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clinical epi
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     Results of clinical
     试验结果表明EDM的临床总有效率高达94.3%,
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     The clinical study.
     临床研究部分。
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     The clinical study of the epithelial flap of painless LASEK and Epi-LASIK
     无痛性准分子激光角膜上皮瓣下磨镶术及微型角膜刀准分子激光角膜上皮瓣下磨镶术的临床研究
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     Clinical Studies on Treating Epi Demic Parotitis with Raduqing Pills
     热毒清片治疗流行性腮腺炎的临床研究
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he agents responsible for the hepatitis in case of he-patitis associaed aplastic anemia (HAAA) have not welldefined. The study was carried out by using clinical epi-demiologic study to seek the relationship between thehepatitis and aplastic anemia (AA). A 1 ; 2 matched andhospital based case control study was conducted among160 cases of acquired AA , a prospective study was car-ried out among 483527 population at Jingan district ofShanghai to follow the incidences of hepatitis and AA for4 years (1986  ̄...

he agents responsible for the hepatitis in case of he-patitis associaed aplastic anemia (HAAA) have not welldefined. The study was carried out by using clinical epi-demiologic study to seek the relationship between thehepatitis and aplastic anemia (AA). A 1 ; 2 matched andhospital based case control study was conducted among160 cases of acquired AA , a prospective study was car-ried out among 483527 population at Jingan district ofShanghai to follow the incidences of hepatitis and AA for4 years (1986  ̄ 1989) , and a serologic study on viralhepatitis was performed among 14 cases of HAAA. Ourstudy showed that no relationship berween hepatitis Aand HAAA could be found in case control study andserologic study. The incidence of AA was not changedbefore and after an outbreak of hepatitis at Jingan dis-trict of Shanghai. Only two cases of HAAA were causedby hepatitis B. The most cases of HAA were caused bynon-A , non-B hepatitis.

病毒性肝炎相关性再生障碍性贫血(HAAA)与何种肝炎病毒相关联,至今尚未明确。我们采用临床流行病学研究方法来探讨肝炎和再生障碍性贫血(再障)发病之间关系。本研究采用1:2配对医院内病例对照研究方法调查160例获得性再障,并且在上海市静安区483527人群中前瞻性随访4年(1986~1989年)肝炎和再障的发病率变迁,同时对临床上确诊为HAAA的14例患者进行肝炎病原的血清学分析。本研究表明,无论在病例对照研究和肝炎病原血清学分析中都不能证实甲型肝炎和HAAA发病有关。上海市静安区甲型肝炎暴发流行前后再障发病率亦无变化。本资料仅证实2例HAAA系由乙型肝炎引起。大多数HAAA病例可能由非甲非乙型肝炎引起。

Objective: To investigate the clinical epi demi ology of epidemic cerebrospinal meningitis in children in recent 20 years. Methods: A retrospective analysis was conducted in 177 hospitali z ed children patients with epidemic cerebrospinal meningitis from 1984 to 2003. C hi-square test was used for statistical analysis. Results:T here were sporadic cases of children epidemic cerebrospinal meningitis in Shangh ai area. However, there was an epidemic outbreak in 1985 to 1986, during which t he number of cases...

