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beta fibrinogen
相关语句
  β纤维蛋白原
     Conclusions:a-249(C/T)pol ymorphism of beta fibrinogen gene is most likely associated with occurrence of C AD in Chinese populations.
     结论:在中国人群中,β纤维蛋白原基因β鄄249(C/T)多态性可能与冠心病的发病有关。
短句来源
     Relationship between Single Nucleotide Polymorphisms in the 5'-Promoter Region of Beta Fibrinogen Gene and Coronary Artery Disease:A Case-Control Study in Chinese Population.
     中国人群β纤维蛋白原基因启动子区域单核苷酸多态性与冠心病的关系
短句来源
     Objective:To evaluate the relationship between single nucleotide polym orphisms(SNPs)in the5'promoter region of beta fibrinogen gene and the occurrence of coronary artery disease(CAD)in Chinese populations.
     目的:在中国人群中检测β纤维蛋白原基因启动子区域的单核苷酸多态性(singlenucleotidepolymorphisms,SNPs),并探讨其与冠心病发病的关系。
短句来源
     Methods:SNPs detec-tion was performed by PCR-sequencing in the5'promoter region of beta fibrinogen gene . The genotype was determined by the method of the ABI PRISM SNaPshot Multiplex K it in a total number of 224 unrelated CAD patients diagnosed by an-giography an d 164 healthy controls.
     方法:应用PCR直接测序技术检测β纤维蛋白原基因启动子区域序列,结合多重SNaPshot反应在224例冠心病病人和164名健康对照者中对所检测的SNPs进行基因分型并统计分析。
短句来源
  β-纤维蛋白原
     AIM:To comprehend the relation between polymorphism of beta fibrinogen gene 455G/A and cerebral infarction(CI) in patients,and study whether abnormal fibrinogen and hemorheology are the danger factors for episode of CI.
     目的:了解β-纤维蛋白原基因-455G/A基因多态性与脑梗死的关系,探讨高纤维蛋白原和血液流变学异常是否为脑梗死发病的危险因素。
短句来源
     Genotype frequencies of beta fibrinogen gene 455G/A polymorphism in CI group and control group were estimated with polymerase chain reaction restrictive fragment length polymorphism(PCR RFLP).
     用PCR-RFLP分析法检测β-纤维蛋白原基因-455G/A多态性在脑梗死组和正常对照组的基因频率。
短句来源
     CONCLUSION:The polymorphism of beta fibrinogen gene 455G/A is associated with genetics of CI and A allele is a susceptible gene for CI.
     结论:脑梗死患者β-纤维蛋白原基因-455G/A的多态性与脑梗死的遗传学基础有关,A等位基因是脑梗死的易感基因之一。
短句来源
  “beta fibrinogen”译为未确定词的双语例句
     The study of beta fibrinogen gene-455 G/A、-148 C/T、448 G/A polymorphisms and their association with plasma fibrinogen levels
     纤维蛋白原β-455G/A、-148C/T、448G/A基因多态性与血浆纤维蛋白原水平的关系
短句来源
     The beta fibrinogen gene-148C/T polymorphism and its association with plasma fibrinogen's function and level in cerebral infarction
     脑梗死纤维蛋白原β-148 C/T基因多态性与血浆纤维蛋白原功能和水平的关系
短句来源
     The study on the polymorphism of beta fibrinogen gene-148C/T in the patients with cerebral infarction
     脑梗死患者纤维蛋白原β-148C/T基因多态性的研究
短句来源
     Single nucleotide polymorphisms -455G/A, -854G/A, -1420G/A in B beta fibrinogen gene and their association with ischemic stroke
     纤维蛋白原Bβ-455G/A、-854G/A、-1420G/A单核苷酸多态性与缺血性脑卒中的关系
短句来源
     Objective To analyze the frequency of beta fibrinogen(β Fg) gene -455 G/A、-148 C/T、448 G/A polymorphisms and their association with plasma fibrinogen levels in Han nationality in Guangdong Chinese.
     目的 调查 15 6名广东汉族健康人纤维蛋白原 (Fg) β - 45 5G/A、- 148C/T、44 8G/A基因多态性频率分布、连锁不平衡关系及与血浆Fg水平的关系。
短句来源
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  beta fibrinogen
Two common, functional polymorphisms in the promoter region of the beta-fibrinogen gene contribute to regulation of plasma fibrinogen concentration.
      


