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drug encapsulated
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  药物包封
     RESULTS:The particle diameters of 88.6% C GMS were between 5 and 25 μm,drug encapsulated ratio was 79.2%, in vitro the drug cumulative release ratio during 8h was 95% and the C GMS had a good lung targeting.
     结果 :所制备微球 88.6%的粒径在 5~ 2 5μm,药物包封率为 79.2 % ,8小时体外药物累积释放百分率达 95 %并有良好的靶向性。
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  “drug encapsulated”译为未确定词的双语例句
     The effect of osmolality on fragility of carrier erythrocyte and the ferrohemogl obin overflowed rate in the process of drug encapsulated into human erythrocyte by hypertonic method
     红细胞载体的渗透脆性及血红蛋白溢出率研究
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  相似匹配句对
     The Progress of Research on Protein-drug Encapsulated in Liposome
     脂质体包裹蛋白质药物的制备及影响因素的控制
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     pylori drug.
     pylori药物. 方法:将建立H.
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     Drug Contraception
     药物避孕
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     Preparation of Polylactic Acid Encapsulated RFP Microspheres and Drug-Releasing Performance
     聚乳酸载利福平微球的制备及其释药性能
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  drug encapsulated
Hypotonic dialysis resulted in 0.3 mg drug encapsulated per milliliter of RBC.
      
administration of drug encapsulated in egg phosphatidylcholine/cholesterol
      
When attached to drug-encapsulated nanoparticles such as liposomes, CaP-specific scFv are expected to deliver the liposomes to the tumor cytosol.
      
Using insulin and coumarin-6 as examples, drug encapsulated PLGA nanospheres were prepared by the spherical crystalliza tion method.
      
The percentage of hydrophilic drug encapsulated by liposomes depends on the liposome bilayer composition and preparation procedure.
      
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OBJECTIVE: To elucidate the mechanism of protein drugs encapsulated by polyalkylcyanoa crytale(PACA)nanoparticles,specifically,we used insulin and took out a series of in vitro investigations on these nanoparticles.METHODS: Size-exclusive chromatography was used to separate freeand encapsulated insulin molecules.Insulin concentration was measured by radioimmunoassay (RIA).Insulin associated to nanoparticles was digested by trypsin. 125 I insulin nanoparticles were dissolved by acetonitrile...

OBJECTIVE: To elucidate the mechanism of protein drugs encapsulated by polyalkylcyanoa crytale(PACA)nanoparticles,specifically,we used insulin and took out a series of in vitro investigations on these nanoparticles.METHODS: Size-exclusive chromatography was used to separate freeand encapsulated insulin molecules.Insulin concentration was measured by radioimmunoassay (RIA).Insulin associated to nanoparticles was digested by trypsin. 125 I insulin nanoparticles were dissolved by acetonitrile and radioactivity distribution was measured by γ Counter.An “antibody capture”procedure was devised.RESULTS: Most insulin (80%) was associated with nanoparticles. This was not due to adsorption,but through tight conjunction. Although the encapsulated insulin was on the surface of the nanoparticles,it could be measured by RIA and was partially resistant to trypsin degradation.When nanoparticles were dissolved,most of the insulin was not free in the solution,but was associated with the dissolved polymer.Finally,we used anti insulin antibody to react with the encapsulated insulin,and this led to capture of the nanoparticles as well,which could be detected by scanning electron microscope (SEM).CONCLUSION: Our results strongly suggested that the insulin was on the surface Of PACA nanoparticles,possibly through covalent bond to the polymer.

目的:为得到稳定有效的口服胰岛素制剂,对氰基丙烯酸异丁酯包裹胰岛素的机制进行了一系列的体外研究。方法:用凝胶层析法分离纳米包裹颗粒和游离的胰岛素,结合RIA法、放射标记示踪以及作者设计的“抗体捕捉”实验,以阐明氰基丙烯酸异丁酯包裹胰岛素纳米颗粒的结构。结果:大部分胰岛素分子(80%)与形成的纳米包裹颗粒紧密相连,处于包裹颗粒的表面,可以用RIA法测到,而且对蛋白酶降解有一定抵抗作用。用乙腈溶解包裹颗粒,大部分胰岛素分子(84%)并不在溶液中,而与聚合物相连。用抗胰岛素抗体与包裹胰岛素的颗粒反应,可以在电镜下观察到包裹颗粒被抗体捕获。结论:这些结果表明胰岛素分子并未被包裹于颗粒内部,也不是以简单吸附的方式与包裹颗粒相连,而可能通过共价结合的方式与氰基丙烯酸酯聚合物相结合

The study of more than 10 cancer drugs encapsulated in liposome worldwide,belonging to four kinds of compounds plant derived semisynthesized products, antibiotics, antimetabolites and proteins, was introduced.

按源于植物的半合成药物、抗生素、抗代谢药及蛋白质药物等四种类型,介绍了10多个以脂质体为载体的抗癌药物的国外研究概况。

OBJECTIVE:To investigate gelatin microspheres loaded carboplatin ( C GMS) for lung targeting.METHOD: C GMS were prepared with the emulsifing method and some factors affecting the technology were analysed with the orthogonal test design. The sustained release of C GMS was studied through the delivery test in vitro. Lung targeting was tested preliminarily by the distribution of C GMS in different tissues in rabbits. RESULTS:The particle diameters of 88.6% C GMS were between 5 and 25...

OBJECTIVE:To investigate gelatin microspheres loaded carboplatin ( C GMS) for lung targeting.METHOD: C GMS were prepared with the emulsifing method and some factors affecting the technology were analysed with the orthogonal test design. The sustained release of C GMS was studied through the delivery test in vitro. Lung targeting was tested preliminarily by the distribution of C GMS in different tissues in rabbits. RESULTS:The particle diameters of 88.6% C GMS were between 5 and 25 μm,drug encapsulated ratio was 79.2%, in vitro the drug cumulative release ratio during 8h was 95% and the C GMS had a good lung targeting.CONCLUSION:The C GMS for lung targeting prepared through the emulsifing method would have a good exploitation.

目的 :研制卡铂肺靶向微球。方法 :用乳化法制备卡铂微球 ,正交试验设计考察影响制备工艺的因素 ,体外释药试验研究其缓释性 ,以微球在家兔的体内分布初步考察其靶向性。结果 :所制备微球 88.6%的粒径在 5~ 2 5μm,药物包封率为 79.2 % ,8小时体外药物累积释放百分率达 95 %并有良好的靶向性。结论 :用乳化法制备的卡铂肺靶向微球有良好的应用研究前景。

 
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