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haplotype groups
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  单倍型组
     The molecular phylogenetic tree of mtDNA D-loop of 8 Chinese cattle breeds was constructed by Neighbor-Joining method. The NJ tree indicated that these mtDNA sequences fell into 3 distinct haplotype groups,it also suggested in molecular level that there were probably 3 maternal origins,of which the main origins of Chinese cattle were from Bos taurus and Bos indicus.
     由此构建了中国 8个黄牛品种的NJ分子系统树 ,聚类分析表明 :所测黄牛的mtDNAD loop序列表现为3个单倍型组 ,从而揭示中国黄牛可能有 3个母系起源 ,以普通牛起源和瘤牛起源为主
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  相似匹配句对
     The haplotype and allele frequency distributions among the three groups were analyzed.
     比较分析在不同组间基因型频率、基因型组合、临床变量等的分布差异。
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     ON THE n-PATH GROUPS
     N路群
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     B, C, D, E as the experimental groups.
     A为对照组,B、C、D、E为实验组,均以双眼为实验眼。
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     And haplotype analysis
     而hap*5(TTCG)与2SNP单倍型-482T≡-455T
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     Principal Component Analysis of Y-chromosome Haplotype Distribution in 18 Ethnic Groups in Yunnan Province
     云南18个民族Y染色体双等位基因单倍型频率的主成分分析
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  haplotype groups
The promoter contains two common, highly diverged haplotype groups, P1 and P7, that differentially affect Est6 expression.
      
Our data suggestthat the 3 haplotype groups probably qualify asESUs, as they show phylogeographicdifferentiation for mtDNA variants as well assignificant divergence of allele frequencies atnuclear loci.
      
Despite therelatively small geographical scale of ourstudy, the analysis of the d-loop sequencesshows that the Flemish bullhead populationscontain 3 haplotype groups, which can beassigned to 3 previously described EuropeanmtDNA clades.
      
Nine distinct haplotypes (A1, A2, A3, B1, B2, C1, C2, D1, and D2) from this site were classified into four haplotype groups (A, B, C, and D) by parsimonious network analysis.
      
The comparisons with bovine mtDNAs were based on the central domains of the ovine control regions, representing both major ovine haplotype groups, and the corresponding domains of Bos taurus and B.
      
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Objective To observe the influence of decreasing conditioning regimen intensity on the engraftment of HLA haplotype peripheral blood stem cell transplantation. Method Twelve patients with leukemia, including 4 in complete remission, whose HLAs were full matched with donors, and 8 with refractory leukemia, whose HLAs were mismatched, were transplanted with G-CSF mobilized allogeneic peripheral blood stem cells after conditioned with a regimen consisting of fludarabine (30 mg/m 2×6 days), busulfan (4...

Objective To observe the influence of decreasing conditioning regimen intensity on the engraftment of HLA haplotype peripheral blood stem cell transplantation. Method Twelve patients with leukemia, including 4 in complete remission, whose HLAs were full matched with donors, and 8 with refractory leukemia, whose HLAs were mismatched, were transplanted with G-CSF mobilized allogeneic peripheral blood stem cells after conditioned with a regimen consisting of fludarabine (30 mg/m 2×6 days), busulfan (4 mg/kg×2 days) and cyclophosphamide (30~60 mg/kg×2 days) (FBC). Donor lymphocytes were infused at day +30,+60 and +90 after transplantation, respectively. Hematopoietic reconstitution was observed. Engraftment was documented by the analysis of short tandem repeats with polymerase chain reaction (STR-PCR). Result Patients in HLA haplotype group received a mean number of 4.87×10 8/kg donor mononuclear cells(MNC), with CD 34 + cells of 4.58×10 6/kg and patients in HLA identical group a mean number of 4.85×10 8/kg MNC with CD 34 + cells of 4.47×10 6/kg. The mean time of white blood cell count more than 1.0×10 9/L was 14 (10~18) days in HLA matched patients and 29 (11~90) days in HLA haplotype group. One three locus mismatched patient failed to engraft, but auto-hematopoiesis was recovered on day +50. Full donor chimerism was observed in all patients except one with mixed chimera. The mixed chimera was converted into full donor chimera after three times donor lymphocyte infusion. One each died from severe acute GVHD, severe VOD and severe chronic GVHD in HLA haplotype group, and one from chronic GVHD in HLA identical group. Conclusion Patients survived engraftment was not influenced by decreasing conditioning intensity as in this regimen. Haplotype stem cells could be engrafted durable in receipents by this regimen combined with donor lymphocyte infusion.

