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cell death form
相关语句
  细胞死亡形式
     OBJECTIVE:To investigate the cytotoxic effects of homoharringtonine(HHT) on HXO RB 44 cell line and the cell death form induced by HHT in vitro.
     目的:观察高三尖杉酯碱(homoharringtonine,HHT)对视网膜母细胞瘤(retinoblastoma,RB)细胞系HXO-RB44细胞的杀伤作用及其诱导的细胞死亡形式
短句来源
     Large empirical study have confirmed that apoptosis was the significant cell death form in secondary brain injury.
     大量实验研究证实,细胞凋亡(apoptosis)是继发性脑损伤重要的细胞死亡形式
短句来源
  相似匹配句对
     Mitotic Cell Death
     有丝分裂细胞死亡
短句来源
     Necrosis has long been recognized as the unique form of cell death in myocardium.
     长期以来,坏死被认为是心肌细胞死亡的唯一方式。
短句来源
     Apoptosis is an active form of cell death,which completely different from necrosis.
     细胞凋亡是细胞的主动死亡过程 ,是与细胞坏死截然不同的细胞死亡方式。
短句来源
     Programmed cell death and adaptability
     细胞程序性死亡与生态适应
短句来源
     On form
     “形式”论
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  cell death form
Biochemical interventions (e.g., with inhibitors of poly-(ADP-riboso)-polymerase) into the signal and executive mechanisms of PCD can change the choice of the cell death form.
      
Mitotic cell death is a cell death form different from apoptosis, on which has been focused in tumor therapy.
      


OBJECTIVE:To investigate the cytotoxic effects of homoharringtonine(HHT) on HXO RB 44 cell line and the cell death form induced by HHT in vitro.METHODS:MTT assay was adopted to establish survival rate of the tumor cells.Agarose gel electrophores was chosen to detect the genomic DNA from the cells exposed to HHT. RESULTS:In the concentration from 10 -9 to 10 -4 mol/L HHT powerfully inhibited the growth...

OBJECTIVE:To investigate the cytotoxic effects of homoharringtonine(HHT) on HXO RB 44 cell line and the cell death form induced by HHT in vitro.METHODS:MTT assay was adopted to establish survival rate of the tumor cells.Agarose gel electrophores was chosen to detect the genomic DNA from the cells exposed to HHT. RESULTS:In the concentration from 10 -9 to 10 -4 mol/L HHT powerfully inhibited the growth of the cells (P<0.05).Regular genomic DNA fragmentation from the cells exposed to 10 -6 mol/L HHT for 48 hours was shown to be typical DNA ladder on agarose gelelectrophoresis.CONCLUSION:HHT can induce retinoblastoma(RB) programmed cell death(PCD),the effects of which has close correlation with incubated period and concentration of HHT.

目的:观察高三尖杉酯碱(homoharringtonine,HHT)对视网膜母细胞瘤(retinoblastoma,RB)细胞系HXO-RB44细胞的杀伤作用及其诱导的细胞死亡形式。方法:用MTT法测定肿瘤细胞存活率,提取药物作用后的细胞核DNA进行琼脂糖凝胶电泳。结果:HHT在10-9mol/L~10-4mol/L浓度范围对HXO-RB44具有较强的杀伤作用(P<0.05)。10-6mol/L的HHT与HXO-RB44作用48小时后,核DNA发生有规律的裂解,琼脂糖凝胶电泳呈典型DNA梯度。结论:HHT诱导RB发生程序性死亡(programmedceldeath,PCD),其诱导活性呈较强的浓度和时间依赖性。

Objective To investigate action of apoptosis in mechanisms of neonatal hypoxiaischemia(HIE). Methods Using HE staining, electronmicroscope, and terminal deoxynuleotidyl transferasemediated dUTP nick end labeling (TUNEL) technique, we observed the histological features, time course and density of apoptotic cells and compared the ipsilateral hemisphere after permanent ischemia 1, 4, 18, 24, 40, 72h, 7 days after 3h hypoxia with that of shamgroup. Results Neurons in the cortex, hippocampus, thalamus...

