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binding domains
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  结合域
     Conclusion Domains between 3-22, 179-183, 190-195, 265-275 were most likely to be the binding domains of C5L2.
     结论人C5L2分子第3~22、179~183、190~195、265~275位等区域满足各项指标,最可能是其配体C5a的结合域
短句来源
     Sequence analysis showed that the GaLAC1 cDNA contained a open reading frame coding for a protein of 566 amino acid residues (63.74KD), with an N-terminal signal peptide of 23 amino acids, four Cu2+ binding domains, and 17 putative carbohydrate moieties.
     序列分析表明,GaLAC1编码含566个氨基酸残基的蛋白质(63.34 KDa),含4个铜离子结合域,17个推断的糖基化位点,其N-端23个氨基酸为信号肽。
短句来源
     Study on Ligand Binding Domains of Human Vascular Endothelial Growth Factor Receptor Flt-1 by Yeast Two-Hybrid System
     利用酵母双杂交系统研究人血管内皮生长因子受体Flt-1的配体结合域
短句来源
     Results Domains between 36-39, 51-60, 113-119, 429-448, and 453-471 were most likely to be the binding domains of TLR9. Conclusion The possible binding domains of TLR9 are found, which may be the base for next laboratory work.
     结果第34~41、51~60、113~119、429~448和453~471位等5个区域满足各项指标,最可能是TLR9的配体结合域。 结论本文的分析结果对人TLR9配体结合域的后继研究具有指导意义。
短句来源
     Objective To predict binding domains of toll like receptor 9 (TLR9) though multiply parameter analysis.
     目的通过生物信息学的多参数评估,综合分析人Toll样受体第9型(TLR9)的配体结合域
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  “binding domains”译为未确定词的双语例句
     Additionally, P14ARF possesses multiple binding domains to bind to the transcription factor E2F-1 and down-regulates the E2F-l-dependant transcription to prompt cell cycle arrest and induce E2Fl-dependant apoptosis.
     另外P14ARF可通过多个结合结构域与转录因子E2F-1结合,下调E2F-1的转录活性,促使细胞周期停滞,引发E2F-1依赖性细胞凋亡。
短句来源
     The ectodomain contains 13 potential N-linked glycosylation sites(NXT/NXS),2 calcium binding domains[DX(D/N)XDGXXD],18 cysteine residues,and a proteolytic cleavage site located between amino acid residue 890 and 891(KR-D).
     在890和891位氨基酸之间有1个蛋白酶裂解位点(KR-D); 胞外域含有13个潜在的糖基化位点(NXT/NXS)、2个Ca2+结合位点[DX(D/N)XDGXXD]、18个半胱氨酸残基。
短句来源
     Objective To predict binding domains of human C5a like receptor 2(C5L2) and further to detect the affinity between C5a and C5L2 by the technology of bioinformatics and BIA.
     目的通过生物信息学分析人C5L2受体的配体结构域,并进一步利用生物分子相互作用测定技术(biomo-lecular interaction analysis,BIA)研究其与配体C5a分子间的相互作用。
短句来源
     It contains protein A' (IgG binding domains of protein A) and TNF protein.
     该融合蛋白是蛋白A的IgG结合区ProA’同TNF的融合蛋白。
短句来源
     Determination of DNA binding domains in hepatitis C virus core protein
     丙型肝炎病毒核心蛋白DNA结合区的测定
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  相似匹配句对
     They are DNA binding domains.
     它们的C末端分别含有SAP和SANTDNA结合结构域。
短句来源
     Progress in Research on DNA-Binding Protein Domains
     DNA结合蛋白结构域的研究进展
短句来源
     On K- representative Domains
     K──表示域
短句来源
     protein binding;
     蛋白结合;
短句来源
     John Domains
     John域
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  binding domains
The catalytic and substrate-binding domains of endoxylanase II were isolated.
      
Transcription factors of the DREBP subgroup and the EREBP subgroup contain conserved DNA-binding domains called AP2/EREBP domains, which specifically bind to DRE cis-element and GCC-box, respectively.
      
MMP-3 generates an angiostatin like fragment (containing kringles 1-4 with the cellular binding domains) from plasminogen.
      
Their catalytic domains are currently grouped into 15 of more than 80 known glycosyl hydrolase families, whereas substrate binding domains fall into 13 families.
      
The structures of catalytic and substrate binding domains, as well as linker sequences, are briefly considered.
      
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Ca2+ and cAMP are ubiquitous intracellular messengers. The message of Ca2+ is relayed by receptor proteins, mainly calcium regulated proteins. Calcium regulated proteins can be divided into two classes according to their localization in living tissues: one exerts their calcium dependent functions extracellularly , such as γ-carboxyglutamic acid containing proteins involved in the regulation of blood clotting; the other is Ca2+ modulated proteins, in which a striking example is calmodulin, postulated to be the...

