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clinical doses
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  临床剂量
     Conclusion After the intestinal I-R,the different clinical doses of propofol have protective effects on the lungs against intestinal I-R-induced injury.
     结论小肠I-R后,不同临床剂量异丙酚可以不同程度地减轻肺组织损伤。
短句来源
     Objective To research the functions of different clinical doses of propofol on the lung injury induced by intestinal ischemia-reperfusion(I-R) in rats.
     目的研究不同临床剂量异丙酚对大鼠小肠缺血再灌注(I-R)中肺损伤的作用。
短句来源
     Conclusion It is concluded that at the concentrations achieved with usual clinical doses, thiopental\, promethazine and droperidol can inhibit the VDC whereas ketamine and fentanyl can not.
     结论 临床剂量的硫喷妥钠、异丙嗪、氟哌利多可抑制VDC的开启,而临床剂量的氯胺酮、芬太尼则不能抑制VDC的开启。
短句来源
     Conclusion The increase in the gene expression of ICAM-1 in the lung vascular endothelial cells plays an important role in acute lung injury induced by intestinal I/R and the clinical doses of propofol have protective effects on the lungs against intestinal I/R-induced injury by inhibiting the ICAM-1 gene expression.
     结论 小肠I-R后肺血管内皮细胞细胞间粘附分子-1表达增高是引起肺组织内中性粒细胞粘附的重要机制,在小肠I-R后肺损伤过程中起重要作用; 临床剂量异丙酚可以不同程度地抑制其表达,减轻肺组织损伤。
短句来源
     Conclusion Ca2+ plays an important role in the lung injury induced by intestinal ischemia reperfusion and the clinical doses of propofol can reduce lung tissue Ca2+ content and have protective effect on the pulmonary ultrastructure.
     结论 钙离子在大鼠小肠缺血再灌注后肺损伤中有重要作用,临床剂量异丙酚可明显降低肺组织钙离子含量,并对肺组织超微结构产生保护作用。
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  “clinical doses”译为未确定词的双语例句
     Varied clinical doses of Ara-C are applied, including small dose (20 m g/m2/d), regular dose (100-150mg/m2/d), medium dose (0.5-1.0g/m2/d) and large dose(1.0-3.0g/m2/each ,two each for one day ).
     Ara-C临床使用剂量相差数十倍,甚至数百倍,其临床用量分别为小剂量Ara-C20mg/m~2/d,常规剂量100-150mg/m~2/d,中剂量0.5-1.0g/m~2/d,大剂量1.0-3.0g/m~2/次,每日二次。
短句来源
     The usual clinical doses were used both in GM group and GM+LAP group in order to observe the safety and effect of the mixed drug.
     1.GM组不同频率下的ABR闭移分别为:IkHz 15一18dB,skHz17一ZOdB,GM+LAP组的阂移分别为:IkHzg一15dB,skHz 10一15dB。 两组间差异显著(尸<0.05)
短句来源
     The adverse reactions of clinical doses of kanamycin can be reduced by the addition of TMP.
     为降低卡那霉素临床用量,达到降低其毒副反应,但尚保持或提高疗效的目的。
短句来源
     Results significant alteration with decreasing percentage of G 1 phase and increasing percentage of G 2 phase of SGC 7901 cell line could be detected after incubating 24 hours with omeprazole at double clinical doses . An apoptosis peak appeared in flow cytometry after incubating 72 hours with omeprazole.
     结果 奥美拉唑作用 2 4h引起SGC 790 1细胞周期发生显著改变 ,G1期百分比减少 ,G2 期百分比增加 ,以后者改变较明显 ,然无细胞凋亡峰出现 ,作用 72h出现细胞凋亡峰。
短句来源
     In part of patients,the levels of serum Cl - and Na + increased temporarily and restored after 24 hours. CONCLUSION: HSS40 was safe and effective in doses of 80ml - 500ml. The clinical doses of 300ml- 500ml are recommended.
     部分受试者血氯、血钠水平有一过性升高,给药后24小时恢复正常结论:HSS40在剂量为80ml~500ml范围内,安全有效,推荐临床用药剂量为300ml~500ml
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  相似匹配句对
     Clinical Observation of Postoperative Analgesia with Diverse Doses of Tramadol
     不同剂量曲马多用于术后静脉镇痛的效果观察
短句来源
     Clinical study on treating dyslipidemia with two doses of Xuezhikang
     2种剂量血脂康胶囊治疗高脂血症的临床研究
短句来源
     In clinical stage C and D.
     其中C、D期与A、B期相比有显著性差异(P<0.01)。
短句来源
     and its clinical significance.
     本研究探讨其在乳腺癌中的作用及临床意义。
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  clinical doses
To test the specificity of fenfluramine in humans with clinical doses, we compared plasma homovanillic acid (pHVA) concentration in healthy volunteers after administration of fenfluramine (60 mg) and placebo.
      
We treated animals with haloperidol and clozapine in clinical doses to investigate the effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits.
      
The effect of clinical doses of etintidine on the disposition of a single oral dose of propranolol was investigated in 12 normal subjects.
      
These dose-dependent clearances for chlorothiazide were found at doses parallel to the most often prescribed clinical doses in humans on a g chlorothiazide per kg body weight basis.
      
We conclude that the wound healing process may be effected by topically applied lidocaine, administered in clinical doses, at least via interference with leukocyte oxygen metabolism.
      
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Toxic hepatitis was induced with carbon tetrachloride in mice. L-4-oxalysine (I-677) l00mg/kg injected daily has been proved to be effective in lowering the serum glutamic-pyruvate transaminase (SGPT) level in both aoute and subacute liver injuries. Pathological examinations also showed that the degeneration and necrosis of liver cells were protected by the administration of I-677. In the course of inducing experimental liver oirrhosis with CCl_4, I-677 administered for 8 weeks affected neither liver function...

