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anti thrombotic     
相关语句
  抗血栓
     The antithrombotic effects of DS and LMWDSs expressed by occlusion times in vivo were 58.12, 50.58, 123.90 and 133.53 min respectively, all of which were significantly higher than that of NS group (19.79 min).
     体内抗血栓活性的血栓堵塞时间(OT)值分别为58.12,50.58,123.90和133.53 min,均较生理盐水组19.79 min显著延长;
短句来源
     T 2,T 3,T 4,T 5,T 6, T 8,T 11,T 12 and T 14 exhibited antithrombotic effects to a certain degree, and the effects of T 5,T 6, T 11,T 12 and T 14 were more potent than those of TMP.
     各试验药物均有一定程度的抗血栓作用 ,其中T 5、T 6、T 11、T 12及T 14抗血栓作用时间和强度明显大于TMP。
短句来源
     Results HI group had significantly higher incidences than non-HI group, of which involved cerebral embolism, large infarct volume, antithrombotic therapy and hyperglycemia(larger than 11.1mmol/L).
     结果HI组的脑栓塞、大面积梗死、抗血栓治疗和高血糖(>11.1mmol/L)等事件的发生率显著高于non-HI组(P<0.01);
短句来源
     Conclusions Cerebral embolism, large infarct volume, antithrombotic therapy and hyperglycemia(larger than 11.1 mmol/L) could be identified as risk factors for hemorrhage transformation of HI.
     结论脑栓塞、大面积梗死、抗血栓治疗和高血糖(>11.1mmol/L)是脑梗死继发出血的危险因素。
短句来源
     ABC of antithrombotic therapy Antithrombotic therapy in special circumstances-pregnancy and cancer
     抗血栓治疗知识(九)特殊情况下的抗血栓治疗——妊娠与癌症
短句来源
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  抗血栓形成
     No significant antithrombotic effect was seen with aspirln alone(17%,P=1.0),whereas a decrease in ADP-induced platelet aggregation was extensive with clopidogrel/aspirin(85%,P=0.001).
     阿司匹林组未见到有意义的抗血栓形成作用(17%,P=1.0); 阿司匹林加氯吡格雷组下降85%(P=0.001)。
短句来源
     Effects of Rongshuan No 1 (F-1) on the antithrombotic and antiplatelet aggregation
     溶栓1号抗血小板聚集及抗血栓形成作用
短句来源
     EXPERIMENTAL STUDY ON ANTICOAGULANT AND ANTITHROMBOTIC EFFECT OF RECOMBINANT HIRUDIN
     重组水蛭素抗凝和抗血栓形成作用的实验研究
短句来源
     Experimental study on anticoagulability and antithrombotic activity of crocetin
     西红花酸抗凝血和抗血栓形成作用的实验研究
短句来源
     It is suggested that polydatin should have evident antithrombotic effects and the mechanisms may be intimately related to its decrease of plasma TXB2 and increase of 6-keto-PGF 1α.
     本实验提示PD有明显的抗血栓形成作用,其机制可能与其降低血浆TXB2含量及升高6KetoPGF1α水平密切相关。
短句来源
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  抗血栓形成的
     Experimental Study on the Antithrombotic Effect of Naja Naja atra Venom
     眼镜蛇毒抗血栓形成的实验研究
短句来源
     At 0.25~1.0 g/kg, its antithrombotic activity was significant.
     在 0 .2 5~ 1.0g kg时 ,有明显抗血栓形成的作用 ;
短句来源
     Effect of Shule Capsule on the antiplatelet aggregation and antithrombotic in rats
     舒络胶囊抗血小板聚集及抗血栓形成的作用
短句来源
     Antithrombotic mechanisms of holothurian glycosaminoglycan extracted from sea cucumber
     玉足海参糖胺聚糖抗血栓形成的研究
短句来源
  抗血栓
     The antithrombotic effects of DS and LMWDSs expressed by occlusion times in vivo were 58.12, 50.58, 123.90 and 133.53 min respectively, all of which were significantly higher than that of NS group (19.79 min).
     体内抗血栓活性的血栓堵塞时间(OT)值分别为58.12,50.58,123.90和133.53 min,均较生理盐水组19.79 min显著延长;
短句来源
     T 2,T 3,T 4,T 5,T 6, T 8,T 11,T 12 and T 14 exhibited antithrombotic effects to a certain degree, and the effects of T 5,T 6, T 11,T 12 and T 14 were more potent than those of TMP.
     各试验药物均有一定程度的抗血栓作用 ,其中T 5、T 6、T 11、T 12及T 14抗血栓作用时间和强度明显大于TMP。
短句来源
     Results HI group had significantly higher incidences than non-HI group, of which involved cerebral embolism, large infarct volume, antithrombotic therapy and hyperglycemia(larger than 11.1mmol/L).
     结果HI组的脑栓塞、大面积梗死、抗血栓治疗和高血糖(>11.1mmol/L)等事件的发生率显著高于non-HI组(P<0.01);
短句来源
     Conclusions Cerebral embolism, large infarct volume, antithrombotic therapy and hyperglycemia(larger than 11.1 mmol/L) could be identified as risk factors for hemorrhage transformation of HI.
     结论脑栓塞、大面积梗死、抗血栓治疗和高血糖(>11.1mmol/L)是脑梗死继发出血的危险因素。
短句来源
     ABC of antithrombotic therapy Antithrombotic therapy in special circumstances-pregnancy and cancer
     抗血栓治疗知识(九)特殊情况下的抗血栓治疗——妊娠与癌症
短句来源
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  anti thrombotic
When compared to equally effective anti thrombotic doses of inogatran, LB-30057 caused less prolongation in aPTT, had no effect on PT, and tended to have less of effect on bleeding time.
      
