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bilateral hippocampus
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  双侧海马
    The volumes of the bilateral hippocampus of the type Ⅰ and the type Ⅱ patients were significantly smaller than those of the controls(P<0.05,t test),but no significant difference was found between the type Ⅰ and type Ⅱ(P>0.05,t test).
    Ⅰ型和Ⅱ型PTSD患者双侧海马容积均较对照组明显缩小(t值分别是2.37、4.20、3.07、4.12,均P<0.05),Ⅰ型和Ⅱ型PTSD患者左右海马容积比较,差异无显著性意义(t值分别是0.55、0.48,均P>0.05)。
短句来源
    The AD models were established by the injection of amyloid β-peptide25-35(Aβ25-35) into the bilateral hippocampus of rats,while the control rats were subjected to injection of normal saline at the same site.
    采用立体定向下双侧海马注射A2β5-35建立AD模型,对照组大鼠采用相同方法注射等量生理盐水。
短句来源
    RESULTS: 1. MDs had significantly lower density of the prefrontal cortex area (BA9、 BA10、 BA11, BA47 and bilateral anterior cingulate cortex) 、 bilateral temporal lob, bilateral hippocampus, bilateral Cerebellum and caudate and putamen in sub-lobe than HCs.
    1.与正常对照组相比,重性抑郁症患者前额叶(BA8、BA9、BA10、BA11和BA47)、左右颞叶、双侧海马、双侧前扣带回、右侧叶下尾状核和壳核、左右小脑灰质密度显著降低。
短句来源
    Results T 2 weighted images showed hyperintensity on the bilateral hippocampus and lateral ventricles in some experimental rats. The T 2 WI intensity was decreased from CA 1 area to CA 3 area of hippocampus.
    结果 T2 WI显示部分动物双侧海马、侧脑室信号增强 ,其信号强度由中线 (CA1区 )向外侧 (CA3区 )逐渐减弱 ,该区T1、T2 弛豫时间延长 ,扩散系数增大。
短句来源
    Methods: D-galactose was intraperitoneally injected in rats for 6 weeks and β-Amyloid 1-40(Aβ 1-40) was injected into bilateral hippocampus to make AD models.
    方法 :连续 6周腹腔内注射D -半乳糖 ,双侧海马内注射Aβ1 4 0 造成AD模型。
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  “bilateral hippocampus”译为未确定词的双语例句
    But Cho had no significant difference in the bilateral hippocampus between PTSD and control subjects (P>0.05).
    Cho两组两侧差异均无统计学意义(P>0.05)。
短句来源
    Each group included 8 subjects. Aβ was injected into the CA3 area of bilateral hippocampus. Iodoacetamide was administered subcutaneously daily for 5 consecutive days before surgery.
    实验大鼠随机分为6组:Aβ组、Aβ+碘乙酰胺组、Aβ+胰岛素组、碘乙酰胺组、胰岛素组和对照组,每组8只。
短句来源
    Methods: Thirty cases of PTSD(type Ⅰand type Ⅱ) and 30 age-matched normal controls were checked on a clinical 1.5 T MRI/MRS system. The volumes of the bilateral hippocampus and the whole brain were measured using volume analysis software,and the resulting data were normalizes according to the individual brain volume.
    方法:30例PTSD患者(其中Ⅰ型13例和Ⅱ型17例)和30例年龄相匹配的健康志愿者(对照组),用1.5超导MR扫描系统对大脑进行MRI扫描,用容积分析软件测量海马和颅腔容积大小并根据颅腔容积的大小,对海马容积进行标准化处理。
短句来源
    The volumes of the bilateral hippocampus were compared among the control,the type Ⅰ,and the type Ⅱ groups respectively.
    把Ⅰ型和Ⅱ型PTSD患者海马容积分别与对照组比较。
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  bilateral hippocampus
This study was performed to evaluate the effect of seizures on the bilateral hippocampus in mesial temporal lobe epilepsy (mTLE) and neocortical epilepsy by single voxel proton magnetic resonance spectroscopy (MRS).
      
The volume of the bilateral hippocampus was significantly smaller in the major depression group than that in control group.
      


Objective To explore brain MRI signal changes of rat model of Alzheimers disease. Methods The model was made by transecting unilateral fimbria fornix on stereotaxic devisor and proved successfully by Morris water maze. The MRI experiments were performed on a 30cm bore 4.7T superconductor MR scanner(T 1 weighted MRI,T 2 weighted MRI and Diffusion weighted MRI). Results T 2 weighted images showed hyperintensity on the bilateral hippocampus and lateral ventricles in some experimental rats. The...

Objective To explore brain MRI signal changes of rat model of Alzheimers disease. Methods The model was made by transecting unilateral fimbria fornix on stereotaxic devisor and proved successfully by Morris water maze. The MRI experiments were performed on a 30cm bore 4.7T superconductor MR scanner(T 1 weighted MRI,T 2 weighted MRI and Diffusion weighted MRI). Results T 2 weighted images showed hyperintensity on the bilateral hippocampus and lateral ventricles in some experimental rats. The T 2 WI intensity was decreased from CA 1 area to CA 3 area of hippocampus. T 1 and T 2 time increased along with the increment of apparent diffusion coefficient(ADC). Enlargement in lateral ventricles and the third ventricl were doserved by T 2 WI.There were also hyperintensity at septal area,but no abnormal signal changes had been found on neocortex and entorhinal cortex,where there were also no atrophic changes. Conclusion Fimbria fornix transection lesion can results in rats learning and memory disorder. There are abnormal MRI signal changes on the bilateral hippocampus and lateral ventricles as wall as septal area,which are the characteristic markers of early diagnosis of Alzheimers disease.

