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toxin induced rat
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  毒素诱导型
     Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation, strong expression of TIMP-1, TIMP-2 mRNA and protein and lasted for longer time, on the other hand, the toxin induced rat liver fibrosis model presented weak expression of TIMP-1, TIMP-2 mRNA and protein , and shorter period of liver fibrosis after stopping toxin attack.
     结果造模结束后,免疫诱导型模型肝组织病理改变具有进行性加重趋势,TIMP1、TIMP2mRNA及蛋白表达强度高、持续时间长; 而毒素诱导型模型具有TIMP1、TIMP2mRNA及蛋白表达强度弱、肝纤维化持续时间短等特点。
短句来源
     Conclusion The toxin induced rat liver fibrosis model was not appropriate for observation of anti-fibrotic drugs due to its fast sponteneous absorption, the immune induced rat liver fibrosis model is good for the observation of anti-fibrotic drug effects and study on the mechanism of liver fibrosis due to its slow sponteneous absorption, and has the trend of aggrevation within three months after.
     结论毒素诱导型肝纤维化模型自然吸收较快,不利于抗肝纤维化药物疗效的观察; 免疫诱导型肝纤维化模型自然吸收时间较慢,且在造模结束后1~3个月有逐渐加重趋势,有利于抗肝纤维化药物疗效观察及肝纤维化机制研究。
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  相似匹配句对
     Induced into E.
     将表达载体转化E.
短句来源
     Study on the Heat-induced Polymer of Cholera Toxin
     霍乱毒素热聚合产物的研究
短句来源
     Experimental study of myocardial injury induced by T-2 toxin
     T-2毒素致大鼠心肌损伤的实验研究
短句来源
     induced seismicity;
     诱发地震;
短句来源
     Cholera toxin
     霍乱毒素
短句来源
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  toxin induced rat
In the third approach, we examined the time course effect of preincubation of toxin A with yeast protease on toxin-induced rat ileal secretion.
      


Objective To investigate the difference of the location and expression of TIMP-1,2 liver fibrosis model in rats between immune induced and toxin induced. Methods Immune rats were injected with 20% human serum albumin and intoxic rats with CCL 4 respectively , then liver tissue of rats stained with HE, VG and observed with electron microscope. The location and expression of TIMP-1, TIMP-2 protein and mRNA were studied. Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation,...

Objective To investigate the difference of the location and expression of TIMP-1,2 liver fibrosis model in rats between immune induced and toxin induced. Methods Immune rats were injected with 20% human serum albumin and intoxic rats with CCL 4 respectively , then liver tissue of rats stained with HE, VG and observed with electron microscope. The location and expression of TIMP-1, TIMP-2 protein and mRNA were studied. Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation, strong expression of TIMP-1, TIMP-2 mRNA and protein and lasted for longer time, on the other hand, the toxin induced rat liver fibrosis model presented weak expression of TIMP-1, TIMP-2 mRNA and protein , and shorter period of liver fibrosis after stopping toxin attack. The TIMP-1, TIMP-2 related antigens in liver of immune induced model were expressed in myofibroblast and fibroblast. This was most obvious in portal area and fibrous septum. The positive signal located at cytoplasm, not in nucleus. Such distribution and location were also revealed in the in situ hybridization.Conclusion The toxin induced rat liver fibrosis model was not appropriate for observation of anti-fibrotic drugs due to its fast sponteneous absorption, the immune induced rat liver fibrosis model is good for the observation of anti-fibrotic drug effects and study on the mechanism of liver fibrosis due to its slow sponteneous absorption, and has the trend of aggrevation within three months after.

目的探讨人血白蛋白免疫诱导型及四氯化碳(CCl4)毒素诱导型所致大鼠肝纤维化模型肝组织中金属蛋白酶组织抑制因子(TIMP)定位及表达状态的差异。方法分别以20%人血白蛋白进行免疫攻击和CCl4毒素攻击大鼠,造模结束后对大鼠肝组织进行HE、VG染色及电镜观察;同时研究TIMP1、TIMP2蛋白及mRNA定位及表达状态。结果造模结束后,免疫诱导型模型肝组织病理改变具有进行性加重趋势,TIMP1、TIMP2mRNA及蛋白表达强度高、持续时间长;而毒素诱导型模型具有TIMP1、TIMP2mRNA及蛋白表达强度弱、肝纤维化持续时间短等特点。免疫诱导实验组肝脏中TIMP1、TIMP2相关抗原表达在肌成纤维细胞、成纤维细胞,以汇管区及纤维间隔中最明显,阳性信号位于细胞胞质中,未见细胞核表达。原位杂交检测结果亦相似。结论毒素诱导型肝纤维化模型自然吸收较快,不利于抗肝纤维化药物疗效的观察;免疫诱导型肝纤维化模型自然吸收时间较慢,且在造模结束后1~3个月有逐渐加重趋势,有利于抗肝纤维化药物疗效观察及肝纤维化机制研究。

 
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