Toxic hepatitis was induced with carbon tetrachloride in mice. L-4-oxalysine (I-677) l00mg/kg injected daily has been proved to be effective in lowering the serum glutamic-pyruvate transaminase (SGPT) level in both aoute and subacute liver injuries. Pathological examinations also showed that the degeneration and necrosis of liver cells were protected by the administration of I-677. In the course of inducing experimental liver oirrhosis with CCl_4, I-677 administered for 8 weeks affected neither liver function besides a lowering of serum bilirubin, nor liver collagen content and histological appearance. The mechanism of serum GPT-lowering was found to be a lowering of hepatic enzyme activity. No direct inhibition on the activity of both liver and serum GPT was observed in vitro. The transaminase-lowering effect of I-677 could not be antagonized by simultaneous administrations of L-lysine. Amino-oxyacetic acid, a GPT inhibitor, showed potent inhibition on the GPT activity in vitro, but not in vivo. Large doses of I-677 (8-32 times the clinical dose) for 11 weeks in rats induced a lowering of serum albumin, a decrease of incorporation of ~3H-lysine into serum protein, and an increase of the lipid of liver. This revealed that albumin synthesis and lipid transport function of liver were inhibited by I-677, but this effect could be antagonized by L-lysine.

用四氯化碳引起小白鼠中毒性肝炎,同时每天注射I-677 100毫克/公斤,对一次中毒的急性肝损伤或反复中毒5次疗程15天的亚急性肝损伤都有明显的降低血清谷丙转氨酶(GPT)作用,病理切片证明肝细胞变性和坏死程度都较对照组为轻。在四氯化碳中毒连续8周引起肝硬化的过程中,每日给予I-677,除血清胆红素降低外,对其他肝功能、肝胶元含量和肝组织切片检查,均无明显影响。I-677作用机理的研究发见,血清GPT的降低与肝组织GPT的降低有关,同时给予L-赖氨酸,不能对抗其降酶作用。I-677与肝匀浆或高GPT血清在体外培养,未观察到对GPT的直接抑制作用。与GPT抑制剂氨氧醋酸比较,后者在体外有明显抑制GPT作用而体内则无降酶效果。大白鼠每日灌胃I-677 80~320毫克/公斤(临床剂量的8~32倍),连续11周,可引起血清白蛋白的降低和丙球蛋白的升高。用氚标记赖氨酸对蛋白的掺入试验也证明,大剂量I-677对肝脏的蛋白质合成和脂肪转运有一定影响,但这种作用可被赖氨酸所对抗。

A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.In mice,rats and rabbits implantation was totally inhibitedwhen the drug was orally administered from day 2 of pregnancy at a daily dose of 0.51,and 2 mg/kg respectively for 3 days.The same effect could also be demonstrated in rats receiving a single dose of 5 or 10mg/kg of the drug on day 2 or 3 of pregnancy.4 healthy rabbits used for testing the toxicity received the drug orally at a dose...

A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.In mice,rats and rabbits implantation was totally inhibitedwhen the drug was orally administered from day 2 of pregnancy at a daily dose of 0.51,and 2 mg/kg respectively for 3 days.The same effect could also be demonstrated in rats receiving a single dose of 5 or 10mg/kg of the drug on day 2 or 3 of pregnancy.4 healthy rabbits used for testing the toxicity received the drug orally at a dose of 10mg/kg/day(about 500 times as much as the clinical dose)for 3 weeks,and all were nor-mal in blood routine and renal function tests but a raised change was shown in their liverfunction(completely restored 2 weeks after cessation of the drug).3 dogs were given the drug at the dose of 1-2 mg/kg/day(about 50-100 times as muchas the clinical dose )for 14 months,no obvious toxic effect being observed.

醋炔诺酮肟对实验动物有明显的抗着床作用。小鼠、大鼠和家兔在妊娠第2天起,分别给予醋炔诺酮肟0.5、1和2毫克/公斤,每天一次,连续3天,均有显著的抗着床作用。大鼠在妊娠第2或3天一次给醋炔诺肟酮5或10毫克/公斤,亦有明显的抗着床作用。家兔4只,每日灌服醋炔诺酮肟10毫克/公斤(约为临床剂量500倍),连续3周,给药后肝功能升高,停药2周后恢复正常,血象和肾功能均无明显变化。犬3只,每日灌服醋炔诺酮肟1~2毫克/公斤(约为临床剂量50~100倍),连服14个月,无明显毒性。

The adverse reactions of clinical doses of kanamycin can be reduced by the addition of TMP. Petri dish tests were performed with B. subtilis as test organism. The optimal composition was found to be ] mi-crogram of TMP for 20 units of kanamycin. The M.I. C. of kanamycin against E.coli., Proteus sp. and pseudomonas aeruginosa were ncreased by 2-4 folds in this compound pre-

为降低卡那霉素临床用量,达到降低其毒副反应,但尚保持或提高疗效的目的。通过平皿试验,以枯草杆菌为检定菌株,优选TMP增效卡那霉素抗菌作用的最适宜比例;不同比例卡那霉素与定量TMP组合的最佳抗菌作用。结果表明卡那霉素与TMP之比为20u:1μg制剂最为理想。其对大肠杆菌、变形杆菌、绿脓杆菌可增效2~4倍;但对金黄色葡萄球菌、八叠球菌不显示增效作用。复方中的TMP不影响卡那霉素与血清蛋白的结合率;对小鼠保护试验结果表明复方卡那霉素的作用强于卡那霉素;但对家鸽平均致死量及对小鼠的LD_(50),两药比较其t值均无显著差异。

 
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