Objective To analyze the frequency of beta fibrinogen(β Fg) gene -455 G/A、-148 C/T、448 G/A polymorphisms and their association with plasma fibrinogen levels in Han nationality in Guangdong Chinese. Methods The β-Fg gene -455 G/A、-148 C/T、448 G/A polymorphisms of 156 individuals were analyzed by restriction fragment length polymorphism(RFLP). Plasma fibrinogen levels were determined by turbidimetry. Results The frequencies of A -455 , T -148 and A 448 allele were 0.276,...

Objective To analyze the frequency of beta fibrinogen(β Fg) gene -455 G/A、-148 C/T、448 G/A polymorphisms and their association with plasma fibrinogen levels in Han nationality in Guangdong Chinese. Methods The β-Fg gene -455 G/A、-148 C/T、448 G/A polymorphisms of 156 individuals were analyzed by restriction fragment length polymorphism(RFLP). Plasma fibrinogen levels were determined by turbidimetry. Results The frequencies of A -455 , T -148 and A 448 allele were 0.276, 0.285 and 0.272, respectively. There were strong linkages of G -455 、C -148 and G 448 , and of A -455 、T -148 and A 448 , the correspondence was more than 97%. The plasma fibrinogen levels in the presence and absence of A -455 allele were (3.13±0.74) g/L and (2.89±0.57) g/L (P<0.05); of T -148 allele were (3.12± 0.73) g/L and (2.89±0.58) g/L (P<0.05); and of A 448 were (3.13±0.74) g/L and (2.89±0.57) g/L (P<0.05), respectively. The plasma fibrinogen levels of the three polymorphisms with the mutant gene are significantly higher than that in the wild type.Conclusion The three polymorphisms loci are strong linkage disequilibrium. It suggests that β Fg gene -455 G/A、-148 C/T、448 G/A polymorphisms are associated with plasma fibrinogen levels.

目的 调查 15 6名广东汉族健康人纤维蛋白原 (Fg) β - 45 5G/A、- 148C/T、44 8G/A基因多态性频率分布、连锁不平衡关系及与血浆Fg水平的关系。方法 用限制性片段长度多态性 (RFLP)分析方法和比浊法检测血浆Fg水平。结果 等位基因A-4 55、T-14 8和A4 48的频率分别是 0 .2 76 ,0 .2 85及 0 .2 72。 15 6人中 3个多态性位点G-4 55、C-14 8和G4 48或A-4 55、T-14 8和A4 48分别紧密连锁 ,符合率超过97%。 3个多态性位点携带及不携带突变基因两组血浆Fg水平分别是 β - 45 5 :(3 .13± 0 .74)g/L和(2 89± 0 .5 7)g/L ;β - 148:(3 .12± 0 .73)g/L和 (2 .89± 0 .5 8)g/L ;β 44 8:(3 .13± 0 .74)g/L和 (2 89±0 5 7)g/L。上述 3个位点携带突变基因组血浆Fg水平均比野生型组明显升高 (P <0 .0 5 )。结论  3对等位基因紧密连锁不平衡 ,携带突变基因者较不携带者血浆Fg水平高 ,提示Fgβ...

目的 调查 15 6名广东汉族健康人纤维蛋白原 (Fg) β - 45 5G/A、- 148C/T、44 8G/A基因多态性频率分布、连锁不平衡关系及与血浆Fg水平的关系。方法 用限制性片段长度多态性 (RFLP)分析方法和比浊法检测血浆Fg水平。结果 等位基因A-4 55、T-14 8和A4 48的频率分别是 0 .2 76 ,0 .2 85及 0 .2 72。 15 6人中 3个多态性位点G-4 55、C-14 8和G4 48或A-4 55、T-14 8和A4 48分别紧密连锁 ,符合率超过97%。 3个多态性位点携带及不携带突变基因两组血浆Fg水平分别是 β - 45 5 :(3 .13± 0 .74)g/L和(2 89± 0 .5 7)g/L ;β - 148:(3 .12± 0 .73)g/L和 (2 .89± 0 .5 8)g/L ;β 44 8:(3 .13± 0 .74)g/L和 (2 89±0 5 7)g/L。上述 3个位点携带突变基因组血浆Fg水平均比野生型组明显升高 (P <0 .0 5 )。结论  3对等位基因紧密连锁不平衡 ,携带突变基因者较不携带者血浆Fg水平高 ,提示Fgβ - 45 5G/A、- 148C/T、44 8G/A 3种基因多态性均与血浆Fg水平关联