Ca2+ and cAMP are ubiquitous intracellular messengers. The message of Ca2+ is relayed by receptor proteins, mainly calcium regulated proteins. Calcium regulated proteins can be divided into two classes according to their localization in living tissues: one exerts their calcium dependent functions extracellularly , such as γ-carboxyglutamic acid containing proteins involved in the regulation of blood clotting; the other is Ca2+ modulated proteins, in which a striking example is calmodulin, postulated to be the major intracellular Ca2+ signal transducer. Calmodulin harbors four Ca2+-binding domains which reversibly bind Ca2+ to form an active protein-Ca2+ complex, whose activity is regulted by the cellular flux of Ca2+ . The active complex operates in two different ways: one is on the target enzymestor proteins) directly, and the other is through the target protein, allowing it to (?) calmodulin regulated protein kinases and phosphatasets). The molveular basis of calcium action, and in particular, the modulation of calmodulin are reviewed here.

生物作用广泛的细胞信使主要是Ca~(2+)和cAMP。Ca~(2+)在生物体内通过其受体蛋白,即钙调节蛋白发挥功能。钙调节蛋白可分为两类:一类主要在胞外起作用,如与凝血有关的钙蛋白;另一类在胞内起作用,如多功能的钙媒介蛋白。后者具有特殊的、但非专一的钙结合区,正常生理条件下能与Ca~(2+)可逆性结合。形成的钙媒介蛋白·Ca~(2+)络合物可直接激活靶蛋白或酶,也可通过靶蛋白间接调节磷酸化和去磷酸化,从而发挥多种生物功能。

Calmodulin(CaM)is a multifunctional regulatory protein.The structure has been determined crystallographically at 3.0A resolution. The molecule has four Ca-binding domains. Each Ca ion is coordinated to main-chain oxygen atoms and to oxygen atoms from the side chains of acidic residues. It is not clear if there are any water molecules in the Ca coordination sphere.In this study, longitudinal proton relaxation rates of water in solutions of CaM have been measured by the use of Mn(Ⅱ) as a probe in order to...

Calmodulin(CaM)is a multifunctional regulatory protein.The structure has been determined crystallographically at 3.0A resolution. The molecule has four Ca-binding domains. Each Ca ion is coordinated to main-chain oxygen atoms and to oxygen atoms from the side chains of acidic residues. It is not clear if there are any water molecules in the Ca coordination sphere.In this study, longitudinal proton relaxation rates of water in solutions of CaM have been measured by the use of Mn(Ⅱ) as a probe in order to determine the hydration number of Ca coordination sphere.From the results the model has been established. It is suggested that the number of water molecules coordinated to Mn(Ⅱ) bound at low-affinity sites has been estimated to be 2. However, there are no water molecules existing in the coordination sphere of Mn(Ⅱ) bount at high-affinity sites.

钙调蛋白(CaM)是一种多功能调节蛋白,它含有4个Ca~(2+)结合域.晶体研究表明所有Ca~(2+)都与主链氧原子及酸性残基侧链氧原子配位,但Ca~(2+)的配位层中是否有水分子存在尚未确定.木文利用核磁共振技术,以Mn~(2+)为探针,通过测定水质子的核磁弛豫速率T_(1P)_(-1)建立了有关Ca~(2+)配位层中水分子数目的模型,该模型指出Cam中高、低亲和位上Ca~(2+)结合水的能力不同,高亲和位上Ca~(2+)的配位层中没有水分子存在,而低亲和位上Ca~(2+)配位层中含两个水分子.

The role of DNA superhelical structure in the regulation of α-crystallin gene expression in a cloned genomic system has been studied. In the experiment reported in this paper, we determined the regulatory gene domain and its effect on transcription. The transcription reactions were carried out in wheat germ pol Ⅱ and the HeLa cell extract system. The incorporation of ~(32)P-UMP into RNA transcripts was measured. The results has indicated that the α-crystallin A_2 gene was specifically activated by RF-...

The role of DNA superhelical structure in the regulation of α-crystallin gene expression in a cloned genomic system has been studied. In the experiment reported in this paper, we determined the regulatory gene domain and its effect on transcription. The transcription reactions were carried out in wheat germ pol Ⅱ and the HeLa cell extract system. The incorporation of ~(32)P-UMP into RNA transcripts was measured. The results has indicated that the α-crystallin A_2 gene was specifically activated by RF- 36 protein factor. Footprint analysis has revealed the regulatory binding domain to be a nucleotide sequence of "-AGGGCTGGAA-".Its interaction with specific DNA binding ligands such as anti-Z-DNA monoclonal antibody and the chiral metal complex indicates that the "GC" rich box possesses a conformation similar to "Z" form DNA. It has also been demonstrated that the high order structure of DNA plays a major role in the regulation of the expression of the α-crystallin gene.

本文在一个克隆化的基因组系统中,研究了DNA超螺旋结构在α-晶体蛋白基因表达中的调控作用;测定了调节基因区及其对转录过程的影响.结果显示α-晶体蛋白基因可被RF-36蛋白因子特异性激活.足迹法分析表明其调控结合区为核苷酸“-AGGGCTGGAA-”,能与特定的DNA配位体结合,例如抗Z-DNA单克隆抗体和Chiral金属复合物,此种结合表明α-晶体蛋白基因富含“GC”盒,并具有类似“Z”型的DNA构型.所获结果还提示,DNA高度有序的结构在α-晶体蛋白基因的表达调控过程中起重要作用.

 
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