Objective To investigate action of apoptosis in mechanisms of neonatal hypoxiaischemia(HIE). Methods Using HE staining, electronmicroscope, and terminal deoxynuleotidyl transferasemediated dUTP nick end labeling (TUNEL) technique, we observed the histological features, time course and density of apoptotic cells and compared the ipsilateral hemisphere after permanent ischemia 1, 4, 18, 24, 40, 72h, 7 days after 3h hypoxia with that of shamgroup. Results Neurons in the cortex, hippocampus, thalamus exhibited cells shrink, chromatin condensation, apoptosis bodys under microscope, as demonstrated by in situ labeling of DNA breaks. The peak for apoptosis was shown at 18h in the cortex. Conclusion In the HIE, apoptosis appears earlier than necrosis, and both of the different cell death forms may exist induced dose relativity.

目的探讨脑细胞凋亡在缺氧缺血脑病(HIE)发病机理中的作用。方法用HE染色、电镜、原位末端标记(Tunel)手段,分别对缺氧3小时后缺血1、4、18、24、40及72小时和7天组大鼠的脑组织中凋亡细胞的形态、出现时间及密度进行观察和比较。结果光、电镜下显示实验侧脑皮质、海马及丘脑神经元皱缩、染色质凝集并出现凋亡小体;Tunel方法证实有裂解DNA存在;缺氧缺血后18小时皮质凋亡最明显。结论在HIE大鼠,脑细胞凋亡出现不但早于坏死,而且与坏死存在着诱导剂量相关性

Objective To investigate the effect of cytokine tumor necrosis factor α(TNFα) on pancreatic β cells apoptosis and the effect of transcription factor nuclear factor of kappa B (NF-kB) on TNFα-mediated apoptosis. Methods INS-1 cells, a pancreatic β cell line, were cultured,and recombinant DNA technique, transfection and reinfection technology were used to obtain INS-1/ IkBΔN cells expressing inhibitor of kB (IkB)αΔN, mutant IkBα (inhibitor of NF-kB). DNA fragmentation assay and fluorescence...

Objective To investigate the effect of cytokine tumor necrosis factor α(TNFα) on pancreatic β cells apoptosis and the effect of transcription factor nuclear factor of kappa B (NF-kB) on TNFα-mediated apoptosis. Methods INS-1 cells, a pancreatic β cell line, were cultured,and recombinant DNA technique, transfection and reinfection technology were used to obtain INS-1/ IkBΔN cells expressing inhibitor of kB (IkB)αΔN, mutant IkBα (inhibitor of NF-kB). DNA fragmentation assay and fluorescence analysis using a kB-luc reporter gene were applied to observe the NF-kB activity and β cell apoptosis. Results NF-kB activity induced by IL-Iβ was detectable in INS-1 cells but not in INS-1/ IkBΔN cells. After incubation of the cells with IL-1β (10 μg/L),TNFα(100 μg/L) and interferon (IFN)γ (100 000 U/L) for 48 hours, the combination of TNFα and IFNγ induced apoptosis in INS-1 cells but not in INS-1/IkBΔN cells. No apoptosis was observed after incubation of INS-1 cells with IL-1β or IFNγ or IL-1β plus IFNγ . Conclusion Apoptosis is one of the TNFα-induced β-cell death forms. NF-kB may play an important role in the TNFα-mediated β-cell apoptosis. Inhibition of NF-kB activation protects β-cells from TNFα-induced apoptosis.

目的 探讨肿瘤坏死因子 (TNFα)是否可引起胰岛 β细胞凋亡以及转录因子核因子kB(NF kB)在TNFα诱导的 β细胞凋亡中所起的作用。 方法 培养INS 1胰岛 β细胞 ,采用DNA重组、转染和再感染技术获得可表达NF kB的特异性抑制物IkBα的突变体IkBαΔN的INS 1/IkBΔN细胞。应用DNA片段分析技术和kB luc报告基因荧光分析技术观察NF kB活性和 β细胞的凋亡情况。 结果 IL Iβ可诱导INS 1细胞的NF kB激活 ,但在INS 1/IkBΔN细胞则无此作用。将细胞与IL 1β( 10 μg/L)、TNFα( 10 0 μg/L)以及IFNγ( 10 0 0 0 0U/L)一道培养 48h后显示 ,TNFα与IFNγ合用可诱导INS 1细胞发生凋亡 ,而在INS 1/IkBΔN细胞未见此现象。单用IL Iβ或IFNγ或IL Iβ加IFNγ均未能诱导INS 1细胞凋亡。结论 凋亡是TNFα导致β细胞死亡的方式之一 ,NF kB在TNFα介导的β细胞凋亡中具有重要作用 ,抑制NF kB激活可能保护 β细胞免于TNFα诱导的凋亡。

 
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