Objective To analyze the frequency of beta-fibrinogen (β-Fg) gene -455G/A,-148C/T and 448G/A polymorphism, fibrinogen molecular reactivity and their association with plasma fibrinogen levels in health adults, myocardial infarction and cerebral infarction disease. Methods The β-Fg gene -455G/A,-148C/T and 448G/A polymorphisms were analyzed by restriction fragment length polymorphism (RFLP). Fibrinogen molecular reactivity was analyzed for the conversion kinetics of fibrinogen...

Objective To analyze the frequency of beta-fibrinogen (β-Fg) gene -455G/A,-148C/T and 448G/A polymorphism, fibrinogen molecular reactivity and their association with plasma fibrinogen levels in health adults, myocardial infarction and cerebral infarction disease. Methods The β-Fg gene -455G/A,-148C/T and 448G/A polymorphisms were analyzed by restriction fragment length polymorphism (RFLP). Fibrinogen molecular reactivity was analyzed for the conversion kinetics of fibrinogen into fibrin by a computer assistant procedure. Plasma fibrinogen levels were determined by Clauss method. Results The frequencies of -455A, -148T, 448A allele in health adults were 0.185, 0.194 and 0.192, in myocardial infarction disease 0.295, 0.318 and 0.307, in cerebral infarction disease 0.177, 0.193 and 0.182, respectively. The frequencies of -455A, -148T, 448A alleles in myocardial infarction disease were apparently higher than that of health adults. There were close linkage between -455G, -148C and 448G or -455A, -148T and 448A, the correspondence was over 98%. There are no differences in the plasma fibrinogen levels of the three polymorphisms in two genotype groups. The fibrinogen molecular reactivity was significantly increased in cardiocerebral vascular disease and related with plasma fibrinogen level. Conclusion The three polymorphisms loci are strong linkage disequilibrium. There are no significant differences in the plasma fibrinogen levels of the three polymorphisms in two genotype groups. The frequencies of -455A, -148T, 448A alleles in myocardial infarction disease were apparently higher than that of health adults. It suggest that there was no association between β-Fg gene -455G/A,-148C/T and 448G/A polymorphisms and plasma fibrinogen levels, but did in myocardial infarction disease. The fibrinogen molecular reactivity was significantly increased in cardiocerebral vascular disease and related with plasma fibrinogen level.

目的 调查健康人、心肌梗死患者及脑梗死患者的纤维蛋白原 (Fg) β - 45 5G/A、- 148C/T、44 8G/A基因多态性频率分布、Fg分子反应性及与血浆Fg水平的关系。方法 用限制性片段长度多态性分析基因频率分布 ,用计算机辅助的纤维蛋白单体聚合反应分析方法和Clauss法分析血浆Fg水平。结果 等位基因 - 45 5A、- 148T和 44 8A在正常人中的频率分别是 0 .185 ,0 .194及 0 .192 ;在心肌梗死患者中的频率分别是 0 .2 95 ,0 .318及 0 .30 7;在脑梗死患者中的频率分别是 0 177,0 .193及 0 .182。心肌梗死患者中 - 45 5A、- 148T和 44 8A的频率比健康人明显升高。 3个多态性位点 - 45 5G、- 148C和44 8G或 - 45 5A、- 148T和 44 8A分别紧密连锁 ,符合率超过 98%。心脑血管病患者的Fg功能明显增高且与Fg水平相关。 3个多态性位点不同基因型组血浆Fg水平差异无显著性。结论  3对等位基因紧密连锁不平衡 ,不同基因型组血浆Fg水平差异无显著性 ,心肌梗死患者中 - 45 5A、-...

