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carcinoma prognosis     
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  癌预后
     Patients whose tumors showed c- myc overexpression had a greater madenec for the thyroid carcinoma prognosis indexes more than or equal to 66 than other patients (P<0.05). It suggests that overexpression of c -myc proto - oncogene may be associated with unfavourable prognosis of thyroid carcinoma .
     具有c-myc基因过度表达的甲状腺癌患者甲状腺癌预后指数≥66的发生率高于其他患者(P<0.05),提示c-myc基因的过度表达可能与甲状腺癌的不良预后有关.
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  癌的预后评估
     Objective To investigate the significance of microvessel density and vascular endothelial growth factor(VEGF)in the determination of biological behaviour of squamous cell cervical carcinoma,in order to present reference in predicting cervical carcinoma prognosis and guiding clinical treatment.
     目的 探讨宫颈鳞癌微血管密度、血管内皮生长因子 (VEGF)蛋白表达在判断肿瘤生物学行为中的意义 ,以期为宫颈癌的预后评估和指导临床治疗提供新的依据。
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  乳腺癌患者预后
     Conclusions The expression of Cerb-B2、P 53 suggested that the carcinoma prognosis is not good;
     结论 乳腺癌中Cerb -B2、P53的表达提示乳腺癌患者预后不良 ;
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     The expression of ER、PR、suggested that the carcinoma prognosis is better.
     ER、PR表达提示乳腺癌患者预后较好。
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  患者预后不良
     Conclusions The expression of Cerb-B2、P 53 suggested that the carcinoma prognosis is not good;
     结论 乳腺癌中Cerb -B2、P53的表达提示乳腺癌患者预后不良 ;
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  carcinoma prognosis
Improvement of the right colon carcinoma prognosis is to be expected of earlier tumor diagnosis.
      
Colorectal carcinoma prognosis can be predicted by alterations in gene p53 exons 5 and 8
      
We hypothesized that genes in certain pathways might play a role in squamous cell carcinoma prognosis.
      


The auther reported expression of ifte r-myc gate was studled by RNA dot - blot hybridization in tumor specimens from 15 patients with promary thyraid caremomas , 3 patients with thyroid adenomas , tissues from 5 normal thyroid tissues P dATP labeled prohe of c - myc fragment of cloned gene was used to hybridize with the cellular total RNA We found that in 9 of the 15 cancer patients , c- myc proto- oncogene was over -expressed (3-11 times higher chan that in normal thyroid tissues ). Patients whose tumors showed...

The auther reported expression of ifte r-myc gate was studled by RNA dot - blot hybridization in tumor specimens from 15 patients with promary thyraid caremomas , 3 patients with thyroid adenomas , tissues from 5 normal thyroid tissues P dATP labeled prohe of c - myc fragment of cloned gene was used to hybridize with the cellular total RNA We found that in 9 of the 15 cancer patients , c- myc proto- oncogene was over -expressed (3-11 times higher chan that in normal thyroid tissues ). Patients whose tumors showed c- myc overexpression had a greater madenec for the thyroid carcinoma prognosis indexes more than or equal to 66 than other patients (P<0.05). It suggests that overexpression of c -myc proto - oncogene may be associated with unfavourable prognosis of thyroid carcinoma .

作者应用核酸打点杂交方法,观察原发性甲状腺癌15例、甲状腺瘤3例和正常甲状腺5例组织中c-myc原癌基因的表达.结果表明:9例甲状腺癌c-myc基因表达较正紧组织增高3-11倍.具有c-myc基因过度表达的甲状腺癌患者甲状腺癌预后指数≥66的发生率高于其他患者(P<0.05),提示c-myc基因的过度表达可能与甲状腺癌的不良预后有关.

ervical carcinoma is a common malignant tumor. In order to study the relationships of the type of HPV or oncogenes to the etiology and prognosis of this diseas,human papilloma virus(HPV)type-16,tpye-18,c-Ha-ras-1 and c-myc oncogenes DNA probes were used to test 44 cases of cervical carcinoma and 17 cases of normal cervical tissues. The hybridization results revealed that positive rates of type-16,type-18,c-Ha-ras-1 and c-myc in cervical carcinoma were 50%、7%、64%and 68%respectively. They were significantly higher...

ervical carcinoma is a common malignant tumor. In order to study the relationships of the type of HPV or oncogenes to the etiology and prognosis of this diseas,human papilloma virus(HPV)type-16,tpye-18,c-Ha-ras-1 and c-myc oncogenes DNA probes were used to test 44 cases of cervical carcinoma and 17 cases of normal cervical tissues. The hybridization results revealed that positive rates of type-16,type-18,c-Ha-ras-1 and c-myc in cervical carcinoma were 50%、7%、64%and 68%respectively. They were significantly higher than those of normal controls.We also found that the higher the differentiation level of the cancer cell was, the lower would be the positive rate. So we think that those factors may help to make a cervical carcinoma prognosis.

为了解人乳头瘤病毒(HPV)的某些类型及某些癌基因与宫颈癌发病及预后的关系,应用HPV16、18,c-Ha-ras-1及c-myc四种分子探针,通过核酸分子杂交技术,对44例子宫颈癌及17例正常子宫颈组织进行检测,并分析其间的关系以及与子宫颈癌发生、发展和预后的关系。结果表明,HPV16、18,c-Ha-ras-1及c-myc在宫颈癌组织中的阳性率分别为50%(22/44)、7%(3/44),64%(28/44)及68%(30/44);正常子宫颈组织均为阴性。并发现宫颈癌细胞分化程度越高者,阳性率越低。据此,认为分子杂交技术检测HPV16、c-Ha-ras-1及c-myc可以作为判断子宫颈癌患者预后的重要指标。

In order to study the relationships of the type of oncogenes to the etiology and prognosis of the disease, C Ha ras 1 and C myc oncogenes DNA probes were used to test 66 cases of cervical carcinoma and 27 cases of normal cervical tissues. The hybridization results revealed the positive rates of C Ha ras 1 and C myc in cervical carcinoma were 63 6%(42/66)and 68 2%(45/66) respectively. They were significantly higher than those of normal control. It's revealed that the positive rates of the...

In order to study the relationships of the type of oncogenes to the etiology and prognosis of the disease, C Ha ras 1 and C myc oncogenes DNA probes were used to test 66 cases of cervical carcinoma and 27 cases of normal cervical tissues. The hybridization results revealed the positive rates of C Ha ras 1 and C myc in cervical carcinoma were 63 6%(42/66)and 68 2%(45/66) respectively. They were significantly higher than those of normal control. It's revealed that the positive rates of the higher differentiation level of the cancer cell was the lower than that of the lower differentiation cancer. The factors may help to make a cervical carcinoma prognosis.

为进一步研究某些癌基因与子宫颈癌发病及预后的关系,本研究应用C-Ha-ras-1及C-myc两种分子探针,通过分子杂交技术对66例子宫颈癌及27例正常子宫颈组织中的癌基因进行检测,并分析其间的关系。结果表明,C-Ha-ras-1和C-myc在子宫颈癌中的阳性率分别为64%(42/66)和68.18%(45/66),正常子宫颈组织中两种癌基因均为阴性。并发现在高分化癌中两种癌基因的阳性率明显低于低分化癌,二者差异显著。

 
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