状腺过氧化物酶(简称TPO)活性,实验组比对照组增高了约三倍。说明LATS可能通过促进摄碘和活化TPO酶,促进甲状腺激素的合成。用离体培养和放射免疫测定方法证明,每毫升培养液中加50μILATS血清(McKenzie活性为4,000%),正常小鼠甲状腺释放T_4和T_3均可增加十多倍。如果先用~(125)I体内标记2小时,再将甲状腺摘出体外培养,则LATS组不仅总的释放率增加,而且释放物的组成成分,也有所不同,激素碘占16.6%,无机碘占83.4%;而对照组分别为2.1%和97.9%。

 
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