目的 调查健康人、心肌梗死患者及脑梗死患者的纤维蛋白原 (Fg) β - 45 5G/A、- 148C/T、44 8G/A基因多态性频率分布、Fg分子反应性及与血浆Fg水平的关系。方法 用限制性片段长度多态性分析基因频率分布 ,用计算机辅助的纤维蛋白单体聚合反应分析方法和Clauss法分析血浆Fg水平。结果 等位基因 - 45 5A、- 148T和 44 8A在正常人中的频率分别是 0 .185 ,0 .194及 0 .192 ;在心肌梗死患者中的频率分别是 0 .2 95 ,0 .318及 0 .30 7;在脑梗死患者中的频率分别是 0 177,0 .193及 0 .182。心肌梗死患者中 - 45 5A、- 148T和 44 8A的频率比健康人明显升高。 3个多态性位点 - 45 5G、- 148C和44 8G或 - 45 5A、- 148T和 44 8A分别紧密连锁 ,符合率超过 98%。心脑血管病患者的Fg功能明显增高且与Fg水平相关。 3个多态性位点不同基因型组血浆Fg水平差异无显著性。结论  3对等位基因紧密连锁不平衡 ,不同基因型组血浆Fg水平差异无显著性 ,心肌梗死患者中 - 45 5A、- 148T和 44 8A的频率比健康人明显升高。提示Fgβ - 45 5G/A、- 148C/T和 44 8G/A三种基因多态性与血浆Fg水平无关 ,而与心肌梗死的发病相关。心脑血管病患者不仅Fg功能明显增高 ,且与Fg水平相关

Objective:To evaluate the relationship between single nucleotide polym orphisms(SNPs)in the5'promoter region of beta fibrinogen gene and the occurrence of coronary artery disease(CAD)in Chinese populations.Methods:SNPs detec-tion was performed by PCR-sequencing in the5'promoter region of beta fibrinogen gene .The genotype was determined by the method of the ABI PRISM SNaPshot Multiplex K it in a total number of 224 unrelated CAD patients diagnosed by an-giography an d 164 healthy controls.Results:Five...

Objective:To evaluate the relationship between single nucleotide polym orphisms(SNPs)in the5'promoter region of beta fibrinogen gene and the occurrence of coronary artery disease(CAD)in Chinese populations.Methods:SNPs detec-tion was performed by PCR-sequencing in the5'promoter region of beta fibrinogen gene .The genotype was determined by the method of the ABI PRISM SNaPshot Multiplex K it in a total number of 224 unrelated CAD patients diagnosed by an-giography an d 164 healthy controls.Results:Five SNPs were discovered in the5'promoter region of beta fibrinogen gene,among them,B-993(C/T)polymorphism was firstly reported .However,the genotype distribution of a-249(C/T) polymophism was obviously dif ferent between the group of CAD (C/C=55,C/T=105,T/T=64) and those without CAD(C/ C=21,C/T=83,T/T=60,÷ 2 =8.847,P=0.012).And the C allele frequency of CAD patients was significantly higher(0.48vs0.38, P=0.006)than the normal controls.Conclusions:a-249(C/T)pol ymorphism of beta fibrinogen gene is most likely associated with occurrence of C AD in Chinese populations.

目的:在中国人群中检测β纤维蛋白原基因启动子区域的单核苷酸多态性(singlenucleotidepolymorphisms,SNPs),并探讨其与冠心病发病的关系。方法:应用PCR直接测序技术检测β纤维蛋白原基因启动子区域序列,结合多重SNaPshot反应在224例冠心病病人和164名健康对照者中对所检测的SNPs进行基因分型并统计分析。结果:在β纤维蛋白原基因启动子区域发现5个SNPs,其中β鄄993(C/T)多态为首次报道,β鄄249(C/T)多态的基因型分布在冠心病组(C/C=55、C/T=105、T/T=64)和对照组(C/C=21、C/T=83、T/T=60)相比差异有显著性(χ2=8.847,P=0.012),冠心病组的C等位基因频率显著高于对照组(分别为0.48和0.38,P=0.006)。结论:在中国人群中,β纤维蛋白原基因β鄄249(C/T)多态性可能与冠心病的发病有关。

 
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