目的 探讨Alzheimer病 (AD)模型大鼠脑MRI信号变化 ,为AD早期诊断提供特征性MRI指标。方法 在脑立体定位仪上切断一侧穹窿海马伞建立AD动物模型。经Morris水迷宫行为学检测确定模型成功后 ,用MRI作脑冠状面T1加权像 (T1 WI)、T2 加权像 (T2 WI)和扩散加权像 (D WI)研究。结果 T2 WI显示部分动物双侧海马、侧脑室信号增强 ,其信号强度由中线 (CA1区 )向外侧 (CA3区 )逐渐减弱 ,该区T1、T2 弛豫时间延长 ,扩散系数增大。侧脑室中央部及其下角呈现轻度扩大 ,手术侧尤为明显。第三脑室也有轻度扩大。隔区有“斑点状”散在增强信号。海马、内嗅区以及新皮质未见明显萎缩。其它脑区未见明显异常改变。结论 切断穹窿海马伞可引起动物学习记忆障碍。动物脑MRI呈现特征性改变 ,海马和侧脑室信号增强 ,尤以CA1区最明显。本文认为这些改变可作为AD早期诊断的特异性MRI指标。

Objective: To study the changes of learning and memory abilities and pathology in alzheimer disease rats. Methods: Incubated Aβ 1-40 was microinjected into the bilateral hippocampus of each rat. Y- maze was used to evaluate learning and memory ability of rats';the sections were stained with haematoxylin-eosin(HE) , Congo Red and silver staining. Results: The capabilities of learning and memory were impaired significantly after Aβ 1-40 injection. Aβ deposition ,neuron death ,glial reaction...

Objective: To study the changes of learning and memory abilities and pathology in alzheimer disease rats. Methods: Incubated Aβ 1-40 was microinjected into the bilateral hippocampus of each rat. Y- maze was used to evaluate learning and memory ability of rats';the sections were stained with haematoxylin-eosin(HE) , Congo Red and silver staining. Results: The capabilities of learning and memory were impaired significantly after Aβ 1-40 injection. Aβ deposition ,neuron death ,glial reaction and neurofibrillary tangles were found in or around the injection sites.Conclusion: These results suggest that the aggregated Aβ 1-40 and its deposition in the hippocampus is related to the impairment of learning and memory and the neuronal degeneration in the rats which shows similar behavior and pathological characterizations of AD. This Aβ-treated rats could be used as an animal model for AD.

目的 :模拟人类Alzheimer病 (AD)的大鼠病理模型 ,观察其学习记忆及病理性改变。方法 :大鼠双侧海马微量注射聚合态Aβ1 40 制备AD动物模型 ,Y 型迷宫测定大鼠学习记忆能力 ,HE染色、刚果红染色和银染检测病理变化。结果 :海马内注射Aβ1 40 可引起大鼠学习记忆能力下降 ,注射区Aβ沉积 ,神经元丢失及胶质细胞增生 ,神经原纤维缠结。结论 :Aβ1 40 海马内注射能较好的模拟AD的学习记忆障碍、神经元损伤等行为学和病理学等方面的特征 ,作为AD研究较好的动物模型。

Objective To study the magnetic resonance imaging (MRI) volume of the amygdala and hippocampus and the changes of magnetic resonance spectroscopy (MRS) in patients with major depression. Methods Quantitative MRI of the amygdala and hippocampus and MRS of the hippocampus were studied in 22 patients with major depression and compared with 13 age-matched controls. Results Both groups exhibited similar significant hippocampal asymmetry (left smaller than right). When compared with the controls, the volume of...

Objective To study the magnetic resonance imaging (MRI) volume of the amygdala and hippocampus and the changes of magnetic resonance spectroscopy (MRS) in patients with major depression. Methods Quantitative MRI of the amygdala and hippocampus and MRS of the hippocampus were studied in 22 patients with major depression and compared with 13 age-matched controls. Results Both groups exhibited similar significant hippocampal asymmetry (left smaller than right). When compared with the controls, the volume of bilateral hippocampus was significantly smaller in patients' group. The patients had significant asymmetry of the amygdalar volumes (right smaller than left), hippocampal volume abnormalities and the duration of illness had no correlation. MRS revealed reduced NAA/Cr ratio in the patients when compared with that of the controls. Conclusion These findings support the hypothesis that the hippocampus and amygdala within limbic-cortical networks may play a crucial role in the pathogenesis of major depression.

目的 探讨抑郁症患者海马及杏仁核容积改变特点及海马的1HMRS表现。方法 探讨 2 2例抑郁症患者及 13例健康志愿者两侧海马及杏仁核容积及海马的1HMRS表现。结果 抑郁症患者及志愿者均显示两侧海马容积不对称 (左侧小于右侧 ) ;抑郁症患者两侧海马容积比志愿者有明显减小 ,杏仁核容积明显不对称 (右侧小于左侧 ) ;抑郁症患者海马容积缩小与病程缺乏相关性。双侧海马NAA/Cr低于对照组 ,差异有显著性 (P <0 .0 5 )。结论 海马及杏仁核容积异常和神经化学的改变可能构成抑郁症的神经生物学基础 ,也说明边缘系统在抑郁症的发病机制中起着重要作用

 
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