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corneal toxicity
相关语句
  角膜毒性
     Corneal toxicity and inflammation secondary to retained perfluorodecalin
     继发于滞留的全氟奈烷的角膜毒性和炎症反应
短句来源
     The results show that topically administer of CsA has slight corneal toxicity and the topical usage is a very safe,true drug delivery mathod.
     本研究结果表明,环孢霉素 A 局部用药对角膜毒性轻微,是安全可靠的一种投药方式。
短句来源
  相似匹配句对
     The Toxicity of Chloramphenicol Eye Drops to Corneal
     氯霉素眼药水对角膜上皮细胞的毒性──组织培养法研究
短句来源
     The toxicity of gentamicin on corneal cells in culture
     庆大霉素对组织培养角膜细胞毒性的影响
短句来源
     The Toxicity of Acrylamide
     丙烯酰胺毒性研究进展
短句来源
     It is of high toxicity.
     该菌具有较强的毒力。
短句来源
     Corneal melts were controlled.
     角膜融解得到控制。
短句来源
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  corneal toxicity
Trabeculectomy with mitomycin C can be successful in controlling IOP without the corneal toxicity noted with 5-fluorouracil.
      
The corneal toxicity of 2 intraocular pressure-lowering agents was compared in a rabbit cornea model with New Zealand White rabbits.
      
Preliminary corneal toxicity was examined in rabbits using a current intensity of 2.5 and 5.1 mA/cm2 for 60 and 120 s.
      
The goal of this study is to identify factors useful in minimizing the occurrence of corneal toxicity.
      
The corneal toxicity reported in these 11 cases does not fulfill these criteria.
      
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The ultrastructural changes of 20 rabbits (40 eyes) after topically administered Cyclosporin A (CsA) were evaluated in this experiment study by means of scanning electron microscope and transmission electron microscope.The results showed that all eyes treated with 2% CsA in olive oil did not have significant corneal damage through clinical examination.Under scanning electron microscope examination,the eyes treated with 2% CsA over a 1,4,24 hours period showed slight corneal epithelium damage.The damages were...

The ultrastructural changes of 20 rabbits (40 eyes) after topically administered Cyclosporin A (CsA) were evaluated in this experiment study by means of scanning electron microscope and transmission electron microscope.The results showed that all eyes treated with 2% CsA in olive oil did not have significant corneal damage through clinical examination.Under scanning electron microscope examination,the eyes treated with 2% CsA over a 1,4,24 hours period showed slight corneal epithelium damage.The damages were the epithelium microvilli reducing in number,the microvilli degeneration and fusion,the“holes”appearing in the plasma membrane of corneal epithelium and epithelium desquamation.Over one week treated with 2% CsA there were more significant microvilli changes with corneal epithelum,but there were no basement membrane exposing and no corneal ulcer formation.Under transmission electron microscope,there were microvilli shortened and reduced in number,but the intercellular banding,the basement membrane of epithelial cell and corneal stroma showed normal appearance.The results show that topically administer of CsA has slight corneal toxicity and the topical usage is a very safe,true drug delivery mathod.

用扫描电镜及透射电镜对兔眼局部应用环孢霉素 A 后,角膜超微结构的变化作了详细研究。结果示所有眼滴用橄榄汕配制的2%环孢素 A 后均无肉眼可见的角膜损害。扫描电镜下,用药1、4、24h 角膜上皮有轻微损害,主要为上皮微绒毛减少、变性、融化,角膜上皮细胞膜出现孔洞及上皮局灶性脱屑.透射电镜下,见上皮微绒毛缩短、减少,上皮细胞间连接及基底膜、基质层正常。本研究结果表明,环孢霉素 A 局部用药对角膜毒性轻微,是安全可靠的一种投药方式。

ostoperative subconjunctival injections of fluorouracil(5 Fu)can improve the success of filtration surgery for refractory glaucoma. To reduce corneal toxicity and eliminate the need for frequent administration,an alternative method for application of 5 Fu was investigated.A prospective,randomized,masked observer,placebo controlled study was performed.Intraoperative application of high dose 5 Fu(40mg/ml)to the filtration site can greatly increase...

