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patients with major depression
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  抑郁症患者
     Methods The genotypes and allelic frequencies of the 5 HT 6 receptor gene were examined with polymerase chain reaction and restriction fragment length polymorphism techniques in 89 patients with major depression and 90 unrelated healthy controls.
     方法 应用聚合酶链反应 (PCR)和限制性片段长度多态性 (RFLP)技术 ,对 89例抑郁症患者 (抑郁症组 )和 90名正常对照者 (对照组 )的 5 HT6受体基因多态性 (2 6 7C/T)进行了检测。
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     MRI and MRS of limbic system in patients with major depression
     抑郁症患者边缘系统异常的MRI和MRS分析
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     Methods:15 patients with major depression co morbidity anxiety(study group) and 15 patients with major depression(control group) diagnosed by DSM-IV were involved in the study using polymerase chain reaction (PCR) and restriction fragment length polymorphism(RFLP) technique.
     方法:应用聚合酶链反应(PCR)和限制性片段长度多态性(RFLP)技术,检测15例重性抑郁症共病焦虑障碍患者(研究组)和15例单纯诊断为重性抑郁症患者(对照组)的COMT基因多态性。
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     Methods: By using a gene-based association analysis of single-nucleotide polymorphisms(SNPs),rs242939 SNPs were identified in CRHR1 gene and genotyped in the diagnosed samples of 206 unrelated patients with major depression and 195 matched health control subjects.
     方法:采用基于Taqman-MGB的荧光定量PCR方法,检测206例抑郁症患者以及195例正常对照者的CRHR1基因rs242939位点单核苷酸多态性,分析该等位基因、基因型频率是否与抑郁症关联。
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     Methods:60 patients with major depression were treated with Luvox and Amitriptyline randomly and the doses were 100~300mg/d and 75~225 mg/d respectively. HAMD,CGI,TESS were evaluated before treatment and at the end of 2,4,6,8 weeks after the treatment.
     方法 :将 6 0例抑郁症患者随机入组 ,兰释最高剂量 10 0mg~ 30 0mg d ,阿米替林最高剂量 75mg~ 2 2 5mg d ,采用HAMD、CGL、TESS量表 ,在用药前及用药后 2、4、6、8周末评定。
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  “patients with major depression”译为未确定词的双语例句
     Methods: In a randomized,double-blind and comparative-controlled study,200 patients with major depression (ICD-10 criteria) were randomized to receive imipramine (75-250mg·d-1) or moclobemide(300-600mg·d-1)for a 6-week course of therapy.
     方法:采用双盲对照研究方法将200例符合ICD-10抑郁障碍诊断标准的住院或门诊患者,随机分组接受吗氯贝胺(300-600mg·d-1)或丙咪嗪(75-250mg·d-1)治疗6周。
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     Personality characteristics and suicidal behaviors in patients with major depression
     抑郁症自杀行为与个性特征的关系
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     A controlled study on bone mineral density between patients with major depression and healthy subjects
     抑郁症病人与正常人骨矿物质密度的对照研究
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     A study on the risk factors of suicidal behaviors in patients with major depression.
     抑郁症自杀行为的相关危险因素研究
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     Conclusions: The polymorphism of gene in the patients with major depression co morbidity anxiety deserved us to study further.
     结论:抑郁与焦虑共病的基因多态性研究值得进一步深入研究。
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  相似匹配句对
     As to the patients;
     患者年龄13~76岁。
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     The patients were
     记录患者平卧10 min(T0)、
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     Ophthalmoplegia in patients with diabetes
     糖尿病性眼肌麻痹17例临床分析
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     Psychoanalysis and Psychotherapy of the patients with ED
     心因性勃起功能障碍患者的心理治疗结果分析(附13例报告)
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     Depression in Patients with Stroke
     脑卒中患者抑郁情绪的初步调查
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  patients with major depression
We found no significant difference in the mean midbrain SERT availability between the studied patients with major depression and healthy controls (0.86 ± 0.27 vs.
      
21 non-medicated patients with major depression and 13 healthy controls were examined by [123I]-ADAM SPECT.
      
We studied the midbrain SERT availability in patients with major depression and assessed the relation of SERT occupancy by citalopram to the treatment response.
      
Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT ligand [1
      
Patients with other depressions like schizoaffective psychosis -depressive subtype- or organic brain syndrome with depressive symptomatology demonstrated similar postbetamethasone cortisol profiles as the group of patients with major depression.
      
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Somatosensory perception threshold (SPT),pain perception threshold (PPT)and the relative pain perception threshold (RPPT) were studied in 30 patients with major depression,compared with the findings in a control group and related to the psychopathological state evaluated by means of the Hamilton Depression Scale (HAMD).We found that SPT,PPT were increased in the patients:SPT,PPT,RPPT, and HAMD or HAMD subscores were not significantly correlated with each other; SPT, PPT, RPPT were nonsignificantly...

Somatosensory perception threshold (SPT),pain perception threshold (PPT)and the relative pain perception threshold (RPPT) were studied in 30 patients with major depression,compared with the findings in a control group and related to the psychopathological state evaluated by means of the Hamilton Depression Scale (HAMD).We found that SPT,PPT were increased in the patients:SPT,PPT,RPPT, and HAMD or HAMD subscores were not significantly correlated with each other; SPT, PPT, RPPT were nonsignificantly decreased in the recovery from major deperssion.The data suggested that the increase of absolute perception thresholds in depressive patients maybe correlated with the change of the endogenous opiate pain-modulating system.

