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brain ischemic model
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  脑缺血模型
     Methods: Thionin staining and GFAP immunohistochemistry staining in rat 4 vessel occlusion (4VO) brain ischemic model was used.
     方法 :采用大鼠四血管闭塞全脑缺血模型 (4 vesselocclusion ,4VO) ,应用硫堇染色和GFAP免疫组化法。
短句来源
     Based on rabbit MCAO focal brain ischemic model, we studied the effect of NO on ischemic brain by using L-Arginine, a precursor of NO and NOS inhibitor L-NNA.
     本文在兔MCAO局灶脑缺血模型基础上,利用外源性一氧化氮(NO)前体物质L-精氨酸和NOS抑制剂L-NNA研究NO对脑缺血后脑水肿和脑梗塞的影响。
短句来源
     We have make the mice' brain ischemic model,then observe Shuluo's penetration to BBB in four groups: mldel+borneol、 model、 sham+borneol and sham groups.
     我们首先复制小鼠的脑缺血模型,利用高效液相色谱技术(HPLC)观察舒络在模型+冰片、模型、假手术+冰片、假手术四种状态下通过血脑屏障的情况,以推测脑缺血及冰片处理对药物透血脑屏障的影响。
短句来源
     METHODS Four vessel occlusion was used to establish the rat global brain ischemic model.
     方法 利用 4-VO法制作大鼠全脑缺血模型 .
短句来源
     Methods Four-vessel occlusion was used to establish the rat global brain ischemic model.
     方法利用4-VO法制作大鼠全脑缺血模型
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  “brain ischemic model”译为未确定词的双语例句
     methods Global brain ischemic model was produced by clamping both common carotid arteries for 10 min in gerbils.
     方法沙鼠全脑缺血再灌注模型,脑缺血时间10min。
短句来源
     I . Establishing the rat standard global brain ischemic model by modified four-vessel occlusion (4-VO) method.
     (一)通过改良4-VO法建立标准化的大鼠全脑缺血再灌注模型。
短句来源
     Methods:The objective of this present study is to make animal brain ischemic model with middle cerebral artery occlusion(MCAO)by nylon thread,then measure the numbers and anatomic distribution of nerve cells apoptosis, assay the SOD and LPO content in same ischemic tissue.
     故测定缺血脑区出现DNA片断化的凋亡细胞数量变化及在缺血脑区的分布状况,以了解脑缺血的病理生理及寻求防治措施。 方法:利用线栓法制成大脑中动脉缺血动物模型,测定脑组织SOD、LPO含量变化及凋亡细胞的密度变化;
短句来源
     Methods:Fourvessel occlusion was used to establish the rat global brain ischemic model.
     方法 :利用四血管闭塞法制作全脑缺血大鼠模型。
短句来源
     Method: The brain ischemic model of the rats were set up using MCAO and observe changes of the model rats' behaviour using Stepdown and Water-maze.
     方法 :采用大鼠大脑中动脉栓塞模型 ,并与都可喜对照 ,通过跳台、水迷路方法检测健脑宁对模型鼠行为障碍的影响。
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  相似匹配句对
     A model of hypoxic-ischemic brain damage in the neonatal rats
     新生大鼠缺氧缺血性脑损伤模型的制作
短句来源
     Oligodendrocytes and Ischemic Brain Injury
     少突胶质细胞与缺血性脑损伤
短句来源
     Investigation of A Neonatal Piglet Model of Hypoxic Ischemic Brain Injury
     新生猪缺氧缺血脑损伤模型制备的研究
短句来源
     ON BRAIN MODEL IN ARTIFICIAL INTELLIGENCE
     关于人工智能中的脑模型研究
短句来源
     Protective effects of moderate hypothermia on the brain of acute ischemic rat model
     亚低温对大鼠急性缺血脑保护作用的研究
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Based on rabbit MCAO focal brain ischemic model,we studied the effect of NOon ischemic brain by using L-Arginine,a precursor of NO and NOS inhibitor-L-NNA, 42NZW rabbits was divided into 7 groups, namely control group,sham-operated group, MCAOischemic group,MCAO+NS group, MCAO+L-Arg group,MCAO+D-Arg group, MCAO+L-Arg +L-NNA group with 6 each. The results verified that the brain tissue H2O ,Na+,Ca2+content was decreased significantly (P<0.01) in L-Arg treated group compared with simpleischemic...

Based on rabbit MCAO focal brain ischemic model,we studied the effect of NOon ischemic brain by using L-Arginine,a precursor of NO and NOS inhibitor-L-NNA, 42NZW rabbits was divided into 7 groups, namely control group,sham-operated group, MCAOischemic group,MCAO+NS group, MCAO+L-Arg group,MCAO+D-Arg group, MCAO+L-Arg +L-NNA group with 6 each. The results verified that the brain tissue H2O ,Na+,Ca2+content was decreased significantly (P<0.01) in L-Arg treated group compared with simpleischemic MCAO group. The brain infarction volume was also decreased remarkably (P<0.01 ). It is suggested that the effect of L-Arg was accomplished through the production of NO,NO has the function of relaxing blood vessels,hence Iessen ischemic brain edema and de-crease the infarction volume,which may improving the clinical prognosis of brain ischemia.

