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toxin receptors
相关语句
  毒素受体
     Progress in research on anthrax toxin receptors and mechanism of their binding to protective antigen
     炭疽毒素受体及其与保护性抗原结合机制的研究进展
短句来源
     Until now,two anthrax toxin receptors have been identified which were encoded by gene of tumor endothelial marker 8(TEM8) and gene of capillary morphogenesis protein 2(CMG2) respectively.
     到目前为止,共发现两种炭疽毒素受体,分别由TEM8和CMG2基因编码。
短句来源
     The discovery and identification of anthrax toxin receptors greatly enriched our knowledge about the pathology of anthrax. The results of in vitro experiments showing high affinity between receptor and toxin also provided a promising future that the recombinant receptor itself might be of therapeutic use.
     炭疽毒素受体的发现和鉴定对炭疽的病理学研究具有重要的意义,而且体外实验发现的受体与毒素的高亲和力也为受体本身作为炭疽的治疗剂带来了希望。
短句来源
  相似匹配句对
     3. Studies on receptors of CrylA(c) toxin in R桾n?
     3.抗性8川-T。 sin细胞膜上受体蛋白的研究 序
短句来源
     Cholera toxin
     霍乱毒素
短句来源
     Phytopathogenic Toxin
     植物病原毒素
短句来源
     GF receptors
     说明SS对EGF受体有下调节作用。
短句来源
     and their receptors.
     DMV含乙酰胆碱、儿茶酚胺、神经肽类等多种递质及相应受体。
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  toxin receptors
GM1 ganglioside has been localized on the surfaces of myelinated, peripheral nerve fibres by using immunofluorescence to detect cholera toxin receptors.
      
In the deduced amino acid sequence the characteristic metallopeptidase sequences, HEXXHX18E and GAMENWG were conserved but the sequence showed only 33-39% identity to other insect APNs, which were also reported to be Cry toxin receptors.
      
Treatment of C6 cells with ganglioside GM1 increased the number of toxin receptors and decreased the lag phase.
      
N18 cells have 500-fold more toxin receptors than C6 cells.
      
When the number of toxin receptors in HeLa and C6 cells is increased by treating the cells with GM1, activation of adenylate cyclase by choleragen is no longer blocked by the oligosaccharide.
      
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Binding of neurotoxin, labelled with 125I has been studied in crude membrane preparation containing plenty of n-AchR from Narcine electric organ. Competition with a variety of receptor agonist and antagonist indicates that toxin binding exhibits the pattern expected nicotinic acetylcholinc receptor. Membrane bound receptors appear to consist of at least two binding subunits, one for specific cholinergic ligands, and the other appears to preferentially bind to inorganic cations (K+, Na+,...

Binding of neurotoxin, labelled with 125I has been studied in crude membrane preparation containing plenty of n-AchR from Narcine electric organ. Competition with a variety of receptor agonist and antagonist indicates that toxin binding exhibits the pattern expected nicotinic acetylcholinc receptor. Membrane bound receptors appear to consist of at least two binding subunits, one for specific cholinergic ligands, and the other appears to preferentially bind to inorganic cations (K+, Na+, Ca2+, Mg2+) . After binding with cations, the toxin binding is inhibited. Kwangtung Snake Drug also interferes with toxin-receptor interaction and the mechanism of interference has been discussed.

从中国电鳐电器官可分离制备含丰富胆碱受体的粗膜制剂。可用来研究受体与~(125)I-神经毒的结合反应。胆碱受体激动剂、对抗剂对~(125)I-神经毒与受体的结合有竞争性抑制作用,这表明该受体为烟碱样的。该受体似含有两个结合点,其一能与胆碱受体配基相结合,另一能与阳离子相结合。受体与阳离子结合后,可抑制受体与神经毒的结合。广东蛇药同样亦能干扰受体与神经毒的结合反应。并讨论了它的作用机制。

Neurotoxins produced by Clostridium cause severe nerve disorder and threat the safety of life.7 kinds of neurotoxins with high homogeneity have similar pathogenesis but different toxicity due to distinct molecular structure and interreaction.Advances in molecular mechanism of action of Clostridium neurotoxins including protein structure,toxin receptor, interreaction between toxin and substrate,modulation by substrate ect are reviewed.

厌氧梭菌产生的神经毒素可以引起严重的神经失调,甚至威胁生命.作为具有很高同源性的7种毒素分子,它们既具有相似的发病机制又有不尽相同的结构基础和分子作用方式,从而产生不同的毒素活性.主要就神经毒素分子作用机制相关的毒素蛋白结构、毒素受体、毒素活性的发生、毒素与底物的作用、底物的调节作用与应用等内容的研究进展作一综述.

The changes of aminopeptidase N(APNs) in site concentration and structure are one of major resistance mechanisms of insects to Bacillus thuringiensis (Bt.) The authors reviewed the progress of research on APN receptor. A few types of APNs exist on the midgut brush border membrane of each species.They are highly homologous,and some of them serve as Bt Cry1A family toxin receptor.APNs maybe bind to different Bt toxins, and confer different level of susceptibility of Bt toxin to the insect.A...

The changes of aminopeptidase N(APNs) in site concentration and structure are one of major resistance mechanisms of insects to Bacillus thuringiensis (Bt.) The authors reviewed the progress of research on APN receptor. A few types of APNs exist on the midgut brush border membrane of each species.They are highly homologous,and some of them serve as Bt Cry1A family toxin receptor.APNs maybe bind to different Bt toxins, and confer different level of susceptibility of Bt toxin to the insect.A few of mutations at the coding region of APN genes were found in some Bt resistant insects species.

鳞翅目昆虫中肠上皮细胞刷状缘膜 (BBM)上的Bt杀虫晶体蛋白毒素受体氨肽酶N(APN)的结构和位点密度的改变是昆虫对Bt毒素的主要抗性机制之一 ,该文简要综述了APN受体的研究进展。每种昆虫中肠上皮细胞中有数种APNs,彼此间同源性较高 ,其中部分APNs为Cry1A家族毒素的功能性受体。不同种类昆虫的APNs受体 ,甚至同一种昆虫的不同类型APNs,其所结合的毒素种类可能不同。APNs决定该昆虫对Cry1A类毒素的敏感程度差异。有些抗性昆虫的APNs基因编码区发生了多个点突变。

 
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