The still-high reocclusion rate emphasizes the need for better an tithrombotic therapy in these patients.
      
The thrombotic process is complicated with various proand anti-thrombotic mediators determining the coagulation status.
      
The recommended protocol for initial anti-thrombotic therapy for VTE with UFH is as in Table 1.
      
The structures serve as a starting point for designing potential anti-thrombotic peptides.
      
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Serum antithrombin Ⅲ (A∫ Ⅲ) was determined in 74 cases with various primary renal diseases. In 17 patients with nephrotic syndrome serum albumin was also determined at the same time. It was found that the serum AT Ⅲ levels in nephrotic syndrome group, uremia group and chronic nephritis group were significantly lower than that of the control. This finding might contribute to the blood hypercoagulability mechanism in renal diseases and could be of use to direct subsequent treatment. In nephrotic syndrome, we have...

Serum antithrombin Ⅲ (A∫ Ⅲ) was determined in 74 cases with various primary renal diseases. In 17 patients with nephrotic syndrome serum albumin was also determined at the same time. It was found that the serum AT Ⅲ levels in nephrotic syndrome group, uremia group and chronic nephritis group were significantly lower than that of the control. This finding might contribute to the blood hypercoagulability mechanism in renal diseases and could be of use to direct subsequent treatment. In nephrotic syndrome, we have also tried to correlate serum AT Ⅲ with serum albumin and have found a positive correlation with an r value of 0.581. It is suggested that in case of nephrotic syndrome with severe hypoalbuminemia prophylactic anti-thrombotic measure can be tried.