Objective: To investigate the clinical epi demi ology of epidemic cerebrospinal meningitis in children in recent 20 years. Methods: A retrospective analysis was conducted in 177 hospitali z ed children patients with epidemic cerebrospinal meningitis from 1984 to 2003. C hi-square test was used for statistical analysis. Results:T here were sporadic cases of children epidemic cerebrospinal meningitis in Shangh ai area. However, there was an epidemic outbreak in 1985 to 1986, during which t he number of cases accounted for 40.7%. of total patients. Most cases occurred i n spring time (from February to April). Children were predominant moving to Shan ghai from other places (70.6%) since 1993. The clinical features of most patient s belonged to “common type” (78.0%), followed by fulminant type (19.8%) and mi ld type (2.2%). Twelve cases (6.8%) died, most of whom were small infants. Total ly 67 strains of Neisseria meningitidis were isolated,with positive culture rate of 37.9% (67/177). The positive rate of cerebrospinal fluid culture was 31. 5% and that of blood culture was 18.9%.The resistance of N. meningitidis to penicillin was on the rise since 1990s. Result of bacterial typing revealed tha t 26 strains belonged to group A, 21 strains group B and 3 strains untypable. th ere were more patients occurred in children aged less than 2 and in non epidemic seasons, more severe cases and more cases complicated with subdural effusion or ventricalitis in patients with gronp B strains.Conclusion: Epidemic cerebrospinal meningitis in children mainly occurred sporadically in Sh anghai area . The majority of patients were moving to Shanghai from other places . Very few of the patients had been vaccinated with group A epidemic cerebrospin al meningitis. Therefore, prophylactic vaccination should be stressed. The third generation cephalosporins are highly active against N. meningitidis. [

目的 :了解近 2 0年上海地区儿童流行性脑脊髓膜炎 (流脑 )的流行特征及临床变迁。方法 :对 1984 - 2 0 0 3年复旦大学附属儿科医院收治的 177例流脑患儿作回顾性分析 ,统计分析采用卡方检验。结果 :近 2 0年上海地区儿童流脑主要呈散发流行 ,1985 - 1986年曾发生流行 ,病例数占总数的 4 0 .7% ,以每年 2 - 4月份为流行季节。 1993年后患儿以外来儿童居多(70 .6 % )。临床表现以普通型为主 ,占 78.0 % ,暴发型为 19.8% ,轻型为 2 .2 %。死亡 12例 (6 .8% ) ,以小婴儿为主。共分离出 6 7株脑膜炎奈瑟球菌 ,培养阳性率 37.9% ,脑脊液培养阳性率 31.5 % ,血培养阳性率 18.9%。 2 0世纪 90年代后脑膜炎奈瑟球菌对青霉素耐药率有所上升。 1984 - 1993年脑膜炎奈瑟球菌分群结果为A群 2 6例 ,B群 2 1例 ,未分群 3例。B群流脑与A群临床比较显示 2岁以下患儿病例数及非流行季节病例数所占比率均明显增高 (P <0 .0 0 1,P <0 .0 5 ) ,病情重 ,易并发硬脑膜下积液和或脑室膜炎。...

目的 :了解近 2 0年上海地区儿童流行性脑脊髓膜炎 (流脑 )的流行特征及临床变迁。方法 :对 1984 - 2 0 0 3年复旦大学附属儿科医院收治的 177例流脑患儿作回顾性分析 ,统计分析采用卡方检验。结果 :近 2 0年上海地区儿童流脑主要呈散发流行 ,1985 - 1986年曾发生流行 ,病例数占总数的 4 0 .7% ,以每年 2 - 4月份为流行季节。 1993年后患儿以外来儿童居多(70 .6 % )。临床表现以普通型为主 ,占 78.0 % ,暴发型为 19.8% ,轻型为 2 .2 %。死亡 12例 (6 .8% ) ,以小婴儿为主。共分离出 6 7株脑膜炎奈瑟球菌 ,培养阳性率 37.9% ,脑脊液培养阳性率 31.5 % ,血培养阳性率 18.9%。 2 0世纪 90年代后脑膜炎奈瑟球菌对青霉素耐药率有所上升。 1984 - 1993年脑膜炎奈瑟球菌分群结果为A群 2 6例 ,B群 2 1例 ,未分群 3例。B群流脑与A群临床比较显示 2岁以下患儿病例数及非流行季节病例数所占比率均明显增高 (P <0 .0 0 1,P <0 .0 5 ) ,病情重 ,易并发硬脑膜下积液和或脑室膜炎。结论 :目前流脑在上海地区儿童中呈散发流行 ,以外来儿童发病为主 ,发病者中A群流脑多糖疫苗接种率低 ,因此应重视预防接种。抗菌治疗以第三代头孢菌素为佳。

 
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