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metoprolol tablets
相关语句
  美托洛尔片
     Determination of metoprolol tablets by ion selective electrode
     美托洛尔片的离子选择电极法测定
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  “metoprolol tablets”译为未确定词的双语例句
     In part VII, the determination of metoprolol, tablets are introduced byHPLC on the Agilent Eclipse XDB-C8 column, with the mobile phase consisted of methanol-water(60:40).
     本沦文的第七部分介绍了美托洛尔片剂含量的高效液相色谱法测定,迭用Agilent EcliPse XDB-CS柱,以甲醇:水场O:40为流动相,建立了测定美托洛尔含量的高效液相色谱法。 本法简便、准确、快速。
短句来源
  相似匹配句对
     HYDRODYNAMICALLY BALANCED TABLETS OF METOPROLOL
     美多心安胃内漂浮型控释制剂的研制
短句来源
     Bioequivalence of Metoprolol Tartrate Tablets in healthy volunteers
     酒石酸美托洛尔片人体生物利用度和生物等效性研究
短句来源
     Weianlin Tablets
     唯安林片
短句来源
     Metoprolol Tartrate
     甲氧乙心安
短句来源
     Sennoside Tablets
     美国药典(24版):番泻苷片
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  metoprolol tablets
In a double-blind study with parallel groups a new controlled-release (CR) formulation of metoprolol1, 100 mg once daily, was compared with conventional metoprolol tablets, 100 mg once daily, in 27 patients with primary hypertension.
      
In previous work, we have developed and validated a correlation for extended release metoprolol tablets using three different releasing formulations.
      


An oral controlled-release system (M-HBS) of metoprolol was developed based on the hydrodynamically balanced controlled drug delivery system. It was found that the in vitro release characteristics showed basically firstorder kinetics(K_r~'= 0.1651 h~(-1)); a tentative two-year expiration date on M-HBS was established; the γ-scintiphotographic study after oral ingestion showed that MHBS was retained in human stomach for longer time (5~6 h) than the conventional metoprolol tablet (1~1.5 h). The blood...

An oral controlled-release system (M-HBS) of metoprolol was developed based on the hydrodynamically balanced controlled drug delivery system. It was found that the in vitro release characteristics showed basically firstorder kinetics(K_r~'= 0.1651 h~(-1)); a tentative two-year expiration date on M-HBS was established; the γ-scintiphotographic study after oral ingestion showed that MHBS was retained in human stomach for longer time (5~6 h) than the conventional metoprolol tablet (1~1.5 h). The blood concentration-time course of M-HBS was demonstrated to fit a one-compartment model with apparent first order absorption and first order elimination. The parameters were calculated using a NONLIN computer program with the values of Ka, K, Vd, t_(max), c_(max), being 0.1944 h~(-1), 0.1867 h~(-1), 2.813, 5.247 h, 125.1 ng/ml, respectively. Moreover, the fraction of the close absorbed from M-HBS in vivo well correlated with dissolution rate in vitro.

本文根据水动力学平衡药物控释系统的设计原理制备了美托洛尔胃内滞留漂浮型控释片剂(简称M-HBS)。实验表明,本品的体外溶出符合一级动力学过程(K′r=0.1651 h~(-1));贮存期为两年;人体胃内γ-闪烁照相结果表明,本品在胃内滞留时间(5~6 h)明显比普通片剂(1.0~1.5 h)长;体内动力学过程符合表观一级吸收与一级消除的单室模型;ⅳ美托洛尔体内为双室模型;体内数据经NONLIN计算机程序处理,求得各项参数:Ka=0.1944 h~(-1),K=0.1867 h~(-1),Vd=2.813,t_(max)=5.247 h,C_(max)=125.1 ng/ml。本品的体内外数据具有显著的相关性(P<0.01)。

Twelve patients (M5, F7; age 40 ?4a) with primary hypertension underwent a crossover study with oral administration of sustained-release formulations of nifedipine tablet 20 mg, each morning at 8AM X 2 wk and metoprolol tablet 0.1g, each morning at 8 AM X 2 wk. The rises of blood pressure (BP) and heart rate (HR) during ergometer exercise test were less under metoprolol than under nifedipine. Both nifedipine and metoprolol lowered the 24-h BP during ambulatory monitoring (P< 0. 05), but...