本文对74例各种原发性肾脏疾病进行血清ATⅢ的测定,对其中17例肾病综合征同时测定了血清白蛋白。发现在肾病综合征组、尿毒症组、慢性肾炎组中,ATⅢ均显著低于对照组,这对阐明肾脏疾病中凝血机制及其治疗可能有益。并观察到在肾病综合征中血清ATⅢ与血清白蛋白有显著的正相关,白蛋白明显降低时,要防止血栓形成和栓塞。

4′-Methyl-7- (2-hydroxy-3-isopropylaminopropoxy)-flavone hydrochloride (SIPI-549) has inhibitory actions in a dose-dependent way on experimental thrombus formation in rats and rabbits. The thrombus wet weight (TWW) of rats was reduced after iv SIPI~549 7.5 mg/kg. In vitro, when SIPI-549 was given in final concentrations of 0.1~1.6 mg/ml in native blood, rabbit TWW was reduced by 28.9~80.5%; thrombus length (SIPI-549 0.2~1.6 mg/ml) was shortened; and thrombus formation time (SIPI-549 0.2~1.6 mg/ml) and snow storm...

4′-Methyl-7- (2-hydroxy-3-isopropylaminopropoxy)-flavone hydrochloride (SIPI-549) has inhibitory actions in a dose-dependent way on experimental thrombus formation in rats and rabbits. The thrombus wet weight (TWW) of rats was reduced after iv SIPI~549 7.5 mg/kg. In vitro, when SIPI-549 was given in final concentrations of 0.1~1.6 mg/ml in native blood, rabbit TWW was reduced by 28.9~80.5%; thrombus length (SIPI-549 0.2~1.6 mg/ml) was shortened; and thrombus formation time (SIPI-549 0.2~1.6 mg/ml) and snow storm appearance time (SIPI-549 0.4~1.6 mg/ml) were prolonged. The results of ex vivo experiment (iv SIPI~549 10 mg/kg) in rabbits were basically concordent with those in vitro.The above results show that SIPI-549 is of value as anti-thrombotic agent in vivo, in vitro or ex vivo.

4′-甲基-7-(2-羟基-3-异丙胺基丙氧基)-黄酮盐酸盐(SIPI-549)对大鼠和家兔实验性血栓形成有剂量(或浓度)依赖性的抑制作用。ⅳ7.5~20.0 mg/kg,使大鼠颈动—静脉旁路血栓湿重减轻。家兔半体内试验(ⅳSIPI-549 10 mg/kg),可使Chandler管中的雪暴现象出现时间和血栓形成时间延长,血栓湿重和干重减轻。家兔体外实验与半体内试验的结果基本一致。

A carotid-jugular extracorporeal shunt model (in vivo) was made in rat, in which 15 min after the restoration of blood flow in the shunt the thrombus was developed on the silk thread placed in the shunt and the wet weight of the thrombus was measured. The thrombus weight was significantly reduced by a calcium antagonist cinnarizine (p. o. 80 and 160 mg/kg and ASA (p.o. 300mg /kg) as compared with the control group. In addition, the thrombus was formed by a modified Chandler's method (ex vivo). The wet weight,...

A carotid-jugular extracorporeal shunt model (in vivo) was made in rat, in which 15 min after the restoration of blood flow in the shunt the thrombus was developed on the silk thread placed in the shunt and the wet weight of the thrombus was measured. The thrombus weight was significantly reduced by a calcium antagonist cinnarizine (p. o. 80 and 160 mg/kg and ASA (p.o. 300mg /kg) as compared with the control group. In addition, the thrombus was formed by a modified Chandler's method (ex vivo). The wet weight, dry weight and length of the thrombus was significantly decreased as compared with the control group after cinnarizine (p.o.40,80 and 160mg/kg) and ASA (p. o. 300mg/kg) were given. The results of ex vivo and in vivo experiments were basically concordant. It was indicated that cinnarizine was a valuable anti-thrombotic agent and its anti-thrombotic potency was much higher than ASA.

脑益嗪是—钙拮抗剂。本实验用颈动—静脉血流旁路术和改良的chandler氏体外血栓法研宄了脑益嗪的抗血栓作用。结果表明:脑益嗪对两种方法形成的血栓均有明显的抑制作用,二种方法的结果基本一致。因此,本文提示脑益嗪除直接扩张血管外,尚有很强的抗血栓作用,其效价强度优于阿斯匹林。

 
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