本文在兔MCAO局灶脑缺血模型基础上,利用外源性NO前体物质L-精氨酸和NO合成酶抑制剂L-NNA研究NO对脑缺血后脑水肿和脑缺血灶的影响、结果提示NO对脑缺血脑水肿具有保护作用,而L-NNA则会扩大脑缺血灶的范围。

Based on rabbit MCAO focal brain ischemic model, we studied the effect of NO on ischemic brain by using L-Arginine, a precursor of NO and NOS inhibitor L-NNA. 42 NZW rabhits were divided into 7 groups, namely control group, sham-operated group, MCAO ischemic group, MCAO + NS group, MCAO + L-Arg group, MCAO + D-Arg group, MCAO +L-Arg+L-NNA group with 6 each. The results verified that the brain tissue H2O, Na+, Ca2+ contents were decreased significantly (P<0. 01) in L-Arg treated...

Based on rabbit MCAO focal brain ischemic model, we studied the effect of NO on ischemic brain by using L-Arginine, a precursor of NO and NOS inhibitor L-NNA. 42 NZW rabhits were divided into 7 groups, namely control group, sham-operated group, MCAO ischemic group, MCAO + NS group, MCAO + L-Arg group, MCAO + D-Arg group, MCAO +L-Arg+L-NNA group with 6 each. The results verified that the brain tissue H2O, Na+, Ca2+ contents were decreased significantly (P<0. 01) in L-Arg treated group compared with simple ischemic MCAO group. The brain infarction volume was also decreased remarkably (P<0.01). It is suggested that the effect of L-Arg was accomplished through the production of NO. NO has the function of relaxing blood vessels, hence lessening ischemic brain edema and decreasing the infarct volume, which may improve the clinical management of brain ischemia.

本文在兔MCAO局灶脑缺血模型基础上,利用外源性一氧化氮(NO)前体物质L-精氨酸和NOS抑制剂L-NNA研究NO对脑缺血后脑水肿和脑梗塞的影响。NZW兔42只随机分为7组,每组6只,计对照组、假手术组、MCAO组、MCAO+NS组、MCAO+L-Arg组、MCAO+D-Arg组及MCAO+L-Arg+L-NNA组。结果提示:与单纯MCAO组比较,L-Arg组的脑组织H_2O、Na~+、Ca~(2+)含量明显下降(P<0.01),脑梗塞灶亦明显缩小(P<0.01)。从而显示L-Arg系通过产生NO促使血管舒张而减轻脑水肿和缩小梗塞灶,为临床改进脑缺血的治疗提供依据。

Nimodipine as a calcium channel antigonist, bas been used in the treatment of acute brain iechemia. The article was oberved the contents of Nitric Oxide (NO) and Endotbelinl (ET1 ) in the circulation and brain tissue in models of acute brain ischemic and sham-operated rats, and the levels of No and ET1 in the circulation arid brain tissue in acute brain ischemic models with nimodipine. It was found that in compared with Sham -operated group, the levels of No in circulation...

Nimodipine as a calcium channel antigonist, bas been used in the treatment of acute brain iechemia. The article was oberved the contents of Nitric Oxide (NO) and Endotbelinl (ET1 ) in the circulation and brain tissue in models of acute brain ischemic and sham-operated rats, and the levels of No and ET1 in the circulation arid brain tissue in acute brain ischemic models with nimodipine. It was found that in compared with Sham -operated group, the levels of No in circulation of the model group had a tendency to decrease, but had no statistical difference (P>0. 05). the levels of ET1 was significantly increase (p<0. 05) ; in brain tissue, the levels of NO and ET1 were all inereased. Nimodipine has definite effects on the increasing the levels of NO in circulatin of the models. decreasing the levels of ET1, inhibiting the increase of NO and ET1 in brain tissue, It was suggested that nimodipine may improve thebrain blood flow, prevent the bain damage resulting from the acute brain ischemia.

尼莫地平是一种钙离子拮抗剂,现巳用于急性脑缺血的治疗。本文通过观察大鼠急性脑缺血模型及假手术组循环中及脑组织内一氧化氮(NO)、内皮素(ET1)水平,并观察尼莫地平对大鼠脑缺血模型循环中及脑组织的NO、ET1水平的影响,发现模型组循环中的NO水平较假手术组有下降趋势,但无明显统计学差异(P>0.05),ET1的水平较假手术组显著升高(P>0.05);脑组织中NO、ET1含量均较假手术组显著升高(P<0.05)。尼莫地平具有显著升高急性脑缺血大鼠循环中NO,显著降低循环中ET1,显著降低脑组织中NO、ET1的水平,说明尼莫地平具有促进脑缺血时大鼠的脑部供血,保护由于脑缺血引起的脑组织损害。

 
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