Twelve patients (M5, F7; age 40 ?4a) with primary hypertension underwent a crossover study with oral administration of sustained-release formulations of nifedipine tablet 20 mg, each morning at 8AM X 2 wk and metoprolol tablet 0.1g, each morning at 8 AM X 2 wk. The rises of blood pressure (BP) and heart rate (HR) during ergometer exercise test were less under metoprolol than under nifedipine. Both nifedipine and metoprolol lowered the 24-h BP during ambulatory monitoring (P< 0. 05), but metoprolol induced a more stable reduction of BP and HR in whole day. Metoprolol lowered diastolic pressure and HR (P<0. 05). There were lower incidences of adverse effects in metoprolol group than nifedipine group. It is suggested that metoprolol is superior to nifedipine.

12例原发性高血压患者(男性5例,女性7例;年龄40±4a)自身交叉服用长效硝苯地平(下称Nif)20mg, qm×2wk;长效美托洛尔(下称Met)0.1g, qm×2wk。结果:踏车运动试验时服Njf者血压及心率明显升高;但服Met者能平稳地控制血压及心率。24h动态血压中平均动脉压在服上述2药后均显著下降(P<0.05),服Met者舒张压、心率下降较明显(P<0.05),且不良反应小,故Met优于Nif。

Objective To study the safety and pharmacokinetics of metoprolol tablet in Chinese healthy volunteers. Methods Twenty two Chinese healthy volunteers were given a single and multiple oral dose 50 mg of metoprolol tartrate tablets. The concentration of metoprolol in blood plasma was measured by an validated HPLC fluorescence method and were assessed with non-compartment model. Results The pharmacokinetic parameters of metoprolol tartrate tablet for orally administered were as...

Objective To study the safety and pharmacokinetics of metoprolol tablet in Chinese healthy volunteers. Methods Twenty two Chinese healthy volunteers were given a single and multiple oral dose 50 mg of metoprolol tartrate tablets. The concentration of metoprolol in blood plasma was measured by an validated HPLC fluorescence method and were assessed with non-compartment model. Results The pharmacokinetic parameters of metoprolol tartrate tablet for orally administered were as follow: AUC 0-t was (395.6±298.95)μg·h·mL -1 , AUC 0-∞ was (433.83±342.94)ng·h·mL -1 ,C max was(63.06±34.61)ng·mL -1 ,t max was(1.573±0.52)h,MRT was(7.40±2.31)h after single dose.AUC ss 0-t was(504.67± 322.35 )ng·h·mL -1 ,C max was(77.72±45.69)ng·mL -1 ,t max was(1.7±0.6)h,C min was(4.12±1.57)ng·mL -1 ,C av was(21.03±13.43)ng·mL -1 ,DF was(367.29±112.56)% after multiple doses. No any adverse events occurred during the whole study.Conclusion There are good safety after administrating single and multiple oral dose of metoprolol tartrate.

目的 研究单剂量和多剂量酒石酸美托洛尔片在中国健康人体的药代动力学。方法 22名健康受试者口服酒石酸美托洛尔片50mg,用HPLC-荧光检测法测定血浆中美托洛尔的浓度。结果 所得药代动力学参数如下。单剂量:AUC0-t为(395. 6±298. 95)ng·h·mL-1,AUC0-∞为(433. 83±342. 94)ng·h·mL-1,Cmax为(63. 06±34. 61)ng·mL-1,tmax为(1. 573±0. 52)h,MRT为(7. 40±2. 31 )h;多剂量:AUCss0-t为( 504. 67±322. 35 )ng·h·mL-1,Cmax为(77. 72±45. 69)ng·mL-1,tmax为(1. 7±0. 6)h,Cmin为(4. 12±1. 57)ng·mL-1,平均稳态血药浓度Cav是( 21. 03±13. 43 )ng·mL-1,血药浓度波动度DF为(367. 29±112. 56)%。结论 酒石酸美托洛尔片单剂量和多剂量给药后,安全性良好。

 
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