目的 观察降低预处理强度对HLA半相合异基因干细胞植入的影响。方法 用氟达拉宾 (30mg m2 × 6d)、白消安 (4mg kg× 2d)、环磷酰胺 [(30~ 6 0 )mg kg× 2d]组成FBC方案。将 12例白血病患者分成两组 ,HLA完全相合移植组 4例 ,移植前患者处完全缓解状态 ;HLA半相合移植组 8例 ,皆为难治性白血病 ,其中 1例HLA 3个位点不合 ,6例二个位点不合 ,1例一个位点不合 ,接受本处理方案后 ,进行G CSF动员的异基因外周血干细胞移植 ,并于移植后第 30天 (+30天 )、+6 0天、+90天输注供者淋巴细胞 ,观察异基因干细胞植入和长期植入情况。结果 HLA半相合组患者平均接受 4.87× 10 8 kg供者外周血单个核细胞 ,其中CD3 4+细胞平均数为 4.5 8× 10 6 kg,HLA全相合组平均接受 4.85× 10 8 kg供者外周血单个核细胞 ,其中CD3 4+细胞 4.47× 10 6 kg。HLA半相合组 7例白细胞升至 1.0×10 9 L的平均时间为 2 9d(11~ 90d) ,血小板升至 2 0× 10 9 L的时间为 36d(14...

目的 观察降低预处理强度对HLA半相合异基因干细胞植入的影响。方法 用氟达拉宾 (30mg m2 × 6d)、白消安 (4mg kg× 2d)、环磷酰胺 [(30~ 6 0 )mg kg× 2d]组成FBC方案。将 12例白血病患者分成两组 ,HLA完全相合移植组 4例 ,移植前患者处完全缓解状态 ;HLA半相合移植组 8例 ,皆为难治性白血病 ,其中 1例HLA 3个位点不合 ,6例二个位点不合 ,1例一个位点不合 ,接受本处理方案后 ,进行G CSF动员的异基因外周血干细胞移植 ,并于移植后第 30天 (+30天 )、+6 0天、+90天输注供者淋巴细胞 ,观察异基因干细胞植入和长期植入情况。结果 HLA半相合组患者平均接受 4.87× 10 8 kg供者外周血单个核细胞 ,其中CD3 4+细胞平均数为 4.5 8× 10 6 kg,HLA全相合组平均接受 4.85× 10 8 kg供者外周血单个核细胞 ,其中CD3 4+细胞 4.47× 10 6 kg。HLA半相合组 7例白细胞升至 1.0×10 9 L的平均时间为 2 9d(11~ 90d) ,血小板升至 2 0× 10 9 L的时间为 36d(14~ 96d) ,1例HLA 3个位点不合的患者移植失败 ,但该患者于 +5 0天恢复自体造血。而HLA全相合的 4例患者白细胞升至 1.0×10 9 L平均需 14d(11~ 18d) ,血小板升至 2 0× 10 9 L平均需 15d(11~ 18d)。经STR PCR检测 ,两组患者除 1例表现为混合嵌合体 ,其余均呈完

The complete mitochondrial D-loop sequences,910 bp in length,in 22 individuals from 8 cattle breeds in China were analyzed.The results showed that A%+T% was about 61.65%.Comparisons of these 22 sequences revealed 66 polymorphic sites,and 5 types of mutation,transition,transversion,insertion,deletion and coexistence site of transition and transversion were observed,with the percentage of 81.82%,6.06%,7.57%,3.03%,1.52%,respectively.In reference to complete mtDNA D-loop of the European cattle as a control,eight...