比较30例重症抑郁病人与正常对照组的躯体感觉阈(SPT)、痛觉阈(PPT)及相对痛觉阈(RPPT),并评定汉密尔顿郁量表(HAMP),观察抑郁程度与痛觉阈值改变的相关性。发现重症抑郁病人SPT和PPT明显高于正常对照组;SPT、PPT、RPPT值与HAMD总分和各因子分之间无明显相关;重症抑郁发作期与缓解期的SPT、PPT和RPPT值的自身对比无显著差异。推测绝对知觉阈的增高可能与抑郁症患者体内鸦片样物质系统的功能改变有关。提示内源性疼痛调节系统与抑郁症病理基础既有内在联系,又有相对的独立性,故疼痛可作为抑郁的躯体症状,也可继发或加重抑郁。

The study was designed to examine the prevalence of attempted suicide in patients with major depression and the associated risk factors. A self-design register form for depression and suicide, and Hamilton Depression rating scales (HAMD) were used in 212 inpatients who met the diagnostic criteria for major depression, described in the revision of the 2nd edition of the Chinese Classification and Diagnostic Criteria of Mental Disorders (CCMD-2-R). SPSS and PEMS procedures were used...

The study was designed to examine the prevalence of attempted suicide in patients with major depression and the associated risk factors. A self-design register form for depression and suicide, and Hamilton Depression rating scales (HAMD) were used in 212 inpatients who met the diagnostic criteria for major depression, described in the revision of the 2nd edition of the Chinese Classification and Diagnostic Criteria of Mental Disorders (CCMD-2-R). SPSS and PEMS procedures were used to perform all statistic analyses. Among 212 patients, 158 cases (74.5%) had suicidal idea and 67 cases (31.6%) had attempted suicied. Taking overdose drugs (47.8%) was the main pattern of suicide. Most of suicide (77.6%) took place inside the rooms. The mean total HAMD scores was significantly higher in attempted suicide subgroup than in non-suicide subgroup. A significantly positive correlation of attempted suicide and hopelessness, depression, inferiority complex and insight in HAMD was noted. The stepwise regression analysis showed that important risk factors involved in attempted suicide were hopeless, depression, inferiority complex and insight shown in HAMD, successively. There was a close relationship between major depression and attempted suicide. The suicide incidence of patinents with frequent suicidal idea was higher than that of those without suicidal idea.

为了获得抑郁症病人的自杀未遂发生率及其危险因素,采用自制的抑郁症与自杀的关系登记表和Hamilton抑郁量表,分别对符合中国精神疾病分类方案与诊断标准第2版修订本的212例住院的抑郁症病人进行调查评分,然后用SPSS和PEMS软件包进行统计分析。结果:在212例抑郁症病人中发生自杀观念158例(74.5%),自杀未遂67例(31.6%)。在自杀未遂组中的自杀方式以过量服药为主(47.8%),自杀地点多在室内(77.6%)。自杀未遂组的抑郁症状评分高于无自杀行为组(t=7.27,P<0.01)。自杀与绝望感、抑郁情绪、自卑感、自知力等呈正相关。逐步回归分析发现,绝望感对自杀的影响最大,其次是抑郁情绪,再次是自卑感和自知力。提示抑郁症与自杀的关系密切,频繁出现≥3次自杀观念的抑郁症病人发生自杀行为的可能性较大。

The purpose of the study was to determine the effectiveness of fluoxetine (Prozac) in patients with major depression and to evaluate its safety. Treatment with fluoxetine in 59 patients was compared with treatment with amitriptyline in 51 patients in a multicenter, randomized, 6-week open trial study. All patients who entered into the study met DSM-III-R criteria for major depression, with a score at least 18 on the 21-item Hamilton Depression Rating Scale (HAMD). The...

The purpose of the study was to determine the effectiveness of fluoxetine (Prozac) in patients with major depression and to evaluate its safety. Treatment with fluoxetine in 59 patients was compared with treatment with amitriptyline in 51 patients in a multicenter, randomized, 6-week open trial study. All patients who entered into the study met DSM-III-R criteria for major depression, with a score at least 18 on the 21-item Hamilton Depression Rating Scale (HAMD). The age of the patients ranged 19~64 years. HAMD, Clinical Global Impression (CGI) and Treatment Emergent Symptom Scale (TESS) were used to assess the therapeutic efficacy and side effect. The result showed that fluoxetine was as effective as amitriptyline for the treatment of major depression, with a positive resonse between 2 and 4 week and a significant improvement rate of 83.0%. Fewer side effects were noted with fluoxetine treatment than with amitriptyline. The results indicated that fluoxetine was effective in the treatment of major depression and was generally well tolerated.

为观察进口氟西汀(百忧解)对中国抑郁症病人的疗效和不良反应,进行了多中心开放性对照研究,对照药物为阿米替林。共110例,其中氟西汀治疗59例,阿米替林治疗51例。年龄19~64岁,符合美国精神障碍诊断统计手册第3版修订版抑郁症诊断标准,Hamilton抑郁量表(HAMD,21项)≥18分,疗程6周。予临床疗效评定和HAMD、临床总体评定量表、副反应量表评定。结果显示,氟西汀抗抑郁疗效肯定,显效率(83.0%)与阿米替林相近,见效时间2~4周,不良反应明显低于阿米替林。提示氟西汀治疗抑郁症有效、安全。

 
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