ostoperative subconjunctival injections of fluorouracil(5 Fu)can improve the success of filtration surgery for refractory glaucoma. To reduce corneal toxicity and eliminate the need for frequent administration,an alternative method for application of 5 Fu was investigated.A prospective,randomized,masked observer,placebo controlled study was performed.Intraoperative application of high dose 5 Fu(40mg/ml)to the filtration site can greatly increase surgical success than postoperative subconjective injections.No significant ocular toxicity was observed clinically.Light microscope showed a patenty bleb cavity in intraoperative 5 Fu treated eyes.Attenuated,disordered collagen fibers were found in both 5 Fu treated groups.when tissues were examined by the electron microscope.

术后结膜下注射5-氟尿嘧啶(5-Fu)能提高难治性青光眼滤过手术的成功率。为降低结角膜毒性,减少频繁用药,用随机盲法对照实验对5-Fu不同用药方式进行了比较研究。术中在滤过部位使用高浓度5-Fu(40mg/ml)比术后用药更能提高手术成功率,临床上未见明显的眼毒副作用。光镜检查术中5-Fu用药组可见潜在的滤腔。电镜检查两组5-Fu用药组均可见减少变细、紊乱排列的胶原纤维。

n order to evaluate the corneal toxicity of adminstered interferonalpha 2b(IFN α2b) as an antifibrotic treatment after glaucoma filtering surgery,We investigated the corneal changes following subconjunctivally applied IFN α2b 5×105IU at filtering bleb for 3—14 days after sclerectomy in white rabbits and directly injection IFN α2b 1×106IU into anterior chamber.Our results showed that no sign of toxicity on corneal epithelium by application of 1% sodium fluorescein and no evidence of corneal endothelium toxicity by viability examination with dual staining of typan blue and alizanin red S.We also did not observe any histologic changes of corneal structure by light microscopy.We believed that rabbits eyes seem to be welltolerate with high doses of interferon by local used,and subconjunctivally injection IFN α2b at filtering bleb after glaucoma filtering surgery may be a safe drugapplied method....

n order to evaluate the corneal toxicity of adminstered interferonalpha 2b(IFN α2b) as an antifibrotic treatment after glaucoma filtering surgery,We investigated the corneal changes following subconjunctivally applied IFN α2b 5×105IU at filtering bleb for 3—14 days after sclerectomy in white rabbits and directly injection IFN α2b 1×106IU into anterior chamber.Our results showed that no sign of toxicity on corneal epithelium by application of 1% sodium fluorescein and no evidence of corneal endothelium toxicity by viability examination with dual staining of typan blue and alizanin red S.We also did not observe any histologic changes of corneal structure by light microscopy.We believed that rabbits eyes seem to be welltolerate with high doses of interferon by local used,and subconjunctivally injection IFN α2b at filtering bleb after glaucoma filtering surgery may be a safe drugapplied method.

为评价青光眼滤过性手术后应用干扰素α-2b预防和治疗滤过道的纤维疤痕化对眼组织的毒性作用,我们对兔眼前房内直接注入干扰素α-2b以及兔眼行巩膜咬切术后滤过区旁结膜下注射药物后进行角膜组织的检查:角膜上皮用1%荧光素钠染色,角膜内皮用锥兰和茜素红进行内皮活性染色,并对全层角膜组织结构作光镜检查。结果发现:抗青光眼术后滤过区旁结膜下注射干扰素α-2b5×105IU/0.2ml连续3~14天,注射总量1.5×106IU~6×106IU,以及前房内直接注入干扰素α-2b1×106IU24小时和第10天后,角膜上皮、内皮以及全层组织结构无变化。说明兔眼对干扰素α-2b具有良好的耐受性,青光眼滤过性手术后经滤过区旁结膜下注射干扰素α-2b是安全的给药途径

 
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