The complete mitochondrial D-loop sequences,910 bp in length,in 22 individuals from 8 cattle breeds in China were analyzed.The results showed that A%+T% was about 61.65%.Comparisons of these 22 sequences revealed 66 polymorphic sites,and 5 types of mutation,transition,transversion,insertion,deletion and coexistence site of transition and transversion were observed,with the percentage of 81.82%,6.06%,7.57%,3.03%,1.52%,respectively.In reference to complete mtDNA D-loop of the European cattle as a control,eight Chinese cattle breeds were classified into 3 groups according to the average percentage of D-loop nucleotide variations.The lowest average percentage of mtDNA D-loop nucleotide variation was in Xizhen cattle,Mongolian cattle,Holstein,Qinchuan cattle with 0.37%,0.44%,0.52%,0.66%,the mediate in Nanyang cattle and Jiaxian cattle with 1.91%,2.02% and the highest in Jinnan cattle and Yueyang cattle with 4.47%,4.73%,respectively.The average sequence divergence estimated from D-loop region within breeds and among breeds in China varied from 0.55%~5.39% and 1.21%~6.59%,respectively.Comparisons of these 22 sequences revealed 19 mitochondrial haplotypes,the percentage of haplotype was (86.36%,)showing that abundant mitochondrial genetic diversity exists in Chinese cattle.The molecular phylogenetic tree of mtDNA D-loop of 8 Chinese cattle breeds was constructed by Neighbor-Joining method.The NJ tree indicated that these mtDNA sequences fell into 3 distinct haplotype groups,it also suggested in molecular level that there were probably 3 maternal origins,of which the main origins of Chinese cattle were from Bos taurus and Bos indicus.

对我国 8个黄牛品种 2 2个个体的mtDNAD loop区 910bp全序列进行了分析。结果表明 :8个黄牛品种D loop区序列中 ,A +T平均含量为 6 1 6 5 % ;经比对 ,共检测到 6 6个核苷酸多态位点 ,约占核苷酸总数的 7 2 5 % ;D loop全序列突变类型有 5种 ,即转换、颠换、插入、缺失及转换与颠换共存 ,它们分别占核苷酸多态位点的 81 82 %、6 0 6 %、7 5 7%、3 0 3%及 1 5 2 %。以欧洲牛mtDNAD loop全序列为标准 ,8个黄牛群体D loop的平均核苷酸变异率分 3个层次 :西镇牛、蒙古牛、黑白花牛及秦川牛的核苷酸变异率最低 ,分别为 0 37%、0 4 4 %、0 5 2 %和 0 6 6 % ;南阳牛与郏县红牛的核苷酸变异率居中 ,分别为 1 91%和 2 0 2 % ;晋南牛与岳阳牛的核苷酸变异率最高 ,分别为4 4 7%和 4 73%。中国黄牛品种内D loop区序列歧异度为 0 5 5 %~ 5 39% ,品种间序列歧异度为 1 2 1%~ 6 5 9%。在所测黄牛个体中 ,mtDNAD loop序列由 ...

对我国 8个黄牛品种 2 2个个体的mtDNAD loop区 910bp全序列进行了分析。结果表明 :8个黄牛品种D loop区序列中 ,A +T平均含量为 6 1 6 5 % ;经比对 ,共检测到 6 6个核苷酸多态位点 ,约占核苷酸总数的 7 2 5 % ;D loop全序列突变类型有 5种 ,即转换、颠换、插入、缺失及转换与颠换共存 ,它们分别占核苷酸多态位点的 81 82 %、6 0 6 %、7 5 7%、3 0 3%及 1 5 2 %。以欧洲牛mtDNAD loop全序列为标准 ,8个黄牛群体D loop的平均核苷酸变异率分 3个层次 :西镇牛、蒙古牛、黑白花牛及秦川牛的核苷酸变异率最低 ,分别为 0 37%、0 4 4 %、0 5 2 %和 0 6 6 % ;南阳牛与郏县红牛的核苷酸变异率居中 ,分别为 1 91%和 2 0 2 % ;晋南牛与岳阳牛的核苷酸变异率最高 ,分别为4 4 7%和 4 73%。中国黄牛品种内D loop区序列歧异度为 0 5 5 %~ 5 39% ,品种间序列歧异度为 1 2 1%~ 6 5 9%。在所测黄牛个体中 ,mtDNAD loop序列由 19种单倍型组成 ,单倍型比例为 86 36 % ,说明中国黄牛mtDNA遗传多态性很丰富。由此构建了中国 8个黄牛品种的NJ分子系统树 ,聚类分析表明 :所测黄牛的mtDNAD loop序列表现为3个单倍型组 ,从而揭示中国黄牛可能有 3个母系起源 ,以普通牛起源和瘤牛起源为主

Objective To investigate the association between genetic polymorphisms of mannose binding lectin (MBL) gene and pulmonary tuberculosis (P.tb) infection in Chinese Han Nationality. Methods A case control study was performed. The genotype and haplotype of four MBL single nucleotide polymorphisms (A/B, H/L, Y/X and P/Q) were determined using sequence specific priming-polymerase chain reaction (PCR-SSP) technique and PCR-sequence specific oligonucleotide probe (PCR-SSOP) assay. The genotype and haplotype...

Objective To investigate the association between genetic polymorphisms of mannose binding lectin (MBL) gene and pulmonary tuberculosis (P.tb) infection in Chinese Han Nationality. Methods A case control study was performed. The genotype and haplotype of four MBL single nucleotide polymorphisms (A/B, H/L, Y/X and P/Q) were determined using sequence specific priming-polymerase chain reaction (PCR-SSP) technique and PCR-sequence specific oligonucleotide probe (PCR-SSOP) assay. The genotype and haplotype frequencies were compared between P. tb cases and controls using an unconditional logistic regression model. Results 133 patients and 177 healthy subjects were recruited. Multifactoral logistic analysis disclosed MBL-HH and LL genotypes were significantly associated with the protection from the disease, with the adjusted OR (95%CI) to be 0.54(0.30-0.95) and 0.50(0.26-0.96), respectively. The XB haplotype group was present at a significantly higher frequency in the patients group than those with the YA group, with OR (95%CI) of1.60(1.07-2.41). Conclusion The sequence variations in the MBL gene might be associated with the susceptibility to P. tb in the Chinese Han Nationality.

目的探讨甘露糖结合凝集素(MBL)基因多态性与中国汉族人群肺结核发病间的关联。方法采用以医院为基础的病例对照研究设计,对结核病相关危险因素进行问卷调查。联合应用引物序列特异性PCR(PCR-SSP)和序列特异性寡核苷酸探针杂交(PCR-SSOP)等方法对MBL基因H/L、X/Y、P/Q和A/B四个多态性位点进行基因型分析及单倍体型分析。将各位点的基因型或单倍体型在病例组和对照组的分布进行比较,并将有显著作用的环境危险因素纳入进行多因素非条件logistic回归分析。结果 133名肺结核病例和177名对照纳入本研究,多因素分析调整结核病暴露史和疫苗接种史两个因素后,MBL基因的HL和LL基因型与疾病的保护作用显著相关,调整OR值(95%CI)分别为0.54(0.30-0.95)和0.50(0.26-0.96)。MBL基因XB组单倍体型与中国汉族人群肺结核发生的易感性显著相关,调整OR值(95%CI)为1.60(1.07-2.41)。而其余多态性位点,包括X/Y、P/Q和A/B位点与肺结核的发生均无显著性关联。结论中国汉族人群MBL基因多态性可能与汉族人群肺结核发生的易感性显著相关。

 
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